Comparative toxicity and apoptosis induced by diorganotins in rat pheochromocytoma (PC12) cells

Food and Chemical Toxicology

Volumn 60, Issue , 2013, Pages 302-308

  Liu, Enli ^a   Du, Xue ^a   Ge, Rui ^a   Liang, Taigang ^a   Niu, Qiao ^a   Li, Qingshan ^a  

^a SHANXI MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Dibutyltin (DBT); Dimethyltin (DMT); Diphenyltin (DPT); Neurotoxicity; PC12 cells

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; DIBUTYLTIN; DIMETHYLTIN; DIPHENYLTIN; ORGANOTIN COMPOUND; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; FLOW CYTOMETRY; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PC12 CELL; PROTEIN SECRETION; RAT;

2′,7′-DICHLOROFLUORESCEIN-DIACETATE; 3-(4,5-DIMETHYLTHIAZOL-2-YL)-2,5-DIPHENYLTETRAZOLIUM BROMIDE; 4-(2-HYDROXYETHYL)-1-PIPERAZINEETHANESULFONIC ACID; 5,5′,6,6′-TETRACHLORO-1,1′,3,3′-TETRAETHYL-IMIDACARBOCYANINE IODIDE; ACRIDINE ORANGE; AIF; AO; APAF-1; APOPTOSIS; APOPTOSIS-INDUCING FACTOR; APOPTOTIC PROTEASE ACTIVATION FACTOR 1; CYT C; CYTOCHROME C; DBT; DCF; DCFH; DCFH-DA; DIBUTYLTIN; DIBUTYLTIN (DBT); DICHLOROFLUORESCEIN; DIMETHYLTIN; DIMETHYLTIN (DMT); DIPHENYLTIN; DIPHENYLTIN (DPT); DITHIOTHREITOL; DMEM; DMT; DPT; DTT; DULBECCO'S MODIFIED EAGLE'S MEDIUM; EB; ECL; ETHIDIUM BROMIDE; FBS; FETAL BOVINE SERUM; FITC; FLUORESCEIN ISOTHIOCYANATE; HEPES; HORSERADISH PEROXIDASE; HRP; JC-1; LC(50); MEDIAN LETHAL CONCENTRATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MMP; MTT; NEUROTOXICITY; ORGANOTIN (IV) COMPOUNDS; OTC; PC12 CELLS; PHENYLMETHANESULFONYL FLUORIDE; PI; PMSF; POLYVINYL CHLORIDE; PROPIDIUM IODIDE; PVC; REACTIVE OXYGEN SPECIES; ROS; TBS-T; THE ENHANCED CHEMILUMINESCENCE; TMT; TRIMETHYLTIN; TRIS-BUFFERED SALINE PLUS TWEEN-20;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; LETHAL DOSE 50; MEMBRANE POTENTIAL, MITOCHONDRIAL; ORGANOTIN COMPOUNDS; PC12 CELLS; RATS; REACTIVE OXYGEN SPECIES;

EID: 84882990316     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.07.072     Document Type: Article

References (38)

