Clinical Syndromes of Metabolic Acidosis

Seldin and Giebisch's The Kidney

Volumn , Issue , 2008, Pages 1667-1720

  Krapf, Reto ^a,b,c   Seldin, Donald W ^a,b,c   Alpern, Robert J ^a,b,c  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882928080     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012088488-9.50062-0     Document Type: Chapter

References (457)

1. Abelow B.J., Holford T.R., Insogna K.L. Cross-cultural association between dietary animal protein and hip fracture. Calcif Tissue Int 1992, 50:14-18.
2. Adrogue H.J., Madias, N.E. Changes in plasma potassium concentration during acid-base disturbances. Am J Med 1981, 71:456-467.
3. Adrogue H.J., Chap Z., Ishida T., Field J. Role of the endocrine pancreas in the kalemic response to acute metabolic acidosis in conscious dogs. J Clin Invest 1985, 75:798-808.
4. Adrogue H.J., Wilson H., Boyd A.E., Suki W.K., Eknoyan G. Plasma acid-base patterns in diabetic ketoacidosis. N Engl J Med 1982, 307:1603-1610.
5. Addae S.K., Lotspeich W.D. Relation between glutamine utilization and production in metabolic acidosis. Am J Physiol 1968, 215:269-277.
6. Adu D., Turney J., Michael J., McMaster P. Hyperkalemia in cyclosporine treated allograft recipients. Lancet 1983, 2:370-373.
7. Agroyannis B., Koutsikos D., Tranatos-Exarchou H., Yatzidis H. Erythrocytosis in type I renal tubular acidosis with nephrocalcinosis. Nephrol Dial Transplant 1992, 7:365-366.
8. Albright F., Burnett C.H., Parson W., Reifenstein E.C., Roos A. Osteomalacia and late rickets. Medicine 1946, 25:399-479.
9. Alper S. Genetic diseases of acid-base transporters. Annu Rev Physiol 2002, 64:899-923.
10. Alpern R.J., Sakhaee K. The clinical spectrum of chronic metabolic acidosis: homeostatic mechanisms produce significant morbidity. Am J Kidney Dis 1997, 29:291-302.
11. Amanzadeh J., Gitomer W.L., Zerwekh J.E., Preisig P.A., Moe O.W., Pak C., Levi M. Effect of high protein diet on stone-forming propensity and bone loss in rats. Kidney Int 2003, 64:2142-2149.
12. Ambühl P.M., Amemyia M., Danczkay M., Lötscher M., Kaissling B., Moe O.W., Preisig P.A., Alpern R.J. Chronic metabolic acidosis increases NHE3 protein abundance in rat kidney. Am J Physiol 1996, 271:F917-F925.
13. Arai K., Tsigos C., Suzuki Y., Irony I., Listwak K.M., Chrousos G.P. Physiological and molecular aspects of mineralocorticoid receptor action in pseudohypoaldosteronism. J Clin Endocrinol Metab 1994, 79:1019-1023.
14. Armanini D., Kuhnle U., Strasser T., Dorr H., Butenandt I., Weber P.C., Stockigt J.R., Pearce P., Funder J.W. Aldosterone receptor deficiency in pseudohypoaldosteronism. N Engl J Med 1985, 313:1178-1181.
15. 3 in experimental lactic acidosis in dogs. Am J Physiol 1982, 242:586-591.
16. Arruda J.A.L., Mascimento L., Arevalo G., Baranowski R.L., Cubria A., Carrasquillo C., Westenfelder C., Kurtzman N.A. Bicarbonate reabsorption in chronic renal failure. Studies in man and the rat. Pflugers Arch 1978, 376:193-199.
17. Ashkar F.S., Miller R. Hospital ketosis in the alcoholic diabetic: a syndrome due to isopropyl alcohol intoxication. South Med J 1971, 64:1409-1411.
18. Aurga S., Wehrli S., Kaissling B., Moe O.W., Preisig P.A., Pajor A.M., Alpern R.J. Chronic metabolic acidosis increases NaDC-a mRNA and protein abundance in rat kidney. Kidney Int 2000, 58:206-215.
19. Ballmer P.E., Mc Nurlan M.A., Hulter H.N., Anderson S.E., Garlick P.J., Krapf R. Chronic metabolic acidosis decreases albumin synthesis and induces negative nitrogen balance in humans. J Clin Invest 1995, 95:39-45.
20. Basir M.A., Bhatia J., Brudno D.S., Kleinman L.I. Effects of carbicarb and sodium bicarbonate on hypoxic lactic acidosis in newborn pigs. J Invest Med 1996, 44:70-74.
21. Batlle D.C. Segmental characterization of defects in collecting tubule acidification. Kidney Int 1986, 30:546-554.
22. Batlle D.C., Arruda J.A.L., Kurtzman N.A. Hyperkalemic distal renal tubular acidosis associated with obstructive uropathy. N Engl J Med 1981, 304:373-380.
23. Batlle D.C., Hizon M., Cohen E., Gutterman C., Gupta R. The use of the urinary anion gap in the diagnosis of hyperchloremic metabolic acidosis. N Engl J Med 1988, 318:594-599.
24. Batlle D.C., Itsarayoungyven K., Arruda J.A.L., Kurtzman N.A. Hyperkalemic hyperchloremic metabolic acidosis in sickle cell hemoglobinopathies. Am J Med 1982, 72:188-192.
25. Batlle D.C., Kurtzman N.A. The defect in distal type I renal tubular acidosis. Renal Tubular Disorders: Pathophysiology Diagnosis and Management 1985, 281-305. Marcel Dekker, New York. H.C. Gonick, V.M. Buckalew (Eds.).
26. Batlle D.C., Mozes M.F., Manaligod J., Arruda J.A.L., Kurtzman N.A. The pathogenesis of hyperchloremic metabolic acidosis associated with kidney transplantation. Am J Med 1981, 70:786-796.
27. Batlle D.C., Subatini S., Kurtzman N.A. On the mechanism of toluene-induced renal tubular acidosis. Nephron 1988, 49:210-218.
28. Batlle D.C., Shehy J.T., Roseman M.K., Arruda J.A.L., Kurtzman N.A. Clinical and pathophysiologic spectrum of acquired distal renal tubular acidosis. Kidney Int 1981, 20:389-396.
29. Bailey J.L., Wang X., England B.K., Price S.R., Ding X., Mitch W.E. The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway. J Clin Invest 1996, 97:1447-1453.
30. Bailey C.J., Turner R.C. Metformin. N Engl J Med 1996, 334:574-579.
31. Bailey J.L., Wang X., Price S.R. The balance between glucocorticoids and insulin regulates muscle proteolysis via the ubiquitin-proteasome pathway. Miner Electrolyte Metab 1999, 25:220-223.
32. Baum M., Cano A., Alpern R.J. Glucocorticoids stimulate Na/H antiporter in OKP cells. Am J Physiol 1993, 264:F1027-F1031.
33. Bendavid C., Kleta R., Long R., Ouspenskaia M., Muenke M., Haddad D., Gahl W.A. FISH diagnosis of the common 57-kb deletion in CTNS causing cystinosis. Hum Genet 1904, 115:510-514.
34. Bennett J.S., Bond J., Singer I, Gottlieb A.J. Hypouricemia in Hodgkin's disease. Ann Intern Med 1972, 76:751-756.
35. Bennett I.L., Freeman H.C., Mitchell G.L., Cooper M.N. Acute methyl alcohol poisoning: a review based on experience in an outbreak of 323 cases. Med (Baltimore) 1953, 32:431-463.
36. Bersin R.M., Arieff A.I. Improved hemodynamic function during hypoxia with carbicarb, a new agent for the treatment of metabolic acidosis. Am J Physiol 1989, 77:227-233.
37. Better O.S., Chaimowitz C., Alroy G.G., Sisman I. Spontaneous remission of the defect of urinary acidification after cadaveric kidney homotransplantation. Lancet 1970, 1:110-112.
38. Better O.S., Chaimowitz C., Naveh Y., Stein A., Nahir A.M., Barzilai A., Erlik D. Syndrome of incomplete renal tubular acidosis after cadaver kidney transplantation. Ann Intern Med 1969, 71:39-46.
39. Bihari D., Gimson A.E.S., Lindridge J., Williams R. Lactic acidosis in fulminant hepatic failure: some aspects of pathogenesis and prognosis. J Hepatol 1985, 1:405-416.
40. Blackshear P.J., Holloway P.A.H., Alberti K.G. The metabolic effects of sodium dichloracetate in the starved rat. Biochem J 1974, 142:279-286.
41. Block J.B., Bronson W.R., Bell W. Metabolic abnormalities of lactic acid in Burkitt type lymphoma with malignant effusions. Ann Intern Med 1966, 65:101-108.
42. Boettger T., Hübner C.A., Maier H., Rust M.B., Beck F.X., Jentsch T.J. Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4. Nature 2002, 416:874-878.
