The cervical malignant cells display a down regulation of ER-α but retain the ER-β expression

International Journal of Clinical and Experimental Pathology

Volumn 6, Issue 8, 2013, Pages 1594-1602

  López Romero, Ricardo ^a   Garrido Guerrero, Efraín ^b   Rangel López, Angélica ^c   Manuel Apolinar, Leticia ^c   Piña Sánchez, Patrica ^a   Lazos Ochoa, Minerva ^d   Mantilla Morales, Alejandra ^a   Bandala, Cindy ^e   Salcedo, Mauricio ^a  

^a HOSPITAL DE ONCOLOGÍA   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

^c HOSPITAL DE ESPECIALIDADES   (Mexico)

^d HOSPITAL GENERAL DE MÉXICO   (Mexico)

^e SECRETARÍA DE SALUD   (Mexico)

Author keywords

Cervical cancer; ER ; ER ; HPV

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR ALPHA, HUMAN; ESTROGEN RECEPTOR BETA; TUMOR MARKER;

ARTICLE; BIOSYNTHESIS; DOWN REGULATION; ER-Α; ER-Β; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA; UTERINE CERVIX CANCER; UTERINE CERVIX TUMOR; WART VIRUS;

CERVICAL CANCER; ER-Α; ER-Β; HPV;

CARCINOMA, SQUAMOUS CELL; DOWN-REGULATION; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS;

