Estrogens and Depression in Women

Treatment of the Postmenopausal Woman: Basic and Clinical Aspects, Third Edition

Volumn , Issue , 2007, Pages 307-320

  Rubinow, David R ^a   Roca, Catherine A ^b   Schmidt, Peter J ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84883226911     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012369443-0/50030-2     Document Type: Chapter

References (195)

1. GH Savage (1893) Some mental disorders associated with the menopause. Lancet ii 1128.
2. GH Savage (1893) Some neuroses of the climacteric and summary of cli-macteric cases at Bethlem, from July 1,1888 to June 30, 1893. Tr Med Soc Lond xvii 31-47.
3. WHS Fosbery (1897) Severe climacteric flushings successfully treated by ovarian extract. Br Med J 1 1039.
4. CC Easterbrook (1900) Organo-therapeutics in mental diseases. Br Med J 2 813-823.
5. S Rosenthal (1968) The involutional depressive syndrome. Am J Psychiatry 124 21-35.
6. RC Kessler, KA McGonagle, S Zhao, et al. (1994) Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States: results from the National Comorbidity Survey. Arch Gen Psychiatry 51 8-19.
7. RC Kessler, KA McGonagle, CB Nelson, et al. (1994) Sex and depression in the National Comorbidity Survey II: cohort effectsJ. Affective Disord 30 15-26.
8. J Johnson, MM Weissman and GL Klerman (1992) Service utilization and so-cial morbidity associated with depressive symptoms in the commu-nity. JAMA 267 1478-1483.
9. RC Kessler, S Zhao, DG Blazer, et al. (1997) Prevalence, correlates, and course of minor depression and major depression in the national co-morbidity survey. J Affective Disord 45 19-30.
10. AD Lopez and CCJL Murray (1998) The global burden of disease, 1990-2020. Nature Med 4 1241-1243.
11. LL Judd, MH Rapaport, MP Paulus, et al. (1994) Subsyndromal symptom-atic depression: a new mood disorder? J Clin Psychiatry 55 18-28.
12. MH Rapaport, LL Judd, PJ Schettler, et al. (2002) A descriptive analysis of minor depression. Am J Psychiatry 159 637-643.
13. LL Judd, PJ Schettler and HS Akiskal (2002) The prevalence, clinical relevance, and public health significance of subthreshold depressions. Psychiatr Clin North Am 25 685-698.
14. WE Broadhead, DG Blazer, LK George, et al. (1990) Depression, disability days, and days lost from work in a prospective epidemiologic survey. JAMA 264 2524-2528.
15. LL Judd, MP Paulus, KB Wells, et al. (1996) Socioeconomic burden of sub-syndromal depressive symptoms and major depression in a sample of the general population. Am J Psychiatry 153 1411-1417.
16. J Angst and K Merikangas (1997) The depressive spectrum: diagnostic classifi-cation and course. J Affective Disord 45 31-40.
17. KS Kendler and C.O.J. Gardner CO Jr (1998) Boundaries of major depression: an evaluation of DSM-IV criteria. Am J Psychiatry 155 172-177.
18. HS Akiskal, LL Judd, C Gillin, et al. (1997) Subthreshold depressions: clinical and polysomnographic validation of dysthymic, residual and masked forms. J Affective Disord 45 53-63.
19. A Kumar, Z Jin, W Bilker, et al. (1998) Late-onset minor and major depres-sion: early evidence for common neuroanatomical substrates detected by using MRI. Proc Natl Acad Sci U S A 95 7654-7658.
20. JC Barefoot and M Schroll (1996) Symptoms of depression, acute myocardial infarction, and total mortality in a community sample. Circulation 93 1976-1980.
21. RM Carney, KE Freedland, GE Miller, et al. (2002) Depression as a risk factor for cardiac mortality and morbidity: a review of potential mechanisms. J Psychosom Res 53 897-902.
22. PW Gold and GP Chrousos (1998) The endocrinology of melancholic and atypical depression: relation to neurocircuitry and somatic conse-quences. Proc Assoc Am Physicians 111 22-34.
23. D Michelson, C Stratakis, J Reynolds, et al. (1996) Bone mineral density in women with depression. N Engl J Med 335 664-666.
24. G Cizza, P Ravn, GP Chrousos, et al. (2001) Depression: a major, unrecog-nized risk factor for osteoporosis? Trends Endocrinol Metab 12 198-203.