43. Boon L., Bloomaart P.J.E., Meijer A.J., Lamers W.H., Schoolwerth A.C. Acute acidosis inhibits liver amino acid transport: no primary role for the urea cycle in acid-base balance. Am J Physiol 1994, 267:F1015-F1020.
44. Booth B.E., Tsai H.C., Morris R.C. Metabolic acidosis in vitamin-D deficient chick. Metabolism 1977, 26:1099-1105.
45. Boubaker K., Flepp M., Sudre P. Hyperlactatemia and antiretroviral therapy. Clin Infect Dis 2001, 33:1931-1937.
46. Bouissou F., Barthe P., Pierragi M.T. Severe idiopathic nephrotic syndrome with tubular dysfunction (report on nine pediatric cases). Clin Nephrol 1980, 14:135-141.
47. Boudry J.F., Stoner L.C., Burg M.B. The effect of lumen pH on potassium transport in renal cortical collecting tubules. Am J Physiol 1976, 230:239-244.
48. Boyd R.E., Brennan P.T., Deng J.-F., Rochester D.F., Spyker D.A. Strychnine poisoning. Am J Med 1983, 74:507-512.
49. Brautbar N., Levi J., Roster A., Leitesdorf E., Djaldeti M., Epstein M., Kleeman C.R. Familial hyperkalemia, hypertension, hyporeninemia with normal aldosterone levels. A tubular defect in potassium handling. Arch Intern Med 1978, 138:607-610.
50. Brenes L.G,, Sanchez M.I. Impaired urinary ammonium excretion in patients with isolated proximal tubular acidosis. J Am Soc Nephrol 1993, 4:1073-1078.
51. Brenes L.G., Brenes J.N., Hernandez M.M. Familial proximal renal tubular acidosis. A distinct clinical entity. Am J Med 1977, 63:244-252.
52. Brennan T.S., Klahr S., Hamm L.L. Citrate transport in rabbit nephron. Am J Physiol 1986, 251:F683-F689.
53. Brenner R.J., Spring D.B., Sebastian A., McSherry E.M., Genat H.K., Palubinskas A.J., Morris R.C. Incidence of radiographically evident bone disease nephrocalcinosis and nephrolithiasis in various types of renal tubular acidosis. N Engl J Med 1982, 307:217-221.
54. Brent J., Mc Martin K., Phlipps S., Burkart K.K., Donovan J.W., Wells M., Kulig K. Fomepizole for treatment of methanol poisoning. N Engl J Med 2001, 344:424-429.
55. Brent J., Mc Martin K., Philips S., Burkhart K.K., Donovan J.W., Wells M., Kulig K. Fomepizole for the treatment of ethylene glycol poisoning. N Engl J Med 1999, 340:832-838.
56. Breslau N.A., Brinkley L., Hill K.D., Pak C.Y.C. Relationship of animal protein rich diet to kidney stone formation and calcium metabolism. J Clin Endocrinol Metab 1988, 66:140-146.
57. Brezis M., Litvin Y. Syndrome of hyporeninemic hypoaldosteronism. Study of two cases and review of the literature. Isr J Med Sci 1977, 13:1013-1021.
58. Brown M.T., Cunningahm M.J., Ingelfinger J.R., Becker A.N. Progressive sensorineural hearing loss in association with distal renal tubular acidosis. Arch Otolaryngol Head Neck Surg 1993, 119:458-460.
59. Bruce L.J., Cope D.L., Jones G.K., Schofield A.E., Burley M., Povey S., Unwin R.J., Wrong O., Tanner M.J.A. Familial distal renal tubular acidosis is associated with mutations in the red cell anion exchanger (Band 3, AE1) gene. J Clin Invest 1997, 100:1693-1701.
60. Bruce R.A., Jones J.W., Strait G.B. Anaerobic metabolic responses to acute maximal exercise in male athletes. Am Heart J 1964, 67:643-650.
61. Brüngger M., Hulter H.N., Krapf R. Effect of chronic metabolic acidosis on the growth hormone/IGF-1 endocrine axis: new cause of growth hormone insensitivity in humans. Kidney Int 1997, 51:216-221.
62. Brüngger M., Hulter H.N., Krapf R. Effect of chronic metabolic acidosis on thyroid hormone homeostasis in humans. Am J Physiol 1997, 272:F648-F653.
63. Buckalew V.M., McCurdy D.K., Ludwig G.D., Chaykin L.B., Elkinton J.R. The syndrome of incomplete renal tubular acidosis. Am J Med 1968, 45:32-42.
64. Buehler J.H., Berns A.S., Webster J.R., Addington W.W., Cugell D.W. Lactic acidosis from carboxyhemoglobinemia after smoke inhalation. Ann Intern Med 1975, 82:803-805.
65. Bushinsky D.A. Net calcium efflux from live bone during chronic metabolic but not respiratory acidosis. Am J Physiol 1989, 256:F836-F842.
66. Bushinsky D.A., Kreiger N.S., Geisser D.I., Grossman E.B., Coe F.L. Effects of pH on bone calcium and proton fluxes in vitro. Am J Physiol 1983, 245:F204-F209.
67. Bushinsky D.A., Nalbantian-Brandt C., Favus M.J.. Elevated Ca++ does not inhibit the 1,25(OH)2D response to phosphorus restriction. Am J Physiol 1989, 256:F285-F289.
68. Bushinsky D.A., Riordon D.R., Chan J.S., Krieger N.S. Decreased potassium stimulates bone resorption. Am J Physiol 1997, 272:F774-F780.
69. Bushinsky D.A., Smith S.B., Gavrilov K.L., Gavrilov L.F., Li J., Levi-Setti R. Acute acidosisinduced alteration in bone bicarbonate and phosphate. Am J Physiol Renal Phys 2002, 283:F1091-F1097.
70. Bushinsky D.A, Gavrilov K.L., Gavrilov L.F., Li J., Levi-Setti R. Chronic acidosisinduced alteration in bone bicarbonate and phosphate. Am J Physiol Renal Phys 2003, 285:F532-F539.
71. Bushinsky D.A., Frick K.K. The effects of acid on bone. Curr Opin Nephrol Hypertens 2000, 9:369-379.
72. Cade R., Spooner G., Juncose L., Fuller T., Tarrant D., Raulerson D., Mahoney J., Pickering M., Grubb W., Marbury T. Chronic renal vein thrombosis. Am J Med 1977, 63:387-397.
73. Caprilli R., Frieri G., Latella G., Gallucci M., Bracoi U. Electrolyte and acid-base imbalance in patients with rectosigmoid bladder. J Urol 1986, 135:148-150.
74. Carlisle E.J.F., Donnelly S.M., Vasuvattakul S., Kamel K.S., Tobe S., Halperin M.D. Gluesniffing and distal renal tubular acidosis: Sticking to the facts. J Am Soc Nephrol 1991, 1:1019-1027.
75. Carroll H.J., Farber S.J. Hyperkalemia and hyperchloremic acidosis in chronic pyelonephritis. Metabolism 1964, 13:808-817.
76. Chan Y.L. Adrenergic control of bicarbonate absorption in the proximal convoluted tubule of the rat kidney. Pflugers Arch 1980, 388:159-164.
77. Chang S.S., Grunder S., Hanukoglu A., Rösler A., Mathew P.M., Hanukoglu I., Schild L., Lu Y., Shimkets R.A., Nelson-Williams C., Rossier B.C., Lifton R.P. Mutations of the epithelial sodium channel cause salt wasting with hyperkalemic acidosis, pseudohypolaldosteronism type 1. Nat Genet 1996, 12:248-253.
78. Chapman B.J., Proudfoot A.T. Adult salicylate poisoning: deaths and outcome in patients with high plasma salicylate concentrations. Q J Med 1989, 72:699-707.
79. Chisolm J.J., Harrison H.C., Eberlein W.R., Harrison H.E. Aminoaciduria, hypophosphatemia, and rickets in lead poisoning. Am J Dis Child 1955, 89:159-168.
80. Clarkson T.W., Kench J.E. Urinary excretion of amino acids by nonabsorbing heavy metals. Biochem J 1956, 62:361-372.
81. Cloutier C.T., Lowery B.D., Carey L.C. Acid-base disturbances in hemorrhagic shock. Arch Surg 1969, 98:551-557.
82. Cogan M.G., Rector F.C. Proximal reabsorption during metabolic acidosis in the rat. Am J Physiol 1982, 242:F499-F507.
83. Cogan M.G., Arieff A.I. Sodium wasting, acidosis and hyperkalemia induced by methicillin interstitial nephritis. Evidence for selective distal tubular dysfunction. Am J Med 1978, 4:500-507.
84. Cogan M.G., Maddox D.A., Warnock D.G., Lin E.T., Rector F.C. Effect of acetazolamide on bicarbonate reabsorption in the proximal tubule of the rat. Am J Physiol 1979, 237:F447-F454.