EID: 84882958268     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Nair HB, Luthra R, Kirma N, Liu YG, Flowers L, Evans D, Tekmal RR. Induction of aromatase expression in cervical carcinomas: effects of endogenous estrogen on cervical cancer cell proliferation. Cancer Res 2005 Dec 1; 65: 11164-73.
2. Harris HA, Bapat AR, Gonder DS, Frail DE. The ligand binding profiles of estrogen receptors alpha and beta are species dependent. Steroids 2002 Apr; 67: 379-84.
3. Mosselman S, Polman J and Dijkema R. ERβ: Identification and characterization of a novel human estrogen receptor. FEBS Lett 1996; 392: 49-53.
4. Kuiper G and Gustafsson A. The novel estrogen receptor-b subtype: potential role in the cell- and promoter-specific actions of estrogens and anti-estrogens. FEBS Lett 1997; 410: 87-90.
5. Pelletier G and El-Alfy M. Immunocytochemical localization of estrogen receptors α and β in the human reproductives organs. J Clin Endocrinol Metabol 2000; 85: 4835-4840.
6. Younes M, Honma N. Estrogen receptor β. Arch Pathol Lab Med 2011 Jan; 135: 63-6.
7. Cavaillès V. Estrogens and receptors: an evolving concept. Climacteric 2002 Jun; 5 Suppl 2: 20-6.
8. Stygar D, Wang H, Vladic YS, Ekman G, Eriksson H, Sahlin L. Co-localization of oestrogen recptor β and leukocyte markers in the human cervix. Mol Hum Reprod 2001; 7: 881-886.
9. Wang H, Stjernholm Y, Ekman G, Eriksson H, Sahlin L. Different regulation of oestrogen receptors alpha and beta in the human cervix at term pregnancy. Mol Hum Reprod 2001 Mar; 7: 293-300.
10. Manos MM, Ting Y, Wright DK. Use of Polymerase Chain Reaction amplification for the detection of genital Human Papillomaviruses. In: Furth M, Greaves M, editors. Cancer cells 7/Molecular Diagnostics of Human Cancer. U.S.A.: Cold Spring Harbor Lab Press 1989; pp: 209-214.
11. Leygue E, Dotzlaw H, Watson PH and Murphy LC. Altered estrogen receptor α and β Messenger RNA expresión during human breast tumorigenesis. Cancer Res 1998; 58: 3197-3201.
12. Kanai M, Shiozawa T, Xin L, Nikaido T, Fujii S. Immunohistochemical detection of sex sterpoid receptor, cyclins, and cyclin-dependent kinases in the normal snd neoplastic squamous epithelia of the uterini cervix. Cancer 1998; 82: 1709-1719.
13. Nonogaki H, Fujii S, Konishi I, Nanbu Y, Ozaki S, Ishikawa Y and Mori T. Estrogen receptor localization in normal and neoplastic epithelium of the uterine cervix. Cancer 1990; 66: 2620-2627.
14. Konishi I, Fujii S, Nonogaki H, Nanbu Y, Iwai T, Mori T. Immnunohistochemical analisys of estrogen receptor, progesterone receptors, Ki-67 antigen, and normal papillomavirus DNA in normal and neoplastic epithelium of the uterine cervix. Cancer 1991; 68: 1340-1350.
15. Mosny DS, Herholz J, Degen W, Bender HG. Immunohistochemical investigations of steroid receptors in normal and neoplastic squamous epithelium of the uterine cervix. Gynecol Oncol 1989 Dec; 35: 373-7.
16. Monsonego J, Magdelenat H, Catalan F, Coscas Y, Sastre X. Estrogen and progesterone receptors in cervical human papillomavirus related lesions. Int J Cancer 1991; 48: 533-539.
17. Zhai Y, Bommer GT, Feng Y, Wiese AB, Fearon ER, Cho KR. Loss of estrogen receptor 1 enhances cervical cancer invasion. Am J Pathol 2010 Aug; 177: 884-95.
18. Chung SH, Wiedmeyer K, Shai A, Korach KS, Lambert PF. Requirement for estrogen receptor alpha in a mouse model for human papillomavirus-associated cervical cancer. Cancer Res 2008 Dec 1; 68: 9928-34.
19. Graham DM, Jin L, Lloyd RV. Detection of estrogen receptor in paraffin-embedded sections of breast carcinoma by immunocytochemistry and in situ hibridization. Am J Surg Pathol 1991; 15: 475-485.
20. Wu X, Subramaniam M, Negron V, Cicek M, Reynolds C, Lingle WL, Goetz MP, Ingle JN, Spelsberg TC, Hawse JR. Development, characterization, and applications of a novel estrogen receptor beta monoclonal antibody. J Cell Biochem 2012 Feb; 113: 711-23.
21. Carder PJ, Murphy CE, Dervan P, Kennedy M, McCann A, Saunders PT, Shaaban AM, Foster CS, Witton CJ, Bartlett JM, Walker RA, Speirs V. A multi-centre investigation towards reaching a consensus on the immunohistochemical detection of erbeta in archival formalinfixed paraffin embedded human breast tissue. Breast Cancer Res Treat 2005; 92: 287-293.
22. Parl FF. Multiple mechanisms of estrogen receptor gene repression contribute to ER-negative breast cancer. Pharmacogenomics J 2003; 3: 251-253.
