메뉴 건너뛰기




Volumn 8, Issue 8, 2013, Pages

Hemochromatosis Enhances Tumor Progression via Upregulation of Intracellular Iron in Head and Neck Cancer

Author keywords

[No Author keywords available]

Indexed keywords

CICLOPIROXOLAMINE; DNA; HEPCIDIN; IRON; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; WNT PROTEIN;

EID: 84883200039     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074075     Document Type: Article
Times cited : (17)

References (50)
  • 3
    • 78650626081 scopus 로고    scopus 로고
    • The molecular biology of head and neck cancer
    • doi: 10.1038/nrc2982
    • Leemans CR, Braakhuis BJ, Brakenhoff RH, (2011) The molecular biology of head and neck cancer. Nat Rev Cancer 11: 9-22. doi:10.1038/nrc2982. PubMed: 21160525.
    • (2011) Nat Rev Cancer , vol.11 , pp. 9-22
    • Leemans, C.R.1    Braakhuis, B.J.2    Brakenhoff, R.H.3
  • 4
    • 84255199531 scopus 로고    scopus 로고
    • Wnt inhibitor screen reveals iron dependence of beta-catenin signaling in cancers
    • doi: 10.1158/0008-5472.CAN-11-2745
    • Song S, Christova T, Perusini S, Alizadeh S, Bao RY, et al. (2011) Wnt inhibitor screen reveals iron dependence of beta-catenin signaling in cancers. Cancer Res 71: 7628-7639. doi:10.1158/0008-5472.CAN-11-2745. PubMed: 22009536.
    • (2011) Cancer Res , vol.71 , pp. 7628-7639
    • Song, S.1    Christova, T.2    Perusini, S.3    Alizadeh, S.4    Bao, R.Y.5
  • 5
    • 77954249308 scopus 로고    scopus 로고
    • Two to tango: regulation of Mammalian iron metabolism
    • doi: 10.1016/j.cell.2010.06.028
    • Hentze MW, Muckenthaler MU, Galy B, Camaschella C, (2010) Two to tango: regulation of Mammalian iron metabolism. Cell 142: 24-38. doi:10.1016/j.cell.2010.06.028. PubMed: 20603012.
    • (2010) Cell , vol.142 , pp. 24-38
    • Hentze, M.W.1    Muckenthaler, M.U.2    Galy, B.3    Camaschella, C.4
  • 6
    • 17644434333 scopus 로고    scopus 로고
    • The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression
    • doi: 10.1074/jbc.272.22.14025
    • Feder JN, Tsuchihashi Z, Irrinki A, Lee VK, Mapa FA, et al. (1997) The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression. J Biol Chem 272: 14025-14028. doi:10.1074/jbc.272.22.14025. PubMed: 9162021.
    • (1997) J Biol Chem , vol.272 , pp. 14025-14028
    • Feder, J.N.1    Tsuchihashi, Z.2    Irrinki, A.3    Lee, V.K.4    Mapa, F.A.5
  • 7
    • 0035914480 scopus 로고    scopus 로고
    • Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites
    • doi: 10.1006/jmbi.2001.5048
    • West AP Jr., Giannetti AM, Herr AB, Bennett MJ, Nangiana JS, et al. (2001) Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites. J Mol Biol 313: 385-397. doi:10.1006/jmbi.2001.5048. PubMed: 11800564.
    • (2001) J Mol Biol , vol.313 , pp. 385-397
    • West Jr., A.P.1    Giannetti, A.M.2    Herr, A.B.3    Bennett, M.J.4    Nangiana, J.S.5
  • 8
    • 60649103774 scopus 로고    scopus 로고
    • Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression
    • doi: 10.1016/j.cmet.2009.01.010
    • Gao J, Chen J, Kramer M, Tsukamoto H, Zhang AS, et al. (2009) Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metab 9: 217-227. doi:10.1016/j.cmet.2009.01.010. PubMed: 19254567.