85. Cohen J.J., Hulter H.N., Smithline N., Melby J.C., Schwartz W.B. The critical role of the adrenal gland in the renal regulation of acid-base equilibrium during chronic hypotonic expansion. Evidence that chronic hyponatremia is a potent stimulus to aldosterone secretion. J Clin Invest 1976, 58:1201-1208.
86. Cohen J.J., Madias N.E., Wolf C.F., Schwartz W.B. Regulation of acid-base equilibrium in chronic hypocapnia. Evidence that the response of the kidney is not geared at the defense of extracellular [H+]. J Clin Invest 1976, 57:1483-1489.
87. Cohen R.D., Iles R.A. Lactic acidosis: Some physiological and clinical considerations. Clin Sci Mol Med 1977, 53:405-410.
88. Cohn D.W., Hruska K.A., Klahr S., Hammerman M.R. Increased Na-H exchange in brush border vesicles from dogs with renal failure. Am J Physiol 1982, 243:F293-F299.
89. Conn J.W., Rovner D.R., Cohen E.L., Annderson J.E. Inhibition of heparinoid of aldosterone biosynthesis in man. J Clin Endocrinol Metab 1966, 26:527-532.
90. Cooper D.J., Walley K.R., Wiggs B.R., Russell J.A. Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis. A prospective, controlled clinical study. Ann Intern Med 1990, 112:492-498.
91. Cotton E.K., Fahlberg V.I. Hypoglycemia with salicylate poisoning. Am J Dis Child 1964, 108:171-173.
92. Cox M., Sterns R.H., Singer I. The defense against hyperkalemia. The roles of insulin and aldosterone. N Engl J Med 1979, 299:525-532.
93. Craig G.M., Crane C.W. Lactic acidosis complicating liver failure after intravenous fructose. BMJ 1971, 4:211-212.
94. Cunningham J., Fraher L.J., Clemens T.L., Revell P.A., Papapoulos S.E. Chronic acidosis with metabolic bone disease. Effect of alkali on bone morphology and vitamin D metabolism. Am J Med 1982, 73:199-204.
95. Cutler G.B., Laue L. Congenital adrenal hyperplasia due to 21-hydroxylase deficiency. N Engl J Med 1990, 323:1806-1813.
96. Dafnis E., Spohn M., Lonis B., Kurtzman N.A., Sabatini S. anadate causes hypokalemic distal renal tubular acidosis. Am J Physiol 1992, 262:F449-F453.
97. D'Agostino A., Leadbetter W.F., Schwartz W.B. Alterations in the ionic composition of isotonic saline solution instilled into the colon. J Clin Invest 1953, 32:444-448.
98. Dai L.J., Friedman P.A., Quamme G.A. Acid-base changes alter Mg++ uptake in mouse distal convoluted tubule cells. Am J Physiol 1997, 272:F759-F766.
99. Davidoff F. Effects of guanidine derivates on mitochondrial function. I. Phenethylbiguanidine inhibition of respiration in mitochondria from guinea pig and rat tissue. J Clin Invest 1968, 47:2331-2343.
100. De Brabander N., Wojciechowski M., De Decker K., de Weerdt A., Jorens P.G. Fomepizole as a therapeutic strategy in paediatric methanol poisoning. Eur J Pediatr 2005, 164:158-161.
101. Dedmon R.E., Wrong O. The excretion of organic anion in renal tubular acidosis with particular reference to citrate. Clin Sci 1962, 22:19-32.
102. De Franco P.E., Haragsim L., Schmitz P.G. Bastani B. J Am Soc Nephrol 1995, 6:295-301.
103. DeFronzo R.A. Hyperkalemia and hyporeninemic hypoaldosteronism. Kidney Int 1980, 17:118-134.
104. DeFronzo R.A., Cooke C.R., Goldberg M., Cow M., Myers A.F., Agus Z.S. Impaired renal tubular potassium secretion in systemic lupus erythematosus. Ann Intern Med 1977, 86:268-271.
105. DeFronzo R.A., Goldberg M., Cooke C.R., Barker C., Grossmann R.A., Agus Z.S. Investigations into the mechanisms of hyperkalemia following renal transplantation. Kidney Int 1977, 11:357-365.
106. DeFronzo R.A., Sherwin R.S., Felig P., Bia M. Nonuremic diabetic hyperkalemia. Possible role of insulin deficiency. Arch Intern Med 1977, 137:842-843.
107. DeFronzo R.A., Taufield P.A., Black H., McPhedran P., Cooke C.R. Impaired renal tubular potassium secretion in sickle cell disease. Ann Intern Med 1979, 90:310-316.
108. DeFronzo R.A., Felig P., Ferranini E., Wahren J. Effect of graded doses of insulin on splanchnic and peripheral potassium metabolism in man. Am J Physiol 1980, 238:E421-E427.
109. Degenhart H.J., Frankena L., Visser J.K.A., Cost W.S., van Seters A.P. Further investigation of a new hereditary defect in the biosynthesis of aldosterone: evidence for a defect in 18- hydroxylation of corticosterone. Acta Physiol Pharmacol Neerl 1967, 14:88-90.
110. DeLeiva A., Christlich A.R., Melby J.C., Graham C.A., Day R.P., Luetscher J.A., Zager P.G. Big renin and biosynthetic defect of aldosterone in diabetes mellitus. N Engl J Med 1976, 295:639-643.
111. Denning H., Dill D.B., Talbott I.H. Bilanzuntersuchung einer Salmiakazidose. Naunyn Arch Exp Pathol Pharm 1929, 144:297-310.
112. De Sousa R.C., Harrington J.T., Ricanati E.S., Skelrot J.W., Schwartz W.B. Renal regulation of acid-base equilibrium during chronic administration of acid. J Clin Invest 1974, 53:47-465.
113. Dillon M.J., Leonard J.V., Buckler J.M., Ogilvie D., Liddystone D. Pseudohypoaldosteronism. Arch Dis Child 1980, 55:427-434.
114. DiTella P.J., Sodhi B., McCreary J., et al. Mechanism of the metabolic acidosis of selective mineralocorticoid deficiency. Kidney Int 1987, 14:466-477.
115. Domrongkitchaiporn S., Pongskul C., Sirikulchayanonta V., Leeprasert V., Onghiphadhanakul B., Radinahamed B., Rajatana V. Bone histology and bone mineral density after correction of acidosis indistal renal tubular acidosis. Kidney Int 2002, 62:2160-2166.
116. Dorhout-Mees E.J., Machado M., Slatopolsky E., Klar S., Bricker N.S. The functional adaptation of the diseased kidney. III. Ammonium excretion. J Clin Invest 1966, 45:289-296.
117. Douglas J.B., Healy J.K. Nephrotoxic effects of amphotericin B, including renal tubular acidosis. Am J Med 1969, 46:154-162.
118. Dubose T.D. Hydrogen ion secretion by the collecting duct as a determinant of the urine to blood PCO2 gradient in alkaline urine. J Clin Invest 1982, 69:145-156.
119. Dubose T.D., Caflish C.R. Validation of the difference in urine and blood CO2 tension during bicarbonate loading as an index of distal nephron acidification in experimental models of distal renal tubular acidosis. J Clin Invest 1985, 75:1116-1123.
120. Dubose T.D., Caflish C.R. Effect of selective aldosterone deficiency on acidification in nephron segments of rat inner medulla. J Clin Invest 1988, 82:1624-1632.
121. Dumoulin A., Lapostolle F., Adnet F., Muzynski J., Baud F.J. Acidosis and hyperlactatemia in acute sodium valproate poisoning. Presse Med 1997, 26:555-557.
122. Ehlers S.M., Petzel R.A., Brown D.C. Ventilatory response in lactic acidosis and diabetic ketoacidosis. Effect of coexistent shock, respiratory disease and severe acidosis. Miner Electrolyte Metab 1980, 3:200-206.
123. Eiam-Ong S., Dafnis E., Spohn M., Kurtzman N.A., Sabatini S. H/K-ATPase in distal tubular acidosis: urinary tract obstruction, lithium, and amiloride. Am J Physiol 1993, 265:F875-F880.
124. Eiseman B., Bricker E.M. Electrolyte absorption following ureteroenterostomy into an isolated intestinal segment. Ann Surg 1952, 136:761-769.
125. Elkinton J.R., Huth E.J., Webster G.D., McCance R.A. The renal excretion of hydrogen ion in renal tubular acidosis. I. Quantitative assessment of the response to ammonium chloride as an acid load. Am J Med 1960, 29:544-575.
126. El-Mallakh R.S., Bryan R.K., Masi T., Kelly C.E., Rakowski K.J. Long-term low dose glucocorticoid therapy associated with remission of overt renal tubular acidosis in Sjögren's syndrome. Am J Med 1985, 79:501-514.
