Determining if telomeres matter in colon cancer initiation or progression

Journal of the National Cancer Institute

Volumn 105, Issue 16, 2013, Pages 1166-1168

  Shay, Jerry W ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC; GENOMIC DNA; ONCOPROTEIN; RIBONUCLEOPROTEIN; TELOMERASE;

AGING; APLASTIC ANEMIA; BONE MARROW DEPRESSION; CANCER GROWTH; CANCER PREVENTION; CELL CYCLE PROGRESSION; CELL DIVISION; CELL GROWTH; CELL IMMORTALIZATION; CELL MATURATION; CHROMOSOMAL INSTABILITY; CHROMOSOME; CHROMOSOME DAMAGE; COLON CANCER; DNA DAMAGE; DNA RECOMBINATION; DNA SEQUENCE; DYSKERATOSIS CONGENITA; EDITORIAL; ENDOTHELIUM CELL; ESCAPE BEHAVIOR; FAMILIAL COLON POLYPOSIS; FIBROBLAST; FIBROSING ALVEOLITIS; GENE EXPRESSION; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; IMMUNE SYSTEM; NONHUMAN; PHENOTYPE; PREMATURE AGING; PRIORITY JOURNAL; SECRETORY PATHWAY; SENESCENCE; TELOMERE; TELOMERE SHORTENING; TUMOR MICROENVIRONMENT;

ADENOMATOUS POLYPOSIS COLI; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMAL INSTABILITY; COLORECTAL NEOPLASMS; HUMANS; TELOMERE SHORTENING;

EID: 84883161267     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/djt200     Document Type: Editorial

References (21)

1. de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 2005;19(18):2100-2110.
2. Garcia CK, Wright WE, Shay JW. Human diseases of telomerase dysfunction: insights into tissue aging. Nucleic Acids Res. 2007;35(22):7406-7416.
3. Wright WE, Piatyszek MA, Rainey WE, Byrd W, Shay JW. Telomerase activity in human germline and embryonic tissues and cells. Dev Genet. 1996;18:173-179.
4. Kim N-W, Harley CB, Prowse KR, et al. Telomeres, telomerase and cancer. Science. 1995;268:1115-1117.
5. Roger L, Jones RE, Heppel NH, Williams GT, Sampson JR, Baird DM. Extensive telomere erosion in the initiation of colorectal adenomas and its association with chromosomal instability. J Natl Cancer Inst. 2013;105(16)1201-1211
6. Wright WE, Pereira-Smith OM, Shay JW. Reversible cellular senescence: a two-stage model for the immortalization of normal human diploid fibro-blasts. Mol Cell Biol. 1989;9(7):3088-3092.
7. Zou Y, Misri S., Shay JW, Pandita TK, Wright WE. Altered states of tel-omere deprotection and the two-stage mechanism of replicative aging. Mol Cell Biol. 2009;29(9):2390-2397.
8. Shay JW, Bacchetti S. A survey of telomerase in human cancer. Eur J Cancer. 1997;33(5):787-791.
9. Shay JW, Wright WE. The reactivation of telomerase activity in cancer progression. Trends Genet. 1996;12:129-131.
10. Bechter O, Zou Y, Walker W, Wright WE, Shay JW. Telomeric recombination in MSH6 deficient human colon cancer cells following telomerase inhibition. Cancer Res. 2004;64(10):3444-3451.
11. Forsyth NR, Morales C P, Damle S, Wright WE, Kopelovich L, Shay JW. Spontaneous immortalization of clinically normal colon-derived fibro-blasts from a familial adenomatous polyposis (FAP) patient. Neoplasia. 2004;6(3):265-272.
12. Meeker AK, Hicks JL, Iacobuzio-Donahue CA, et al. Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis. Clin Cancer Res. 2004;10(1):317-326.
13. O'Sullivan JN, Bronner M P, Brentnall TA, et al. 2002. Chromosomal instability in ulcerative colitis is related to telomere shortening. Nat Genet. 2002;32:280-284.
14. Riques RA, Lai LA, Brentnall TA, et al. Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage. Gastroenterology. 2008;135(2):410-418.
15. Vogelstein B, Kinzler KW. The multistep nature of cancer. Trends Genet. 1993;9(4):138-141.
16. Engelhardt M, Drullinsky P, Guillem J, Moore MA. Telomerase and tel-omere length in the development and progression of premalignant lesions to colorectal cancer. Clin Cancer Res. 1997;3(11):1931-1941.
17. Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol. 2011; 192(4):547-556.
18. Roig AI, Wright WE, Shay JW. Is telomerase a novel target for metastatic colon cancer? Curr Colorectal Cancer Rep. 2009;5:203-208.
19. Wong K-K, DePinho RA. Walking the telomere plank into cancer. J Natl Cancer Inst. 2003;95(16):1184-1186.
20. Weischer M, Nordestgaard BG, Cawthon RM, Freiberg JJ, Tybjaerg-Hansen A, Bojesen SW. Short telomere length, cancer survival, and cancer risk in 47102 individuals. J Natl Cancer Inst. 2013;105(7):459-468.
21. Wu X, Amos CI, Zhu Y, et al. Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst. 2003;95(13):1211-1218.