25. RM Carney, MW Rich, KE Freedland, et al. (1988) Major depressive disor-der predicts cardiac events in patients with coronary artery disease. Psychosom Med 50 627-633.
26. N Frasure-Smith, F Lesperance and M Talajic (1993) Depression following myocardial infarction: impact on 6-month survival. JAMA 270 1819-1825.
27. S Wassertheil-Smoller, S Shumaker, J Ockene, et al. (2004) Depression cardiovascular sequelae in postmenopausal women. The Women's Health Initiative (WHI). Arch Intern Med 164 289-298.
28. R Schulz, SR Beach, DG Ives, et al. (2000) Association between depression mortality in older adults. The Cardiovascular Health Study. Arch Intern Med 160 1761-1768.
29. CD Sherbourne, KB Wells, RD Hays, et al. (1994) Subthreshold depression and depressive disorder: clinical characteristics of general medical and mental health specialty outpatients. Am J Psychiatry 151 1777-1784.
30. RL Spitzer, K Kroenke, M Linzer, et al. (1995) Health-related quality of life in primary care patients with mental disorders: results from the PRIME-MD 1000 study. JAMA 1274 1511-1517.
31. PS Wang, P Berglund and RC Kessler (2000) Recent care of common mental disorders in the United States. J Gen Intern Med 15 284-292.
32. JF Greden (2001) The burden of recurrent depression: causes, consequences, and future prospects. J Clin Psychiatry 62 5-9.
33. RC Kessler, P Berglund, O Dernier, et al. (2003) The epidemiology of major depressive disorder Results from the National Comorbidity Survey Replication. (NCS-R). JAMA 289 3095-3105.
34. Diagnostic and statistical manual of mental disorders, fourth edition Washington, DC: American Psychiatric Association
35. MB First, RL Spitzer and M Gibbon (1996) Structured clinical interview for DSM-IV Axis I disorders-patient edition. New York: Biometrics Research Department, New York State Psychiatric Institute
36. M Zimmerman and JL Mattia (1999) The reliability and validity of a screening questionnaire for 13 DSM-IV Axis I disorders (the Psychiatric Diag-nostic Screening Questionnaire) in psychiatric. Psychiatry 60 677-683.
37. RL Spitzer, JBW Williams, K Kroenke, et al. (1994) Utility of a new proce-dure for diagnosing mental disorders in primary care: the PRIME-MD 1000 study. JAMA 272 1749-1756.
38. M Linzer, R Spitzer, K Kroenke, et al. (1996) Gender, quality of life, and mental disorders in primary care: results from the PRIME-MD 1000 study. Am J Med 101 526-533.
39. RL Spitzer, JBW Williams, K Kroenke, et al. (2000) Validity and utility of the PRIME-MD patient health questionnaire in assessment of 3000 obstetric-gynecologic patients: the PRIME-MD patient health ques-tionn. Am J Obstet Gynecol 183 759.
40. WZ Potter and HK Manji (1994) Catecholamines in depression: an update. Clin Chem 40 279-282.
41. L Booij, AJW Van der Does and WJ Riedel (2003) Monoamine depletion in psychiatric and healthy populations: review. Mol Psychiatry 8 951-973.
42. A Neumeister, AC Nugent, T Waldeck, et al. (2004) Neural and behavioral responses to tryptophan depletion in unmedicated patients with re-mitted major depressive disorder and controls. Arch Gen Psychiatry 61 765-773.
43. JD Bremner, M Vythilingam, CK Ng, et al. (2003) Regional brain metabolic correlates of a-methylparatyrosine-induced depressive symptoms: implications for the neural circuitry of depression. JAMA 289 3125-3134.
44. HK Manji, WC Drevets and DS Charney (2001) The cellular neurobiology of depression. Nature Med 7 541-547.
45. WC Drevets (2000) Neuroimaging studies of mood disorders. Biol Psychia-try 48 813-829.
46. WC Drevets (2001) Neuroimaging and neuropathological studies of depres-sion: implications for the cognitive-emotional features of mood disor-ders. Curr Opin Neurobiol 11 240-249.
47. RC Kessler, KA McGonagle, M Swartz, et al. (1993) Sex and depression in the National Comorbidity Survey I: lifetime prevalence, chronicity and recurrence. J Affective Disord 29 85-96.
48. SB Patten and RC Lee (2004) Refining estimates of major depression incidence and episode duration in Canada using a Monte Carlo Markov model. Med Decis Making 24 351-358.
