메뉴 건너뛰기




Volumn 9, Issue 2, 2009, Pages 214-219

Neuregulin-1/ErbB signaling: a druggable target for treating heart failure

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRAIN NATRIURETIC PEPTIDE; CARDIAC SPECIFIC MYOSIN LIGHT CHAIN KINASE; CARDIOVASCULAR AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR; NEU DIFFERENTIATION FACTOR; RECOMBINANT HUMAN NEU DIFFERENTIATION FACTOR; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 62249192069     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2008.11.004     Document Type: Review
Times cited : (39)

References (57)
  • 1
    • 34247863773 scopus 로고    scopus 로고
    • The neuregulin-I/ErbB signaling system in development and disease
    • Britsch S. The neuregulin-I/ErbB signaling system in development and disease. Adv Anat Embryol Cell Biol 190 (2007) 1-65
    • (2007) Adv Anat Embryol Cell Biol , vol.190 , pp. 1-65
    • Britsch, S.1
  • 2
    • 34548023654 scopus 로고    scopus 로고
    • Distinct ErbB-2 coupled signaling pathways promote mammary tumors with unique pathologic and transcriptional profiles
    • Schade B., Lam S.H., Cernea D., Sanguin-Gendreau V., Cardiff R.D., Jung B.L., Hallett M., and Muller W.J. Distinct ErbB-2 coupled signaling pathways promote mammary tumors with unique pathologic and transcriptional profiles. Cancer Res 67 (2007) 7579-7588
    • (2007) Cancer Res , vol.67 , pp. 7579-7588
    • Schade, B.1    Lam, S.H.2    Cernea, D.3    Sanguin-Gendreau, V.4    Cardiff, R.D.5    Jung, B.L.6    Hallett, M.7    Muller, W.J.8
  • 3
    • 33645960993 scopus 로고    scopus 로고
    • Activation of multiple cancer-associated genes at the ERBB2 amplicon in breast cancer
    • Kauraniemi P., and Kallioniemi A. Activation of multiple cancer-associated genes at the ERBB2 amplicon in breast cancer. Endocr Relat Cancer 13 (2006) 39-49
    • (2006) Endocr Relat Cancer , vol.13 , pp. 39-49
    • Kauraniemi, P.1    Kallioniemi A2
  • 4
    • 59749094475 scopus 로고    scopus 로고
    • Neuregulin-1 modulates hippocampal gamma oscillations: implications for schizophrenia
    • Fisahn A., Neddens J., Yan L., and Buonanno A. Neuregulin-1 modulates hippocampal gamma oscillations: implications for schizophrenia. Cereb Cortex 19 (2009) 612-618
    • (2009) Cereb Cortex , vol.19 , pp. 612-618
    • Fisahn, A.1    Neddens, J.2    Yan, L.3    Buonanno, A.4
  • 6
    • 62249153317 scopus 로고    scopus 로고
    • The role of Neuregulin-1beta/ErbB signaling in the heart
    • Epub ahead of print
    • Pentassuglia L., and Sawyer D.B. The role of Neuregulin-1beta/ErbB signaling in the heart. Exp Cell Res (2008) Epub ahead of print
    • (2008) Exp Cell Res
    • Pentassuglia, L.1    Sawyer, D.B.2
  • 7
    • 0026659262 scopus 로고
    • Identification of heregulin, a specific activator of p185erbB2
    • The original identification of NRG-1 in a research for activators of ErbB2.
    • Holmes W.E., Sliwkowski M.X., Akita R.W., Henzel W.J., Lee J., Park J.W., Yansura D., Abadi N., Raab H., Lewis G.D., et al. Identification of heregulin, a specific activator of p185erbB2. Science 256 (1992) 1205-1210. The original identification of NRG-1 in a research for activators of ErbB2.