23. Wentzensen N, Sherman ME, Schiffman M, Wang SS. Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-science. Gynecol Oncol 2009; 112: 293-299.
24. Jarzabek K, Koda M, Kozlowski L, Mittre H, Sulkowski S, Kottler ML, Wolczynski S. Distinct mRNA, protein expression patterns and distribution of oestrogen receptors α and β in human primary breast cancer: Correlation with proliferation marker Ki-67 and clinicopathological factors. Eur J Cancer 2005; 41: 2924-2934.
25. Smith L, Coleman LJ, Cummings M, Satheesha S, Shaw SO, Speirs V, Hughes TA. Expression of oestrogen receptor beta isoforms is regulated by transcriptional and post-transcriptional mechanisms. Biochem J 2010 Jul 15; 429: 283-90.
26. Bekkers RL, van der Avoort IA, Melchers WJ, Bulten J, de Wilde PC, Massuger LF. Down regulation of estrogen receptor expression is an early event in human papillomavirus infected cervical dysplasia. Eur J Gynaecol Oncol 2005; 26: 376-82.
27. Böttner M, Thelen P, Jarry H. Estrogen receptor beta: Tissue distribution and the still largely enigmatic physiological function. J Steroid Biochem Mol Biol 2013 Mar 20; pii: S0960-0760(13)00052-6.
28. Chang EC, Frasor J, Komm B, Katzenellenbogen BS. Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells. Endocrinology 2006 Oct; 147: 4831-42.
29. Morani A, Warner M, Gustafsson JA. Biological functions and clinical implications of oestrogen receptors alfa and beta in epithelial tissues. J Intern Med 2008 Aug; 264: 128-42.
30. Takama F, Kanuma T, Wang D, Kagami I, Mizunuma H. Oestrogen receptor β expression and depth of myometrial invasion in human endometrial cancer. Br J Cancer 2001; 84: 545-549.
31. Merlo S, Sortino MA. Estrogen activates matrix metalloproteinases-2 and -9 to increase beta amyloid degradation. Mol Cell Neurosci 2012 Apr; 49: 423-9.
32. Rouyer N, Wolf C, Chenard MP, Rio MC, Chambon P, Bellocq JP, Basset P. Stromelysin-3 gene expression in human cancer: an overview. Invasion Metastasis 1994-1995; 14: 269-75.
33. Lu T, Achari Y, Rattner JB, Hart DA. Evidence that estrogen receptor beta enhances MMP-13 promoter activity in HIG-82 cells and that this enhancement can be influenced by ligands and involves specific promoter sites. Biochem Cell Biol 2007 Jun; 85: 326-36.
34. Vazquez-Ortiz G, Pina-Sanchez P, Vazquez K, Duenas A, Taja L, Mendoza P, Garcia JA, Salcedo M. Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer. BMC Cancer 2005 Jun 30; 5: 68.
35. Yoshizaki T, Sato H, Murono S, Pagano JS, Furukawa M. Matrix metalloproteinase 9 is induced by the Epstein-Barr virus BZLF1 transactivator. Clin Exp Metastasis 1999 Jul; 17: 431-6.
36. Stefano I, Vizzielli G, Tortorella L, Fagotti A, Scambia G, Gallo D. Cytoplasmic expression of oestrogen receptor beta (ERβ) as a prognostic factor in vulvar squamous cell carcinoma in elderly women. Histopathology 2011 Nov; 59: 909-17.
37. Fuqua SA, Schiff R, Parra I, Moore JT, Mohsin SK, Osborne CK, Clark GM, Allred DC. Estrogen receptor beta protein in human breast cancer: correlation with clinical tumor parameters. Cancer Res 2003 May 15; 63: 2434-9.
38. Xie LQ, Yu JP, Luo HS. Expression of estrogen receptor beta in human colorectal cancer. World J Gastroenterol 2004 Jan 15; 10: 214-7.
39. Björnström L, Sjöberg M. Estrogen receptor-dependent activation of AP-1 via non-genomic signalling. Nucl Recept 2004 Jun 14; 2: 3.
40. Shaaban AM, Green AR, Karthik S, Alizadeh Y, Hughes TA, Harkins L, Ellis IO, Robertson JF, Paish EC, Saunders PT, Groome NP, Speirs V. Nuclear and Cytoplasmic Expression of ERB1, ERB2, and ERB5 Identifies Distinct Prognostic Outcome for Breast Cancer Patients. Clin Cancer Res 2008 Aug 15; 14: 5228-35.
41. Shaaban AM, O'Neill PA, Davies MP, Sibson R, West CR, Smith PH, Foster CS. Declining estrogen receptor-h expression defines malignant progression of human breast neoplasia. Am J Surg Pathol 2003; 27: 1502-12.
42. Shaaban AM, Jarvis C, Moore F. Prognostic significance of estrogen receptor h in epithelial hyperplasia of usual type with known outcome. Am J Surg Pathol 2005; 29: 1593-9.
43. Leung YK, Lam HM, Wu S, Song D, Levin L, Cheng L, Wu CL, Ho SM. Estrogen receptor β2 and β5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion. Endocr Relat Cancer 2010 Sep; 17: 675-689.