49. J Spijker, R de Graaf, RV Bijl, et al. (2002) Duration of major depressive episodes in the general population: results from The Netherlands Mental Health Survey and Incidence Study (NEMESIS). Br J Psy-chiatry 181 208-213.
50. CB Nemeroff and MJ Owens (2002) Treatment of mood disorders. NatNeurosci 5 1068-1070.
51. M Fava and KS Kendler (2000) Major depressive disorder. Neuron 28 335-341.
52. AE Treloar (1981) Menstrual cyclicity and the pre-menopause. Maturitas 3 249-264.
53. PA Kaufert, P Gilbert and R Täte (1987) Defining menopausal status: the im-pact of longitudinal data. Maturitas 9 217-226.
54. J Guthrie, L Dennerstein and H Burger (2002) How reliably does 12-month amenorrhea define final menstrual period? Data from a longitudinal study.Letter to the editor. Climacteric 5 92.
55. MR Soules, S Sherman, E Parrott, et al. (2001) Executive summary: Stages of Reproductive Aging Workshop (STRAW). Fertil Steril 76 874-878.
56. EW Freeman, MD Sammel, L Liu, et al. (2004) Hormones and menopausal status as predictors of depression in women in transition to meno-pause. Arch Gen Psychiatry 61 62-70.
57. JB McKinlay, SM McKinlay and D Brambilla (1987) The relative contributions of endocrine changes and social circumstances to depression in mid-aged womenJ. Health Soc Behav 28 345-363.
58. NF Woods and ES Mitchell (1997) Pathways to depressed mood for midlife women: observations from the Seattle midlife women's health study. Res Nurs Health 20 119-129.
59. N Frasure-Smith, F Lesperance and M Talajic (1995) Depression and 18-month prognosis after myocardial infarction. Circulation 91 999-1005.
60. GR Williams and JA Franklyn (1994) Physiology of the steroid-thyroid hor-mone nuclear receptor superfamily. Baillieres Clin Endocrinol Metab 8 241-266.
61. RM Evans (1988) The steroid and thyroid hormone receptor superfamily. Science 240 889-895.
62. M-J Tsai and BW O'Malley (1994) Molecular mechanisms of action of steroid Jthyroid receptor superfamily members. Annu Rev Biochem 63 451-486.
63. S Mosselman, J Polman and R Dijkema (1996) ERβ: identification and charac-terization of a novel human estrogen receptor. FEBS Lett 392 49-53.
64. GGJM Kuiper, E Enmark, M Pelto-Huikko, et al. (1996) Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci U S A 93 5925-5930.
65. EP-HM Enmark, K Grandien, S Lagercrantz, et al. (1997) Human estrogen receptor β-gene structure, chromosomal localization, and expression pattern. J Clin Endocrinol Metab 82 4258-4265.
66. BM Jones and MK Jones (1976) Women and alcohol: intoxication, metabolism and the menstrual cycle. M Greenblatt, M Schuckit,(Eds) Alcoholism problems in women and children New York: Grune and Stratton
67. X Li, PE Schwartz and EF Rissman (1997) Distribution of estrogen receptor-β-like immunoreactivity in rat forebrain. Neuroendocrinology 66 63-67.
68. PJ Shughrue, B Komm and I Merchenthaler (1996) The distribution of estrogen reeeptor-β mRNA in the rat hypothalamus. Steroids 61 678-681.
69. K Pettersson, K Grandien, GGJM Kuiper, et al. (1997) Mouse estrogen re-ceptor β forms estrogen response element-binding heterodimers with estrogen receptor a. Mol Endocrinol 11 1486-1496.
70. CH Clarke, KA Cunningham, DA Bland, et al. (1997) Sex hormone regula-tion of estrogen receptor (ERα and ERβ) mRNA in female rat brain. Abstr 27th Annu Meeting Soc Neurosci 23 1501.
71. M Bixo, T Backstrom, B Winblad, et al. (1995) Estradiol and testosterone in specific regions of the human female brain in different endocrine states. J Steroid Biochem Mol Biol 55 297~303.
72. FPM Kruijver, R Balesar, AM Espila, et al. (2003) Estrogen-receptor-β distribution in the human hypothalamus: similarities and differences with ERa distribution. J CompNeurol 466 251-277.
73. AH Taylor and F Al-Azzawi (2000) Immunolocalisation of oestrogen receptor beta in human tissues. J Mol Endocrinol 24 145-155.
74. DR Ciocca and R.L.M. Vargas Roig LM (1995) Estrogen receptors in human nontarget tissues: biological and clinical implications. Endocr Rev 16 35-62.
