Anti-cancer mechanisms of clinically acceptable colchicine concentrations on hepatocellular carcinoma

Life Sciences

Volumn 93, Issue 8, 2013, Pages 323-328

  Lin, Zu Yau ^a,b   Wu, Chun Chieh ^a   Chuang, Yen Hwang ^a   Chuang, Wan Long ^a,b  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

AKAP12; Animal study; Cancer associated fibroblast; Colchicine; Hepatocellular carcinoma; TGFB2

Indexed keywords

COLCHICINE; EPIRUBICIN;

AKAP12 GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL DEATH; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; GENE; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MALE; MICROARRAY ANALYSIS; MOUSE; MX1 GENE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TGFB2 GENE; TUMOR GROWTH; TUMOR NECROSIS; TUMOR VOLUME; UPREGULATION;

AKAP12; ANIMAL STUDY; CANCER-ASSOCIATED FIBROBLAST; COLCHICINE; HEPATOCELLULAR CARCINOMA; TGFB2;

A KINASE ANCHOR PROTEINS; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; COLCHICINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FIBROBLASTS; GTP-BINDING PROTEINS; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROARRAY ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFORMING GROWTH FACTOR BETA2; TUBULIN MODULATORS; TUMOR BURDEN; UP-REGULATION;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 84883251108     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2013.07.002     Document Type: Article

References (44)

