The dopamine D1 receptor is expressed and facilitates relaxation in airway smooth muscle

Respiratory Research

Volumn 14, Issue 1, 2013, Pages

  Mizuta, Kentaro ^a,b   Zhang, Yi ^a   Xu, Dingbang ^a   Mizuta, Fumiko ^a,b   D'Ovidio, Frank ^a   Masaki, Eiji ^b   Emala, Charles W ^a  

^a College of Physicians and Surgeons of Columbia University ^*  (United States)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Cyclic AMP; Dopamine; Epac; Gs coupled receptor; Immunoblot; PKA; RT PCR

Indexed keywords

1 AMINOMETHYL 5,6 DIHYDROXY 3 PHENYLISOCHROMAN; 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DOPAMINE 1 RECEPTOR; ECOPIPAM; IBERIOTOXIN; MESSENGER RNA; ACETYLCHOLINE; BRONCHODILATING AGENT; CHROMAN DERIVATIVE; DOPAMINE; DOPAMINE RECEPTOR STIMULATING AGENT; G PROTEIN COUPLED RECEPTOR;

ANIMAL TISSUE; ARTICLE; BREATHING MUSCLE; CONTROLLED STUDY; EX VIVO STUDY; GUINEA PIG; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MEASUREMENT; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SMOOTH MUSCLE; SMOOTH MUSCLE RELAXATION; ANIMAL; ANIMAL MODEL; BRONCHOCONSTRICTION; BRONCHUS; CELL CULTURE; CYTOLOGY; DRUG EFFECT; METABOLISM;

2,3,4,5-TETRAHYDRO-7,8-DIHYDROXY-1-PHENYL-1H-3-BENZAZEPINE; ACETYLCHOLINE; ANIMALS; BRONCHI; BRONCHOCONSTRICTION; BRONCHODILATOR AGENTS; CELLS, CULTURED; CHROMANS; DOPAMINE; DOPAMINE AGONISTS; GUINEA PIGS; HUMANS; MALE; MODELS, ANIMAL; MUSCLE, SMOOTH; RECEPTORS, DOPAMINE D1; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84883163422     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-14-89     Document Type: Article

References (48)

