An in silico approach for understanding the molecular evolution of clinically important metallo-beta-lactamases

Infection, Genetics and Evolution

Volumn 20, Issue , 2013, Pages 39-47

  Pal, Arijit ^a   Tripathi, Anusri ^a  

^a CALCUTTA SCHOOL OF TROPICAL MEDICINE   (India)

Author keywords

Binding stability; Evolutionary trajectory; IMP VIM NDM; Meropenem affinity; Metallo beta lactamase

Indexed keywords

BETA LACTAM; MEROPENEM; METALLO BETA LACTAMASE; OXYGEN; ZINC ION;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BINDING AFFINITY; CATALYSIS; COMPUTER ANALYSIS; CONTROLLED STUDY; DRUG BINDING; DRUG STABILITY; ENZYME BINDING; EPISTASIS; GENETIC VARIABILITY; IMP 1 GENE; IMP 20 GENE; IMP 21 GENE; IMP 26 GENE; IMP 27 GENE; IMP 8 GENE; IMP 9 GENE; MBL GENE; MICHAELIS CONSTANT; MOLECULAR EVOLUTION; NONHUMAN; PHYLOGENETIC TREE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; VIM 1 GENE; VIM 13 GENE; VIM 18 GENE; VIM 2 GENE; VIM 29 GENE; VIM 7 GENE;

ENTEROBACTERIACEAE;

BINDING STABILITY; EVOLUTIONARY TRAJECTORY; IMP/VIM/NDM; MEROPENEM AFFINITY; METALLO-BETA-LACTAMASE;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; BINDING SITES; CARBAPENEMS; ENTEROBACTERIACEAE INFECTIONS; EVOLUTION, MOLECULAR; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; PHYLOGENY; PROTEIN BINDING; RECEPTORS, CELL SURFACE; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; THIENAMYCINS;

EID: 84883343949     PISSN: 15671348     EISSN: 15677257     Source Type: Journal    
DOI: 10.1016/j.meegid.2013.07.028     Document Type: Article

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