    • (2009) Cell Metab , vol.9 , pp. 217-227
    • Gao, J.1    Chen, J.2    Kramer, M.3    Tsukamoto, H.4    Zhang, A.S.5
  • 9
    • 84861344055 scopus 로고    scopus 로고
    • Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2
    • doi: 10.1002/ajh.23173
    • Schmidt PJ, Fleming MD, (2012) Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2. Am J Hematol 87: 588-595. doi:10.1002/ajh.23173. PubMed: 22460705.
    • (2012) Am J Hematol , vol.87 , pp. 588-595
    • Schmidt, P.J.1    Fleming, M.D.2
  • 10
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • doi: 10.1126/science.1104742
    • Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, et al. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306: 2090-2093. doi:10.1126/science.1104742. PubMed: 15514116.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5
  • 11
    • 0037180545 scopus 로고    scopus 로고
    • The hemochromatosis protein HFE inhibits iron export from macrophages
    • doi: 10.1073/pnas.242614699
    • Drakesmith H, Sweetland E, Schimanski L, Edwards J, Cowley D, et al. (2002) The hemochromatosis protein HFE inhibits iron export from macrophages. Proc Natl Acad Sci U S A 99: 15602-15607. doi:10.1073/pnas.242614699. PubMed: 12429850.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 15602-15607
    • Drakesmith, H.1    Sweetland, E.2    Schimanski, L.3    Edwards, J.4    Cowley, D.5
  • 12
    • 2942537827 scopus 로고    scopus 로고
    • Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells
    • doi: 10.1074/jbc.M400537200
    • Davies PS, Enns CA, (2004) Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells. J Biol Chem 279: 25085-25092. doi:10.1074/jbc.M400537200. PubMed: 15044462.
    • (2004) J Biol Chem , vol.279 , pp. 25085-25092
    • Davies, P.S.1    Enns, C.A.2
  • 13
    • 77955508573 scopus 로고    scopus 로고
    • Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment
    • doi: 10.1053/j.gastro.2010.06.013, e391-392
    • Pietrangelo A, (2010) Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment. Gastroenterology 139: 393-408.e391-392 doi:10.1053/j.gastro.2010.06.013. PubMed: 20542038.
    • (2010) Gastroenterology , vol.139 , pp. 393-408
    • Pietrangelo, A.1
  • 14
    • 0035127525 scopus 로고    scopus 로고
    • Increased cancer risk in a cohort of 230 patients with hereditary hemochromatosis in comparison to matched control patients with non-iron-related chronic liver disease
    • doi: 10.1053/jhep.2001.22506
    • Fracanzani AL, Conte D, Fraquelli M, Taioli E, Mattioli M, et al. (2001) Increased cancer risk in a cohort of 230 patients with hereditary hemochromatosis in comparison to matched control patients with non-iron-related chronic liver disease. Hepatology 33: 647-651. doi:10.1053/jhep.2001.22506. PubMed: 11230745.
    • (2001) Hepatology , vol.33 , pp. 647-651
    • Fracanzani, A.L.1    Conte, D.2    Fraquelli, M.3    Taioli, E.4    Mattioli, M.5
  • 15
    • 0026764093 scopus 로고
    • Sublethal damage repair in squamous cell carcinoma cell lines
    • doi: 10.1002/hed.2880140306
    • Pekkola-Heino K, Kulmala J, Grenman R, (1992) Sublethal damage repair in squamous cell carcinoma cell lines. Head Neck 14: 196-199. doi:10.1002/hed.2880140306. PubMed: 1587736.
    • (1992) Head Neck , vol.14 , pp. 196-199
    • Pekkola-Heino, K.1    Kulmala, J.2    Grenman, R.3
  • 16
    • 33846546485 scopus 로고    scopus 로고
    • Head and neck squamous cell carcinoma cell lines: established models and rationale for selection
    • doi: 10.1002/hed.20478
    • Lin CJ, Grandis JR, Carey TE, Gollin SM, Whiteside TL, et al. (2007) Head and neck squamous cell carcinoma cell lines: established models and rationale for selection. Head Neck 29: 163-188. doi:10.1002/hed.20478. PubMed: 17312569.
