2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 22, 2012, Pages 6867-6870

  Chen, Yingyi ^a   Wen, Donghua ^a   Huang, Zhimin ^a   Huang, Min ^a   Luo, Yu ^a   Liu, Bin ^a   Lu, Han ^a   Wu, Yingli ^a   Peng, Yuefeng ^b   Zhang, Jian ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b University Town of Shenzhen   (China)

Author keywords

SENP1; Structure activity relationship; Virtual screening

Indexed keywords

2 (4 CHLOROPHENYL) 2 OXOETHYL 4 BENZAMIDOBENZOATE DERIVATIVE; 4 AMINOBENZOIC ACID DERIVATIVE; PROTEIN INHIBITOR; SUMO 1 PROTEIN; SUMO 1 PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL; SIMULATION; STRUCTURE ACTIVITY RELATION; VIRTUAL REALITY;

BENZAMIDES; BINDING SITES; ENDOPEPTIDASES; HUMANS; MOLECULAR DOCKING SIMULATION; PARA-AMINOBENZOATES; PROTEASE INHIBITORS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867841806     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.09.037     Document Type: Article

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