127. Farfel Z., Iaina A., Rosenthal T., Waks U., Shibolet S., Gafni J. Familial hyperpotassemia and hypertension accompanied by normal plasma aldosterone levels. Possible hereditary cell membrane defect. Arch Intern Med 1978, 138:1828-1832.
128. Fawcett J., Hsu F.W., Tsao T., Rabkin R. Effect of metabolic acidosis on the insulin-like growth factor-1 system and cathepsins B and L gene expression in the kidney. J Lab Clin Med 2000, 36:468-475.
129. Fejes-Toth N., Snyder P.M., Fejes-Toth G. The kidney-specific WK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport. Proc Natl Acad Sci U S A 2004, 101:17434-17439.
130. Ferris T., Kasgarian M., Levitin H., Brandt I., Epstein F.H. Renal tubular acidosis and renal potassium wasting acquired as a result of hypercalcemic nephropathy. N Engl J Med 1961, 265:924-928.
131. Field M., Block M.B., Levin R., Rall D.P. Significance of blood lactate elevations among patients with acute leukemia and other nephroplastic proliferative disorders. Am J Med 1966, 40:528-547.
132. Fields A.L.A., Wolmana S.L., Halperin M.L. Chronic lactic acidosis in a patient with cancer. Therapy and metabolic consequences. Cancer 1981, 47:2026-2029.
133. Finch C.A., Gollnick P.D., Hlastala M.P., Miller L.R., Dillmann E., Mackler B. Lactic acidosis as a result of iron deficiency. J Clin Invest 1979, 64:129-137.
134. Finkel P.N., Kronenberg K., Pesce A.J., Pollack V.E. Adult Fanconi syndrome amyloidosis and marked κ-light chain proteinuria. Nephron 1973, 10:1-24.
135. Fordtran J.S., Walsh J.H. Gastric acid secretion rate and buffer content of the stomach after eating. J Clin Invest 1973, 52:645-657.
136. Friendman A.L., Chesney R.W., Trygstaad C. Autosomal dominant idiopathic Fanconi syndrome with early renal failure. Am J Med Genet 1978, 2:225-232.
137. Fraley D.S., Adler S., Bruns F., Segal D. Metabolic acidosis after hyperalimentation with casein hydrolysate. Ann Intern Med 1978, 88:352-354.
138. Fraley D.S., Adler S., Bruns F.J., Zett B. Stimulation of lactate production by administration of bicarbonate in a patient with a solid neoplasm and lactic acidosis. N Engl J Med 1980, 303:1100-1102.
139. Franch H.A., Raissi S., Wang X., Zheng B., Bailey J.L., Price S.R. Acidosis impairs insulin receptor substrate-1 associated phosphoinositide 3-kinase signaling in muscle cells: consequences on proteolysis. Am J Physiol Renal Physiol 2004, 287:F700-F706.
140. Frassetto L., Morris R.C., Sebastian A. Potassium bicarbonate reduces urinary nitrogen excretion in postmenopausal women. J Clin Endocrinol Metab 1997, 82:254-259.
141. Frassetto L., Morris R.C., Sebastian A. Effect of age on blood acid-base composition in adult humans: role of age-related renal functional decline. Am J Physiol 1996, 271:F1114-F1122.
142. Frommer J.P., Agus J.C. Acute ethylene glycol intoxication. Am J Nephrol 1982, 2:1-5.
143. Fulop M., Drapkin A. Potassium-depleted syndrome secondary to nephropathy apparently caused by "outdated tetracycline". N Engl J Med 1965, 272:986-989.
144. Fulop M., Dreyer N., Tannenbaum H. The ventilatory response in diabetic ketoacidosis. Clin Sci Mol Med 1974, 45:539-549.
145. Gabow P.A., Anderson R.J., Potts D.E., Schrier R.W. Acid-base disturbances in the salicylateintoxicated adult. Arch Intern Med 1978, 138:1481-1484.
146. Gabow P.A., Clay K., Sullivan J.B., Lepoff R. Organic acids in ethylene glycol intoxication. Ann Intern Med 1986, 105:16-20.
147. Gabow P.A., Moore S., Schrier R.W. Spironolactone-induced hyperchloremic acidosis in cirrhosis. Ann Intern Med 1979, 90:338-340.
148. Gahl W.A., Reed G.F., Thoem J.G., Schulman J.D., Rizzo W.B., Jonas A.J., Denman D.W., Schlesselman J.J., Corden B.J., Schneider J.A. Cysteamine therapy for children with nephropathic cysteinosis. N Engl J Med 1987, 316:971-977.
149. Gamba G. Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension. Am J Renal Physiol 2005, 288:F245-F252.
150. Ganote C.E., Peterson D.R., Carone F.A. The nature of d-serine induced nephrotoxicity. Am J Pathol 1974, 77:269-282.
151. Garella S. Extracorporal techniques in the treatment of exogenous intoxications. Kidney Int 1988, 33:735-754.
152. Garella S., Chang B.S., Kahn S.I. Dilution acidosis and contraction alkalosis: review of a concept. Kidney Int 1975, 8:279-283.
153. Garella S., Dana C.L., Chazan J.A. Severity of metabolic acidosis as a determinant of bicarbonate requirements. N Engl J Med 1973, 289:121-126.
154. Garibotto G., Sofia A., Robaudo C., Saffioti S., Sala M.R., Verzola D., Russo R., Procopio V., Deferrari G., Tessari P. Kidney protein dynamics and ammoniagenesis in humans with chronic metabolic acidosis. J Am Soc Nephrol 2004, 15:1606-1615.
155. Geller D.S., Rodriguez-Soriano J., Vallo A., Schiffer S., Bayer M., Chang S.S., Lifton R.P. Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism. Nat Genet 1998, 19:279-281.
156. Gennari F.J., Goldstein M.B., Schwartz W.B. The nature of the renal adaptation to chronic hypocapnia. J Clin Invest 1972, 51:1722-1730.
157. Gerst P.H., Fleming W.H., Malm J.R. Increased susceptibility of the heart to ventricular fibrillation during metabolic acidosis. Circ Res 1966, 19:63-70.
158. Gold L.W., Massry S.G., Arieff A.I., Coburn J.W. Renal bicarbonate wasting during phosphate depletion. J Clin Invest 1973, 52:2556-2562.
159. Golding P.L. Renal tubular acidosis in chronic liver disease. Postgrad Med J 1975, 51:5.
160. Goldstein M.B., Bear R., Richardson R.M.A., Mardsen P.A., Halperin M.L. The urine anion gap: a clinically useful index of ammonium excretion. Am J Med Sci 1986, 292:198-202.
161. Goldsweig H.G., Brissond M.L., Davidman M. Proximal tubular dysfunction associated with Burkitt's lymphoma. Cancer 1978, 41:568-577.
162. Golimbu M., Morales P. Jejunal conduits: technique and complications. J Urol 1975, 113:787-795.
163. Gonick H.C. Trace metals and the kidney. Miner Electrolyte Metab 1978, 1:107-120.
164. Good D.W. Inhibition of bicarbonate absorption by peptide hormones and cyclic adenosine monophosphate in rat medullary thick ascending limb. J Clin Invest 1990, 85:1006-1013.
165. Goodman A.D., Lemann C., Lennon E.J.,, Relman A.S. Production, excretion and net balance of fixed acids in patients with renal acidosis. J Clin Invest 1965, 44:495-506.
166. Gordon R.D. Syndrome of hyperkalemia and hypertension with normal glomerular filtration rate. Hypertension 1986, 8:93-102.
167. Graf H., Leach W., Arieff A.I. Evidence for a detrimental effect of bicarbonate therapy in lactic acidosis. Science 1985, 227:754-756.
168. Graham D.L., Laman D., Theodore J., Robin E.D. Acute cyanide poisoning complicated by lactic acidosis and pulmonary edema. Arch Intern Med 1977, 137:1051-1055.
169. Greenberg A.J., McNamara H., McCrory W.W. Metabolic balance studies in primary renal tubular acidosis: effects of acidosis on external calcium and phosphorus balance. J Pediatr 1967, 69:610-618.
170. Greene N.M. Effect of epinephrine on lactate, pyruvate and excess lactate production in normal human subjects. J Lab Clin Med 1961, 58:682-686.
171. Groggel G.C., Border W.A., Westernfelder C. The kidney in hypergammaglobulinemia disorders. Am J Kidney Dis 1987, 9:172-195.
172. Gross J.B., Kokko J.P. Effects of aldosterone and potassium-sparing diuretics on electrical potential differences across the distal nephron. J Clin Invest 1977, 59:82-89.
173. Gross J.M. Fanconi syndrome (adult type) developing secondary to the ingestion of outdated tetracycline. Ann Intern Med 1963, 58:523-528.
174. Guignard J.P., Torrado A. Proximal renal tubular acidosis in vitamin D deficiency rickets. Acta Paediatr Scand 1973, 62:543-546.
