Do therapeutic bile acids hit the sweet spot of glucose metabolism in nafld?

Gastroenterology

Volumn 145, Issue 3, 2013, Pages 508-510

  Karpen, Saul J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FARNESOID X RECEPTOR; FIBROBLAST GROWTH FACTOR 19; G PROTEIN COUPLED RECEPTOR; GAMMA GLUTAMYLTRANSFERASE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OBETICHOLIC ACID; PLACEBO; TRIACYLGLYCEROL;

BILE ACID SYNTHESIS; BODY MASS; BODY WEIGHT; DRUG MEGADOSE; EDITORIAL; GLUCOSE METABOLISM; HISTOPATHOLOGY; HUMAN; INSULIN SENSITIVITY; LIVER BIOPSY; LOW DRUG DOSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; OBESITY; PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SIGNAL TRANSDUCTION;

EID: 84883159277     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.07.017     Document Type: Editorial

References (17)

1. T.T. Lu, M. Makishima, and J.J. Repa Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors Mol Cell 6 2000 507 515
2. S. Karpen Bile acids go nuclear! (Reprinted from Science, vol 824, pg 1362, 1999 and Science, vol 284, pg 1365, 1999) Hepatology 30 1999 1107 1109
3. M. Makishima, A.Y. Okamoto, and J.J. Repa Identification of a nuclear receptor for bile acids Science 284 1999 1362 1365
4. D.J. Parks, S.G. Blanchard, and R.K. Bledsoe Bile acids: natural ligands for an orphan nuclear receptor Science 284 1999 1365 1368
5. T.Q. de Aguiar Vallim, E.J. Tarling, and P.A. Edwards Pleiotropic roles of bile acids in metabolism Cell Metab 17 2013 657 669
6. E. Halilbasic, T. Claudel, and M. Trauner Bile acid transporters and regulatory nuclear receptors in the liver and beyond J Hepatol 58 2013 155 168
7. T.W.H. Pols, L.G. Noriega, and M. Nomura The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation J Hepatol 54 2011 1263 1272
8. P.B. Hylemon, H. Zhou, and W.M. Pandak Bile acids as regulatory molecules J Lipid Res 50 2009 1509 1520
9. F.J. Gonzalez Nuclear receptor control of enterohepatic circulation Compr Physiol 2 2012 2811 2828
10. A.C. Calkin, and P. Tontonoz Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR Nat Rev Mol Cell Biol 2012 1 12
11. H. Gronemeyer, J. Gustafsson, and V. Laudet Principles for modulation of the nuclear receptor superfamily Nat Rev Drug Discov 3 2004 950 964
12. L.P. Bechmann, R.A. Hannivoort, and G. Gerken The interaction of hepatic lipid and glucose metabolism in liver diseases J Hepatol 56 2012 952 964
13. M. Wagner, G. Zollner, and M. Trauner Nuclear receptors in liver disease Hepatology 53 2011 1023 1034
14. S.J. Karpen, and M. Trauner The new therapeutic frontier-nuclear receptors and the liver J Hepatol 52 2010 455 462
15. C. Thomas, R. Pellicciari, and M. Pruzanski Targeting bile-acid signalling for metabolic diseases Nat Rev Drug Discov 7 2008 678 693
16. S. Mudaliar, R.R. Henry, and A.J. Sanyal Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease Gastroenterology 145 2013 574 582
17. Pollack A. A.M.A. recognizes obesity as a disease. nytimes.com 2013. Available at: http://www.nytimes.com/2013/06/19/business/ama-recognizes-obesity- as-a-disease.html.