β-1 adrenergic agonist mitigates unloading-induced bone loss by maintaining formation

Medicine and Science in Sports and Exercise

Volumn 45, Issue 9, 2013, Pages 1665-1673

  Swift, Joshua M ^a,d   Hogan, Harry A ^b,c   Bloomfield, Susan A ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b Department of Electrical and Computer Engineering   (United States)

^c Texas A M University   (United States)

^d UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Bone Biomechanics; Disuse; Dobutamine; Histomorphometry; Rodents; Sympathetic Nervous System

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; DOBUTAMINE;

ANIMAL; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE DEVELOPMENT; COMPUTER ASSISTED TOMOGRAPHY; DRUG EFFECT; IMMOBILIZATION; MALE; OSTEOLYSIS; PATHOPHYSIOLOGY; PHOTON ABSORPTIOMETRY; PHYSIOLOGY; RADIOGRAPHY; RAT; SPRAGUE DAWLEY RAT; TIBIA;

ABSORPTIOMETRY, PHOTON; ADRENERGIC BETA-1 RECEPTOR AGONISTS; ANIMALS; BIOMECHANICAL PHENOMENA; BONE DENSITY; BONE RESORPTION; DOBUTAMINE; HINDLIMB SUSPENSION; MALE; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY; TIBIA; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84883298973     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e31828d39bc     Document Type: Article

References (40)