    • (2007) Head Neck , vol.29 , pp. 163-188
    • Lin, C.J.1    Grandis, J.R.2    Carey, T.E.3    Gollin, S.M.4    Whiteside, T.L.5
  • 17
    • 84872386811 scopus 로고    scopus 로고
    • MicroRNA-193b enhances tumor progression via down regulation of neurofibromin 1
    • doi: 10.1371/journal.pone.0053765
    • Lenarduzzi M, Hui AB, Alajez NM, Shi W, Williams J, et al. (2013) MicroRNA-193b enhances tumor progression via down regulation of neurofibromin 1. PLOS ONE 8: e53765. doi:10.1371/journal.pone.0053765. PubMed: 23335975.
    • (2013) PLOS ONE , vol.8
    • Lenarduzzi, M.1    Hui, A.B.2    Alajez, N.M.3    Shi, W.4    Williams, J.5
  • 18
    • 79251504609 scopus 로고    scopus 로고
    • Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer
    • 21270338
    • Ito E, Yue S, Moriyama EH, Hui AB, Kim I, et al. (2011) Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer. Sci Transl Med 3: 67ra67. PubMed: 21270338.
    • (2011) Sci Transl Med , vol.3
    • Ito, E.1    Yue, S.2    Moriyama, E.H.3    Hui, A.B.4    Kim, I.5
  • 19
    • 66649117733 scopus 로고    scopus 로고
    • Therapeutic efficacy of seliciclib in combination with ionizing radiation for human nasopharyngeal carcinoma
    • doi: 10.1158/1078-0432.CCR-08-2790
    • Hui AB, Yue S, Shi W, Alajez NM, Ito E, et al. (2009) Therapeutic efficacy of seliciclib in combination with ionizing radiation for human nasopharyngeal carcinoma. Clin Cancer Res 15: 3716-3724. doi:10.1158/1078-0432.CCR-08-2790. PubMed: 19470731.
    • (2009) Clin Cancer Res , vol.15 , pp. 3716-3724
    • Hui, A.B.1    Yue, S.2    Shi, W.3    Alajez, N.M.4    Ito, E.5
  • 20
    • 1642377561 scopus 로고    scopus 로고
    • ONCOMINE: a cancer microarray database and integrated data-mining platform
    • 15068665
    • Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, et al. (2004) ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia 6: 1-6. PubMed: 15068665.
    • (2004) Neoplasia , vol.6 , pp. 1-6
    • Rhodes, D.R.1    Yu, J.2    Shanker, K.3    Deshpande, N.4    Varambally, R.5
  • 21
    • 1642494850 scopus 로고    scopus 로고
    • Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck
    • doi: 10.1158/0008-5472.CAN-03-2144
    • Ginos MA, Page GP, Michalowicz BS, Patel KJ, Volker SE, et al. (2004) Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck. Cancer Res 64: 55-63. doi:10.1158/0008-5472.CAN-03-2144. PubMed: 14729608.
    • (2004) Cancer Res , vol.64 , pp. 55-63
    • Ginos, M.A.1    Page, G.P.2    Michalowicz, B.S.3    Patel, K.J.4    Volker, S.E.5
  • 22
    • 34250311964 scopus 로고    scopus 로고
    • Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers
    • doi: 10.1158/0008-5472.CAN-06-3619
    • Pyeon D, Newton MA, Lambert PF, den Boon JA, Sengupta S, et al. (2007) Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers. Cancer Res 67: 4605-4619. doi:10.1158/0008-5472.CAN-06-3619. PubMed: 17510386.