    • (1992) Science , vol.256 , pp. 1205-1210
    • Holmes, W.E.1    Sliwkowski, M.X.2    Akita, R.W.3    Henzel, W.J.4    Lee, J.5    Park, J.W.6    Yansura, D.7    Abadi, N.8    Raab, H.9    Lewis, G.D.10
  • 11
    • 1042268178 scopus 로고    scopus 로고
    • Localization of neuregulin isoforms and erbB receptors in myelinating glial cells
    • Raabe T.D., Deadwyler G., Varga J.W., and Devries G.H. Localization of neuregulin isoforms and erbB receptors in myelinating glial cells. Glia 45 (2004) 197-207
    • (2004) Glia , vol.45 , pp. 197-207
    • Raabe, T.D.1    Deadwyler, G.2    Varga, J.W.3    Devries, G.H.4
  • 12
    • 33847718214 scopus 로고    scopus 로고
    • The EGF receptor family: spearheading a merger of signaling and therapeutics
    • This is a good review that concentrates on recent advances in understanding the mechanism of allosteric activation of ErbB proteins, as well as the current implications of ErbB signaling in diseases.
    • Bublil E.M., and Yarden Y. The EGF receptor family: spearheading a merger of signaling and therapeutics. Curr Opin Cell Biol 19 (2007) 124-134. This is a good review that concentrates on recent advances in understanding the mechanism of allosteric activation of ErbB proteins, as well as the current implications of ErbB signaling in diseases.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 124-134
    • Bublil, E.M.1    Yarden, Y.2
  • 14
    • 0032860819 scopus 로고    scopus 로고
    • Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers
    • Muthuswamy S.K., Gilman M., and Brugge J.S. Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers. Mol Cell Biol 19 (1999) 6845-6857
    • (1999) Mol Cell Biol , vol.19 , pp. 6845-6857
    • Muthuswamy, S.K.1    Gilman, M.2    Brugge, J.S.3
  • 15
  • 16
    • 0028785406 scopus 로고
    • Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
    • Gassmann M., Casagranda F., Orioli D., Simon H., Lai C., Klein R., and Lemke G. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378 (1995) 390-394
    • (1995) Nature , vol.378 , pp. 390-394
    • Gassmann, M.1    Casagranda, F.2    Orioli, D.3    Simon, H.4    Lai, C.5    Klein, R.6    Lemke, G.7
  • 17
    • 0028884413 scopus 로고
    • Requirement for neuregulin receptor erbB2 in neural and cardiac development
    • Lee K.F., Simon H., Chen H., Bates B., Hung M.C., and Hauser C. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378 (1995) 394-398
    • (1995) Nature , vol.378 , pp. 394-398
    • Lee, K.F.1    Simon, H.2    Chen, H.3    Bates, B.4    Hung, M.C.5    Hauser, C.6
  • 20
    • 2342444610 scopus 로고    scopus 로고
    • Essential roles of Her2/erbB2 in cardiac development and function
    • Negro A., Brar B.K., and Lee K.F. Essential roles of Her2/erbB2 in cardiac development and function. Recent Prog Horm Res 59 (2004) 1-12
    • (2004) Recent Prog Horm Res , vol.59 , pp. 1-12
    • Negro, A.1    Brar, B.K.2    Lee, K.F.3
  • 21
    • 0031454062 scopus 로고    scopus 로고
    • ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice
    • Erickson S.L., O'Shea K.S., Ghaboosi N., Loverro L., Frantz G., Bauer M., Lu L.H., and Moore M.W. ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development 124 (1997) 4999-5011
    • (1997) Development , vol.124 , pp. 4999-5011
    • Erickson, S.L.1    O'Shea, K.S.2    Ghaboosi, N.3    Loverro, L.4    Frantz, G.5    Bauer, M.6    Lu, L.H.7    Moore, M.W.8
  • 22
    • 0036344533 scopus 로고    scopus 로고
    • Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors
    • Camenisch T.D., Schroeder J.A., Bradley J., Klewer S.E., and McDonald J.A. Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors. Nat Med 8 (2002) 850-855
