The effects of aerobic exercise intensity and duration on levels of brain- derived neurotrophic factor in healthy men

Journal of Sports Science and Medicine

Volumn 12, Issue 3, 2013, Pages 502-511

  Schmolesky, Matthew T ^a   Webb, David L ^a   Hansen, Rodney A ^a  

^a WEBER STATE UNIVERSITY   (United States)

Author keywords

Aerobic; Brain derived neurotrophic factor (BDNF); Exercise; Human; Neurotrophins

Indexed keywords

EID: 84883179126     PISSN: None     EISSN: 13032968     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Adlard, P.A., Perreau, V.M., Engesser-Cesar, C. and Cotman, C.W. (2004) The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise. Neuroscience Letters 363, 43-48.
2. Anderson, B.J., Rapp, D.N., Baek, D.H., McCloskey, D.P., Coburn-Litvak, P.S. and Robinson, J.K. (2000) Exercise influences spatial learning in the radial arm maze. Physiology & Behavior 70, 425-429.
3. Ang, E.T., Wong, P.T.H., Moochhala, S. and Ng, Y.K. (2003) Neuroprotection associated with running: Is it a result of increased endogenous neurotrophic factors? Neuroscience 118, 335-345.
4. Baker, L.D., Frank, L.L., Foster-Schubert, K., Green, P.S., Wilkinson, C.W., McTiernan, A., Plymate, S.R., Fishel, M.A., Watson, G.S., Cholerton, B.A., Duncan, G.E., Mehta, P.D. and Craft, S. (2010) Effects of aerobic exercise on mild cognitive impairment: A controlled trial. Archives of Neurology 67, 71-79.
5. Begliuomini, S., Casarosa, N. Pluchino, E., Lenzi, M., Centofanti, L., Freschi, M., Pieri, A.D., Genazzani, S., Luisi, L. and Genazzani, A.R. (2007) Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor. Human Reproduction 22, 995-1002.
6. Chan, K.L., Tong, K.Y. and Yip, S.P. (2008) Relationship of serum brain-derived neurotrophic factor (BDNF) and health-related lifestyle in healthy human subjects. Neuroscience Letters 447, 124-128.
7. Chen, M. J and Russo-Neustadt, A.A. (2009) Running exercise-induced up-regulation of hippocampal brain-derived neurotrophic factor is CREB-dependent. Hippocampus 19, 962-972.
8. Cunha, A.B., Frey, B.N., Andreazza, A.C., Goi, J.D., Rosa, A.R., Goncalves, C.A., Santin, A. and Kapczinski, F. (2006) Serum brainderived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes. Neuroscience Letters 398, 215-219.
9. Currie, J., Ramsbottom, R., Ludlow, H., Nevill, A. and Gilder, M. (2009) Cardio-respiratory fitness, habitual physical activity and serum brain-derived neurotrophic factor (BDNF) in men and women. Neuroscience Letters 451, 152-155.
10. Ding, Y., Li, J., Luan, X., Ding, Y.H., Lai, Q., Rafols, J.A., Phillis, J.W., Clark, J.C. and Diaz, F.G. (2004) Exercise pre-conditioning reduces brain damage in ischemic rats that may be associated with regional angiogenesis and cellular overexpression of neurotrophin. Neuroscience 124, 583-591.
11. Ferris, L.T., Williams, J.S. and Shen, C.L. (2007) The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function. Medicine and Science in Sports and Exercise 39, 728-734.
12. Goekint, M., De Pauw, K., Roelands, B., Njemini, R., Bautmans, I., Mets, T. and Meeusen, R. (2010) Strength training does not influence serum brain-derived neurotrophic factor. European Journal of Applied Physiology 110, 285-293.
13. Gold, S.M., Schulz, K.H., Hartmann, S., Mladek, M., Lang, U.E., Hellweg, R., Reer, R., Braumann, K.M. and Heesen, C. (2003) Basal serum levels and reactivity of nerve growth factor and brainderived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls. Journal of Neuroimmunology 138, 99-105.
14. Griesbach, G.S., Hovda, D.A., Molteni, R., Wu, A. and Gómez-Pinilla, F. (2004) Voluntary exercise following traumatic brain injury: Brain-derived neurotrophic factor upregulation and recovery of function. Neuroscience 125, 129-139.