1. Aschner M., Aschner J.L. Cellular and molecular effects of trimethyltin and triethyltin: relevance to organotin neurotoxicity. Neurosci. Biobehav. Rev. 1992, 16:427-435.
2. Bhushan S., Malik F., Kumar A., Isher H.K., Kaur I.P., Taneja S.C., Singh J. Activation of p53/p21/PUMA alliance and disruption of PI-3/Akt in multimodal targeting of apoptotic signaling cascades in cervical cancer cells by a pentacyclic triterpenediol from Boswellia serrata. Mol. Carcinogenesis 2009, 48:1093-1108.
3. Bourassa M.W., Miller L.M. Metal imaging in neurodegenerative diseases. Metallomics 2012, 4:721-738.
4. Delgado Filho V.S., Lopes P.F., Podratz P.L., Graceli J.B. Triorganotin as a compound with potential reproductive toxicity in mammals. Braz. J. Med. Biol. Res. 2011, 4:958-965.
5. Derouet-Hümbert E., Drǎgan C.A., Hakki T., Bureik M. ROS production by adrenodoxin does not cause apoptosis in fission yeast. Apoptosis 2007, 12:2135-2142.
6. Earley B., Burke M., Leonard B.E. Behavioural, biochemical and histological effects of trimethyltin (TMT) induced brain damage in the rat. Neurochem. Int. 1992, 21:351-366.
7. Eskes C., Honegger P., Jones-Lepp T., Varner K., Matthieu J.M., Monnet-Tschudi F. Neurotoxicity of dibutyltin in aggregating brain cell cultures. Toxicol. In Vitro 1999, 13:555-560.
8. Fargasová A. Comparative study of ecotoxicological effect of triorganotin compounds on various biological subjects. Ecotoxicol. Environ. Saf. 1997, 36:38-42.
9. Fleury C., Mignotte B., Vayssière J.L. Mitochondrial reactive oxygen species in cell death signaling. Biochimie 2002, 84:131-141.
10. Garg M. Gain of antitumor functions and induction of differentiation in cancer stem cells contribute to complete cure and no relapse. Crit. Rev. Oncog. 2009, 15:65-90.
11. Graceli J.B., Sena G.C., Lopes P.F., Zamprogno G.C., da Costa M.B., Godoi A.F., Dos Santos D.M., de Marchi M.R., Dos Santos, Fernandez M.A. Organotins: a review of their reproductive toxicity, biochemistry, and environmental fate. Reprod. Toxicol. 2013, 36:40-52.
12. Greene L.A., Tischler A.S. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA 1976, 73:2424-2428.
13. Harino H., Fukushima M., Kawai S. Accumulation of butyltin and phenyltin compounds in various fish species. Arch. Environ. Contam. Toxicol. 2000, 39:13-19.
14. Hoch M. Organotin compounds in the environment-an overview. Appl. Geochem. 2001, 16:719-743.
15. Hu J., Zhen H., Wan Y., Gao J., An W., An L., Jin P., Jin X. Trophic magnification of triphenyltin in a marine food web of Bohai Bay, North China: comparison to tributyltin. Environ. Sci. Technol. 2006, 40:3142-3147.
16. Ishida N., Akaike M., Tsutsumi S., Kanai H., Masui A., Sadamatsu M., Kuroda Y., Watanabe Y., McEwen B.S., Kato N. Trimethyltin syndrome as a hippocampal degeneration model: temporal changes and neurochemical features of seizure susceptibility and learning impairment. Neuroscience 1997, 81:1183-1191.
17. Jenkins S.M., Ehman K., Barone S. Structure-activity comparison of organotin species: dibutyltin is a developmental neurotoxicant in vitro and in vivo. Brain Res. 2004, 151:1-12.
18. Jiang G.B., Zhou Q.F., He B. Tin compounds and major trace metal elements in organotin-poisoned patient's urine and blood measured by gas chromatography-flame photometric detector and inductively coupled plasma-mass spectrometry. Bull. Environ. Contam. Toxicol. 2000, 65:277-284.
19. Kim H.E., Du F.H., Fang M., Wang X.D. Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1. PNAS 2005, 102:17545-17550.
20. Koczyk D. How does trimethyltin affect the brain: facts and hypotheses. Acta. Neurobiol. Exp. (Wars) 1996, 56:587-596.
21. Koczyk D., Skup M., Zaremba M., Oderfeld-Nowak B. Trimethyltin-induced plastic neuronal changes in rat hippocampus are accompanied by astrocytic trophic activity. Acta. Neurobiol. Exp. 1996, 56:237-241.
22. Konstantinou I.K., Albanis T.A. Worldwide occurrence and effects of antifouling paint booster biocides in the aquatic environment: a review. Environ. Int. 2004, 30:235-248.
23. Kreyberg S., Torvik A., Bjørneboe A., Wiik-Larsen W., Jacobsen D. Trimethyltin poisoning: report of a case with postmortem examination. Clin. Neuropathol. 1992, 11:256-259.
24. Limón-Pacheco J., Gonsebatt M.E. The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress. Mutat. Res. 2009, 674(1-2):137-147.
25. Liu B., Wang K., Gao H.M., Mandavilli B., Wang J.Y., Hong J.S. Molecular consequences of activated microglia in the brain: overactivation induces apoptosis. J. Neurochem. 2001, 77:182-189.
26. n+ complexes formed with biologically active ligands: equilibrium and structural studies, and some biological aspects. Coord. Chem. Rev. 2002, 224:111-150.
27. Mignini F., Nasuti C., Artico M., Giovannetti F., Fabrizi C., Fumagalli L., Iannetti G., Pompili E. Effects of trimethyltin on hippocampal dopaminergic markers and cognitive behaviour. Int. J. Immunopathol. Pharmacol. 2012, 25:1107-1119.
28. Mundy W.R., Freudenrich T.M. Apoptosis of cerebellar granule cells induced by organotin compounds found in drinking water: involvement of MAP kinases. Neurotoxicology 2006, 27:71-81.
29. Okoro H.K., Fatoki O.S., Adekola F.A., Ximba B.J., Snyman R.G., Opeolu B. Human exposure, biomarkers, and fate of organotins in the environment. Rev. Environ. Contam. Toxicol. 2011, 213:27-54.
30. Pagliarani A., Nesci S., Trombetti F., Ventrella V. Organotin effects on membranebound ATPase activities. Organometallic Compounds: Preparation Structure and Properties 2010, 225-253. Nova Science Publishers, Inc., New York. H.F. Chin (Ed.).
31. Philbert M.A., Billingsley M.L., Reuhl K.R. Mechanisms of injury in the central nervous system. Toxicol. Pathol. 2000, 28:43-53.
32. Pieters R.H., Bol M., Penninks A.H. Immunotoxic organotins as possible model compounds in studying apoptosis and thymocyte differentiation. Toxicology 1994, 91:189-202.
33. Pitrak D.L., Tsai H.C., Mullane K.M., Sutton S.H., Stevens P. Accelerated neutrophil apoptosis in the acquired immunodeficiency syndrome. J. Clin. Invest. 1996, 98:2714-2719.
34. Rüdel H. Case study: bioavailability of tin and tin compounds. Ecotoxicol. Environ. Saf. 2003, 56:180-189.
35. Shim W.J., Hong S.H., Yim U.H., Kim N.S., Oh J.R. Horizontal and vertical distribution of butyltin compounds in sediments from shipyards in Korea. Arch. Environ. Contam. Toxicol. 2002, 43:277-283.
36. Slee M., Finkemeyer J., Krupa M., Raghupathi R., Gardner J., Blumbergs P., Agzarian M., Thyagarajan D. A novel mitochondrial DNA deletion producing progressive external ophthalmoplegia associated with multiple sclerosis. J. Clin. Neurosci. 2011, 18:1318-1324.
37. Snoeij N.J., Penninks A.H., Seinen W. Dibutyltin and tributyltin compounds induce thymus atrophy in rats due to a selective action on thymic lymphoblasts. Int. J. Immunopharmacol. 1988, 10:891-899.
38. White J.S., Tobin J.M., Cooney J.J. Organotin compounds and their interactions with microorganisms. Can. J. Microbiol. 1999, 45:541-554.