NR2B subunit of the NMDA glutamate receptor regulates appetite in the parabrachial nucleus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 36, 2013, Pages 14765-14770

  Wu, Qi ^a,b   Zheng, Ruimao ^a   Srisai, Dollada ^b   McKnight, G Stanley ^a   Palmiter, Richard D ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Feeding behavior; Nausea; NR2B signaling

Indexed keywords

4 BENZYL ALPHA (4 HYDROXYPHENYL) BETA METHYL 1 PIPERIDINEPROPANOL; AGOUTI RELATED PROTEIN; LITHIUM CHLORIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; IMMUNOLOGICAL ADJUVANT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NR2A NMDA RECEPTOR; NR2B NMDA RECEPTOR; PHENOL DERIVATIVE; PIPERIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; APHAGIA; APPETITE; ARTICLE; CONTROLLED STUDY; FEEDING; MOUSE; NONHUMAN; PARABRACHIAL NUCLEUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STARVATION; VAGOTOMY; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BODY WEIGHT; CYTOLOGY; DEFICIENCY; DEGLUTITION DISORDERS; DRUG EFFECTS; EATING; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; PONS; RHOMBENCEPHALON; TIME;

AGOUTI; MUS;

ADJUVANTS, IMMUNOLOGIC; AGOUTI-RELATED PROTEIN; ANIMALS; ANOREXIA; APPETITE; BLOTTING, WESTERN; BODY WEIGHT; DEGLUTITION DISORDERS; EATING; LITHIUM CHLORIDE; MALE; MICE; MICE, KNOCKOUT; NEURONS; PHENOLS; PIPERIDINES; PONS; RECEPTORS, N-METHYL-D-ASPARTATE; RHOMBENCEPHALON; TIME FACTORS; VAGOTOMY;

EID: 84883331308     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1314137110     Document Type: Article

References (41)