    • (2002) Nat Med , vol.8 , pp. 850-855
    • Camenisch, T.D.1    Schroeder, J.A.2    Bradley, J.3    Klewer, S.E.4    McDonald, J.A.5
  • 23
    • 17444423730 scopus 로고    scopus 로고
    • Endothelin-1 and Neuregulin-1 convert embryonic cardiomyocytes into cells of the conduction system in the mouse
    • Patel R., and Kos L. Endothelin-1 and Neuregulin-1 convert embryonic cardiomyocytes into cells of the conduction system in the mouse. Dev Dyn 233 (2005) 20-28
    • (2005) Dev Dyn , vol.233 , pp. 20-28
    • Patel, R.1    Kos, L.2
  • 25
    • 33645729418 scopus 로고    scopus 로고
    • Notch1b and neuregulin are required for specification of central cardiac conduction tissue
    • Milan D.J., Giokas A.C., Serluca F.C., Peterson R.T., and MacRae C.A. Notch1b and neuregulin are required for specification of central cardiac conduction tissue. Development 133 (2006) 1125-1132
    • (2006) Development , vol.133 , pp. 1125-1132
    • Milan, D.J.1    Giokas, A.C.2    Serluca, F.C.3    Peterson, R.T.4    MacRae, C.A.5
  • 26
    • 33847133446 scopus 로고    scopus 로고
    • Enrichment of cardiac pacemaker-like cells: neuregulin-1 and cyclic AMP increase I(f)-current density and connexin 40 mRNA levels in fetal cardiomyocytes
    • Ruhparwar A., Er F., Martin U., Radke K., Gruh I., Niehaus M., Karck M., Haverich A., and Hoppe U.C. Enrichment of cardiac pacemaker-like cells: neuregulin-1 and cyclic AMP increase I(f)-current density and connexin 40 mRNA levels in fetal cardiomyocytes. Med Biol Eng Comput 45 (2007) 221-227
    • (2007) Med Biol Eng Comput , vol.45 , pp. 221-227
    • Ruhparwar, A.1    Er, F.2    Martin, U.3    Radke, K.4    Gruh, I.5    Niehaus, M.6    Karck, M.7    Haverich, A.8    Hoppe, U.C.9
  • 27
    • 33745805840 scopus 로고    scopus 로고
    • Role of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-talk
    • Lemmens K., Segers V.F., Demolder M., and De Keulenaer G.W. Role of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-talk. J Biol Chem 281 (2006) 19469-19477
    • (2006) J Biol Chem , vol.281 , pp. 19469-19477
    • Lemmens, K.1    Segers, V.F.2    Demolder, M.3    De Keulenaer, G.W.4
  • 28
    • 0032562770 scopus 로고    scopus 로고
    • Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes
    • A study to examine the role of NRG and their receptors in developing and postnatal myocardium and suggests a continuing role for neuregulins in the myocardial adaptation to physiologic stress or injury.
    • Zhao Y.Y., Sawyer D.R., Baliga R.R., Opel D.J., Han X., Marchionni M.A., and Kelly R.A. Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes. J Biol Chem 273 (1998) 10261-10269. A study to examine the role of NRG and their receptors in developing and postnatal myocardium and suggests a continuing role for neuregulins in the myocardial adaptation to physiologic stress or injury.
    • (1998) J Biol Chem , vol.273 , pp. 10261-10269
    • Zhao, Y.Y.1    Sawyer, D.R.2    Baliga, R.R.3    Opel, D.J.4    Han, X.5    Marchionni, M.A.6    Kelly, R.A.7
  • 29
    • 0026349336 scopus 로고
    • Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response
    • Chien K.R., Knowlton K.U., Zhu H., and Chien S. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response. FASEB J 5 (1991) 3037-3046
    • (1991) FASEB J , vol.5 , pp. 3037-3046
    • Chien, K.R.1    Knowlton, K.U.2    Zhu, H.3    Chien, S.4
  • 30
    • 33748929841 scopus 로고    scopus 로고
    • Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy
    • A study to examine the role of NRG and their receptors in developing and postnatal myocardium and suggests a continuing role for neuregulins in the myocardial adaptation to physiologic stress or injury.