175. Haldane J.B.S. Experiments on the regulation of blood's alkalinity. J Physiol 1921, 55:265-282.
176. Haeussinger D., Gerok W. Hepatocyte heterogeneity in glutamate uptake by isolated perfused rat liver. Eur J Biochem 1983, 136:421-425.
177. Haeussinger D., Gerok W. Hepatocyte heterogeneity in ammonia metabolism. Chem Biol Interact 1984, 48:191-194.
178. Halperin M.L., Kamel K.S. D-lactic acidosis: turning sugars into acids in the gastrointestinal tract. Kidney Int 1996, 49:1-8.
179. Halperin M.L., Chen C.B., Cheema-Dhadli S., West M.L., Junga R.L. Is urea formation regulated primarily by acid-base balance in vivo?. Am J Physiol 1986, 250:F605-F612.
180. Halperin M.L., Hammeke M., Josse R.G., Jungas R.L. Metabolic acidosis in the alcoholic: a pathophysiologic approach. Metabolism 1983, 32:308-315.
181. Halperin M.L., Goldstein M.B., Haig A., Johnson M.D., Stinebaugh B.J. Studies on the pathogenesis of type I (distal) renal tubular acidosis as revealed by the urinary pCO2 tensions. J Clin Invest 1974, 53:669-677.
182. Harrington T.M., Lemann J. The metabolic production and disposal of acid and alkali. Med Clin N Am 1970, 54:1543-1554.
183. Harrison H.E., Harrison H.C. Experimental production of renal glycosuria, phosphaturia and amino-aciduria by injection of maleic acid. Science 1954, 120:606-608.
184. Harrison J.F., Blainey J.D. Adult Fanconi syndrome with monoclonal abnormality of immunoglobulin light chains. J Clin Pathol 1967, 20:42-48.
185. Hart G.R., Anderson R.J., Crumpler C.P., Shulkin A., Reed G., Knochel J.P. Epidemic classical heat stroke: Clinical characteristics and course of 28 patients. Med (Baltimore) 1982, 61:189-197.
186. Heaney R.P. Protein intake and bone health: the influence of belief systems on the conduct of nutritional science. Am J Clin Nutr 2001, 73:5-6.
187. Rizzoli R., Bonjour J.P. Dietary protein and bone health. J Bone Miner Res 2004, 19:527-531.
188. Heffner J.E., Sahn S.A. Salicylate-induced pulmonary edema. Clinical features and prognosis. Ann Intern Med 1981, 95:405-409.
189. Heird W.C., Dell R.B., Driscoll J.M., Grebin B., Winters R.W. Metabolic acidosis resulting from intravenous alimentation mixtures containing synthetic amino acids. N Engl J Med 1972, 287:943-948.
190. Henger A., Tutt P., Riesen W.F., Hulter H.N., Krapf R. Acid-base and endocrine effects of aldosterone and angiotensin II inhibition in metabolic acidosis in human patients. J Lab Clin Med 2000, 136:379-389.
191. Hood V.L., Keller U., Haymond M.W., Kury D. Systemic pH modifies ketone body production rates and lipolysis in humans. Am J Physiol 1990, 259:E321-E334.
192. Hood V.L., Schubert C., Keller U., Müller S. Effect of systemic pH on pHi and lactic acid generation in exhaustive forearm exercise. Am J Physiol 1988, 255:F479-F485.
193. Hoopes R.R., Shrimpton A.E., Knohl S.J., Hueber P., Hoppe B., Matyus J., Simckes A., Tasic V., Toenshoff B., Suchy S.F., Nussbaum R.L., Scheinman S.J. Dent disease with mutations in OCLR1. Am J Hum Genet 2005, 76:260-267.
194. Hosch M., Muser J., Hulter H.N., Krapf R. Ureagenesis: evidence for lack of hepatic regulation of acid-base equilibrium in humans. Am J Renal Physiol 2003, 286:F94-F99.
195. Houillier P., Borensztein P., Bichara M., Paillard M., Prigent A. Chronic neutral phosphate supplementation induces sustained renal metabolic alkalosis. Kidney Int 1992, 41:1182-1191.
196. Huckabee W.E. Relationships of pyruvate and lactate during anaerobic metabolism. III. Effect of breathing low-oxygen gases. J Clin Invest 1958, 37:264-271.
197. Huckabee W.E. Abnormal resting lactate. II. Lactic acidosis. Am J Med 1961, 30:840-848.
198. Hulter H.N., Halloran B.P., Toto R.D., Peterson C. Long-term control of plasma calcitriol concentrations in dogs and humans: dominant role of plasma calcium concentration in experimental hyperparathyroidism. J Clin Invest 1986, 76:695-702.
199. Hulter H.N,, Peterson J.C. Acid-base homeostasis during chronic PTH excess in humans. Kidney Int 1985, 28:187-192.
200. Hulter H.N., Sebastian A., Toto R.D., Bonner E.L., Ilnicki L.P. Renal
201. Hulter HN. Effects and interrelationships of PTH, Ca++, vitamin D and Pi in acid-base homeostasis. Am J Physiol 248;F739-F752.
202. Hulter H.N. Hypophosphaturia impairs the renal defense against metabolic acidosis. Kidney Int 1984, 26:302-307.
203. Hulter H.N., Licht J.H., Bonner E.L., Glynn R.D., Sebastian A. Effects of glucocorticoid steroids on renal and systemic acid-base metabolism. Am J Physiol 1980, 239:F30-F43.
204. Hulter H.N., Bonne E.L., Glynn R.D., Sebastian A. Renal and systemic acid-base effects of chronic spironolactone administration. Am J Physiol 1981, 240:F381-F387.
205. Hulter H.N., Ilnicki L.P., Harbottle J.A., Sebastian A. Impaired renal H+ secretion and NH3 production in mineralocorticoid-deficient glucocorticoid-replete dogs. Am J Physiol 1977, 326:F136-F146.
206. Hummler E., Barker P., Talbot C., Wang Q., Verdumo C., Grubb B., Gatzy J., Burnier M., Horisberger J.D., Beermann F., Boucher R., Rossier B,C. A mouse model for the renal saltwasting sydnrome pseudohypoaldosteronism. Proc Natl Acad Sci U S A 1997, 94:11710-11715.
207. Humphrey S.H., Nash D.A. Lactic acidosis complicating sodium nitroprusside therapy. Ann Intern Med 1978, 88:58-59.
208. Huth E.J., Mayock R.L., Kerr R.M. Hyperthyroidism associated with renal tubular acidosis: discussion of possible relationship. Am J Med 1959, 26:818-826.
209. Igarashi T., Sekine T., Inatomi J., Seki G. Unraveling the molecular pathogenesis of isolated proximal renal tubular acidosis. J Am Soc Nephrol 2002, 13:2171-2177.
210. Igarashi T., Shibuya K., Kaoshita S., Higahihara E., Kawato H. Renal cyst formation as a complication of primary distal renal tubular acidosis. Nephron 1991, 59:75-79.
211. Isozaki U., Mitch W.E., England B.K., Price S.R. Protein degradation and increased mRNA encoding proteins of the ubiquitin-proteasome proteolytic pathway in BC3H1 myocytes require interaction between glucocorticoids and acidification. Proc Natl Acad Sci U S A 1996, 93:1967-1971.
212. Izraeli S., Rachmel A., Frishberg Y., Ereman A., Flasterstein B., Nitzan M., Boner G. Transient renal acidification during acute infantile diarrhea: the role of urinary sodium. J Pediatr 1990, 117:711-716.
213. Jacobsen D., Wiik-Larsen E., Bredensen J.E. Haemodialysis or haemoperfusion in severe salicylate poisoning?. Hum Toxicol 1988, 7:161-163.
214. Jehle A.W., Forgo J., Biber J., Lederer E., Krapf R., Murer H. Acid-induced stimulation of Na/Pi-cotransport in OK cells. Am J Physiol 1997, 273:F396-F403.
215. Jehle A.W., Hilfiker H., Pfister M.F., Biber J., Lederer E.,, Krapf R., Murer H. Type II Na-Picotransport is regulated transcriptionally by ambient bicarbonate/carbon dioxide tension OK cells. Am J Physiol 1999, 276:F46-F53. (1Ptz).
216. Jenkins A.D., Dousa T.P., Smith L.H. Transport of citrate across renal brush border membrane: effects of dietary acid and alkali loading. Am J Physiol 1985, 249:F590-F595.
217. Jonsson S., O'Meara M., Young J.B. Acute cocaine poisoning. Am J Med 1983, 75:1061-1064.
218. Julka N.K., Arruda J.A.L., Kurtzman N.A. The mechanism of amphotericin-induced distal acidification defect in rats. Clin Sci 1979, 56:555-562.