1. S. Akakura, and I.H. Gelman Pivotal role of AKAP12 in the regulation of cellular adhesion dynamics: control of cytoskeletal architecture, cell migration, and mitogenic signaling J Signal Transduct 2012 2012 529179
2. O. Arrieta, J.L. Rodriguez-Diaz, V. Rosas-Camargo, D. Morales-Espinosa, S. Ponce de Leon, and D. Kershenobich Colchicine delays the development of hepatocellular carcinoma in patients with hepatitis virus-related liver cirrhosis Cancer 107 2006 1852 1858
3. B. Bhattacharyya, D. Panda, S. Gupta, and M. Banerjee Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin Med Res Rev 28 2008 155 183
4. G. Cocco, D.C. Chu, and S. Pandolfi Colchicine in clinical medicine. A guide for internists Eur J Intern Med 21 2010 503 508
5. G.M. Ferron, M. Rochdi, W.J. Jusko, and J.M. Scherrmann Oral absorption characteristics and pharmacokinetics of colchicine in healthy volunteers after single and multiple doses J Clin Pharmacol 36 1996 874 883
6. Y. Finkelstein, S.E. Aks, J.R. Hutson, D.N. Juurlink, P. Nguyen, and G. Dubnov-Raz Colchicine poisoning: the dark side of an ancient drug Clin Toxicol (Phila) 48 2010 407 414
7. I.H. Gelman Emerging roles for SSeCKS/Gravin/AKAP12 in the control of cell proliferation, cancer malignancy, and barriergenesis Genes Cancer 1 2010 1147 1156
8. M. Hayashi, S. Nomoto, M. Kanda, Y. Okamura, Y. Nishikawa, and S. Yamada Identification of the A kinase anchor protein 12 (AKAP12) gene as a candidate tumor suppressor of hepatocellular carcinoma J Surg Oncol 105 2012 381 386
9. M. Imazio, M. Bobbio, E. Cecchi, D. Demarie, B. Demichelis, and F. Pomari Colchicine in addition to conventional therapy for acute pericarditis: results of the COlchicine for acute PEricarditis (COPE) trial Circulation 112 2005 2012 2016
10. M. Imazio, A. Brucato, R. Trinchero, D. Spodick, and Y. Adler Colchicine for pericarditis: hype or hope? Eur Heart J 30 2009 532 539
11. T. Kallinich, D. Haffner, T. Niehues, K. Huss, E. Lainka, and U. Neudorf Colchicine use in children and adolescents with familial Mediterranean fever: literature review and consensus statement Pediatrics 119 2007 e474 e483
12. Y.H. Kang, M.Y. Park, D.Y. Yoon, S.R. Han, C.I. Lee, and N.Y. Ji Dysregulation of overexpressed IL-32α in hepatocellular carcinoma suppresses cell growth and induces apoptosis through inactivation of NF-κB and Bcl-2 Cancer Lett 318 2012 226 233
13. L. Kask, L.A. Trouw, B. Dahlbäck, and A.M. Blom The C4b-binding protein-protein S complex inhibits the phagocytosis of apoptotic cells J Biol Chem 279 2004 23869 23873
14. Z.Y. Lin, W.L. Chuang, Y.H. Chuang, M.L. Yu, M.Y. Hsieh, and L.Y. Wang Discordant influence of amphotericin B on epirubicin cytotoxicity in primary hepatic malignant cells collected by a new primary culture technique J Gastroenterol Hepatol 21 2006 398 405
15. Z.Y. Lin, W.L. Chuang, and Y.H. Chuang Amphotericin B up-regulates angiogenic genes in hepatocellular carcinoma cell lines Eur J Clin Invest 39 2009 239 245
16. Z.Y. Lin, Y.H. Chuang, and W.L. Chuang Cancer-associated fibroblasts up-regulate CCL2, CCL26, IL6 and LOXL2 genes related to promotion of cancer progression in hepatocellular carcinoma cells Biomed Pharmacother 66 2012 525 529
17. Y. Liu, J. Lagowski, A. Sundholm, A. Sundberg, and M. Kulesz-Martin Microtubule disruption and tumor suppression by mitogen-activated protein kinase phosphatase 4 Cancer Res 67 2007 10711 10719
18. W. Liu, M. Guan, T. Hu, X. Gu, and Y. Lu Re-expression of AKAP12 inhibits progression and metastasis potential of colorectal carcinoma in vivo and in vitro PLoS One 6 2011 e24015
19. Y. Lu, J. Chen, M. Xiao, W. Li, and D.D. Miller An overview of tubulin inhibitors that interact with the colchicine binding site Pharm Res 29 2012 2943 2971
20. G. Lunardi, M.O. Vannozzi, C. Bighin, L. Del Mastro, I. Stevani, and G. Schettini Influence of trastuzumab on epirubicin pharmacokinetics in metastatic breast cancer patients Ann Oncol 14 2003 1222 1226
21. E.N. Maldonado, J. Patnaik, M.R. Mullins, and J.J. Lemasters Free tubulin modulates mitochondrial membrane potential in cancer cells Cancer Res 70 2010 10192 10201
22. A. Mazzocca, F. Dituri, L. Lupo, M. Quaranta, S. Antonaci, and G. Giannelli Tumor-secreted lysophostatidic acid accelerates hepatocellular carcinoma progression by promoting differentiation of peritumoral fibroblasts in myofibroblasts Hepatology 54 2011 920 930