    • (2007) Cancer Res , vol.67 , pp. 4605-4619
    • Pyeon, D.1    Newton, M.A.2    Lambert, P.F.3    den Boon, J.A.4    Sengupta, S.5
  • 23
    • 11144354901 scopus 로고    scopus 로고
    • Identification of genes associated with tumorigenesis and metastatic potential of hypopharyngeal cancer by microarray analysis
    • doi: 10.1038/sj.onc.1207345
    • Cromer A, Carles A, Millon R, Ganguli G, Chalmel F, et al. (2004) Identification of genes associated with tumorigenesis and metastatic potential of hypopharyngeal cancer by microarray analysis. Oncogene 23: 2484-2498. doi:10.1038/sj.onc.1207345. PubMed: 14676830.
    • (2004) Oncogene , vol.23 , pp. 2484-2498
    • Cromer, A.1    Carles, A.2    Millon, R.3    Ganguli, G.4    Chalmel, F.5
  • 24
    • 0037165140 scopus 로고    scopus 로고
    • Prediction of central nervous system embryonal tumour outcome based on gene expression
    • doi: 10.1038/415436a
    • Pomeroy SL, Tamayo P, Gaasenbeek M, Sturla LM, Angelo M, et al. (2002) Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 415: 436-442. doi:10.1038/415436a. PubMed: 11807556.
    • (2002) Nature , vol.415 , pp. 436-442
    • Pomeroy, S.L.1    Tamayo, P.2    Gaasenbeek, M.3    Sturla, L.M.4    Angelo, M.5
  • 25
    • 23844524767 scopus 로고    scopus 로고
    • Gene signatures of progression and metastasis in renal cell cancer
    • doi: 10.1158/1078-0432.CCR-04-2225
    • Jones J, Otu H, Spentzos D, Kolia S, Inan M, et al. (2005) Gene signatures of progression and metastasis in renal cell cancer. Clin Cancer Res 11: 5730-5739. doi:10.1158/1078-0432.CCR-04-2225. PubMed: 16115910.
    • (2005) Clin Cancer Res , vol.11 , pp. 5730-5739
    • Jones, J.1    Otu, H.2    Spentzos, D.3    Kolia, S.4    Inan, M.5
  • 26
    • 84866002291 scopus 로고    scopus 로고
    • The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
    • doi:10.1158/2159-8290.CD
    • Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, et al. (2012) The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2: 401-404. doi:10.1158/2159-8290.CD-12-0095 PubMed: 22588877.
    • (2012) Cancer Discov , vol.2 , pp. 401-404
    • Cerami, E.1    Gao, J.2    Dogrusoz, U.3    Gross, B.E.4    Sumer, S.O.5
  • 27
    • 65349171821 scopus 로고    scopus 로고
    • A general map of iron metabolism and tissue-specific subnetworks
    • doi: 10.1039/b816714c
    • Hower V, Mendes P, Torti FM, Laubenbacher R, Akman S, et al. (2009) A general map of iron metabolism and tissue-specific subnetworks. Mol Biosyst 5: 422-443. doi:10.1039/b816714c. PubMed: 19381358.
    • (2009) Mol Biosyst , vol.5 , pp. 422-443
    • Hower, V.1    Mendes, P.2    Torti, F.M.3    Laubenbacher, R.4    Akman, S.5
  • 28
    • 34548820978 scopus 로고    scopus 로고
    • Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative
    • doi: 10.1158/1078-0432.CCR-07-1041
    • Molinolo AA, Hewitt SM, Amornphimoltham P, Keelawat S, Rangdaeng S, et al. (2007) Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Clin Cancer Res 13: 4964-4973. doi:10.1158/1078-0432.CCR-07-1041. PubMed: 17785546.
    • (2007) Clin Cancer Res , vol.13 , pp. 4964-4973
    • Molinolo, A.A.1    Hewitt, S.M.2    Amornphimoltham, P.3    Keelawat, S.4    Rangdaeng, S.5
  • 29
    • 84871434445 scopus 로고    scopus 로고
    • mTOR regulates cellular iron homeostasis through tristetraprolin
    • doi: 10.1016/j.cmet.2012.10.001
    • Bayeva M, Khechaduri A, Puig S, Chang HC, Patial S, et al. (2012) mTOR regulates cellular iron homeostasis through tristetraprolin. Cell Metab 16: 645-657. doi:10.1016/j.cmet.2012.10.001. PubMed: 23102618.