219. Kahlhoff H., Manz F., Diekman L. Decreased growth rate of low-birth-weight infants with prolonged maximum renal acid stimulation. Acta Pediatr 1993, 82:522-537.
220. Karet F.E. Inherited distal renal tubular acidosis. J Am Soc Nephrol 2002, 13:2178-2184.
221. Karet F.E., Gainza F.J., Gyory A.Z., Unwin R.J., Wrong O., Tanner M.J.A., Nayir A., Alpay H., Santos F., Hulton S.A., Bakkaloglu A., Ozen S., Cunningham M.J., di Pietro A., Walker W.G., Lifton R.P. Mutations in the chloride-bicarbonate exchanger gene AE1 cause autosomal dominant but not autosomal recessive distal renal tubular acidosis. Proc Natl Acad Sci U S A 1998, 95:6337-6342.
222. Keller U., Mall T., Walter M., Bertel O., Mihatsch M., Ritz R. Pheochromocytoma with lactic acidosis. BMJ 1978, 2:606-607.
223. Kellum J.A., Kramer d.J., Lee K., Mankad S., Bellomo R., Pinsky M.R. Release of lactate by the lung in acute lung injury. Chest 1997, 111:1301-1395.
224. Keyvan-Laigarni H., Tannenberg A. Methanol intoxication-comparison of peritoneal dialysis and hemodialysis treatment. Arch Intern Med 1974, 134:293-296.
225. Khanna A., Simoni J., Hacker C., Duran M.J., Wesson D.E. Increased endothelin acitivty mediates augmented distal nephron acidification induced by dietary protein. J Am Soc Neprhol 2004, 15:2266-2275.
226. Kinsella J., Cujdik T., Sacktor B. Na/H exchange activity in renal brush border membrane vesicles in response to metabolic acidosis: the role of glucocorticoids. Proc Natl Acad Sci U S A 1984, 81:630-634.
227. Kittanakom S., Cordat E., Akkarapatumwong V., Yenchitsomanus P.T., Reithmeier R.A. Trafficking defects of a novel autosomal recessive distal renal tubular acidosis mutant (S773P) of the human kidney anion exchanger (kAE1). J Biol Chem 2004, 279:40960-40971.
228. Kleger G.R., Turgay M., Imoberdorf R., McNurlan M.A., Garlick P.J., Ballmer P.E. Acute metabolic acidosis decreases muscle protein synthesis but not albumin syntheis in humans. Am J Kidney Dis 2001, 38:1199-1207.
229. Kleinman P.K. Chloestyramine and metabolic acidosis. N Engl J Med 1974, 290:861.
230. Koch M., McDougal W.S. The pathophysiology of hyperchloremic metabolic acidosis after urinary diversion through intestinal segments. Surgery 1985, 561-570.
231. Kotler D.P., Tierney A.R., Wang J., Peterson R.N. Magnitude of body-cell mass depletion and the timing of death. Am J Clin Nutr 1989, 50:444-447.
232. Kozeny G.A., Barr W., Bansal V.K., Vertuno L.L., Fresco R., Robinson J., Hano J.E. Occurrence of renal tubular dysfunction in lupus nephritis. Arch Intern Med 1987, 147:891-895.
233. Kerstetter J.E., O'Brien K.O., Caseria D.M., Wall D.E., Insogna K.L. The impact of dietary protein on calcium absorption and kinetic measures of bone turnover in women. J Clin Endocrinol Metab 2005, 90:26-31.
234. Krapf R., Glatz M., Hulter H.N. Neutral phosphate administration generates and maintains renal metabolic alkalosis and hyperparathyroidism. Am J Physiol 1995, 268:F802-F807.
235. Krapf R., Vetsch R., Vetsch W., Hulter H.N. Chronic metabolic acidosis increases the serum concentration of 1,25-dihydroxyvitamin D in humans by stimulating its production rate. Critical role of acidosis-induced renal hypophosphatemia. J Clin Invest 1992, 90:2456-2463.
236. Krapf R., Hulter H.N. Renal response to chronic hypocapnia: qualitative differences between dogs and humans?. Clin Chem 1992, 38:444-445.
237. Krapf R., Beeler I., Hertner D., Hulter H.N. Chronic respiratory alkalosis. The effect of sustained hyperventilation on renal regulation of acid-base equilibrium. N Engl J Med 1991, 324:1394-1401.
238. Krapf R., Schaffner T., Iten P.X. Abuse of germanium associated with fatal lactic acidosis. Nephron 1992, 62:351-356.
239. Kreisberg R.A., Owen O.W.C., Siegal A.M. Ethanol-induced hyperlactatemia: inhibition of lactate utilization. J Clin Invest 1971, 50:164-174.
240. Krieger N.S., Frick K.K., Bushinsky D.A. Cortisol inhibits acid-induced bone resorption. J Am Soc Nephrol 2002, 13:2534-2539.
241. Kruse J.A., Zaidi S.A.J., Carlson R.W. Significance of blood lactate levels in critically ill patients with liver disease. Am J Med 1987, 83:77-82.
242. Kuo P.C., Johnson L.B., Schweitzer E.J., Bartlett S.T. Simultaneous pancreas-kidney transplantation-a comparison of enteric and bladder drainage of exocrine pancreatic secretions. Transplantation 1997, 63:238-243.
243. Kurtz I., Maher T., Hulter H.N., Schambelan M., Sebastian A. Effect of diet on plasma acid-base composition in normal humans. Kidney Int 1983, 24:670-680.
244. Kurtzman N.A., Arruda J.A.L. Physiologic significance of urinary carbon dioxide tension. Miner Electrolyte Metab 1978, 1:241-246.
245. Laghmani K., Preisig P.A., Moe O.W., Yanagisawa M., Alpern R.J. Enothelin-1/endothelin-B receptor-mediated increases in NHE3 acitivity in chronic metabolic acidosis. J Clin Invest 2001, 107:1563-1569.
246. Lameire N., Mathys E. Influence of progressive salt restriction on urinary bicarbonate wasting in uremic acidosis. Am J Kidney Dis 1987, 8:151-158.
247. Langman C.B. Calcitriol metabolism during chronic metabolic acidosis. Semin Nephrol 1989, 9:65-71.
248. Lee S.W., Russell J., Avioli V. 25-hydroxycholecalciferol: conversion inhibited by systemic acidosis. Science 1977, 195:994-996.
249. Lee D.B.N., Drinkard J.P., Rosen V.J., Gonick H.C. The adult Fanconi syndrome. Med (Baltimore) 1972, 51:107-138.
250. Leehey D., Gantt C., Lim V. Heparin-induced hypoaldosteronism. Report of a case. JAMA 1981, 246:2189-2190.
251. Lemann J., Pleuss J.J., Gray R.W., Hoffman R.G. Potassium administration decreases and potassium deprivation increases urinary calcium excretion and improves calcium balance in healthy men. Kidney Int 1989, 35:688-695.
252. Lemann J., Wilz D.R., Brenes L.G. Acid, calcium and phosphate balances in proximal renal tubular acidosis. Kidney Int 1976, 10:561.
253. Lemann J., Litzow J.R., Lennon E.J.. Studies on the mechanism by which chronic metabolic acidosis augments urinary calcium excretion in man. J Clin Invest 1967, 46:1318-1328.
254. Lemann J., Litzow J.R., Lennon E.J. The effects of chronic acid loads in normal man: further evidence for the participation of bone mineral in the defense against chronic metabolic acidosis. J Clin Invest 1966, 45:1608-1614.
255. Lemann J., Bushinsky D.A., Hamm L.L. Bone buffering of acid and base in humans. Am J Physiol Renal Physiol 2003, 54:F811-F832.
256. Lennon E.J., Lemann J., Litzow J.R. The effects of diet and stool composition on the net external acid balance of normal subjects. J Clin Invest 1966, 45:1601-1607.
257. Leu M.L., Strickland G.T. Renal tubular acidosis in Wilson's disease: characteristics, mechanisms a.nd implications. J Formosan Med Assoc 1977, 76:829-842.
258. Levine D.L., Chou S.Y., Ferder L.F., Liebman P.H., Porush J.G. The effect of plamsa bicarbonate levels on proximal tubule sodium reabsorption in NH4Cl-loaded dogs. J Clin Lab Med 1976, 87:804-812.
259. Li S., Sato S., Yang X., Preisig P.A., Alpern R.J. Pyk 2 activation is integral to acid stimulation of sodium/hydrogen exchanger 3. J Clin Invest 2004, 114:1782-1789.
260. Licata A.A., Bou E., Bartter F.C., Cox J. Effects of dietary protein on urinary calcium in normal subjects and in patients with nephrolithiasis. Metabolism 1979, 28:895-900.
261. Liddle G.W. Specific and non-specific inhibition of mineralocorticoid activity. Metabolism 1961, 10:1021-1030.
262. Lloyd S.E., Pearce S.H., Fisher S.E., Steinmeyer K., Swappbach B., Scheinman S.J. A common molecular basis for three inherited kidney diseases. Nature 1996, 379:445-449.