75. IR Cohen and PM Wise (1988) Effects of estradiol on the diurnal rhythm of serotonin activity in microdissected brain areas of ovariectomized rats. Endocrinology 122 2619-2625.
76. M Pecins-Thompson, NA Brown and CL Bethea (1998) Regulation of sero-tonin re-uptake transporter mRNA expression by ovarian steroids in rhesus macaques. Brain Res Mol Brain Res 53 120.
77. G Fink and BEH Sumner (1996) Oestrogen and mental state. Nature 383 306.
78. BEH Sumner and G Fink (1995) Estrogen increases the density of 5-hydroxy-tryptamine2A receptors in cerebral cortex and nucleus accumbens in the female rat. J Steroid Biochem Mol Biol 54 15-20.
79. CT Fischette, A Biegon and BS McEwen (1983) Sex differences in serotonin 1 receptor binding in rat brain. Science 222 333-335.
80. T Matsuda, Y Nakano, T Kanda, et al. (1991) Gonadal hormones affect the hypothermia induced by serotonin 1A (5-HT1A) receptor activation. Life Sci 48 1627-1632.
81. JA Katzenellenbogen, BW O'Malley and BS Katzenellenbogen (1996) Tripar-tite steroid hormone receptor pharmacology: interaction with multi-ple effector sites as a basis for the cell-and promoter-specific action of these hor. Mol Endocrinol 10 119-131.
82. NN Yang, M Venugopalan, S Hardikar, et al. (1996) Identification of an es-trogen response element activated by metabolites of 17β-estradiol and raloxifene. Science 273 1222-1225.
83. RF Power, SK Mani, J Codina, et al. (1991) Dopaminergic and ligand-inde-pendent activation of steroid hormone receptors. Science 254 1636-1639.
84. M Tzukerman, X Zhang, T Hermann, et al. (1990) The human estrogen re-ceptor has transcriptional activator and repressor functions in the absence of ligand. New Biologist 2 613-620.
85. M Wong and RL Moss (1992) Long-term and short-term electrophysiological effects of estrogen on the synaptic properties of hippocampal CAl neurons. J Neurosci 12 3217-3225.
86. PG Mermelstein, JB Becker and DJ Surmeier (1996) Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci 16 595-604.
87. MA Valverde, P Rojas, J Amigo, et al. (1999) Acute activation of Maxi-K channels (hSlo) by estradiol binding to the b subunit. Science 285 1929-1931.
88. L Zhang, M Sukhareva, JL Barker, et al. (2005) Direct binding of estradiol enhances Slack (sequence like a calcium-activated potassium channel) channels' activity. Neuroscience 131 275-282.
89. JJ Watters, JS Campbell, MJ Cunningham, et al. (1997) Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mito-gen activated protein kinase signalling cascade and c-fos immediate ear. Endocrinology 138 4030-4033.
90. M Sngh, G Sétáló Jr, X Guan, et al. (1999) Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical expiants: conver-gence of estrogen and neurotrophin signaling pathways. JNeurosci 19 1179-1188.
91. M Razandi, A Pedram, ST Park, et al. (2003) Proximal events in signaling by plasma membrane estrogen receptors. J Biol Chemistry 278 2701-2712.
92. L Zhang, B Li, W Zhao, et al. (2002) Sex-related differences in MAPKs activation in rat astrocytes: effects of estrogen on cell death. Mol Brain Res 103 1-11.
93. L Zhang, DR Rubinow, G Xaing, et al. (2001) Estrogen protects against beta-amyloid-induced neurotoxicity in rat hippocampal neurons by activation of Akt. Neuro Report 12 1919-1923.
94. K Honda, H Sawada, T Kihara, et al. (2000) Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons. J Neurosci Res 60 321-327.
95. CV Mobbs, M Kaplitt, LM Kow, et al. (1991) At the cutting edge: PLC-a: a common mediator of the action of estrogen and other hormones? Mol CellEndocrinol 80 C187-C191.
96. M Maus, P Bertrand, S Drouva, et al. (1989) Differential modulation of Dl and D2 dopamine-sensitive adenylate cyclases by 17β-estradiol in cultured striatal neurons and anterior pituitary cells. J Neurochem 52 410-418.
97. AL Mize, LJ Young and RH Alper (2003) Uncoupling of 5-HTlA receptors in the brain by estrogens: regional variations in antagonism by ICI 182,780. Neuropharmacology 44 584-591.
