Dysregulation of overexpressed IL-32α in hepatocellular carcinoma suppresses cell growth and induces apoptosis through inactivation of NF-κB and Bcl-2

Cancer Letters

Volumn 318, Issue 2, 2012, Pages 226-233

  Kang, Yun Hee ^a   Park, Mi Young ^a   Yoon, Do Young ^b   Han, Seung Ro ^c   Lee, Chung Il ^a   Ji, Na Young ^a   Myung, Pyung Keun ^d   Lee, Hee Gu ^a   Kim, Jae Wha ^a   Yeom, Young Il ^a   Jang, Ye Jin ^a   Ahn, Dong Kuk ^c   Kim, Jong Wan ^e   Song, Eun Young ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Konkuk University   (South Korea)

^c Kyungpook National University   (South Korea)

^d Chungnam National University   (South Korea)

^e Dankook University   (South Korea)

Author keywords

Apoptosis; Cell growth; Diagnostic marker; Hepatocellular carcinoma; IL 32

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 32; INTERLEUKIN 32ALPHA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BCL 2; PROTEIN P53; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE RELEASE; DNA MICROARRAY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; BASE SEQUENCE; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL DIVISION; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKINS; LIVER NEOPLASMS; NF-KAPPA B; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR MARKERS, BIOLOGICAL;

EID: 84858153678     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.12.023     Document Type: Article

References (26)

1. Gomaa A.I., Khan S.A., Toledano M.B., Waked I., Taylor-Robinson S.D. Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis. World J. Gastroenterol. 2008, 14:4300-4308.
2. Zhou L., Liu J., Luo F. Serum tumor markers for detection of hepatocellular carcinoma. World J. Gastroenterol. 2006, 12:1175-1181.
3. Dahl C.A., Schall R.P., He H.L., Cairns J.S. Identification of a novel gene expressed in activated natural killer cells and T cells. J. Immunol. 1992, 148:597-603.
4. Kim S.H., Han S.Y., Azam T., Yoon D.Y., Dinarello C.A. Interleukin-32: a cytokine and inducer of TNFalpha. Immunity 2005, 22:131-142.
5. Netea M.G., Azam T., Ferwerda G., Girardin S.E., Walsh M., Park J.S., Abraham E., Kim J.M., Yoon D.Y., Dinarello C.A., Kim S.H. IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc. Natl. Acad. Sci. USA 2005, 102:16309-16314.
6. Chen Q., Carroll H.P., Gadina M. The newest interleukins: recent additions to the ever-growing cytokine family. Vitam. Horm. 2006, 74:207-228.
7. Peyrin-Biroulet L., Vignal C., Dessein R., Simonet M., Desreumaux P., Chamaillard M. NODs in defence: from vulnerable antimicrobial peptides to chronic inflammation. Trends Microbiol. 2006, 14:432-438.
8. Hugot J.P. CARD15/NOD2 mutations in Crohn's disease. Ann. NY Acad. Sci. 2006, 1072:9-18.
9. Hugot J.P., Chamaillard M., Zouali H., Lesage S., Cezard J.P., Belaiche J., Almer S., Tysk C., O'Morain C.A., Gassull M., Binder V., Finkel Y., Cortot A., Modigliani R., Laurent-Puig P., Gower-Rousseau C., Macry J., Colombel J.F., Sahbatou M., Thomas G. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001, 411:599-603.
10. Netea M.G., Ferwerda G., de Jong D.J., Girardin S.E., Kullberg B.J., van der Meer J.W. NOD2 3020insC mutation and the pathogenesis of Crohn's disease: impaired IL-1beta production points to a loss-of-function phenotype. Neth. J. Med. 2005, 63:305-308.
11. Netea M.G., Ferwerda G., de Jong D.J., Jansen T., Jacobs L., Kramer M., Naber T.H., Drenth J.P., Girardin S.E., Kullberg B.J., Adema G.J., Van der Meer J.W. Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release. J. Immunol. 2005, 174:6518-6523.
12. Netea M.G., Kullberg B.J., de Jong D.J., Franke B., Sprong T., Naber T.H., Drenth J.P., Van der Meer J.W. NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease. Eur. J. Immunol. 2004, 34:2052-2059.
13. Maeda S., Hsu L.C., Liu H., Bankston L.A., Iimura M., Kagnoff M.F., Eckmann L., Karin M. Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science 2005, 307:734-738.
14. Joosten L.A., Netea M.G., Kim S.H., Yoon D.Y., Oppers-Walgreen B., Radstake T.R., Barrera P., van de Loo F.A., Dinarello C.A., van den Berg W.B. IL-32, a proinflammatory cytokine in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 2006, 103:3298-3303.
15. Shioya M., Nishida A., Yagi Y., Ogawa A., Tsujikawa T., Kim-Mitsuyama S., Takayanagi A., Shimizu N., Fujiyama Y., Andoh A. Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease. Clin. Exp. Immunol. 2007, 149:480-486.
16. Kim K.H., Shim J.H., Seo E.H., Cho M.C., Kang J.W., Kim S.H., Yu D.Y., Song E.Y., Lee H.G., Sohn J.H., Kim J., Dinarello C.A., Yoon D.Y. Interleukin-32 monoclonal antibodies for immunohistochemistry, Western blotting, and ELISA. J. Immunol. Methods 2008, 333:38-50.
17. Vakkila J., Lotze M.T. Inflammation and necrosis promote tumour growth. Nat. Rev. Immunol. 2004, 4:641-648.
18. Kobayashi H., Lin P.C. Molecular characterization of IL-32 in human endothelial cells. Cytokine 2009, 46:351-358.
19. Nishida A., Andoh A., Inatomi O., Fujiyama Y. Interleukin-32 expression in the pancreas. J. Biol. Chem. 2009, 284:17868-17876.
20. Sorrentino C., Di Carlo E. Expression of IL-32 in human lung cancer is related to the histotype and metastatic phenotype. Am. J. Respir. Crit. Care. Med. 2009, 180:769-779.
21. Zou A.P., Cheng G., Pi Y.Q., Wang W.H., Yu S.B., Wang D.X. The role of lipoxygenase and cyclooxygenase metabolites in acute hypoxic pulmonary vasoconstriction in piglets. J. Tongji Med. Univ. 1989, 9:239-243.
22. Green D.R., Reed J.C. Mitochondria and apoptosis. Science 1998, 281:1309-1312.
23. Reed J.C., Pellecchia M. Apoptosis-based therapies for hematologic malignancies. Blood 2005, 106:408-418.
24. Lopez J.B. Recent developments in the first detection of hepatocellular carcinoma. Clin. Biochem. Rev. 2005, 26:65-79.
25. Mantovani A., Allavena P., Sica A., Balkwill F. Cancer-related inflammation. Nature 2008, 454:436-444.
26. Baud V., Karin M. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat. Rev. Drug Discov. 2009, 8:33-40.