Rapid tissue engineering of biomimetic human corneal limbal crypts with 3D niche architecture

Biomaterials

Volumn 34, Issue 35, 2013, Pages 8860-8868

  Levis, Hannah J ^a   Massie, Isobel ^a   Dziasko, Marc A ^a   Kaasi, Andreas ^b   Daniels, Julie T ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b SARTORIUS STEDIM BIOTECH GMBH   (Germany)

Author keywords

Bioengineered limbal crypt; Biomimetic material; Collagen; Cornea; Limbal stem cell niche; Ophthalmology

Indexed keywords

BIOENGINEERED LIMBAL CRYPT; COLLAGEN CONSTRUCTS; CORNEA; EPITHELIAL CELLS; MICROENVIRONMENTS; ONE-STEP METHODS; STEM-CELL NICHES; TOPOGRAPHICAL FEATURES;

BIOMIMETIC MATERIALS; BIOMIMETICS; COLLAGEN; OPHTHALMOLOGY; SURFACE TOPOGRAPHY; TISSUE ENGINEERING;

STEM CELLS;

BIOMIMETIC MATERIAL; COLLAGEN; PROTEIN P63;

ARTICLE; CORNEA EPITHELIUM; CORNEA LIMBUS; HUMAN; HUMAN CELL; HYDROGEL; HYDROPHILICITY; POROSITY; PRIORITY JOURNAL; STEM CELL; STEM CELL NICHE; TISSUE ENGINEERING; TISSUE STRUCTURE;

BIOENGINEERED LIMBAL CRYPT; BIOMIMETIC MATERIAL; COLLAGEN; CORNEA; LIMBAL STEM CELL NICHE; OPHTHALMOLOGY;

BIOMIMETIC MATERIALS; BIOMIMETICS; CELL LINE; COLLAGEN; EPITHELIAL CELLS; EPITHELIUM, CORNEAL; FIBROBLASTS; HUMANS; LIMBUS CORNEAE; MICROSCOPY, ELECTRON, SCANNING; STEM CELL NICHE; TISSUE ENGINEERING;

EID: 84883240152     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.08.002     Document Type: Article

References (28)