98. CD Toran-Allerand (1994) Developmental interactions of estrogens with the neurotrophins and their receptors. P Micevych, RP Hamer,(Eds) Neurobiological effects of sex steroid hormones Cambridge: Cambridge University Press
99. MA Smith and G Cizza (1996) Stress-induced changes in brain-derived neuro-trophic factor expression are attenuated in aged Fischer 344/N rats. Neurobiol Aging 17 859-864.
100. RS Duman, GR Heninger and EJ Nestler (1997) A molecular and cellular the-ory of depression. Arch Gen Psychiatry 54 597-606.
101. JA Siuciak, DR Lewis, SJ Wiegand, et al. (1997) Antidepressant-like effect of brain-derived neuro trophic factor (BDNF). Pharmacol Biochem Behav 56 131-137.
102. L. Knorring Lv, L Oreland, J Häggendal, et al. (1986) Relationship between platelet MAO activity and concentrations of 5-HIAA and H VA in cerebrospinal fluid in chronic pain patients. J Neural Transm [Gen Sect] 66 37-46.
103. SN Young, S Gauthier, GM Anderson, et al. (1980) Tryptophan, 5-hydroxy-indoleacetic acid and indoleacetic acid in human cerebrospinal fluid: interrelationships and the influence of age, sex, epilepsy and ant. J Neurol Neurosurg Psychiatry 43 438-445.
104. H Agren, IN Mefford, MV Rudorfer, et al. (1986) Interacting neurotrans-mitter systems. A non-experimental approach to the 5-HIAA-HVA correlation in human CSF. J Psychiatr Res 20 175-193.
105. F Biver, F Lotstra, M Monclus, et al. (1996) Sex difference in 5HT2 receptor in the living human brain. Neurosci Lett 204 25-28.
106. S Nishizawa, C Benkelfat, SN Young, et al. (1997) Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci U S A 94 5308-5313.
107. MA Ellenbogen, SN Young, P Dean, et al. (1996) Mood response to acute tryptophan depletion in healthy volunteers: sex differences and tem-poral stability. Neuropsychopharmacology 15 465-474.
108. IM Anderson, M Parry-Billings, EA Newsholme, et al. (1990) Dieting re-duces plasma tryptophan and alters brain 5-HT function in women. PsycholMed 20 785-791.
109. AES Walsh, AD Oldman, M Franklin, et al. (1995) Dieting decreases plasma tryptophan and increases the prolactin response to d-fenflura-mine in women but not men. J Affective Disord 33 89-97.
110. T-P Su, PJ Schmidt, M Danaceau, et al. (1997) Effect of menstrual cycle phase on neuroendocrine and behavioral responses to the serotonin agonist m-chlorophenylpiperazine in women with premenstrual syn-dr. J Clin Endocrinol Metab 82 1220-1228.
111. EA Young (1995) The role of gonadal steroids in hypothalamic-pituitary-adrenal axis regulation. Crit Rev Neurobiol 9 371-381.
112. J Bancroft, A Cook, D Davidson, et al. (1991) Blunting of neuroendocrine responses to infusion of L-tryptophan in women with perimenstrual mood change. Psychol Med 21 305-312.
113. BB Sherwin and BE Suranyi-Cadotte (1990) Up-regulatory effect of estrogen on platelet 3H-imipramine binding sites in surgically menopausal women. Biol Psychiatry 28 339-348.
114. JK McQueen, H Wilson and G Fink (1997) Estradiol-17β increases serotonin transporter (SERT) mRNA levels and the density of SERT-binding sites in female rat brain. Brain Res Mol Brain Res 45 13-23.
115. NR Best, DH Barlow, MP Rees, et al. (1989) Lack of effect of oestradiol implant on platelet imipramine and 5-HT2 receptor binding in menopausal subjects. Psychopharmacology 98 561.
116. U Halbreich, N Rojansky, S Palter, et al. (1995) Estrogen augments seroto-nergic activity in postmenopausal women. Biol Psychiatry 37 434-441.
117. PJ Schmidt, J Raju, M Danaceau, et al. (2002) The effects of gender and gonadal steroids on the neuroendocrine and temperature response to m-Chlorophenylpiperazine in leuprolide-induced hypogonadism in wo. Neuropsychopharmacology 27 800-812.
118. F Sohbrabji, RC Miranda and CD Toran-Allerand (1994) Estrogen differen-tially regulates estrogen and nerve growth factor receptor mRNAs in adult sensory neurons. J Neurosci 14 459-471.
