Inhibition of SENP1 induces radiosensitization in lung cancer cells

Experimental and Therapeutic Medicine

Volumn 6, Issue 4, 2013, Pages 1054-1058

  Wang, Ruo Tian ^a   Zhi, Xiu Yi ^a   Zhang, Yi ^a   Zhang, Jian ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Lung carcinoma; Radiosensitivity; Radiotherapy; SENP1

Indexed keywords

BROXURIDINE; CASPASE 3; HISTONE H2AX; MESSENGER RNA; PROTEINASE; SMALL INTERFERING RNA; SMALL UBIQUITIN RELATED MODIFIER SPECIFIC PROTEASE 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CLONOGENIC ASSAY; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IONIZING RADIATION; LUNG CANCER; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION EXPOSURE; RADIOSENSITIZATION; RNA INTERFERENCE; WESTERN BLOTTING;

EID: 84883216034     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2013.1259     Document Type: Article

References (22)

1. Sculier JP: Nonsmall cell lung cancer. Eur Respir Rev 22: 33-36, 2013.
2. Saadeddin A: Radiotherapy for NSCLC: review of conventional and new treatment techniques. J Infect Public Health 5 (Suppl 1): S45-S49, 2012.
3. Hennon MW and Yendamuri S: Advances in lung cancer surgery. J Carcinog 11: 21, 2012.
4. Nadkar A, Pungaliya C, Drake K, et al: Therapeutic resistance in lung cancer. Expert Opin Drug Metab Toxicol 2: 753-777, 2006.
5. Ryan JL: Ionizing radiation: the good, the bad, and the ugly. J Invest Dermatol 132: 985-993, 2012.
6. Verger A, Perdomo J and Crossley M: Modification with SUMO. A role in transcriptional regulation. EMBO Rep 4: 137-142, 2003.
7. Wang Y and Dasso M: SUMOylation and deSUMOylation at a glance. J Cell Sci 122: 4249-4252, 2009.
8. Yeh ET: SUMOylation and De-SUMOylation: wrestling with life's processes. J Biol Chem 284: 8223-8227, 2009.
9. Bawa-Khalfe T and Yeh ET: SUMO losing balance: SUMO proteases disrupt SUMO homeostasis to facilitate cancer development and progression. Genes Cancer 1: 748-752, 2010.
10. Cheng J, Kang X, Zhang S and Yeh ET: SUMO-specific protease 1 is essential for stabilization of HIF1α during hypoxia. Cell 131: 584-595, 2007.
11. Yu L, Ji W, Zhang H, et al: SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis. J Exp Med 207: 1183-1195, 2010.
12. Bawa-Khalfe T, Cheng J, Lin SH, Ittmann MM and Yeh ET: SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms. J Biol Chem 285: 25859-25866, 2010.
13. Bettermann K, Benesch M, Weis S, and Haybaeck J: SUMOylation in carcinogenesis. Cancer Lett 316: 113-125, 2012.
14. Qiao Z, Wang W, Wang L, et al: Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors. Bioorg Med Chem Lett 21: 6389-6392, 2011.
15. Chen Y, Wen D, Huang Z, et al: 2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation. Bioorg Med Chem Lett 22: 6867-6870, 2012.
16. Hanai K, Babazono T, Nyumura I, et al: Involvement of visceral fat in the pathogenesis of albuminuria in patients with type 2 diabetes with early stage of nephropathy. Clin Exp Nephrol 14: 132-136, 2010.
17. Taneja N, Davis M, Choy JS, et al: Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy. J Biol Chem 279: 2273-2280, 2004.
18. Xu Y, Li J, Zuo Y, et al: SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors. Cancer Lett 309: 78-84, 2011.
19. Li X, Lee YK, Jeng JC, et al: Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression. J Biol Chem 282: 36177-36189, 2007.
20. Yang Y, Fu W, Chen J, et al: SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat Cell Biol 9: 1253-1262, 2007.
21. Lindberg MJ, Popko-Scibor AE, Hansson ML, and Wallberg AE: SUMO modification regulates the transcriptional activity of MAML1. FASEB J 24: 2396-2404, 2010.
22. Van Nguyen T, Angkasekwinai P, Dou H, et al: SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation. Mol Cell 45: 210-221, 2012.