Structure-based computational study of the hydrolysis of New Delhi metallo-β-lactmase-1

Biochemical and Biophysical Research Communications

Volumn 431, Issue 1, 2013, Pages 2-7

  Zhu, Kongkai ^a,b   Lu, Junyan ^b   Ye, Fei ^b   Jin, Lu ^b   Kong, Xiangqian ^b   Liang, Zhongjie ^c   Chen, Yong ^a   Yu, Kunqian ^b   Jiang, Hualiang ^b   Li, Jun Qian ^a   Luo, Cheng ^b,c  

^a FUZHOU UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c SOOCHOW UNIVERSITY   (China)

Author keywords

Metallo lactamase; Molecular dynamics simulations; Molecular mechanics Poisson Boltzmann surface area; New Delhi metallo lactmase 1

Indexed keywords

AMPICILLIN; ISOLEUCINE; LYSINE; MEROPENEM; METALLO BETA LACTAMASE; NEW DELHI METALLO BETA LACTAMASE 1; NITROCEFIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; CALCULATION; CATALYSIS; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MUTANT; PRIORITY JOURNAL;

AMPICILLIN; BETA-LACTAMASES; CATALYSIS; CEPHALOSPORINS; HYDROGEN BONDING; HYDROLYSIS; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY; THIENAMYCINS;

EID: 84873097635     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.12.141     Document Type: Article

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