119. I Cavus and RS Duman (2003) Influence of estradiol, stress, and 5-HT2A ago-nist treatment on brain-derived neurotrophic factor expression in fe-male rats. Biol Psychiatry 54 59-69.
120. Y Zhou, JJ Watters and DM Dorsa (1996) Estrogen rapidly induces the phos-phorylation of the cAMP response element binding protein in rat brain. Endocrinology 137 2163-2166.
121. F Sohrabji, LA Greene, RC Miranda, et al. (1994) Reciprocal regulation of estrogen and NGF receptors by their ligands in PC12 cells. J Neuro-biol 25 974-988.
122. P Cardona-Gomez, M Perez, J Avila, et al. (2004) Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus. Mol Cell Neurosci 25 363-373.
123. MM Weissman, PJ Leaf, GL Tischler, et al. (1988) Affective disorders in five United States communities. Psychol Med 18 141-153.
124. PA Kaufert, P Gilbert and R Tate (1992) The Manitoba project: a re-examina-tion of the link between menopause and depression. Maturitas 14 143-155.
125. NE Avis, D Brambilla, SM McKinlay, et al. (1994) A longitudinal analysis of the association between menopause and depression: results from the Massachusetts Women's Health Study. Ann Epidemiol 4 214-220.
126. KA Matthews (1992) Myths and realities of the menopause. Psychosom Med 54 1-9.
127. M Hunter (1992) The South-East England longitudinal study of the cli-macteric and postmenopause. Maturitas 14 117-126.
128. DE Stewart, K Boydell, C Derzko, et al. (1992) Psychologic distress during the menopausal years in women attending a menopause clinic. Int J Psychiatry Med 22 213-220.
129. L Dennerstein, AMA Smith, C Morse, et al. (1993) Menopausal symptoms in Australian women. Med J Aust 159 232-236.
130. AG Hay, J Bancroft and EC Johnstone (1994) Affective symptoms in women attending a menopause clinic. Br J Psychiatry 164 513-516.
131. LWF Maartens, JA Knottnerus and VJ Pop (2002) Menopausal transition and increased depressive symptomatology: a community based prospective study. Maturitas 42 195-200.
132. JT Bromberger, PM Meyer, HM Kravitz, et al. (2001) Psychologic distress and natural menopause: a multiethnic community study. Am J Public Health 91 1435-1442.
133. PJ Schmidt, NA Haq and DR Rubinow (2004) A longitudinal evaluation of the relationship between reproductive status and mood in perimenopausal women. Am J Psychiatry 161 2238-2244.
134. N Santoro, JR Brown, T Adel, et al. (1996) Characterization of reproductive hormonal dynamics in the perimenopause J Clin Endocrinol. Metab 81 1495-1501.
135. HG Burger, EC Dudley, JL Hopper, et al. (1995) The endocrinology of the menopausal transition: a cross-sectional study of a population-based sample J Clin Endocrinol. Metab 80 3537-3545.
136. L Dennerstein, EC Dudley, JL Hopper, et al. (2000) A prospective population-based study of menopausal symptoms. Obstet Gynecol 96 351-358.
137. NE Avis, R Stellato, S Crawford, et al. (2001) Is there a menopausal syn-drome? Menopausal status and symptoms across racial/ethnic groups. Soc Sci Med 52 345-356.
138. DE Stewart and KM Boydell (1993) Psychologic distress during menopause: associations across the reproductive cycle. Int J Psychiatry Med 23 157-162.
139. CD Soares and OP Almeida (2001) Depression during the perimenopause. Arch Gen Psychiatry 58 306.
140. BL Harlow, LS Cohen, MW Otto, et al. (1999) Prevalence and predictors of depressive symptoms in older premenopausal women: the Harvard study of mood and cycles. Arch Gen Psychiatry 56 418-424.
141. NF Woods and ES Mitchell (1996) Patterns of depressed mood in midlife women: observations from the Seattle midlife women's health study. Res Nurs Health 19 111-123.
142. L Dennerstein, P Lehert, H Burger, et al. (1999) Mood and the menopausal transition. J Nerv Ment Dis 187 685-691.
143. ES Mitchell and NF Woods (1996) Symptom experiences of midlife women: observations from the Seattle midlife women's health study. Maturitas 25 1-10.
144. JF Owens and KA Matthews (1998) Sleep disturbance in healthy middle-aged women. Maturitas 30 41-50.
145. JT Bromberger, SF Assmann, NE Avis, et al. (2003) Persistent mood symp-toms in a multiethnic community cohort of pre-and perimenopausal women. Am J Epidemiol 158 347-356.