    • Liu X., Gu X., Li Z., Li X., Li H., Chang J., Chen P., Jin J., Xi B., Chen D., et al. Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy. J Am Coll Cardiol 48 (2006) 1438-1447. A study to examine the role of NRG and their receptors in developing and postnatal myocardium and suggests a continuing role for neuregulins in the myocardial adaptation to physiologic stress or injury.
    • (2006) J Am Coll Cardiol , vol.48 , pp. 1438-1447
    • Liu, X.1    Gu, X.2    Li, Z.3    Li, X.4    Li, H.5    Chang, J.6    Chen, P.7    Jin, J.8    Xi, B.9    Chen, D.10
  • 31
    • 0344924865 scopus 로고    scopus 로고
    • Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt
    • Fukazawa R., Miller T.A., Kuramochi Y., Frantz S., Kim Y.D., Marchionni M.A., Kelly R.A., and Sawyer D.B. Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt. J Mol Cell Cardiol 35 (2003) 1473-1479
    • (2003) J Mol Cell Cardiol , vol.35 , pp. 1473-1479
    • Fukazawa, R.1    Miller, T.A.2    Kuramochi, Y.3    Frantz, S.4    Kim, Y.D.5    Marchionni, M.A.6    Kelly, R.A.7    Sawyer, D.B.8
  • 32
    • 10944236872 scopus 로고    scopus 로고
    • Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling
    • Kuramochi Y., Cote G.M., Guo X., Lebrasseur N.K., Cui L., Liao R., and Sawyer D.B. Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling. J Biol Chem 279 (2004) 51141-51147
    • (2004) J Biol Chem , vol.279 , pp. 51141-51147
    • Kuramochi, Y.1    Cote, G.M.2    Guo, X.3    Lebrasseur, N.K.4    Cui, L.5    Liao, R.6    Sawyer, D.B.7
  • 34
    • 33746048823 scopus 로고    scopus 로고
    • Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes
    • By experiments on adult rat ventricular myocytes in primary culture, the authors firstly suggested a potential role of NRG-1β/erbB2/Src/FAK signaling in the maintenance and repair of electrical and mechanical coupling in cardiomyocytes.
    • Kuramochi Y., Guo X., and Sawyer D.B. Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes. J Mol Cell Cardiol 41 (2006) 228-235. By experiments on adult rat ventricular myocytes in primary culture, the authors firstly suggested a potential role of NRG-1β/erbB2/Src/FAK signaling in the maintenance and repair of electrical and mechanical coupling in cardiomyocytes.
    • (2006) J Mol Cell Cardiol , vol.41 , pp. 228-235
    • Kuramochi, Y.1    Guo, X.2    Sawyer, D.B.3
  • 36
    • 10644245099 scopus 로고    scopus 로고
    • RGD and YIGSR synthetic peptides facilitate cellular adhesion identical to that of laminin and fibronectin but alter the physiology of neonatal cardiac myocytes
    • Boateng S.Y., Lateef S.S., Mosley W., Hartman T.J., Hanley L., and Russell B. RGD and YIGSR synthetic peptides facilitate cellular adhesion identical to that of laminin and fibronectin but alter the physiology of neonatal cardiac myocytes. Am J Physiol Cell Physiol 288 (2005) C30-C38
    • (2005) Am J Physiol Cell Physiol , vol.288
    • Boateng, S.Y.1    Lateef, S.S.2    Mosley, W.3    Hartman, T.J.4    Hanley, L.5    Russell, B.6
  • 37
    • 1642263252 scopus 로고    scopus 로고
    • Restoration of resting sarcomere length after uniaxial static strain is regulated by protein kinase Cepsilon and focal adhesion kinase
    • Mansour H., de Tombe P.P., Samarel A.M., and Russell B. Restoration of resting sarcomere length after uniaxial static strain is regulated by protein kinase Cepsilon and focal adhesion kinase. Circ Res 94 (2004) 642-649
    • (2004) Circ Res , vol.94 , pp. 642-649
    • Mansour, H.1    de Tombe, P.P.2    Samarel, A.M.3    Russell, B.4
  • 38
    • 0037007076 scopus 로고    scopus 로고
    • Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity
    • Sawyer D.B., Zuppinger C., Miller T.A., Eppenberger H.M., and Suter T.M. Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity. Circulation 105 (2002) 1551-1554
    • (2002) Circulation , vol.105 , pp. 1551-1554
    • Sawyer, D.B.1    Zuppinger, C.2    Miller, T.A.3    Eppenberger, H.M.4    Suter, T.M.5
  • 39
    • 1642458136 scopus 로고    scopus 로고
    • Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase
    • This paper shows a direct effect of NRG-1 on contractility of adult cardiac muscle. It also concluded that the inotropic effect of NRG-1 was preserved during adrenergic stimulation and desensitized the myocardium to isoproterenol.
