Gene expression profile analysis of human intervertebral disc degeneration

Genetics and Molecular Biology

Volumn 36, Issue 3, 2013, Pages 448-454

  Chen, Kai ^a   Wu, Dajiang ^a   Zhu, Xiaodong ^a   Ni, Haijian ^a   Wei, Xianzhao ^a   Mao, Ningfang ^a   Xie, Yang ^a   Niu, Yunfei ^a   Li, Ming ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Genes; Intervertebral disc degeneration; Molecular classification; Protein protein interaction

Indexed keywords

BETA CATENIN; CALCIUM; COLLAGEN TYPE 2; FIBRONECTIN; WNT PROTEIN;

ARTICLE; CALCIUM BINDING; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE COURSE; EXTRACELLULAR MATRIX; GENE CLUSTER; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; INTERVERTEBRAL DISK DEGENERATION; INTERVERTEBRAL DISK HERNIA; MEMBRANE VESICLE; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PROTEIN PROTEIN INTERACTION;

EID: 84883282397     PISSN: 14154757     EISSN: 16784685     Source Type: Journal    
DOI: 10.1590/S1415-47572013000300021     Document Type: Article

References (42)

1. Barabasi AL and Albert R (1999) Emergence of scaling in random networks. Science 286:509-512.
2. Bou-Gharios G, Ponticos M, Rajkumar V and Abraham D (2004) Extra-cellular matrix in vascular networks. Cell Prolif 37:207-220.
3. Brisby H, Wei AQ, Molloy T, Chung SA, Murrell GA and Diwan AD (2010) The effect of running exercise on intervertebral disc extracellular matrix production in a rat model. Spine (Phila Pa 1976) 35:1429-1436.
4. Cutting GR, McGinniss MJ, Kasch LM, Tsipouras P and Antonarakis SE (1990) Physical mapping by PFGE localizes the COL3A1 and COL5A2 genes to a 35-kb region on human chromosome 2. Genomics 8:407-410.
5. Dai M, Wang P, Boyd AD, Kostov G, Athey B, Jones EG, Bunney WE, Myers RM, Speed TP, Akil H, et al. (2005) Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Res 33:e175.
6. Greg Anderson D, Li X, Tannoury T, Beck G and Balian G (2003) A fibronectin fragment stimulates intervertebral disc degeneration in vivo. Spine (Phila Pa 1976) 28:2338-2345.
7. Gruber HE and Hanley EN (2007) Do we need biomarkers for disc degeneration? Biomark Insights 1:131-133.
8. Gruber HE, Hoelscher G, Loeffler B, Chow Y, Ingram JA, Halligan W and Hanley Jr EN (2009a) Prostaglandin E1 and misoprostol increase epidermal growth factor production in 3D-cultured human annulus cells. Spine J 9:760-766.
9. Gruber HE, Ingram JA, Hoelscher GL, Zinchenko N, Hanley R.- EN and Sun Y (2009b) Asporin, a susceptibility gene in osteoarthritis, is expressed at higher levels in the more degenerate human intervertebral disc. Arthritis Res Ther 11:R47.
10. Gruber HE, Ingram JA, Hoelscher GL, Zinchenko N, Norton HJ and Hanley Jr EN (2011) Constitutive expression of cathepsin K in the human intervertebral disc: New insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-kappaB ligand. Arthritis Res Ther 13:R140.
11. Gruber HE, Hoelscher GL, Ingram JA and Hanley Jr. EN (2012) Genome-wide analysis of pain-, nerve- and neurotrophinrelated gene expression in the degenerating human annulus. Mol Pain 8:63.
12. Hartikka H, Kuurila K, Körkkö J, Kaitila I, Grénman R, Pynnönen S, Hyland JC and Ala-Kokko L (2004) Lack of correlation between the type of COL1A1 or COL1A2 mutation and hearing loss in osteogenesis imperfecta patients. Hum Mutat 24:147-154.
13. Henry SP, Takanosu M, Boyd TC, Mayne PM, Eberspaecher H, Zhou W, de Crombrugghe B, Hook M and Mayne R (2001) Expression pattern and gene characterization of asporin, a newly discovered member of the leucine-rich repeat protein family. J Biol Chem 276:12212-12221.
14. Huang da W, Sherman BT and Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:44-57.
15. Hughes SP, Freemont AJ, Hukins DW, McGregor AH and Roberts S (2012) The pathogenesis of degeneration of the intervertebral disc and emerging therapies in the management of back pain. J Bone Joint Surg Br 94:1298-1304.
16. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U and Speed TP (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4:249-264.
17. Jiang J, Huang L, Yu W, Wu X, Zhou P and Li X (2012) Overexpression of HTRA1 leads to down-regulation of fibronectin and functional changes in RF/6A cells and HUVECs. PLoS One 7:e46115.
18. Johnson WE, Li C and Rabinovic A (2007) Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 8:118-127.
