Expression of Wnt pathway mediators in metaplasic tissue in animal model and clinical samples of tendinopathy

Rheumatology (United Kingdom)

Volumn 52, Issue 9, 2013, Pages 1609-1618

  Lui, Pauline Po Yee ^a   Lee, Yuk Wa ^b   Wong, Yin Mei ^b   Zhang, Xiaoling ^c   Dai, Kerong ^c   Rolf, Christer Gustav ^d  

^a Hospital Authority   (Hong Kong)

^b Prince of Wales Hospital   (Hong Kong)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Metaplasia; Ossification; Tendinopathy; Tendon stem progenitor cells; Tendon derived stem cells (TDSC); Wnt signalling

Indexed keywords

BETA CATENIN; COLLAGENASE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; TRANSCRIPTION FACTOR 7; WNT3A PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; HEALING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; METAPLASIA; NONHUMAN; OSSIFICATION; OSTEOBLAST; PATELLA TENDON; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STEM CELL; TENDINITIS; TENDON DERIVED STEM CELL; WNT SIGNALING PATHWAY;

METAPLASIA; OSSIFICATION; TENDINOPATHY; TENDON STEM/PROGENITOR CELLS; TENDON-DERIVED STEM CELLS (TDSC); WNT SIGNALLING;

ADULT; ANIMALS; BETA CATENIN; CALCINOSIS; CHONDROCYTES; FEMALE; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HUMANS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-5; MALE; METAPLASIA; OSTEOGENESIS; PATELLAR LIGAMENT; RATS; RATS, SPRAGUE-DAWLEY; STEM CELLS; TENDINOPATHY; WNT SIGNALING PATHWAY; WNT3A PROTEIN;

EID: 84882945454     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/ket214     Document Type: Article

References (33)