263. Lotspeich W.D. Renal hypertrophy in metabolic acidosis and its relation to ammonia excretion. Am J Physiol 1965, 208:1135-1142.
264. Luft F.C. Lactic acidosis update for critical care clinicians. J Am Soc Nephrol 2001, 12:S15-S19.
265. Luke R.G., Allison M.E.M., Davidson J.F., Duguid W.P. Hyperkalemia and renal tubular acidosis due to renal amyloidosis. Ann Intern Med 1969, 70:1211-1217.
266. Maclean A.J., Hayslett J.P. Adaptive changes in ammonia excretion in renal insufficiency. Kidney Int 1980, 17:595-606.
267. Madsen P.O. The etiology of hyperchloremic acidosis following urointestinal anastamosis: an experimental study. J Urol 1964, 92:448-454.
268. Madias N.E., Adrogue H.G., Cohen J.J. Maladaptive renal response to secondary hypercapnia in chronic metabolic alkalosis. Am J Physiol 1980, 238:F283-F289.
269. Madison L.L., Lochner A., Wulff J. Ethanol-induced hypoglycemia. II. Mechanism of suppression of hepatic gluconeogenesis. Diabetes 1967, 16:252-258.
270. Madison L.L., Mebane D., Unger R.H., Lochner A. The hypoglycemic action of ketones. II. Evidence for a stimulatory feedback of ketones on the pancreatic beta cells. J Clin Invest 1964, 43:408-415.
271. Madison L.L., Seldin D.W. Ammonia excretion and renal enzymatic adaptation in human subjects, as disclosed by administration of precursor amino acids. J Clin Invest 1958, 37:1615-1627.
272. Magner P.O., Robinson L., Halperin R.M. The plasma potassium concentration during acute metabolic acidosis: a re-evaluation. Am J Kdiney Dis 1988, 11:220-224.
273. Maher T., Schambelan M., Kurtz I., Hulter H.N., Jones J.W., Sebastian A. Amelioration of metabolic acidosis by dietary potassium restriction in hyperkalemic patients with chronic renal insufficiency. J Lab Clin Med 1984, 103:432-445.
274. Mahlbacher K., Sicuro A., Gerber H., Hulter H.N., Krapf R. Growth hormone corrects acidosis induced negative nitrogen balance and renal phosphate depletion and attenuates renal magnesium wasting in humans. Metabolism 1999, 48:763-770.
275. Mahnensmith R., Thier S.O., Cooke C.R., Broadus de Fronzo R.A. Effect of acute metabolic acidemia on renal electrolyte transport in man. Metab Clin Exp 1979, 28:831-842.
276. Malnic G., Klose R.M., Giebisch G. Micropuncture study of distal tubular potassium and sodium transport in rat nephron. Am J Physiol 1966, 211:529-547.
277. Maniar S., Laouari D., Dechaux M., Motel V., Uyvert J.P., Mathian B., Kleinknecht C. In vivo unaltered muscle protein synthesis in experimental chronic metabolic acidosis. Kidney Int 1994, 46:1705-1712.
278. Massry S.G., Kurokawa K., Arieff A.I., Ben-Issac C. Metabolic acidosis of hyperparathyroidism. Arch Intern Med 1974, 134:385-387.
279. Matsuda O., Nonoguchi H., Tomita K., Shiigai T., Ida T., Shinohara S., Ideurat T., Takeuhi J. Primary role of hyperkalemia in the acidosis of hyporeninemic hypoaldosteronism. Nephron 1988, 49:203-209.
280. Maurer M., Reisen W., Muser J., Hulter H.N., Krapf R. Neutralization of Western diet inhibits bone resorption independently of K intakte and reduces cortisol secretion in humans. Am J Renal Physiol 2003, 284:F32-F40.
281. May R.C., Hara Y., Kelly R.A., Block K.P., Buse M.G., Mitch W.E. Branch-chain amino acid metabolism in rat muscle: abnormal regulation by acidosis. Am J Physiol 1987, 252:E712-E718.
282. May R.C., Kelly R.A., Mitch W.E. Metabolic acidosis stimulates protein breakdown from skeletal muscle. J Clin Invest 1986, 77:614-621.
283. McConnell J.B., Murison J., Stewart W.K. The role of the colon in the pathogenesis of hyperchloremic acidosis in ureterosigmoid anastomosis. Clin Sci 1979, 57:305-312.
284. McCoy H.G., Cipolle R.J., Ehlers S.M., Sawchuk R.J., Zaske D.E. Severe methanol poisoning. Application of a pharmacokinetic model for ethanol therapy and hemodialysis. Am J Med 1979, 67:804-807.
285. McCurdy D.K., Frederic M., Elkinton J.R. Renal tubular acidosis due to amphotericin B. N Engl J Med 1968, 278:124-130.
286. McMartin K.E., Ambre J.J., Tephly T.R. Methanol poisoning in human subjects.Role for formic acid accumulation in the metabolic acidosis. Am J Med 1980, 68:414-418.
287. McSherry E., Morris R.C. Attainment and maintenance of normal stature with alkali therapy in infants and children with classic renal tubular acidosis. J Clin Invest 1978, 61:509-527.
288. Medalle R., Webb R., Waterhouse C. Lactic acidosis and associated hypoglycemia. Arch Intern Med 1971, 128:273-278.
289. Melnick J.Z., Elshourbagy N.A., Moe O.W., Preisig P.A., Alpern R.J. Adenosine triphosphate lyase mediates hypocitraturia in rats. J Clin Invest 1996, 98:2381-2387.
290. Melnick J.Z., Preisig P.A., Moe O.W., Srere P., Alpern R.J. Renal cortical mitochondrial aconitase is regulated in hypo-and hypercitraturia. Kidney Int 1998, 54:160-165.
291. Miller P.D., Helnig R.E., Waterhouse C. Treatment of alcoholic acidosis. The role of dextrose and phosphorus. Arch Intern Med 1978, 138:67-72.
292. Millhorn D.E., Eldridge F.L., Waldrop T.G. Effects of salicylate and 2,4-dinitrophenol on respiration and metabolism. Am J Physiol 1982, 53:925-929.
293. Mitch W.E., Medina W.E., Grieber S., May R.C., England B.K., Price S.R., Bailey J.L., Goldberg A.L. Metabolic acidosis stimulates prtoein degradation by activating the adenosinetriphosphate- dependent pathway involving ubiquitin and proteasomes. J Clin Invest 1994, 93:2127-2133.
294. Mitchell J.H., Wildenthall K., Johnson R.L. The effects of acid-base disturbances on cardiovascular and pulmonary function. Kidney Int 1972, 1:375-389.
295. Mohler J.L. Metabolic acidosis after bladder replacement: comparison of severity and reversibility in ileal and colonic reservoirs. J Urol 1988, 139:628-633.
296. Molitoris B.A., Froment D.H., MacKenzie T.A., Huffer W.H., Alfrey A.C. Citrate: a major factor in the toxicity of orally administered aluminum compounds. Kidney Int 1989, 36:949-953.
297. Mookerjee B., Gault M.H., Dossetor J.B. Hyperchloremic acidosis in early diagnosis of renal allograft rejection. Ann Intern Med 1969, 71:47-58.
298. Morris R.C. An experimental renal acidification defect in patients with hereditary fructose intolerance. I. Its resemblance to renal tubular acidosis. J Clin Invest 1968, 47:1389-1398.
299. Morris R.C., McSherry E., Sherwood L.M. Evidence of a pathogenetic role of hyperparathyroidism in the renal tubular dysfunction of patients with Fanconi's syndrome. J Clin Invest 1970, 50:68a.
300. Morrissey J.F., Oschoa M., Lotspeich W.D., Waterhouse C. Citrate excretion in RTA. Ann Intern Med 1963, 58:159-166.
301. Moss A.H., Gabow P.A., Kaehny W.D., Goodman S.I., Haut L.L., Haussler M.R. Fanconi's syndrome and distal renal tubular acidosis after glue sniffing. Ann Intern Med 1980, 92:69-70.
302. Muggia F.M., Heinemann H.O., Farbongi M., Osseman E.F. Lysozymuria and renal tubular dysfunction in monocytic and myelomonocytic leukemia. Am J Med 1969, 47:351-366.
303. Muldowney F.P., Carroll D.V., Donohoe D.V., Donohoe J.F., Freaney R.. Correction of renal bicarbonate wastage by parathyroidectomy. Q J Med 1971, 40:487-498.
304. Muldowney F.P., Freaney R., McGeeney D. Renal tubular acidosis and amino-aciduria in osteomalacia of dietary or intestinal origin. Q J Med 1968, 38:517-539.
