BMP-2 stimulated non-tenogenic differentiation and promoted proteoglycan deposition of tendon-derived stem cells (TDSCs) in vitro

Journal of Orthopaedic Research

Volumn 31, Issue 5, 2013, Pages 746-753

  Rui, Yun Feng ^a   Lui, Pauline Po Yee ^a,b   Wong, Yin Mei ^a   Tan, Qi ^a   Chan, Kai Ming ^a,b  

^a Prince of Wales Hospital   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

bone morphogenetic protein 2; glycoaminoglycans; proteoglycans; tendinopathy; tendon stem progenitor cells

Indexed keywords

AGGRECAN; BIGLYCAN; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 2; DECORIN; FIBROMODULIN; GLYCOSAMINOGLYCAN; MESSENGER RNA; PROTEOGLYCAN;

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CHONDROGENESIS; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING; STEM CELL; TENDON; TENDON DERIVED STEM CELL;

ADIPOCYTES; ANIMALS; ANIMALS, OUTBRED STRAINS; BIOLOGICAL MARKERS; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; CHONDROCYTES; MALE; PATELLAR LIGAMENT; PROTEOGLYCANS; RATS; RATS, SPRAGUE-DAWLEY; STEM CELLS; TENDINOPATHY;

EID: 84875218188     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22290     Document Type: Article

References (29)

1. Fu SC, Chan BP, Wang W, et al. 2002. Increased expression of matrix metalloproteinase 1(MMP1) in 11 patients with patellar tendinosis. Acta Orthop Scand 73: 658-662.
2. Fu SC, Chan KM, Rolf CG., 2007. Increased deposition of sulfated glycosaminoglycans in human patellar tendinopathy. Clin J Sport Med 17: 129-134.
3. Maffulli N, Reaper J, Ewen SWB, et al. 2006. Chondral metaplasia in calcific tendinopathy of the Achilles tendon. Clin J Sport Med 16: 329-334.
4. Riley GP, Harrall RL, Constant CR, et al. 1996. Prevalence and possible pathological significance of calcium phosphate salt accumulation in tendon matrix degeneration. Ann Rheum Dis 55: 109-115.
5. Zhang J, Wang JH., 2010. Characterization of differential properties of rabbit tendon stem cells and tenocytes. BMC Musculoskelet Disord 11: 10.
6. Rui YF, Lui PP, Wong YM, et al. 2012. Altered fate of tendon-derived stem cells (TDSCs) isolated from a failed tendon healing animal model of tendinopathy. Stem Cells Dev DOI: 10.1089/scd.2012.0555. [Epub ahead of print].
7. Rui YF, Lui PP, Rolf CG, et al. 2012. Expression of chondro-osteogenic BMPs in clinical samples of patellar tendinopathy. Knee Surg Sports Traumatol Arthrosc 20: 1409-1417.
8. Yee Lui PP, Wong YM, Rui YF, et al. 2011. Expression of chondro-osteogenic BMPs in ossified failed tendon healing model of tendinopathy. J Orthop Res 29: 816-821.
9. Rui YF, Lui PP, Ni M, et al. 2011. Mechanical loading increased BMP-2 expression which promoted osteogenic differentiation of tendon-derived stem cells. J Orthop Res 29: 390-396.
10. Schulz TJ, Tseng YH., 2009. Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism. Cytokine Growth Factor Rev 20: 523-531.
11. Chen D, Zhao M, Mundy GR., 2004. Bone morphogenetic proteins. Growth Factors 22: 233-241.
12. Rui YF, Lui PP, Li G, et al. 2010. Isolation and characterization of multipotent rat tendon-derived stem cells. Tissue Eng Part A 16: 1549-1558.
13. Hata K, Nishimura R, Ikeda F, et al. 2003. Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor gamma during bone morphogenetic protein 2-indcued adipogenesis. Mol Biol Cell 14: 545-555.
14. Shea CM, Edgar CM, Einhorn TA, et al. 2003. BMP treatment of C3H10T1/2 mesenchymal stem cells induces both chondrogenesis and osteogenesis. J Cell Biochem 90: 1112-1127.
15. Toh WS, Yang Z, Liu H, et al. 2007. Effects of culture conditions and bone morphogenetic protein 2 on extent of chondrogenesis from human embryonic stem cells. Stem Cells 25: 950-960.
16. Asahina I, Sampath TK, Hauschka PV., 1996. Human osteogenic protein-1 induces chondroblastic, osteoblastic, and/or adipocytic differentiation of clonal murine target cells. Exp Cell Res 222: 38-47.
17. Knippenberg M, Helder MN, Zandieh Doulabi B, et al. 2006. Osteogenesis versus chondrogenesis by BMP-2 and BMP-7 in adipose stem cells. Biochem Biophys Res Commun 342: 902-908.
18. Schweitzer R, Chyung JH, Murtaugh LC, et al. 2001. Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments. Development 128: 3855-3866.
19. Parkinson J, Samiric T, Ilic MZ, et al. 2010. Change in proteoglycan metabolism is a characteristic of human patellar tendinopathy. Arthritis Rheum 62: 3028-3035.
20. Riley GP, Harrall RL, Constant CR, et al. 1994. Glycosaminoglycans of human rotator cuff tendons: changes with age and in chronic rotator cuff tendinitis. Ann Rheum Dis 53: 367-376.
21. Lui PP, Chan LS, Lee YW, et al. 2010. Sustained expression of proteoglycans and collagen type III/type I ratio in a calcified tendinopathy model. Rheumatology (Oxford) 49: 231-239.
22. Riley GP., 2005. Gene expression and matrix turnover in overused and damaged tendons. Scand J Med Sci Sports 15: 241-251.
23. Riley G., 2005. Chronic tendon pathology: molecular basis and therapeutic implications. Expert Rev Mol Med 7: 1-25.
24. Smith MM, Sakurai G, Smith SM, et al. 2008. Modulation of aggrecan and ADAMTS expression in ovine tendinopathy induced by altered strain. Arthritis Rheum 58: 1055-1066.
25. Ameye L, Aria D, Jepsen K, et al. 2002. Abnormal collagen fibrils in tendons of biglycan/fibromodulin-deficient mice lead to gait impairment, ectopic ossification, and osteoarthritis. FASEB J 16: 673-680.
26. Danielson KG, Baribault H, Holmes DF, et al. 1997. Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. J Cell Biol 136: 729-743.
27. Kato S, Kawabata N, Suzuki N, et al. 2009. Bone morphogenetic protein-2 induces the differentiation of a mesenchymal progenitor cell line, ROB-C26, into mature osteoblasts and adipocytes. Life Sci 84: 302-310.
28. Bi Y, Ehirchiou D, Kilts TM, et al. 2007. Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche. Nat Med 13: 1219-1227.
29. Ahrens M, Ankenbauer T, Schroder D, et al. 1993. Expression of human bone morphogenetic proteins-2 or -4 in murine mesenchymal progenitor C3H10T1/2 cells induces differentiation into distinct mesenchymal cell lineages. DNA Cell Biol 12: 871-880.