1. Goto Y, Grace AA. The dopamine system and the pathophysiology of schizophrenia: a basic science perspective. Int Rev Neurobiol 2007, 78:41-68.
2. Pivonello R, Ferone D, Lombardi G, Colao A, Lamberts SW, Hofland LJ. Novel insights in dopamine receptor physiology. Eur J Endocrinol 2007, 156(Suppl 1):S13-S21.
3. Missale C, Nash SR, Robinson SW, Jaber M, Caron MG. Dopamine receptors: from structure to function. Physiol Rev 1998, 78(1):189-225.
4. Ozono R, O'Connell DP, Wang ZQ, Moore AF, Sanada H, Felder RA, Carey RM. Localization of the dopamine D1 receptor protein in the human heart and kidney. Hypertension 1997, 30(3 Pt 2):725-729.
5. Hussain T, Lokhandwala MF. Renal dopamine receptors and hypertension. Exp Biol Med (Maywood) 2003, 228(2):134-142.
6. Ricci A, Mignini F, Tomassoni D, Amenta F. Dopamine receptor subtypes in the human pulmonary arterial tree. Auton Autacoid Pharmacol 2006, 26(4):361-369. 10.1111/j.1474-8673.2006.00376.x, 16968475.
7. Zizzo MG, Mule F, Mastropaolo M, Serio R. D1 receptors play a major role in the dopamine modulation of mouse ileum contractility. Pharmacol Res 2010, 61(5):371-378. 10.1016/j.phrs.2010.01.015, 20138148.
8. Neve KA, Seamans JK, Trantham-Davidson H. Dopamine receptor signaling. J Recept Signal Transduct Res 2004, 24(3):165-205. 10.1081/RRS-200029981, 15521361.
9. Cabezas GA, Israili ZH, Velasco M. The actions of dopamine on the airways. Am J Ther 2003, 10(6):477-486. 10.1097/00045391-200311000-00019, 14624291.
10. Cabezas GA, Lezama Y, Vidal A, Velasco M. Inhaled dopamine induces bronchodilatation in patients with bronchial asthma. Int J Clin Pharmacol Ther 1999, 37(10):510-513.
11. Michoud MC, Amyot R, Jeanneret-Grosjean A. Dopamine effect on bronchomotor tone in vivo. Am Rev Respir Dis 1984, 130(5):755-758.
12. Advenier C, Saint-Aubin A, Mallard B, Boissier JR. Bronchopulmonary effects of dopamine in the guinea-pig. Arch Int Pharmacodyn Ther 1980, 243(2):261-274.
13. Cabezas GA, Velasco M. DA1 receptors modulation in rat isolated trachea. Am J Ther 2010, 17(3):301-305. 10.1097/MJT.0b013e3181c122fa, 20496460.
14. Mizuta K, Zhang Y, Xu D, Masaki E, Panettieri RA, Emala CW. The dopamine D2 receptor is expressed and sensitizes adenylyl cyclase activity in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2012, 302(3):L316-L324. 10.1152/ajplung.00130.2011, 3289275, 21964403.
15. Billington CK, Penn RB. Signaling and regulation of G protein-coupled receptors in airway smooth muscle. Respir Res 2003, 4:2. 152647, 12648290.
16. Penn RB. Embracing emerging paradigms of G protein-coupled receptor agonism and signaling to address airway smooth muscle pathobiology in asthma. Naunyn Schmiedebergs Arch Pharmacol 2008, 378(2):149-169. 10.1007/s00210-008-0263-1, 18278482.
17. Roscioni SS, Maarsingh H, Elzinga CR, Schuur J, Menzen M, Halayko AJ, Meurs H, Schmidt M. Epac as a novel effector of airway smooth muscle relaxation. J Cell Mol Med 2011, 15(7):1551-1563. 10.1111/j.1582-4934.2010.01150.x, 20716113.
18. Zieba BJ, Artamonov MV, Jin L, Momotani K, Ho R, Franke AS, Neppl RL, Stevenson AS, Khromov AS, Chrzanowska-Wodnicka M, et al. The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity. J Biol Chem 2011, 286(19):16681-16692. 10.1074/jbc.M110.205062, 3089510, 21454546.
19. Panettieri RA, Murray RK, DePalo LR, Yadvish PA, Kotlikoff MI. A human airway smooth muscle cell line that retains physiological responsiveness. Am J Physiol 1989, 256(2 Pt 1):C329-C335.
20. Gosens R, Stelmack GL, Dueck G, McNeill KD, Yamasaki A, Gerthoffer WT, Unruh H, Gounni AS, Zaagsma J, Halayko AJ. Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2006, 291(3):L523-L534. 10.1152/ajplung.00013.2006, 16617096.
21. Jooste E, Zhang Y, Emala CW. Rapacuronium preferentially antagonizes the function of M2 versus M3 muscarinic receptors in guinea pig airway smooth muscle. Anesthesiology 2005, 102(1):117-124. 10.1097/00000542-200501000-00020, 15618795.
22. Kebabian JW, DeNinno MP, Schoenleber R, MacKenzie R, Britton DR, Asin KE. A68930: a potent agonist specific for the dopamine D1 receptor. Neurochem Int 1992, 20(Suppl):157S-160S.
23. Torphy TJ. β-adrenoceptors, cAMP and airway smooth muscle relaxation: challenges to the dogma. Trends Pharmacol Sci 1994, 15(10):370-374. 10.1016/0165-6147(94)90157-0, 7809952.
24. Felder CC, McKelvey AM, Gitler MS, Eisner GM, Jose PA. Dopamine receptor subtypes in renal brush border and basolateral membranes. Kidney Int 1989, 36(2):183-193. 10.1038/ki.1989.178, 2528652.
25. Lokhandwala MF, Amenta F. Anatomical distribution and function of dopamine receptors in the kidney. Faseb J 1991, 5(15):3023-3030.
26. Missale C, Pizzi M, Memo M, Picotti GB, Carruba MO, Spano PF. Postsynaptic D1 and D2 dopamine receptors are present in rabbit renal and mesenteric arteries. Neurosci Lett 1985, 61(1-2):207-211.
27. Drolet P, Bilodeau L, Chorvatova A, Laflamme L, Gallo-Payet N, Payet MD. Inhibition of the T-type Ca2+ current by the dopamine D1 receptor in rat adrenal glomerulosa cells: requirement of the combined action of the Gβγ protein subunit and cyclic adenosine 3′,5′-monophosphate. Mol Endocrinol 1997, 11(4):503-514. 10.1210/me.11.4.503, 9092802.