15. Griffin, E.W., Mullally, S., Foley, C., Warmington, S.A., O'Mara, S.M. and Kelly, A.M. (2011) Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiology & Behavior 104, 934-941.
16. Huang, A.M., Jen, C.J., Chen, H.F., Yu, L., Kuo, Y.M. and Chen, H.I. (2006) Compulsive exercise acutely upregulates rat hippocampal brain-derived neurotrophic factor. Journal of Neural Transmission 113, 803-811.
17. Karege, F., Perret, G., Dondolfi, G., Schwald, M., Bertschy, G. and Aubry, J.M. (2002) Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Research 109, 143-148.
18. Klintsova, A.Y., Dickson, E., Yoshida, R. and Greenough, W.T. (2004) Altered expression of BDNF and its high-affinity receptor TRkB in response to complex motor learning and moderate exercise. Brain Research 1028, 92-104.
19. Knaepen, K., Goekint, M., Heyman, E.M. and Meeusen, R. (2010) Neuroplasticity-Exercise-induced response of peripheral brain-derived neurotrophic factor: A systematic review of experimental studies in human subjects. Sports Medicine 40, 765-801.
20. Lassarre, C., Girard, F., Durand, J., and Ravnaud, J. (1974) Kinetics of human growth hormone during submaximal exercise. Journal of Applied Physiology 37, 826-830.
21. Levinger, I., Goodman, C., Matthews, V., Hare, D.C., Jerums, G., Garnham, A. and Selig, S. (2008) BDNF, metabolic risk factors, and resistance training in middle-aged individuals. Medicine and Science in Sports Exercise 40, 535-541.
22. Liu, Y.F., Chen, H.I., Yu, L., Kuo, Y.M., Wu, F.S., Chuang, J.I., Liao, P.C. and Jen, C.J. (2008) Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice. Neurobiology of Learning and Memory 90, 81-89.
23. Marais, L., Stein, D.J. and Daniels, W.M. (2009) Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats. Metabolic Brain Disease 24, 587-97.
24. Molteni, R., Ying, Z. and Gómez-Pinilla, F. (2002) Differential effects of acute and chronic expression on plasticity-related genes in the rat hippocampus revealed by microarray. European Journal of Neuroscience 16, 1107-1116.
25. Neeper, S.A., Gómez-Pinilla, F., Choi, J. and Cotman, C.W. (1996) Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Research 726, 49-56.
26. Nofuji, Y., Suwa, M., Moriyama, Y., Nakano, H., Ichimiya, A., Nishichi, R., Sasaki, H., Radak, Z. and Kumagai, S. (2008) Decreased serum brain-derived neurotrophic factor in trained men. Neuroscience Letters 437, 29-32.
27. Nofuji, Y., Masataka, S., Sasaki, H., Ichimiya, A., Nishichi, R. and Kumagi, S. (2012) Different circulating brain-derived neurotrophic factor responses to acute exercise between physically active and sedentary subjects. Journal of Sports Science and Medicine 11, 83-88.
28. O'Callaghan, R.M., Ohle, R. and Kelly, Á.M. (2007) The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial-and non-spatial learning. Behavioral Brain Research 176, 362-366.
29. Oliff, H.S., Berchtold, N.C., Isackson, P. and Cotman, C.W. (1998) Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus. Molecular Brain Research 61, 147-153.
30. Pluchino, N., Russo, M., Santoro, A.N., Litta, P., Cela, V. and Genazzani, A.R. (2013) Sterioids hormones and BDNF. Neuroscience 239, 271-279.
31. Raastad, T., Bjoro, T., and Hallen, J. (2000) Hormonal responses to high-and moderate-intensity strength exercise. European Journal of Applied Physiology 82, 121-128.
32. Radak, Z., Toldy, A., Szabo, Z., Siamilis, S., Nyakas, C., Silye, G., Jakus, J. and Goto, S. (2006) The effects of training and detraining on memory, neurotrophins, and oxidative stress markers in rat brain. Neurochemistry International 49, 387-392.
33. Rasmussen, P., Brassard, P., Adser, H., Pedersen, M.V., Leick, L., Hart, E., Secher, N.H., Pedersen, B.K. and Pilegaard, H. (2009) Evidence for a release of brain-derived neurotrophic factor from the brain during exercise. Experimental Physiology 94, 1062-1069.