1. Paoletti P, Neyton J (2007) NMDA receptor subunits: Function and pharmacology. Curr Opin Pharmacol 7(1):39-47. (Pubitemid 46238036)
2. Traynelis SF, et al. (2010) Glutamate receptor ion channels: Structure, regulation, and function. Pharmacol Rev 62(3):405-496.
3. Yashiro K, Philpot BD (2008) Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity. Neuropharmacology 55(7):1081-1094.
4. Hung CY, Covasa M, Ritter RC, Burns GA (2006) Hindbrain administration of NMDA receptor antagonist AP-5 increases food intake in the rat. Am J Physiol Regul Integr Comp Physiol 290(3):R642-R651.
5. Burns GA, Ritter RC (1997) The non-competitive NMDA antagonist MK-801 increases food intake in rats. Pharmacol Biochem Behav 56(1):145-149. (Pubitemid 27016118)
6. Stanley BG, Urstadt KR, Charles JR, Kee T (2011) Glutamate and GABA in lateral hypothalamic mechanisms controlling food intake. Physiol Behav 104(1):40-46.
7. Liu T, et al. (2012) Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone. Neuron 73(3):511-522.
8. Wu Q, Palmiter RD (2011) GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism. Eur J Pharmacol 660(1):21-27.
9. Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW (2006) Central nervous system control of food intake and body weight. Nature 443(7109):289-295. (Pubitemid 44435142)
10. Sternson SM (2013) Hypothalamic survival circuits: Blueprints for purposive behaviors. Neuron 77(5):810-824.
11. Luquet S, Perez FA, Hnasko TS, Palmiter RD (2005) NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310(5748):683-685. (Pubitemid 41528162)
12. Wu Q, Howell MP, Palmiter RD (2008) Ablation of neurons expressing agouti-related protein activates fos and gliosis in postsynaptic target regions. J Neurosci 28(37):9218-9226.
13. Wu Q, Boyle MP, Palmiter RD (2009) Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation. Cell 137(7):1225-1234.
14. Wu Q, Clark MS, Palmiter RD (2012) Deciphering a neuronal circuit that mediates appetite. Nature 483(7391):594-597.
15. Chuang DM (2005) The antiapoptotic actions of mood stabilizers: Molecular mechanisms and therapeutic potentials. Ann N Y Acad Sci 1053:195-204.
16. Schloesser RJ, Huang J, Klein PS, Manji HK (2008) Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology 33(1):110-133. (Pubitemid 350191320)
17. Nonaka S, Hough CJ, Chuang DM (1998) Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-Daspartate receptor-mediated calcium influx. Proc Natl Acad Sci USA 95(5):2642-2647. (Pubitemid 28145996)
18. Livingstone C, Rampes H (2006) Lithium: A review of its metabolic adverse effects. J Psychopharmacol 20(3):347-355.
19. Lamprecht R, Dudai Y (1995) Differential modulation of brain immediate early genes by intraperitoneal LiCl. Neuroreport 7(1):289-293. (Pubitemid 26078183)
20. Swank MW, Bernstein IL (1994) c-Fos induction in response to a conditioned stimulus after single trial taste aversion learning. Brain Res 636(2):202-208. (Pubitemid 24044636)
21. Spector AC, Norgren R, Grill HJ (1992) Parabrachial gustatory lesions impair taste aversion learning in rats. Behav Neurosci 106(1):147-161.
22. Goel A, Buonomano DV (2013) Chronic electrical stimulation homeostatically decreases spontaneous activity, but paradoxically increases evoked network activity. J Neurophysiol 109(7):1824-1836.
23. Goold CP, Nicoll RA (2010) Single-cell optogenetic excitation drives homeostatic synaptic depression. Neuron 68(3):512-528.
24. Abraham WC, Bear MF (1996) Metaplasticity: The plasticity of synaptic plasticity. Trends Neurosci 19(4):126-130. (Pubitemid 26086492)
25. Turrigiano G (2012) Homeostatic synaptic plasticity: Local and global mechanisms for stabilizing neuronal function. Cold Spring Harb Perspect Biol 4(1):a005736.
26. Zorumski CF, Izumi Y (2012) NMDA receptors and metaplasticity: Mechanisms and possible roles in neuropsychiatric disorders. Neurosci Biobehav Rev 36(3):989-1000.
27. Yasoshima Y, Yamamoto T (1998) Short-term and long-term excitability changes of the insular cortical neurons after the acquisition of taste aversion learning in behaving rats. Neuroscience 84(1):1-5. (Pubitemid 28081519)
28. Lacaille JC, Cloutier S, Reader TA (1992) Lithium reduced synaptic transmission and increased neuronal excitability without altering endogenous serotonin, norepinephrine and dopamine in rat hippocampal slices in vitro. Prog Neuropsychopharmacol Biol Psychiatry 16(3):397-412.
29. Butler-Munro C, Coddington EJ, Shirley CH, Heyward PM (2010) Lithium modulates cortical excitability in vitro. Brain Res 1352:50-60.
30. Niijima A, Yamamoto T (1994) The effects of lithium chloride on the activity of the afferent nerve fibers from the abdominal visceral organs in the rat. Brain Res Bull 35(2):141-145. (Pubitemid 24256375)
31. Yamamoto T, et al. (1992) C-fos expression in the rat brain after intraperitoneal injection of lithium chloride. Neuroreport 3(12):1049-1052. (Pubitemid 23034698)
32. Taniguchi S, et al. (2009) Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour. EMBO J 28(23):3717-3729.
33. Hashimoto R, Hough C, Nakazawa T, Yamamoto T, Chuang DM (2002) Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: Involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation. J Neurochem 80(4):589-597. (Pubitemid 34809967)
34. Liu Y, et al. (2007) NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J Neurosci 27(11):2846-2857. (Pubitemid 46438991)
35. Carter ME, Soden ME, Zweifel LS, Palmiter RD (2013) Genetic identification of a neural circuit that suppresses appetite. Nature, in press.
36. Rai S, Kamat PK, Nath C, Shukla R (2013) A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats. J Neuroimmunol 254(1-2):1-9.
37. Jing T, et al. (2010) Soluble factors from IL-1β-stimulated astrocytes activate NR1a/NR2B receptors: Implications for HIV-1-induced neurodegeneration. Biochem Biophys Res Commun 402(2):241-246.
38. Lundborg C, Westerlund A, Björklund U, Biber B, Hansson E (2011) Ifenprodil restores GDNF-evoked Ca(2+) signalling and Na(+)/K(+) -ATPase expression in inflammation-pretreated astrocytes. J Neurochem 119(4):686-696.
39. Palkovits M (1973) Isolated removal of hypothalamic or other brain nuclei of the rat. Brain Res 59:449-450.
40. Paxinos G, Franklin KBJ (2004) The Mouse Brain in Stereotaxic Coordinates (Elsevier Academic, Amsterdam), Compact 2nd Ed.
41. Yin X, Feng X, Takei Y, Hirokawa N (2012) Regulation of NMDA receptor transport: A KIF17-cargo binding/releasing underlies synaptic plasticity and memory in vivo. J Neurosci 32(16):5486-5499.