Prostaglandin E1 and misoprostol increase epidermal growth factor production in 3D-cultured human annulus cells

Spine Journal

Volumn 9, Issue 9, 2009, Pages 760-766

  Gruber, Helen E ^a   Hoelscher, Gretchen ^a   Loeffler, Bryan ^a   Chow, Yin ^a   Ingram, Jane A ^a   Halligan, Will ^a   Hanley Jr , Edward N ^a  

^a CAROLINAS MEDICAL CENTER   (United States)

Author keywords

Annulus; Cell proliferation; Epidermal growth factor; Growth factor; Immunohistochemistry; Misoprostol; Prostaglandin E1; Proteoglycan

Indexed keywords

COLLAGEN SPONGE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; MISOPROSTOL; PROSTAGLANDIN E1; PROTEOGLYCAN;

ADULT; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; IN VITRO STUDY; IN VIVO STUDY; LUMBAR DISK; MALE; MICROARRAY ANALYSIS; MONOLAYER CULTURE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STATISTICAL ANALYSIS;

ADULT; AGED; ALPROSTADIL; CELL PROLIFERATION; CELLS, CULTURED; EPIDERMAL GROWTH FACTOR; FEMALE; FETUS; FIBRINOLYTIC AGENTS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK; MALE; MIDDLE AGED; MISOPROSTOL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEOGLYCANS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER;

EID: 68749117436     PISSN: 15299430     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.spinee.2009.04.024     Document Type: Article

References (26)

1. Nanney L.B., Caldwell R.L., Pollins A.C., et al. Novel approaches for understanding the mechanisms of wound repair. J Investig Dermatol Symp Proc 11 (2006) 132-139
2. Groenestege W.M.T., Thebault S., van der Wijst J., et al. Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia. J Clin Invest 117 (2007) 2260-2267
3. Choi M.E. Mechanism of transforming growth factor-beta1 signaling. Kidney Int 77 Suppl (2000) S53-S58
4. Tian Y.-C., Chen Y.-C., Chang C.-T., et al. Epidermal growth factor and transforming growth factor-β1 enhance HK-2 cell migration through a synergistic increase of matrix metalloproteinase and sustained activation of ERK signaling pathway. Exp Cell Res 313 (2007) 2367-2377
5. Hata R., Hori H., Nagai Y., et al. Selective inhibition of type I collagen synthesis in osteoblastic cells by epidermal growth factor. Endocrinology 115 (1984) 867-876
6. Konttinen Y.T., Kemppinen P., Li T.F., et al. Transforming and epidermal growth factors in degenerated discs. J Bone Joint Surg Br 81-B (1999) 1058-1063
7. Thompson J.P., Pearce R.H., Schechter M.T., et al. Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine 15 (1990) 411-415
8. Gruber H.E., Fisher Jr. E.C., Desai B., Stasky A.A., et al. Human intervertebral disc cells from the annulus: three- dimensional culture in agarose or alginate and responsiveness to TGF-β1. Exp Cell Res 235 (1997) 13-21
9. Gruber H.E., Hoelscher G.L., Leslie K., et al. Three-dimensional culture of human disc cells within agarose or a collagen sponge: assessment of proteoglycan production. Biomaterials 27 (2006) 371-376
10. Gruber H.E., and Hanley Jr. E.N. Human disc cells in monolayer vs 3D culture: cell shape, division and matrix formation. BMC Musculoskelet Disord 1 (2000) 1-11. http://www.biomedcentral.com/1471-2474/1/1 Accessed October 23, 2008
11. Gruber H.E., Leslie K., Ingram J., et al. Cell-based tissue engineering for the intervertebral disc: In vitro studies of human disc cell gene expression and matrix production within selected cell carriers. Spine J 4 (2004) 44-55
12. Anastassiades T., Chopra R., Law C., and Wong E. In vitro suppression of transforming growth factor-β induced stimulation of glycosaminoglycan synthesis by acetylsalicylic acid and its reversal by misoprostol. J Rheumatol 25 (1998) 1962-1966
13. Kakita A., Suzuki A., Ono Y., Miura Y., et al. Possible involvement of p38 MAP kinase in prostaglandin E1-induced ALP activity in osteoblast-like cells. Prostaglandins Leukot Essent Fatty Acids 70 (2004) 469-474
14. Conconi M.T., Tommasini M., Baiguera S., et al. Effects of prostaglandins E1 and E2 on the growth and differentiation of osteoblast-like cells cultured in vitro. Int J Mol Med 10 (2002) 451-456
15. Muller G., and Hanschke M. Quantitative and qualitative analyses of proteoglycans in cartilage extracts by precipitation with 1,9-dimethylmethylene blue. Connect Tissue Res 33 (1996) 243-248
16. 2α stimulate differentiation and proliferation, respectively, of clonal osteoblastic MC3T3-E1 cells by different second messengers in vitro. Endocinrology 121 (1987) 1966-1973
17. 1-induced alkaline phosphatase activity in osteoblast-like cells: regulation at a point downstream from protein kinase a. Prostaglandins Leukot Essent Fatty Acids 55 (1996) 357-361
18. Normanno N., De Luca A., Bianco C., et al. Epidermal growth factor receptor (EGFR) signaling in cancer. Gene 366 (2006) 2-16
19. Chen D.J., and Nirodi C.S. The epidermal growth factor receptor: a role in repair of radiation-induced DNA damage. Clin Cancer Res 13 (2007) 6555-6559
20. Deng Y, Gerard D, An HA, Cz-Szabo G. The small proteoglycan biglycan regulates growth factor/cytokine-induced signaling in annulus fibrosus and nucleus pulposus cells of the intervertebral disc. Proceedings of the 54th Annual Meeting of the Orthopaedic Research Society, abstract #335; 2008.
21. Sobota R.M., Müller P.J., Heinrich P.C., and Schaper F. Prostaglandin E1 inhibits LI-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation. Biochem J 412 (2008) 65-72
22. Kim J.H., Studer R.K., Sowa G.A., et al. Activated macrophage-like THP-1 cells modulate annulus fibrosus cell production of inflammatory mediators in response to cytokines. Spine 33 (2008) 2253-2259
23. Burke J.G., Watson R.W.G., McCormack D., et al. Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. J Bone Joint Surg [Br] 84B (2002) 196-201
24. Thompson J.P., Oegema Jr. T.R., and Bradford D.S. Stimulation of mature canine intervertebral disc by growth factors. Spine 16 (1991) 253-260
25. Milcan A., Colak M., and Eskandari G. Misoprostol enhances early fracture healing: a preliminary biochemical study on rats. Bone 41 (2007) 611-613
26. Sonmez A.S., Birincioglu M., Ozer M., et al. Effects of misoprostol on bone loss in ovariectomized rats. Prostaglandins Other Lipid Mediat 57 (1999) 113-118