1. Aguirre JI, Plotkin LI, Stewart SA, et al. Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. J Bone Miner Res. 2006;21(4):605-15
2. Allen MR, Bloomfield SA. Hindlimb unloading has a greater effect on cortical compared with cancellous bone in mature female rats. J Appl Physiol. 2003;94(2):642-50
3. Basso N, Heersche JN. Effects of hind limb unloading and reloading on nitric oxide synthase expression and apoptosis of osteocytes and chondrocytes. Bone. 2006;39(4):807-14
4. Bloomfield SA, Allen MR, Hogan HA, Delp MD. Site-And compartment-specific changes in bone with hindlimb unloading in mature adult rats. Bone. 2002;31(1):149-57
5. Bloomfield SA, Girten BE, Weisbrode SE. Effects of vigorous exercise training and beta-Agonist administration on bone response to hindlimb suspension. J Appl Physiol. 1997;83(1):172-8
6. Bojanic D, Nahorski SR. Identification and subclassification of rat adipocyte beta-Adrenoceptors using (+/-)-[125I]cyanopindolol. Eur J Pharmacol. 1983;93(3-4):235-43
7. Bonnet N, Benhamou CL, Brunet-Imbault B, et al. Severe bone alterations under beta2 agonist treatments: Bone mass, microarchitecture and strength analyses in female rats. Bone. 2005;37(5): 622-33
8. Bonnet N, Benhamou CL, Malaval L, et al. Low dose beta-blocker prevents ovariectomy-induced bone loss in rats without affecting heart functions. J Cell Physiol. 2008;217(3):819-27
9. Bonnet N, Brunet-Imbault B, Arlettaz A, et al. Alteration of trabecular bone under chronic beta2 agonists treatment. Med Sci Sports Exerc. 2005;37(9):1493-501
10. Bonnet N, Laroche N, Beaupied H, et al. Doping dose of salbutamol and exercise training: Impact on the skeleton of ovariectomized rats. J Appl Physiol. 2007;103(2):524-33
11. Bonnet N, Pierroz DD, Ferrari SL. Adrenergic control of bone remodeling and its implications for the treatment of osteoporosis. J Musculoskelet Neuronal Interact. 2008;8(2):94-104
12. Cavalie H, Lac G, Lebecque P, Chanteranne B, Davicco MJ, Barlet JP. Influence of clenbuterol on bone metabolism in exercised or sedentary rats. J Appl Physiol. 2002;93(6):2034-7
13. Chen X, Song IH, Dennis JE, Greenfield EM. Endogenous PKI gamma limits the duration of the anti-Apoptotic effects of PTH and beta-Adrenergic agonists in osteoblasts. J Bone Miner Res. 2007; 22(5):656-64
14. Colleran PN, Wilkerson MK, Bloomfield SA, Suva LJ, Turner RT, Delp MD. Alterations in skeletal perfusion with simulated microgravity: A possible mechanism for bone remodeling. J Appl Physiol. 2000;89(3):1046-54
15. de Bruin ED, Dietz V, Dambacher MA, Stussi E. Longitudinal changes in bone in men with spinal cord injury. Clin Rehabil. 2000;14(2):145-52
16. Dehority W, Halloran BP, Bikle DD, et al. Bone and hormonal changes induced by skeletal unloading in the mature male rat. Am J Physiol. 1999;276(1 Pt 1):E62-9
17. Dufour C, Holy X, Marie PJ. Skeletal unloading induces osteoblast apoptosis and targets alpha5beta1-PI3K-Bcl-2 signaling in rat bone. Exp Cell Res. 2007;313(2):394-403
18. Elefteriou F, Ahn JD, Takeda S, et al. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature. 2005;434(7032):514-20
19. Frey-Rindova P, de Bruin ED, Stussi E, Dambacher MA, Dietz V. Bone mineral density in upper and lower extremities during 12 months after spinal cord injury measured by peripheral quantitative computed tomography. Spinal Cord. 2000;38(1):26-32
20. Giangregorio L, McCartney N. Bone loss and muscle atrophy in spinal cord injury: Epidemiology, fracture prediction, and rehabilitation strategies. J Spinal Cord Med. 2006;29(5):489-500
21. Holick MF. Perspective on the impact of weightlessness on calcium and bone metabolism. Bone. 1998;22(5 suppl):105S-11S
22. Keyak JH, Koyama AK, LeBlanc A, Lu Y, Lang TF. Reduction in proximal femoral strength due to long-duration spaceflight. Bone. 2009;44(3):449-53
23. Kitaura T, Tsunekawa N, Kraemer WJ. Inhibited longitudinal growth of bones in young male rats by clenbuterol. Med Sci Sports Exerc. 2002;34(2):267-73
24. Kurabayashi T, Tomita M, Matsushita H, Honda A, Takakuwa K, Tanaka K. Effects of a beta 3 adrenergic receptor agonist on bone and bone marrow adipocytes in the tibia and lumbar spine of the ovariectomized rat. Calcif Tissue Int. 2001;68(4):248-54
25. Lang TF, Leblanc AD, Evans HJ, Lu Y. Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight. J Bone Miner Res. 2006;21(8):1224-30
26. Moore RE, Smith CK 2nd, Bailey CS, Voelkel EF, Tashjian AH Jr. Characterization of beta-Adrenergic receptors on rat and human osteoblast-like cells and demonstration that beta-receptor agonists can stimulate bone resorption in organ culture. Bone Miner. 1993; 23(3):301-15
27. Morey-Holton E, Globus RK, Kaplansky A, Durnova G. The hindlimb unloading rat model: Literature overview, technique update and comparison with space flight data. Adv Space Biol Med. 2005;10:7-40
28. Parfitt AM, Drezner MK, Glorieux FH, et al. Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res. 1987;2(6):595-610
29. Pierroz DD, Bonnet N, Bianchi EN, et al. Deletion of A-Adrenergic receptor 1, 2, or both leads to different bone phenotypes and response to mechanical stimulation. J Bone Miner Res. 2012; 27(6):1252-62
30. Prisby RD, Swift JM, Bloomfield SA, Hogan HA, Delp MD. Altered bone mass, geometry and mechanical properties during the development and progression of type 2 diabetes in the Zucker diabetic fatty rat. J Endocrinol. 2008;199(3):379-88
31. Robie NW, Nutter DO, Moody C, McNay JL. In vivo analysis of adrenergic receptor activity of dobutamine. Circ Res. 1974;34(5): 663-71
32. Roer RD, Dillaman RM. Decreased femoral arterial flow during simulated microgravity in the rat. J Appl Physiol. 1994;76(5): 2125-9
33. Shackelford LC, LeBlanc AD, Driscoll TB, et al. Resistance exercise as a countermeasure to disuse-induced bone loss. J Appl Physiol. 2004;97(1):119-29
34. Swift JM, Nilsson MI, Hogan HA, Sumner LR, Bloomfield SA. Simulated resistance training during hindlimb unloading abolishes disuse bone loss and maintains muscle strength. J Bone Miner Res. 2010;25(3):564-74
35. Thomsen JS, Morukov BV, Vico L, Alexandre C, Saparin PI, Gowin W. Cancellous bone structure of iliac crest biopsies following 370 days of head-down bed rest. Aviat Space Environ Med. 2005;76(10):915-22
36. Togari A, Arai M. Pharmacological topics of bone metabolism: The physiological function of the sympathetic nervous system in modulating bone resorption. J Pharmacol Sci. 2008;106(4):542-6
37. Vico L, Collet P, Guignandon A, et al. Effects of long-Term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts. Lancet. 2000;355(9215):1607-11
38. Williams RS, Bishop T. Selectivity of dobutamine for adrenergic receptor subtypes: In vitro analysis by radioligand binding. J Clin Invest. 1981;67(6):1703-11
39. Zeman RJ, Hirschman A, Hirschman ML, Guo G, Etlinger JD. Clenbuterol, a beta 2-receptor agonist, reduces net bone loss in denervated hindlimbs. Am J Physiol. 1991;261(2 Pt 1):E285-9
40. Zheng M, Han QD, Xiao RP. Distinct beta-Adrenergic receptor subtype signaling in the heart and their pathophysiological relevance. Sheng Li Xue Bao. 2004;56(1):1-15