    • Lemmens K., Fransen P., Sys S.U., Brutsaert D.L., and De Keulenaer G.W. Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase. Circulation 109 (2004) 324-326. This paper shows a direct effect of NRG-1 on contractility of adult cardiac muscle. It also concluded that the inotropic effect of NRG-1 was preserved during adrenergic stimulation and desensitized the myocardium to isoproterenol.
    • (2004) Circulation , vol.109 , pp. 324-326
    • Lemmens, K.1    Fransen, P.2    Sys, S.U.3    Brutsaert, D.L.4    De Keulenaer, G.W.5
  • 40
    • 27244441434 scopus 로고    scopus 로고
    • Letter regarding article by Okoshi et al, 'neuregulins regulate cardiac parasympathetic activity: muscarinic modulation of {beta}-adrenergic activity in myocytes from mice with neuregulin-1 gene deletion'
    • author reply e175
    • Lemmens K., Segers F., and De Keulenaer G.W. Letter regarding article by Okoshi et al, 'neuregulins regulate cardiac parasympathetic activity: muscarinic modulation of {beta}-adrenergic activity in myocytes from mice with neuregulin-1 gene deletion'. Circulation 111 (2005) e175 author reply e175
    • (2005) Circulation , vol.111
    • Lemmens, K.1    Segers, F.2    De Keulenaer, G.W.3
  • 41
    • 4043110498 scopus 로고    scopus 로고
    • Neuregulins regulate cardiac parasympathetic activity: muscarinic modulation of beta-adrenergic activity in myocytes from mice with neuregulin-1 gene deletion
    • Okoshi K., Nakayama M., Yan X., Okoshi M.P., Schuldt A.J., Marchionni M.A., and Lorell B.H. Neuregulins regulate cardiac parasympathetic activity: muscarinic modulation of beta-adrenergic activity in myocytes from mice with neuregulin-1 gene deletion. Circulation 110 (2004) 713-717
    • (2004) Circulation , vol.110 , pp. 713-717
    • Okoshi, K.1    Nakayama, M.2    Yan, X.3    Okoshi, M.P.4    Schuldt, A.J.5    Marchionni, M.A.6    Lorell, B.H.7
  • 44
    • 25144465666 scopus 로고    scopus 로고
    • Neuregulin receptors erbB2 and erbB4 in failing human myocardium-depressed expression and attenuated activation
    • Rohrbach S., Niemann B., Silber R.E., and Holtz J. Neuregulin receptors erbB2 and erbB4 in failing human myocardium-depressed expression and attenuated activation. Basic Res Cardiol 100 (2005) 240-249
    • (2005) Basic Res Cardiol , vol.100 , pp. 240-249
    • Rohrbach, S.1    Niemann, B.2    Silber, R.E.3    Holtz, J.4
  • 45
    • 34247149885 scopus 로고    scopus 로고
    • Inhibition of ErbB2/neuregulin signaling augments paclitaxel-induced cardiotoxicity in adult ventricular myocytes
    • Pentassuglia L., Timolati F., Seifriz F., Abudukadier K., Suter T.M., and Zuppinger C. Inhibition of ErbB2/neuregulin signaling augments paclitaxel-induced cardiotoxicity in adult ventricular myocytes. Exp Cell Res 313 (2007) 1588-1601
    • (2007) Exp Cell Res , vol.313 , pp. 1588-1601
    • Pentassuglia, L.1    Timolati, F.2    Seifriz, F.3    Abudukadier, K.4    Suter, T.M.5    Zuppinger, C.6
  • 46
    • 0028809084 scopus 로고
    • Differential regulation of two types of intracellular calcium release channels during end-stage heart failure