146. EW Freeman, MD Sammel, PJ Rinaudo, et al. (2004) Premenstrual syn-drome as a predictor of menopausal symptoms. Obstet Gynecol 103 960-966.
147. M Richards, DR Rubinow, RC Daly, et al. (2006) Premenstrual symptoms and perimenopausal depression. Am J Psychiatry 163 133-137.
148. H Joffe, JE Hall, CN Soares, et al. (2002) Vasomotor symptoms are associ-ated with depression in perimenopausal women seeking primary care. Menopause 9 392-398.
149. PK Maciejewski, HG Prigerson and CM Mazure (2001) Sex differences in event-related risk for major depression. Psychol Med 31 593-604.
150. J Ormel, AJ Oldehinkel and EL Brilman (2001) The interplay and etiological continuity of neuroticism, difficulties, and life events in the etiology of major and subsyndromal, first and recurrent depressi. Am J Psychiatry 158 885-891.
151. KS Kendler, RC Kessler, EE Walters, et al. (1995) Stressful life events, ge-netic liability, and onset of an episode of major depression in women. Am J Psychiatry 152 833-842.
152. JG Greene and DJ Cooke (1980) Life stress and symptoms at the climacterium. BrJ Psychiatry 136 486-491.
153. S Ballinger, D Cobbin, J Krivanek, et al. (1979) Life stresses and depression in the menopause. Maturitas 1 191-199.
154. PJ Schmidt, JH Murphy, NA Haq, et al. (2004) Stressful life events, personal losses, and perimenopause-related depression. Arch Womens Ment Health 7 19-26.
155. L Dennerstein, E Dudley and J Guthrie (2002) Empty nest or revolving door? A prospective study of women's quality of life in midlife during the phase of children leaving and re-entering the home. Psychol Med 32 545-550.
156. AA Werner, GA Johns, EF Hoctor, et al. (1934) Involutional melancholia: probable etiology and treatment. JAMA 103 13-16.
157. L Dennerstein, GO Burows and GJ Hyman (1979) Hormone therapy and af-fect. Maturitas 1 247-259.
158. J Zohar, B Shapira, G Oppenheim, et al. (1985) Addition of estrogen to imipramine in female-resistant depressives. Psychopharmacol Bull 21 705-706.
159. M Brincat, JWW Studd, T O'Dowd, et al. (1984) Subcutaneous hormone implants for the control of climacteric symptoms: a prospective study. Lancet 1 16-18.
160. JC Montgomery, M Brincat, A Tapp, et al. (1987) Effect of oestrogen and testosterone implants on psychological disorders in the climacteric. Lancet 1 297-299.
161. RC Strickler, R Borth, A Cecutti, et al. (1977) The role of oestrogen replace-ment in the climacteric syndrome. Psychol Med 7 631-639.
162. J Coope (1981) Is oestrogen therapy effective in the treatment of meno-pausal depression? J R Coll Gen Pract 31 134-140.
163. BB Sherwin and MM Gelfand (1985) Sex steroids and affect in the surgical menopause: a double-blind, cross-over study. Psychoneuroendocrinology 10 325-335.
164. BB Sherwin (1991) The impact of different doses of estrogen and progestin on mood and sexual behavior in postmenopausal women. J Clin En-docrinol Metab 72 336-343.
165. BB Sherwin (1988) Affective changes with estrogen and androgen replace-ment therapy in surgically menopausal women. J Affective Disord 14 177-187.
166. EC Ditkoff, WG Crary, M Cristo, et al. (1991) Estrogen improves psycho-logical function in asymptomatic postmenopausal women. Obstet Gynecol 78 991-995.
167. LS Schneider, GW Small and CM Clary (2001) Estrogen replacement therapy and antidepressant response to sertraline in older depressed women. Am J Geriatr Psychiatry 9 393-399.
168. LS Schneider, GW Small, SH Hamilton, et al. (1997) Estrogen replacement and response to fluoxetine in a multicenter geriatric depression trial. Am J Geriatr Psychiatry 5 97-106.
169. GW Small, LS Schneider, S Holman, et al. (1994) Estrogen plus fluoxetine for geriatric depression. Abstr APA 147th Ann Meeting 203.
170. J Amsterdam, F Garcia-Espana, J Fawcett, et al. (1999) Fluoxetine efficacy in menopausal women with and without estrogen replacement. J Affec-tive Disord 55 11-17.