1. Davanger M., Evensen A. Role of the pericorneal papillary structure in renewal of corneal epithelium. Nature 1971, 229:560-561.
2. Tseng S.C. Regulation and clinical implications of corneal epithelial stem cells. Mol Biol Rep 1996, 23:47-58.
3. Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 1978, 4:7-25.
4. Fuchs E., Tumbar T., Guasch G. Socializing with the neighbors: stem cells and their niche. Cell 2004, 116:769-778.
5. Theise N.D., Saxena R., Portmann B.C., Thung S.N., Yee H., Chiriboga L., et al. The canals of hering and hepatic stem cells in humans. Hepatology 1999, 30:1425-1433.
6. Schlötzer-Schrehardt U., Kruse F.E. Identification and characterization of limbal stem cells. Exp Eye Res 2005, 81:247-264.
7. Shortt A., Secker G., Munro P., Khaw P., Tuft S., Daniels J. Characterization of the limbal epithelial stem cell niche: novel imaging techniques permit invivo observation and targeted biopsy of limbal epithelial stem cells. Stem Cells 2007, 25:1402-1409.
8. Ahmad S. Concise review: limbal stem cell deficiency, dysfunction, and distress. Stem Cells Transl Med 2012, 1:110-115.
9. Notara M., Shortt A.J., Galatowicz G., Calder V., Daniels J.T. Il6 and the human limbal stem cell niche: a mediator of epithelial-stromal interaction. Stem Cell Res 2010, 5:188-200.
10. Mendez-Ferrer S., Michurina T.V., Ferraro F., Mazloom A.R., Macarthur B.D., Lira S.A., et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010, 466:829-834.
11. Levis H.J., Brown R.A., Daniels J.T. Plastic compressed collagen as a biomimetic substrate for human limbal epithelial cell culture. Biomaterials 2010, 31:7726-7737.
12. Lutolf M.P., Blau H.M. Artificial stem cell niches. Adv Mater 2009, 21:3255-3268.
13. Phillippi J.A., Miller E., Weiss L., Huard J., Waggoner A., Campbell P. Microenvironments engineered by inkjet bioprinting spatially direct adult stem cells toward muscle- and bone-like subpopulations. Stem Cells 2008, 26:127-134.
14. Albrecht D.R., Underhill G.H., Wassermann T.B., Sah R.L., Bhatia S.N. Probing the role of multicellular organization in three-dimensional microenvironments. Nat Methods 2006, 3:369-375.
15. Nelson C.M., Tien J. Microstructured extracellular matrices in tissue engineering and development. Curr Opin Biotechnol 2006, 17:518-523.
16. Levis H.J., Menzel-Severing J., Drake R.A., Daniels J.T. Plastic compressed collagen constructs for ocular cell culture and transplantation: a new and improved technique of confined fluid loss. Curr Eye Res 2013, 38:41-52.
17. Araki-Sasaki K., Ohashi Y., Sasabe T., Hayashi K., Watanabe H., Tano Y., et al. An sv40-immortalized human corneal epithelial cell line and its characterization. Invest Ophthalmol Vis Sci 1995, 36:614-621.
18. Miri A., Al-Aqaba M., Otri A.M., Fares U., Said D.G., Faraj L.A., et al. Invivo confocal microscopic features of normal limbus. Br J Ophthalmol 2012, 96:530-536.
19. Romano A.C., Espana E.M., Yoo S.H., Budak M.T., Wolosin J.M., Tseng S.C.G. Different cell sizes in human limbal and central corneal basal epithelia measured by confocal microscopy and flow cytometry. Invest Ophthalmol Vis Sci 2003, 44:5125-5129.
20. Barrandon Y., Green H. Cell size as a determinant of the clone-forming ability of human keratinocytes. Proc Natl Acad Sci U S A 1985, 82:5390-5394.
21. Arpitha P., Prajna N.V., Srinivasan M., Muthukkaruppan V. Asubset of human limbal epithelial cells with greater nucleus-to-cytoplasm ratio expressing high levels of p63 possesses slow-cycling property. Cornea 2008, 27:1164-1170.
22. Barker N., van Es J.H., Kuipers J., Kujala P., Van Den Born M., Cozijnsen M., et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007, 449:1003-1007.
23. Ortega I., Deshpande P., Gill A.A., Macneil S., Claeyssens F. Development of a microfabricated artificial limbus with micropockets for cell delivery to the cornea. Biofabrication 2013, 5:025008.
24. Bush K.A., Pins G.D. Development of microfabricated dermal epidermal regenerative matrices to evaluate the role of cellular microenvironments on epidermal morphogenesis. Tissue Eng Part A 2012, 18:2343-2353.
25. Brown R.A., Wiseman M., Chuo C., Cheema U., Nazhat S.N. Ultrarapid engineering of biomimetic materials and tissues: fabrication of nano-and microstructures by plastic compression. Adv Funct Mater 2005, 15:1762-1770.
26. Hadjipanayi E., Ananta M., Binkowski M., Streeter I., Lu Z., Cui Z.F., et al. Mechanisms of structure generation during plastic compression of nanofibrillar collagen hydrogel scaffolds: towards engineering of collagen. JTissue Eng Regen Med 2011, 5:505-519.
27. Alekseeva T., Hadjipanayi E., Abou Neel E.A., Brown R.A. Engineering stable topography in dense bio-mimetic 3D collagen scaffolds. Eur Cell Mater 2012, 23:28-40.
28. Levis H.J., Peh G.S., Toh K.P., Poh R., Shortt A.J., Drake R.A., et al. Plastic compressed collagen as a novel carrier for expanded human corneal endothelial cells for transplantation. PLoS ONE 2012, 7:e50993.