34. Rojas Vega, S., Strüder, H.K., Wahrmann, B.V., Schmidt, A., Bloch, W. and Hollmann, W. (2006) Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans. Brain Research 1121, 56-65.
35. Rojas Vega, S., Abel, T., Lindschulten, R., Hollmann, W., Bloch, W. and Strüder, H.K. (2008) Impact of exercise on neuroplasticityrelated proteins in spinal cord injured humans. Neuroscience 153, 1064-1070.
36. Schiffer, T., Schulte, S., Hollmann, W., Bloch, W. and Strüder, H.K. (2009) Effects of strength and endurance training on brainderive neurotrophic factor and insulin-like growth factor 1 in humans. Hormone and Metabolic Research 41, 250-254.
37. Seifert, T., Brassard, P., Wissenberg, M., Rasmussen, P., Nordby, P., Stallknecht, B., Adser, H., Jakobsen, A.H., Pilegaard, H., Nielsen, H.B. and Secher, N.H. (2010) Endurance training enhances BDNF release from the human brain. American Journal of Physiology-Regulatory, Integrative & Comparative 298, 372-377.
38. Shim, S.H., Hwangbo, Y., Kwon, Y.J., Jeong, H.Y., Lee, H.B., Lee, H.J. and Kim, Y.K. (2008) Increased levels of plasma brain-derived neurotrophic factor (BDNF) in children with attention deficithyperactivity disorder (ADHD). Progress in Neuropsychopharmacology & Biological Psychiatry 32, 1824-1828.
39. Suijo, K., Inoue, S., Ohya, Y., Odagiri, Y., Takamiya, T., Ishibashi, H., Itoh, M., Fujieda, Y., and Shimomitsu, T. (2013) Resistance exercise enhances cognitive function in mouse. International Journal of Sports Medicine 34, 368-75.
40. Tang, S.W., Chu, E., Hui, T., Helmeste, D. and Law, C. (2008) Influence of exercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects. Neuroscience Letters 431, 62-65.
41. Thompson, W.R., Gordon, N.F. and Pescatello, L.S. (2010) ACSM's guidelines for exercise testing and prescription. 8th edition. Wolters, Kluwer/Lippincott, Williams, and Wilkins, Philadelphia.
42. Van der Borght, K., Havekes, R., Bos, T., Eggen, B.J., and Van der Zee, E.A. (2007) Exercise improves memory acquisition and retrieval in Y-maze task: Relationship with hippocampal neurogenesis. Behavioral Neuroscience 121, 324-334.
43. Vanhelder, W.P., Goode, R.C., and Radomski, M.W. (1984) Effect of anaerobic and aerobic exercise of equal duration and work expenditure on plasma growth hormone levels. European Journal of Applied Physiology and Occupational Physiology 52, 255-257.
44. Vaynman, S., Ying, Z. and Gómez-Pinilla, F. (2004a) Exercise induces BDNF and Synapsin I to specific hippocampal subfields. Journal of Neuroscience Research 76, 356-362.
45. Vaynman, S., Ying, Z. and Gómez-Pinilla, F. (2004b) Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. European Journal of Neuroscience 20, 2580-2590.
46. Widenfalk, J., Olson, L. and Thorén, P. (1999) Deprived of habitual running, rats down regulate BDNF and TrkB messages in the brain. Neuroscience Research 34, 125-132.
47. Yarrow, J.F., White, L.J., McCoy, S.C., and Borst, S.E. (2010) Training augments resistance exercise induced elevation of circulating brain derived neurotrophic factor (BDNF). Neuroscience Letters 479, 161-165.
48. Yu, H., Zhang, Z., Shi, Y., Bai, F., Xie, C., Qian, Y., Yuan, Y., and Deng, L. (2008) Association study of the decreased serum BDNF concentrations in amnestic mild cognitive impairment and the Val66Met polymorphism in Chinese Han. Journal of Clinical Psychiatry 69, 1104-1111.
49. Zhang, X.Y., Tan, Y.L., Zhou, D.F., Cao, L.Y., Wu, G.Y., Xu, Q., Shen, Y., Haile, C.N., Kosten, T.A., and Kosten, T.R. (2007) Serum BDNF levels and weight grain in schizophrenic patients on long-term treatment with antipsychotics. Journal of Psychiatric Research 41, 997-1004.
50. Zoladz, J.A., Pilc, A., Majerczak, J., Grandys, M., Zapart-Bukowska, J. and Duda, K. (2008) Endurance training increases plasma brainderived neurotrophic factor concentration in young healthy men. Journal of Physiological Pharmacology 59, 119-132.