171. PJ Schmidt, L Nieman, MA Danaceau, et al. (2000) Estrogen replacement in perimenopause-related depression: a preliminary report. Am J Ob-stet Gynecol 183 414-420.
172. CD Soares, OP Almeida, H Joffe, et al. (2001) Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a double-blind, randomized, placebo-controlled trial. Arch Gen Psychiatry 58 529-534.
173. MF Morrison, MJ Kalian, H.T. Ten Have T, et al. (2004) Lack of efficacy of estra-diol for depression in postmenopausal women: a randomized, con-trolled trial. Biol Psychiatry 55 406-412.
174. JE Zweifel and WH O'Brien (1997) A meta-analysis of the effect of hormone replacement therapy upon depressed mood. Psychoneuroendocrinology 22 189-212.
175. R Nass and S Baker (1991) Androgen effects on cognition: congenital adrenal hyperplasia. Psychoneuroendocrinology 16 189-201.
176. B Saletu, N Brandstatter, M Metka, et al. (1995) Double-blind, placebo-controlled, hormonal, syndromal and EEG mapping studies with transdermal oestradiol therapy in menopausal depression. Psychophar-macology 122 321-329.
177. RN Butler and MI Lewis (1995) Late-life depression: when and how to inter-vene. Geriatrics 50 44-55.
178. RNJ Smith, EFN Holland and JWW Studd (1994) The symptomatology of progestogen intolerance. Maturitas 18 87-91.
179. S Hammarback, T Backstrom, J Hoist, et al. (1985) Cyclical mood changes as in the premenstrual tension syndrome during sequential estrogen-progestagen postmenopausal replacement therapy. Acta Obstet Gynecol Scand 64 393-397.
180. AL Magos, E Brewster, R Singh, et al. (1986) The effects of norethisterone in postmenopausal women on oestrogen replacement therapy: a model for the premenstrual syndrome. Br J Obstet Gynaecol 93 1290-1296.
181. C Kirkham, PM Hahn, DA VanVugt, et al. (1991) A randomized, double-blind, placebo-controlled, cross-over trial to assess the side effects of medroxyprogesterone acetate in hormone replacement therapy. Obstet Gynecol 78 93-97.
182. JC Prior, N Alojado, DW McKay, et al. (1994) No adverse effects of me-droxyprogesterone treatment without estrogen in postmenopausal women: double-blind, placebo-controlled, crossover trial. Obstet Gy-necol 83 24-28.
183. L Appleby, J Montgomery and J Studd (1981) Oestrogens and affective disorders. J Studd,(Eds) Progress in obstetrics and gynaecology Edinburgh: Churchill Livingstone
184. K Yaffe, G Sawaya, I Lieberburg, et al. (1998) Estrogen therapy in post-menopausal women: effects on cognitive function and dementia. JAMA 279 688-695.
185. ES LeBlanc, J Janowsky, BKS Chan, et al. (2001) Hormone replacement therapy and cognition: systematic review and meta-analysis. JAMA 285 1489-1499.
186. RB Gibbs (2000) Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats. Neurobiol Aging ,21 107-116.
187. PP Zandi, MC Carlson, BL Plassman, et al. (2002) Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County study. JAMA 288 2123-2129.
188. SM Resnick and VW Henderson (2002) Hormone therapy and risk of Alz-heimer disease: a critical time. JAMA 288 2170-2172.
189. TS Mikkola and TB Clarkson (2002) Estrogen replacement therapy, atheroscle-rosis, and vascular function. Cardiovasc Res 53 605-619.
190. KA Brownley, AL Hinderliter, SG West, et al. (2004) Cardiovascular effects of 6 months of hormone replacement therapy versus placebo: differ-ences associated with years since menopause. Am J Obstet Gynecol 190 1052-1058.
191. Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal result. JAMA 288 321-333.
192. SA Shumaker, C Legault, SR Rapp, et al. (2003) Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a ran. JAMA 289 2651-2662.
193. F Grodstein, TB Clarkson and JE Manson (2003) Understanding the divergent data on postmenopausal hormone therapy. N Engl J Med 348 645-650.
194. DM Herrington, TD Howard, GA Hawkins, et al. (2002) Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease. N Engl J Med 346 967-974.
195. K Yaffe, LY Lui, D Grady, et al. (2002) Estrogen receptor 1 polymorphism and risk of cognitive impairment in older women. Bio JPsychiatry 51