    • (2012) Cell Metab , vol.16 , pp. 645-657
    • Bayeva, M.1    Khechaduri, A.2    Puig, S.3    Chang, H.C.4    Patial, S.5
  • 30
    • 9344224529 scopus 로고    scopus 로고
    • A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
    • doi: 10.1038/ng0896-399
    • Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, et al. (1996) A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 13: 399-408. doi:10.1038/ng0896-399. PubMed: 8696333.
    • (1996) Nat Genet , vol.13 , pp. 399-408
    • Feder, J.N.1    Gnirke, A.2    Thomas, W.3    Tsuchihashi, Z.4    Ruddy, D.A.5
  • 31
    • 34250865977 scopus 로고    scopus 로고
    • The molecular mechanism of hepcidin-mediated ferroportin down-regulation
    • doi: 10.1091/mbc.E07-01-0060
    • De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, et al. (2007) The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell 18: 2569-2578. doi:10.1091/mbc.E07-01-0060. PubMed: 17475779.
    • (2007) Mol Biol Cell , vol.18 , pp. 2569-2578
    • De Domenico, I.1    Ward, D.M.2    Langelier, C.3    Vaughn, M.B.4    Nemeth, E.5
  • 32
    • 77955607931 scopus 로고    scopus 로고
    • Ferroportin and iron regulation in breast cancer progression and prognosis
    • 20686179
    • Pinnix ZK, Miller LD, Wang W, D'Agostino R Jr., Kute T, et al. (2010) Ferroportin and iron regulation in breast cancer progression and prognosis. Sci Transl Med 2: 43ra56. PubMed: 20686179.
    • (2010) Sci Transl Med , vol.2
    • Pinnix, Z.K.1    Miller, L.D.2    Wang, W.3    D'Agostino Jr., R.4    Kute, T.5
  • 33
    • 41149148161 scopus 로고    scopus 로고
    • Increased hepcidin expression in colorectal carcinogenesis
    • doi: 10.3748/wjg.14.1339
    • Ward DG, Roberts K, Brookes MJ, Joy H, Martin A, et al. (2008) Increased hepcidin expression in colorectal carcinogenesis. World J Gastroenterol 14: 1339-1345. doi:10.3748/wjg.14.1339. PubMed: 18322945.
    • (2008) World J Gastroenterol , vol.14 , pp. 1339-1345
    • Ward, D.G.1    Roberts, K.2    Brookes, M.J.3    Joy, H.4    Martin, A.5
  • 34
    • 69249166103 scopus 로고    scopus 로고
    • Increased serum hepcidin-25 level and increased tumor expression of hepcidin mRNA are associated with metastasis of renal cell carcinoma
    • doi: 10.1186/1471-2407-9-270
    • Kamai T, Tomosugi N, Abe H, Arai K, Yoshida K, (2009) Increased serum hepcidin-25 level and increased tumor expression of hepcidin mRNA are associated with metastasis of renal cell carcinoma. BMC Cancer 9: 270. doi:10.1186/1471-2407-9-270. PubMed: 19656379.
    • (2009) BMC Cancer , vol.9 , pp. 270
    • Kamai, T.1    Tomosugi, N.2    Abe, H.3    Arai, K.4    Yoshida, K.5
  • 35
    • 50349085287 scopus 로고    scopus 로고
    • Involvement of hepcidin in the anemia of multiple myeloma
    • doi: 10.1158/1078-0432.CCR-07-4153
    • Sharma S, Nemeth E, Chen YH, Goodnough J, Huston A, et al. (2008) Involvement of hepcidin in the anemia of multiple myeloma. Clin Cancer Res 14: 3262-3267. doi:10.1158/1078-0432.CCR-07-4153. PubMed: 18519751.