28. Einstein R, Jordan H, Zhou W, Brenner M, Moses EG, Liggett SB. Alternative splicing of the G protein-coupled receptor superfamily in human airway smooth muscle diversifies the complement of receptors. Proc Natl Acad Sci USA 2008, 105(13):5230-5235. 10.1073/pnas.0801319105, 2278184, 18362331.
29. Hack CJ. Integrated transcriptome and proteome data: the challenges ahead. Brief Funct Genom Proteomic 2004, 3(3):212-219.
30. Cox B, Kislinger T, Emili A. Integrating gene and protein expression data: pattern analysis and profile mining. Methods 2005, 35(3):303-314. 10.1016/j.ymeth.2004.08.021, 15722226.
31. Griffin TJ, Gygi SP, Ideker T, Rist B, Eng J, Hood L, Aebersold R. Complementary profiling of gene expression at the transcriptome and proteome levels in Saccharomyces cerevisiae. Mol Cell Proteomics 2002, 1(4):323-333. 10.1074/mcp.M200001-MCP200, 12096114.
32. Tian Q, Stepaniants SB, Mao M, Weng L, Feetham MC, Doyle MJ, Yi EC, Dai H, Thorsson V, Eng J, et al. Integrated genomic and proteomic analyses of gene expression in Mammalian cells. Mol Cell Proteomics 2004, 3(10):960-969. 10.1074/mcp.M400055-MCP200, 15238602.
33. Washburn MP, Koller A, Oshiro G, Ulaszek RR, Plouffe D, Deciu C, Winzeler E, Yates JR. Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 2003, 100(6):3107-3112. 10.1073/pnas.0634629100, 152254, 12626741.
34. Ellis KE, Mistry R, Boyle JP, Challiss RA. Correlation of cyclic AMP accumulation and relaxant actions of salmeterol and salbutamol in bovine tracheal smooth muscle. Br J Pharmacol 1995, 116(5):2510-2516. 10.1111/j.1476-5381.1995.tb15103.x, 1909057, 8581292.
35. Hoiting BH, Meurs H, Schuiling M, Kuipers R, Elzinga CR, Zaagsma J. Modulation of agonist-induced phosphoinositide metabolism, Ca2+ signalling and contraction of airway smooth muscle by cyclic AMP-dependent mechanisms. Br J Pharmacol 1996, 117(3):419-426. 10.1111/j.1476-5381.1996.tb15207.x, 1909321, 8821529.
36. d'Emmanuele di Villa Bianca R, Sorrentino R, Roviezzo F, Imbimbo C, Palmieri A, De Dominicis G, Montorsi F, Cirino G, Mirone V. Peripheral relaxant activity of apomorphine and of a D1 selective receptor agonist on human corpus cavernosum strips. Int J Impot Res 2005, 17(2):127-133. 10.1038/sj.ijir.3901293, 15549138.
37. Grenader A, Healy DP. A68930 is a potent, full agonist at dopamine1 (D1) receptors in renal epithelial LLC-PK1 cells. Br J Pharmacol 1992, 106(2):229-230. 10.1111/j.1476-5381.1992.tb14320.x, 1907500, 1356555.
38. Penn RB, Benovic JL. Regulation of heterotrimeric G protein signaling in airway smooth muscle. Proc Am Thorac Soc 2008, 5(1):47-57. 10.1513/pats.200705-054VS, 2645302, 18094084.
39. Spicuzza L, Belvisi MG, Birrell MA, Barnes PJ, Hele DJ, Giembycz MA. Evidence that the anti-spasmogenic effect of the β-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase. Br J Pharmacol 2001, 133(8):1201-1212. 10.1038/sj.bjp.0704213, 1621162, 11498504.
40. Roscioni SS, Elzinga CR, Schmidt M. Epac: effectors and biological functions. Naunyn Schmiedebergs Arch Pharmacol 2008, 377(4-6):345-357.
41. Koike K, Yamashita Y, Horinouchi T, Yamaki F, Tanaka Y. cAMP-independent mechanism is significantly involved in β2-adrenoceptor-mediated tracheal relaxation. Eur J Pharmacol 2004, 492(1):65-70. 10.1016/j.ejphar.2004.03.039, 15145708.
42. Tanaka Y, Horinouchi T, Koike K. New insights into β-adrenoceptors in smooth muscle: distribution of receptor subtypes and molecular mechanisms triggering muscle relaxation. Clin Exp Pharmacol Physiol 2005, 32(7):503-514. 10.1111/j.1440-1681.2005.04222.x, 16026507.
43. Palmqvist M, Persson G, Lazer L, Rosenborg J, Larsson P, Lotvall J. Inhaled dry-powder formoterol and salmeterol in asthmatic patients: onset of action, duration of effect and potency. Eur Respir J 1997, 10(11):2484-2489. 10.1183/09031936.97.10112489, 9426083.
44. Anderson GP, Linden A, Rabe KF. Why are long-acting beta-adrenoceptor agonists long-acting?. Eur Respir J 1994, 7(3):569-578. 10.1183/09031936.94.07030569, 7912202.
45. Szczuka A, Wennerberg M, Packeu A, Vauquelin G. Molecular mechanisms for the persistent bronchodilatory effect of the β2-adrenoceptor agonist salmeterol. Br J Pharmacol 2009, 158(1):183-194. 10.1111/j.1476-5381.2009.00296.x, 2795256, 19594756.
46. Johnson M. Molecular mechanisms of β2-adrenergic receptor function, response, and regulation. J Allergy Clin Immunol 2006, 117(1):18-24. quiz 25, 10.1016/j.jaci.2005.11.012, 16387578.
47. DeNinno MP, Schoenleber R, MacKenzie R, Britton DR, Asin KE, Briggs C, Trugman JM, Ackerman M, Artman L, Bednarz L, Bhatt R, Curzon P, Gomez E, Kang CH, Stittsworth J, Kebabian JW. A68930: a potent agonist selective for the dopamine D1 receptor. Eur J Pharmacol 1991, 199(2):209-219. 10.1016/0014-2999(91)90459-4, 1683288.
48. Nergardh R, Oerther S, Fredholm BB. Differences between A 68930 and SKF 82958 could suggest synergistic roles of D1 and D5 receptors. Pharmacol Biochem Behav 2005, 82(3):495-505. 10.1016/j.pbb.2005.09.017, 16318870.