23. E. Mehrara, E. Forssell-Aronsson, H. Ahlman, and P. Bernhardt Specific growth rate versus doubling time for quantitative characterization of tumor growth rate Cancer Res 67 2007 3970 3975
24. B. Moghadaszadeh, and A.H. Beggs Selenoproteins and their impact on human health through diverse physiological pathways Physiology (Bethesda) 21 2006 307 315
25. J.F. Mushinski, P. Nguyen, L.M. Stevens, C. Khanna, S. Lee, and E.J. Chung Inhibition of tumor cell motility by the interferon-inducible GTPase MxA J Biol Chem 284 2009 15206 15214
26. A. Numajiri Haruki, T. Naito, T. Nishie, S. Saito, and K. Nagata Interferon-inducible antiviral protein MxA enhances cell death triggered by endoplasmic reticulum stress J Interferon Cytokine Res 31 2011 847 856
27. A. Numajiri, M. Mibayashi, and K. Nagata Stimulus-dependent and domain-dependent cell death acceleration by an IFN-inducible protein, human MxA J Interferon Cytokine Res 26 2006 214 219
28. E.H. Rabbitt, G.G. Lavery, E.A. Walker, M.S. Cooper, P.M. Stewart, and M. Hewison Prereceptor regulation of glucocorticoid action by 11beta- hydroxysteroid dehydrogenase: a novel determinant of cell proliferation FASEB J 16 2002 36 44
29. M. Rochdi, A. Sabouraud, C. Girre, R. Venet, and J.M. Scherrmann Pharmacokinetics and absolute bioavailability of colchicine after i.v. and oral administration in healthy human volunteers and elderly subjects Eur J Clin Pharmacol 46 1994 351 354
30. B. Rubiś, S. Grodecka-Gazdecka, R. Lecybył, M. Ociepa, Z. Krozowski, and W.H. Trzeciak Contribution of protein kinase A and protein kinase C signalling pathways to the regulation of HSD11B2 expression and proliferation of MCF-7 cells Acta Biochim Pol 51 2004 919 924
31. T. Sakai, K. Balasubramanian, S. Maiti, J.B. Halder, and A.J. Schroit Plasmin-cleaved beta-2-glycoprotein 1 is an inhibitor of angiogenesis Am J Pathol 171 2007 1659 1669
32. Y. Si, X. Liu, M. Cheng, M. Wang, Q. Gong, and Y. Yang Growth differentiation factor 15 is induced by hepatitis C virus infection and regulates hepatocellular carcinoma-related genes PLoS One 6 2011 e19967
33. G. Sivakumar Colchicine semisynthetics: chemotherapeutics for cancer? Curr Med Chem 20 2013 892 898
34. R.A. Stanton, K.M. Gernert, J.H. Nettles, and R. Aneja Drugs that target dynamic microtubules: a new molecular perspective Med Res Rev 31 2011 443 481
35. C.K. Sun, M.S. Chua, J. He, and S.K. So Suppression of glypican 3 inhibits growth of hepatocellular carcinoma cells through up-regulation of TGF-β2 Neoplasia 13 2011 735 747
36. T. Tao, Y. Ji, C. Cheng, H. Yang, H. Liu, and L. Sun Tumor necrosis factor-alpha inhibits Schwann cell proliferation by up-regulating Src-suppressed protein kinase C substrate expression J Neurochem 111 2009 647 655
37. R.A. Terkeltaub, D.E. Furst, K. Bennett, K.A. Kook, R.S. Crockett, and M.W. Davis High versus low dosing of oral colchicine for early acute gout flare: twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine study Arthritis Rheum 62 2010 1060 1068
38. L.A. Trouw, S.C. Nilsson, I. Gonçalves, G. Landberg, and A.M. Blom C4b-binding protein binds to necrotic cells and DNA, limiting DNA release and inhibiting complement activation J Exp Med 201 2005 1937 1948
39. R.G. Wells, E. Kruglov, and J.A. Dranoff Autocrine release of TGF-beta by portal fibroblasts regulates cell growth FEBS Lett 559 2004 107 110
40. S. Wu, Y. Wang, L. Sun, Z. Zhang, Z. Jiang, and Z. Qin Decreased expression of dual-specificity phosphatase 9 is associated with poor prognosis in clear cell renal cell carcinoma BMC Cancer 11 2011 413
41. X. Wu, Y. Zhang, Z. Pei, S. Chen, X. Yang, and Y. Chen Methylseleninic acid restricts tumor growth in nude mice model of metastatic breast cancer probably via inhibiting angiopoietin-2 BMC Cancer 12 2012 192
42. B. Xie, D.H. Wang, and S.J. Spechler Sorafenib for treatment of hepatocellular carcinoma: a systematic review Dig Dis Sci 57 2012 1122 1129
43. J.D. Yang, I. Nakamura, and L.R. Roberts The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets Semin Cancer Biol 21 2011 35 43
44. A.X. Zhu Molecularly targeted therapy for advanced hepatocellular carcinoma in 2012: current status and future perspectives Semin Oncol 39 2012 493 502