1. Clancy W. Failed healing responses. In: Leadbetter W, Buckwater J, Gordon S, eds. Sports-induced Inflammation: Clinical and Basic Science Concepts. Park Ridge, IL: American Orthopedic Society for Sports Medicine, 1989.
2. Fu SC, Rolf C, Cheuk YC et al. Deciphering the pathogenesis of tendinopathy: a three-stages process. Sports Med Arthrosc Rehabil Ther Technol 20102:30.
3. Lui PPY, Fu SC, Chan LS et al. Chondrocyte phenotype and ectopic ossification in collagenase-induced tendon degeneration. J Histochem Cytochem 200957:91-100.
4. Lui PPY, Maffulli N, Rolf C et al. What are the validated animal models of tendinopathy? Scand J Med Sci Sports 201121:3-17.
5. Lui PPY, Chan LS, Cheuk YC et al. Expression of bone morphogenetic protein-2 in the chondrogenic and ossifying sites of calcific tendinopathy and traumatic tendon injury rat models. J Orthop Surg Res 20094:27.
6. Yee Lui PP, Wong YM, Rui YF et al. Expression of chondro-osteogenic BMPs in ossified failed tendon healing model of tendinopathy. J Orthop Res 201129:816-21.
7. Rui YF, Lui PP, Rolf CG et al. Expression of chondroosteogenic BMPs in clinical samples of patellar tendinopathy. Knee Surg Sports Traumatol Arthrosc 201220: 1409-17.
8. Rui YF, Lui PP, Wong YM et al. Altered fate of tendonderived stem cells (TDSCs) isolated from a failed tendon healing animal model of tendinopathy. Stem Cells Dev 201322:1076-85.
9. Rui YF, Lui PPY, Wong YM et al. BMP-2 stimulated nontenogenic differentiation and promoted proteoglycan deposition of tendon-derived stem cells (TDSCs). J Orthop Res 201331:746-53.
10. Lui PP, Chan KM. Tendon-derived stem cells (TDSCs): from basic science to potential roles in tendon pathology and tissue engineering applications. Stem Cell Rev 20117: 883-97.
11. Ling L, Nurcombe V, Cool SM. Wnt signaling controls the fate of mesenchymal stem cells. Gene 2009;433:1-7.
12. Shao JS, Pingsterhaus JM, Cheng SL et al. Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals. J Clin Invest 2005115:1210-20.
13. Shao JS, Aly ZA, Lai CF et al. Vascular BMP Msx2 Wnt signaling and oxidative stress in arterial calcification. Ann N Y Acad Sci 20071117:40-50.
14. Al-Aly Z, Shao JS, Lai CF et al. Aortic Msx2-Wnt calcification cascade is regulated by TNF-alpha-dependent signals in diabetic Ldlr-/- mice. Arterioscler Thromb Vasc Biol 200727:2589-96.
15. Caira FC, Stock SR, Gleason TG et al. Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation. J Am Coll Cardiol 200647: 1707-12.
16. Kim SY, Choi HY, Myung KB et al. The expression of molecular mediators in the idiopathic cutaneous calcification and ossification. J Cutan Pathol 200835:826-31.
17. Rawadi G, Vayssiere B, Dunn F et al. BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res 200318: 1842-53.
18. Winkler DG, Sutherland MS, Ojala E et al. Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins. J Biol Chem 2005280:2498-2502.
19. Chen Y, Whetstone HC, Youn A et al. b-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation. J Biol Chem 2007282: 526-33.
20. Shea CM, Edgar CM, Einhorn TA et al. BMP treatment of C3H10T1/2 mesenchymal stem cells induces both chondrogenesis and osteogenesis. J Cell Biochem 200390: 1112-27.
21. Rui YF, Lui PPY, Ni M et al. Mechanical loading increased BMP-2 expression which promoted osteo-chondrogenic and inhibited tenogenic differentiation of tendon-derived stem cells. J Orthop Res 201129:390-6.
22. Tan Q, Lui PP, Rui YF. Effect of in vitro passaging on the stem cell-related properties of tendon-derived stem cellsimplications in tissue engineering. Stem Cells Dev 201221: 790-800.
23. Molloy TJ, Wang Y, Horner A et al. Microarray analysis of healing rat Achilles tendon: evidence for glutamate signaling mechanisms and embryonic gene expression in healing tendon tissue. J Orthop Res 200624: 842-55.
24. Kitagaki J, Iwamoto M, Liu JG et al. Activation of betacatenin-LEF/TCF signal pathway in chondrocytes stimulates ectopic endochondral ossification. Osteoarthritis Cartilage 200311:36-43.
25. Fu SC, Chan BP, Wang W et al. Increase expression of matrix metalloproteinase 1(MMP1) in 11 patients with patellar tendinosis. Acta Orthop Scand 200273: 658-62.
26. Nakashima A, Tamura M. Regulation of matrix metalloproteinase-13 and tissue inhibitor of matrix metalloproteinase-1 gene expression by WNT3A and bone morphogenetic protein 2 in osteoblastic differentiation. Front Biosci 200611:1667-78.
27. Yuasa T, Otani T, Koike T et al. Wnt/beta-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration. Lab Invest 200888:264-74.
28. Hens JR, Wilson KM, Dann P et al. TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro. J Bone Miner Res 200520:1103-13.
29. Robling AG, Niziolek PJ, Baldridge LA et al. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem 2008283: 5866-75.
30. Armstrong VJ, Muzylak M, Sunters A et al. Wnt/betacatenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha. J Biol Chem 2007282: 20715-27.
31. Sen B, Styner M, Xie Z et al. Mechanical loading regulates NFATc1 and beta-catenin signaling through a GSK3beta control node. J Biol Chem 2009284: 34607-17.
32. Kuo CK, Tuan RS. Mechanoactive tenogenic differentiation of human mesenchymal stem cells. Tissue Eng Part A 200814:1615-27.
33. Shi Y, Fu Y, Tong W et al. Uniaxial mechanical tension promoted osteogenic differentiation of rat tendon-derived stem cells (rTDSCs) via the Wnt5a-RhoA pathway. J Cell Biochem 2012113:3133-42.