    • (2008) Clin Cancer Res , vol.14 , pp. 3262-3267
    • Sharma, S.1    Nemeth, E.2    Chen, Y.H.3    Goodnough, J.4    Huston, A.5
  • 36
    • 0018850974 scopus 로고
    • Transferrin and transferrin receptors in carcinoma of the breast
    • 6105517
    • Faulk WP, Hsi BL, Stevens PJ, (1980) Transferrin and transferrin receptors in carcinoma of the breast. Lancet 2: 390-392. PubMed: 6105517.
    • (1980) Lancet , vol.2 , pp. 390-392
    • Faulk, W.P.1    Hsi, B.L.2    Stevens, P.J.3
  • 37
    • 33745280621 scopus 로고    scopus 로고
    • PIK3CA and TFRC located in 3q are new prognostic factors in esophageal squamous cell carcinoma
    • doi: 10.1245/ASO.2006.08.006
    • Wada S, Noguchi T, Takeno S, Kawahara K, (2006) PIK3CA and TFRC located in 3q are new prognostic factors in esophageal squamous cell carcinoma. Ann Surg Oncol 13: 961-966. doi:10.1245/ASO.2006.08.006. PubMed: 16788758.
    • (2006) Ann Surg Oncol , vol.13 , pp. 961-966
    • Wada, S.1    Noguchi, T.2    Takeno, S.3    Kawahara, K.4
  • 38
    • 0025327937 scopus 로고
    • Transferrin receptor expression in adenocarcinoma of the lung as a histopathologic indicator of prognosis
    • doi: 10.1378/chest.97.6.1367
    • Kondo K, Noguchi M, Mukai K, Matsuno Y, Sato Y, et al. (1990) Transferrin receptor expression in adenocarcinoma of the lung as a histopathologic indicator of prognosis. Chest 97: 1367-1371. doi:10.1378/chest.97.6.1367. PubMed: 2189695.
    • (1990) Chest , vol.97 , pp. 1367-1371
    • Kondo, K.1    Noguchi, M.2    Mukai, K.3    Matsuno, Y.4    Sato, Y.5
  • 39
    • 0027053689 scopus 로고
    • Cytosol and serum ferritin in breast carcinoma
    • doi: 10.1016/0304-3835(92)90132-F
    • Güner G, Kirkali G, Yenisey C, Töre IR, (1992) Cytosol and serum ferritin in breast carcinoma. Cancer Lett 67: 103-112. doi:10.1016/0304-3835(92)90132-F. PubMed: 1483258.
    • (1992) Cancer Lett , vol.67 , pp. 103-112
    • Güner, G.1    Kirkali, G.2    Yenisey, C.3    Töre, I.R.4
  • 41
    • 0023184215 scopus 로고
    • Ferritin content in human cancerous and noncancerous colonic tissue
    • doi: 10.3109/07357908709020300
    • Vaughn CB, Weinstein R, Bond B, Rice R, Vaughn RW, et al. (1987) Ferritin content in human cancerous and noncancerous colonic tissue. Cancer Invest 5: 7-10. doi:10.3109/07357908709020300. PubMed: 3580949.
    • (1987) Cancer Invest , vol.5 , pp. 7-10
    • Vaughn, C.B.1    Weinstein, R.2    Bond, B.3    Rice, R.4    Vaughn, R.W.5
  • 42
    • 80155131215 scopus 로고    scopus 로고
    • An iron regulatory gene signature predicts outcome in breast cancer
    • doi: 10.1158/0008-5472.CAN-11-1870
    • Miller LD, Coffman LG, Chou JW, Black MA, Bergh J, et al. (2011) An iron regulatory gene signature predicts outcome in breast cancer. Cancer Res 71: 6728-6737. doi:10.1158/0008-5472.CAN-11-1870. PubMed: 21875943.
    • (2011) Cancer Res , vol.71 , pp. 6728-6737
    • Miller, L.D.1    Coffman, L.G.2    Chou, J.W.3    Black, M.A.4    Bergh, J.5
  • 43
    • 0034254794 scopus 로고    scopus 로고
    • Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis
    • doi: 10910932
    • Montosi G, Paglia P, Garuti C, Guzman CA, Bastin JM, et al. (2000) Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis. Blood 96: 1125-1129. PubMed: 10910932.