19. Kalb S, Martirosyan NL, Kalani MY, Broc GG and Theodore N (2012) Genetics of the degenerated intervertebral disc. World Neurosurg 77:491-501.
20. Kannu P, Bateman JF, Randle S, Cowie S, du Sart D, McGrath S, Edwards M and Savarirayan R (2010) Premature arthritis is a distinct type II collagen phenotype. Arthritis Rheum 62:1421-1430.
21. Kondo N, Yuasa T, Shimono K, Tung W, Okabe T, Yasuhara R, Pacifici M, Zhang Y, Iwamoto M and Enomoto-Iwamoto M (2011) Intervertebral disc development is regulated by Wnt/beta-catenin signaling. Spine (Phila Pa 1976) 36:E513-E518.
22. Leask A and Abraham DJ (2004) TGF-beta signaling and the fibrotic response. FASEB J 18:816-827.
23. Loughlin J (2005) Polymorphism in signal transduction is a major route through which osteoarthritis susceptibility is acting. Curr Opin Rheumatol 17:629-633.
24. Luoma K, Riihimaki H, Luukkonen R, Raininko R, ViikariJuntura E and Lamminen A (2000) Low back pain in relation to lumbar disc degeneration. Spine (Phila Pa 1976) 25:487492.
25. Martin S, Richards AJ, Yates J, Scott JD, Pope M and Snead MP (1999) Stickler syndrome: further mutations in COL11A1 and evidence for additional locus heterogeneity. Eur J Hum Genet 7:807-814
26. Oegema Jr. TR, Johnson SL, Aguiar DJ and Ogilvie JW (2000) Fibronectin and its fragments increase with degeneration in the human intervertebral disc. Spine (Phila Pa 1976) 25:2742-2747.
27. Rodriguez R, Seegmiller R, Stark M and Bridgewater L (2004) A type XI collagen mutation leads to increased degradation of type II collagen in articular cartilage. Osteoarthritis Cartilage 12:314-320.
28. Samartzis D, Karppinen J, Chan D, Luk KD and Cheung KM (2012) The association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: a population-based study. Arthritis Rheum 64:1488-1496.
29. Superti-Furga A, Gugler E, Gitzelmann R and Steinmann B (1988) Ehlers-Danlos syndrome type IV: a multi-exon deletion in one of the two COL3A1 alleles affecting structure, stability, and processing of type III procollagen. J Biol Chem 263:6226-6232.
30. Szklarczyk D, Franceschini A, Kuhn M, Simonovic M, Roth A, Minguez P, Doerks T, Stark M, Muller J, Bork P, et al. (2011) The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res 39:D561-D568.
31. Tang D, Xu G, Hou W, Ye X, Shi Q, Chen D and Wang Y (2012) β-Catenin plays a key role in lumbar intervertebral disc degeneration. Spine(Phila Pa 1976)18-37
32. Thompson JP, Pearce RH, Schechter MT, Adams ME, Tsang IK and Bishop PB (1990) Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine (Phila Pa 1976) 15:411-415.
33. Tiaden AN, Klawitter M, Lux V, Mirsaidi A, Bahrenberg G, Glanz S, Quero L, Liebscher T, Wuertz K, Ehrmann M, et al. (2012) Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration. J Biol Chem 287:21335-21345.
34. Tusher VG, Tibshirani R and Chu G (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 98:5116-5121.
35. Urban JP and Roberts S (2003) Degeneration of the intervertebral disc. Arthritis Res Ther 5:120-130.
36. Vasan NS, Kuivaniemi H, Vogel BE, Minor R, Wootton J, Tromp G, Weksberg R and Prockop D (1991) A mutation in the pro alpha 2 (I) gene (COL1A2) for type I procollagen in EhlersDanlos syndrome type VII: Evidence suggesting that skipping of exon 6 in RNA splicing may be a common cause of the phenotype. Am J Hum Genet 48:305-317.
37. Ward L, Lalic L, Roughley P and Glorieux F (2001) Thirty-three novel COL1A1 and COL1A2 mutations in patients with osteogenesis imperfecta types I-IV. Hum Mutat 17:434-434.
38. Wuertz K, Urban JP, Klasen J, Ignatius A, Wilke HJ, Claes L and Neidlinger-Wilke C (2007) Influence of extracellular osmolarity and mechanical stimulation on gene expression of intervertebral disc cells. J Orthop Res 25:1513-1522.
39. Xu P, Yao J and Hou W (2011) Relationships between COL2A1 gene polymorphisms and knee osteoarthritis in Han Chinese women. Mol Biol Rep 38:2377-2381.
40. Yang F, Leung VY, Luk KD, Chan D and Cheung KM (2009) Injury-induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse. J Pathol 218:113-121.
41. Zhang Q, Huang M, Wang X, Xu X, Ni M and Wang Y (2012) Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation. J Orthop Res 30:12381243.
42. Zuo C, Wen F, Li M, Zhang X, Chen H, Wu K and Zeng R (2012) COL1A2 polymorphic markers confer an increased risk of neovascular age-related macular degeneration in a Han Chinese population. Mol Vision 18:1787-1793.