Endoplasmic reticulum stress and apoptosis contribute to the pathogenesis of dominantly inherited isolated GH deficiency due to GH1 gene splice site mutations

Endocrinology

Volumn 154, Issue 9, 2013, Pages 3228-3239

  Ariyasu, Daisuke ^a   Yoshida, Hiderou ^b   Yamada, Makoto ^c   Hasegawa, Yukihiro ^a  

^a TOKYO METROPOLITAN CHILDREN'S MEDICAL CENTER   (Japan)

^b UNIVERSITY OF HYOGO   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CASPASE; CASPASE 3; CASPASE 7; DOXYCYCLINE; INOSITOL; PROTEASOME; X BOX BINDING PROTEIN 1;

ALLELE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL LINE; CELL VIABILITY; DNA FRAGMENTATION; DONOR SITE; DOWNSTREAM PROCESSING; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; EXON; GENE; GENE DELETION; GENE OVEREXPRESSION; GH1 GENE; GROWTH HORMONE DEFICIENCY; LYSOSOME; MOLECULAR MECHANICS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ALLELES; ANIMALS; ANTI-BACTERIAL AGENTS; APOPTOSIS; CELL LINE; CELL SURVIVAL; CLONE CELLS; DOXYCYCLINE; DWARFISM, PITUITARY; ENDOPLASMIC RETICULUM STRESS; GENE DELETION; HUMAN GROWTH HORMONE; HUMANS; MUTATION; PROMOTER REGIONS, GENETIC; RATS; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; RNA SPLICE SITES; SIGNAL TRANSDUCTION; SOMATOTROPHS; UP-REGULATION;

EID: 84883204961     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-1249     Document Type: Article

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