    • (2000) Blood , vol.96 , pp. 1125-1129
    • Montosi, G.1    Paglia, P.2    Garuti, C.3    Guzman, C.A.4    Bastin, J.M.5
  • 45
    • 79956196320 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS)--induced genetic and epigenetic alterations in human carcinogenesis
    • doi: 10.1016/j.mrfmmm.2011.02.015
    • Ziech D, Franco R, Pappa A, Panayiotidis MI, (2011) Reactive oxygen species (ROS)--induced genetic and epigenetic alterations in human carcinogenesis. Mutat Res 711: 167-173. doi:10.1016/j.mrfmmm.2011.02.015. PubMed: 21419141.
    • (2011) Mutat Res , vol.711 , pp. 167-173
    • Ziech, D.1    Franco, R.2    Pappa, A.3    Panayiotidis, M.I.4
  • 46
    • 77956377651 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS) reduce the expression of BRAK/CXCL14 in human head and neck squamous cell carcinoma cells
    • doi: 10.3109/10715762.2010.490836
    • Maehata Y, Ozawa S, Kobayashi K, Kato Y, Yoshino F, et al. (2010) Reactive oxygen species (ROS) reduce the expression of BRAK/CXCL14 in human head and neck squamous cell carcinoma cells. Free Radic Res 44: 913-924. doi:10.3109/10715762.2010.490836. PubMed: 20815772.
    • (2010) Free Radic Res , vol.44 , pp. 913-924
    • Maehata, Y.1    Ozawa, S.2    Kobayashi, K.3    Kato, Y.4    Yoshino, F.5
  • 47
    • 0037179894 scopus 로고    scopus 로고
    • Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas
    • doi: 10.1038/sj.onc.1205920
    • Rhee CS, Sen M, Lu D, Wu C, Leoni L, et al. (2002) Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas. Oncogene 21: 6598-6605. doi:10.1038/sj.onc.1205920. PubMed: 12242657.
    • (2002) Oncogene , vol.21 , pp. 6598-6605
    • Rhee, C.S.1    Sen, M.2    Lu, D.3    Wu, C.4    Leoni, L.5
  • 48
    • 70449466605 scopus 로고    scopus 로고
    • Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells
    • doi: 10.1182/blood-2009-03-209965
    • Eberhard Y, McDermott SP, Wang X, Gronda M, Venugopal A, et al. (2009) Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. Blood 114: 3064-3073. doi:10.1182/blood-2009-03-209965. PubMed: 19589922.
    • (2009) Blood , vol.114 , pp. 3064-3073
    • Eberhard, Y.1    McDermott, S.P.2    Wang, X.3    Gronda, M.4    Venugopal, A.5
  • 49
    • 0034915003 scopus 로고    scopus 로고
    • Redox metal chelation ameliorates radiation-induced bone marrow toxicity in a mouse model
    • doi: 10.1667/0033-7587(2001)156[0205:RMCARI]2.0.CO;2
    • Nagler RM, Eichen Y, Nagler A, (2001) Redox metal chelation ameliorates radiation-induced bone marrow toxicity in a mouse model. Radiat Res 156: 205-209. doi:10.1667/0033-7587(2001)156[0205:RMCARI]2.0.CO;2. PubMed: 11448242.
    • (2001) Radiat Res , vol.156 , pp. 205-209
    • Nagler, R.M.1    Eichen, Y.2    Nagler, A.3
  • 50
    • 84871575976 scopus 로고    scopus 로고
    • The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action
    • doi: 10.1124/mol.112.081893
    • Lui GY, Obeidy P, Ford SJ, Tselepis C, Sharp DM, et al. (2013) The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action. Mol Pharmacol 83: 179-190. doi:10.1124/mol.112.081893. PubMed: 23074173.
    • (2013) Mol Pharmacol , vol.83 , pp. 179-190
    • Lui, G.Y.1    Obeidy, P.2    Ford, S.J.3    Tselepis, C.4    Sharp, D.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.