The role of renal proximal tubule P450 enzymes in chloroform-induced nephrotoxicity: Utility of renal specific P450 reductase knockout mouse models

Toxicology and Applied Pharmacology

Volumn 272, Issue 1, 2013, Pages 230-237

  Liu, Senyan ^a,b   Yao, Yunyi ^b   Lu, Shijun ^b   Aldous, Kenneth ^b   Ding, Xinxin ^b   Mei, Changlin ^a   Gu, Jun ^b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Chloroform; Cytochrome P450; Gene knockout; Mice; Nephrotoxicity; P450 reductase

Indexed keywords

BETA ACTIN; CHLOROFORM; CREATININE; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; CYTOCHROME P450 2B9; CYTOCHROME P450 2E1; CYTOCHROME P450 3A11; CYTOCHROME P450 REDUCTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE SEVERITY; ENZYME ACTIVITY; GENE; GENE DELETION; GENE EXPRESSION; KIDNEY PARENCHYMA; KIDNEY PROXIMAL TUBULE; LIVER; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; UREA NITROGEN BLOOD LEVEL; WILD TYPE;

ALANINE AMINOTRANSFERASE; ALT; BLOOD UREA NITROGEN; BUN; CHLOROFORM; CPR; CYTOCHROME P450; GENE KNOCKOUT; MICE; NADPH-CYTOCHROME P450 REDUCTASE; NEPHROTOXICITY; P450 OR CYP; P450 REDUCTASE; SCR; SERUM CREATININE;

ANIMALS; BLOOD UREA NITROGEN; BLOTTING, WESTERN; CELL LINE; CHLOROFORM; CREATININE; CYTOCHROME P-450 ENZYME SYSTEM; IMMUNOHISTOCHEMISTRY; ISOENZYMES; KIDNEY; KIDNEY DISEASES; KIDNEY TUBULES, PROXIMAL; MICE; MICE, KNOCKOUT; NADPH-FERRIHEMOPROTEIN REDUCTASE; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 84882996468     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.05.022     Document Type: Article

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