    • Go L.O., Moschella M.C., Watras J., Handa K.K., Fyfe B.S., and Marks A.R. Differential regulation of two types of intracellular calcium release channels during end-stage heart failure. J Clin Invest 95 (1995) 888-894
    • (1995) J Clin Invest , vol.95 , pp. 888-894
    • Go, L.O.1    Moschella, M.C.2    Watras, J.3    Handa, K.K.4    Fyfe, B.S.5    Marks, A.R.6
  • 48
    • 0037195427 scopus 로고    scopus 로고
    • Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure
    • Jiang M.T., Lokuta A.J., Farrell E.F., Wolff M.R., Haworth R.A., and Valdivia H.H. Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure. Circ Res 91 (2002) 1015-1022
    • (2002) Circ Res , vol.91 , pp. 1015-1022
    • Jiang, M.T.1    Lokuta, A.J.2    Farrell, E.F.3    Wolff, M.R.4    Haworth, R.A.5    Valdivia, H.H.6
  • 49
    • 0029029280 scopus 로고
    • Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes
    • Bassani J.W., Yuan W., and Bers D.M. Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes. Am J Physiol 268 (1995) C1313-C1319
    • (1995) Am J Physiol , vol.268
    • Bassani, J.W.1    Yuan, W.2    Bers, D.M.3
  • 50
    • 0026794257 scopus 로고
    • Functional difference between SERCA2a and SERCA2b Ca2+ pumps and their modulation by phospholamban
    • Verboomen H., Wuytack F., De Smedt H., Himpens B., and Casteels R. Functional difference between SERCA2a and SERCA2b Ca2+ pumps and their modulation by phospholamban. Biochem J 286 Pt 2 (1992) 591-595
    • (1992) Biochem J , vol.286 , Issue.PART 2 , pp. 591-595
    • Verboomen, H.1    Wuytack, F.2    De Smedt, H.3    Himpens, B.4    Casteels, R.5
  • 51
    • 0026016543 scopus 로고
    • Identification of the major protein phosphatases in mammalian cardiac muscle which dephosphorylate phospholamban
    • MacDougall L.K., Jones L.R., and Cohen P. Identification of the major protein phosphatases in mammalian cardiac muscle which dephosphorylate phospholamban. Eur J Biochem 196 (1991) 725-734
    • (1991) Eur J Biochem , vol.196 , pp. 725-734
    • MacDougall, L.K.1    Jones, L.R.2    Cohen, P.3
  • 52
    • 0344009618 scopus 로고    scopus 로고
    • Cardiac SR-coupled PP1 activity and expression are increased and inhibitor 1 protein expression is decreased in failing hearts
    • Gupta R.C., Mishra S., Rastogi S., Imai M., Habib O., and Sabbah H.N. Cardiac SR-coupled PP1 activity and expression are increased and inhibitor 1 protein expression is decreased in failing hearts. Am J Physiol Heart Circ Physiol 285 (2003) H2373-H2381
    • (2003) Am J Physiol Heart Circ Physiol , vol.285
    • Gupta, R.C.1    Mishra, S.2    Rastogi, S.3    Imai, M.4    Habib, O.5    Sabbah, H.N.6
  • 56
    • 39749191084 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Rosamond W., Flegal K., Furie K., Go A., Greenlund K., Haase N., Hailpern S.M., Ho M., Howard V., Kissela B., et al. Heart disease and stroke statistics-2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 117 (2008) e25-e146
    • (2008) Circulation , vol.117
    • Rosamond, W.1    Flegal, K.2    Furie, K.3    Go, A.4    Greenlund, K.5    Haase, N.6    Hailpern, S.M.7    Ho, M.8    Howard, V.9    Kissela, B.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.