305. Murphy R.V., Coffman E.W., Pringle B.H., Iseri L.T. Studies of sodium and potassium metabolism in salt-losing nephritis. Arch Intern Med 1952, 90:750-762.
306. Nahum H., Paillard M., Prigent A., Leviel F., Bichard M., Gardin J.P. Pseudohypoaldosteronism type II: proximal renal tubular acidosis and dDAVP sensitive renal hyperkalemia. Am J Nephrol 1986, 6:253-262.
307. Nash M.A., Torrada A.D., Greifer I., Spritzer A., Edelmann C.M. Renal tubular acidosis in infants and children. Clinical course, response to treatment, and prognosis. J Pediatr 1972, 80:738-748.
308. Nath K.A., Hostetter M.K., Hostetter T.H. Increased ammoniagenesis as a determinant of progressive renal injury. Am J Kidney Dis 1991, 17:654-657.
309. Nath K.A., Hostetter M.K., Hostetter T.H. Pathophysiology of chronic tubulointerstitial disease in rats: Interaction of dietary acid load, ammonia and complement component C3. J Clin Invest 1985, 76:667-675.
310. New M.I., White P.C., Pang B., Speiser P.W. The adrenal hyperplasias. The Metabolic Basis of Inherited Disease 1989, 1881-1918. McGraw-Hill, New York. C.R. Scriver, A.L. Beaudet, W.S. Sly, D. Valle (Eds.).
311. Nghiem D.D., Gonwa T.A., Corry R.J. Metabolic effects of urinary diversion of exocrine secretions in pancreatic transplantation. Transplantation 1987, 43:70-73.
312. Nicar M.J., Skurla C., Sakhaee K., Pak C.Y.C. Low citrate excretion in nephrolithiasis. Urology 1983, 21:8-14.
313. Nilwarangkur S., Nimmannit S., Chaovakul V., Susaengrat W., Ong-aj-Yooth S., Vasuvattakul S., Pidetcha P., Malasit P. Endemic primary distal renal tubular acidosis in Thailand. Q J Med 1990, 74:289-301.
314. Nimmannit S., Malasit P., Chaovakul V., Susaengrat W., Vasuvattakul S., Nilwarangkur S. Pathogenesis of sudden unexplained death (lai tai) and endemic distal renal tubular acidosis. Lancet 1991, 338:930-932.
315. Norby L.H., Ramwell P., Weidig J., Slotkoff L., Flambenbaum W. Possible role for impaired renal prostaglandin production in pathogenesis of hyporeninaemic hypoaldosteronism. Lancet 1978, 2:1118-1122.
316. Nordstrom T., Shrode L.D., Rotstein O.D., Romanek R., Goto T., Heersche J.N.M., Manolson M.F., Brisseau G.F., Grinstein S. Chronic extracellular acidosis induces plasmalemmal vacuolar type H+ ATPase activity in osteoclasts. J Biol Chem 1997, 272:6354-6360.
317. Norman M.E., Feldman N.I., Cohn R.M., Roth K.S., McCurdy D.K. Urinary citrate excretion in the diagnosis of distal renal tubular acidosis. J Pediatr 1978, 92:394-400.
318. Notarianni L. A reassessment of the treatment of salicylate poisoning. Drug Saf 1992, 7:292-303.
319. Oberfield S.E., Levine L.S., Carey R.M., Bejarw R., New M.I. Pseudohypoaldosteronism. Multiple target organ unresponsiveness to mineralocorticoid hormones. J Clin Endocrinol Metab 1979, 48:228-234.
320. Ochwadt B.K., Pitts R.F. Effect of intravenous infusion of carbonic anhydrase on carbon dioxide tension of alkaline urine. Am J Physiol 1956, 185:426-429.
321. O'Gorman M., Fivush B., Wise B., Colombani P., Burdick J., Schwarz K.B. Proximal renal tubular acidosis secondary to FK506 in pediatric liver transplant patients. Clin Transplant 1995, 9:312-316.
322. Oh M.S. A new method for estimating GI-absorption of alkali. Kidney Int 1989, 36:915-917.
323. Oh M.S., Carroll H.J., Clemmons J.E., Vagnucci A.H., Levinson S.P., Whange E.S.M. A mechanism for hyporeninemic hypoaldosteronism in chronic renal disease. Metabolism 1974, 23:1157-1166.
324. Oliver J., Koelz A.M., Costello J., Bourke E. Acid-base induced alterations in glutamine metabolism and ureogenesis in perfused muscle and liver of the rat. Eur J Clin Invest 1977, 7:445-449.
325. Ordonez F.A., Santos F., martinez V., Garcia E.,, Fernandez P., Rodriguez J., Fernandez M., Alvarez J., Ferrando S. Resistance to growth hormone and insulin-like growth factor-1 in acidotic rats. Pediatr Nephrol 2000, 14:720-725.
326. Orringer C.E., Eustage J.C., Wunsch C.D., Gardener L.B. Natural history of lactic acidosis after grand-mal seizures. A model for the study of an anion-gap acidosis not associated with hyperkalemia. N Engl J Med 1977, 297:796-799.
327. Oster J.R., Hotchkiss J.L., Carbon M., Farmer M.,, Vaamonde C.A. A short duration renal acidification test using calcium chloride. Nephron 1975, 14:281-292.
328. Oster J.R., Moss S., Perez G.O., Vaamonde C.A. Renal acidification in patients with chronic renal insufficiency: pCO2 of alkaline urine and response to NH4Cl. Miner Electrolyte Metab 1978, 1:253-262.
329. Otten J., Vis H.L. Acute reversible renal tubular dysfunction following intoxication with methyl-3-chromone. J Pediatr 1968, 73:422-425.
330. Owen O.E., Felig P., Morgan A.P., Wahren H., Cahill G.F. Liver and kidney metabolism during prolonged starvation. J Clin Invest 1969, 48:58-574.
331. Papadoyannakis N.J., Stefanidis C.J., McGeown M. The effect of correction of metabolic acidosis on nitrogen and potassium balance of patients with chronic renal failure. Am J Clin Nutr 1984, 40:623-627.
332. Pares A., Rimola A., Bruguera M., Mas E., Rodes J. Renal tubular acidosis in primary biliary cirrhosis. Gastroenterology 1981, 80:681-686.
333. Pastoriza-Munoz E., Harrington R.M., Graber M.L. Parathyroid hormone decreases HCO3 reabsorption in the rat proximal tubule by stimulating phosphatidylinositol metabolism and inhibiting base exit. J Clin Invest 1992, 89:1485-1495.
334. Peraino R.A., Suki W.N. Urine HCO-3 augments renal Ca2+ absorption independent of systemic acid-base changes. Am J Physiol 1980, 238:F394-F398.
335. Perez G.O., Lespier L., Jacobi J., Oster J.R., Katz F.H., Vaamonde C.A., Fishman L.M. Hyporeninemia and hypoaldosteronism in diabetes mellitus. Arch Intern Med 1977, 137:852-855.
336. Perez G.O., Oster J.R., Vaamonde C.A. Renal acidosis and renal potassium handling in selective hypoaldosteronism. Am J Med 1974, 57:809-816.
337. Perez G.O., Seigel L., Schreiner G.E. Selective hypoaldosteronism with hyperkalemia. Ann Intern Med 1972, 76:757-763.
338. Pines K.L., Mudge G.H. Renal tubular acidosis with osteomalacia. Am J Med 1951, 11:302-311.
339. Pitts R.F. The renal excretion of acid. Fed Proc 1948, 7:418.
340. Pitts R.F., Lotspeich W.D. Bicarbonate and the renal regulation of acid-base balance. Am J Physiol 1946, 147:138-154.
341. Price S.R., England B.K., Bailey J.L., van Vreede K., Mitch W.E. Acidosis and glucocorticoids concomitantly increase ubiquitin and proteasome subunit mRNA in rat muscle. Am J Physiol 1994, 267:C955-C960.
342. Rampini S., Fanconi A., Illig R., Prader A. Effect of hypochlorothiazide on proximal renal tubular acidosis in a with idiopathic "de Toni-Debre-Fanconi syndrome". Helv Paediatr Acta 1968, 23:13-21.
343. Reaich D., Channon S.M., Scrimbeour C.M., Goodship T.H.J. Ammonium chloride induced acidosis increases protein breakdown and amino acid oxidation in humans. Am J Physiol 1992, 263:E735-E739.
344. Record C.O., Iles R.A., Cohen R.D., Williams R. Acid-base and metabolic disturbances in fulminant hepatic failure. Gut 1975, 16:144-149.
345. Relman A.S., Schwartz W.B. The effect of DOCA on electrolyte balance in normal man and its relation to sodium chloride intake. Yale J Biol Med 1952, 24:540-552.
346. Relman A.S. Renal acidosis and renal excretion of acid in health and disease. Adv Intern Med 1964, 12:295-347.
347. Reynolds I.B., Bethune J.E. Renal tubular acidosis secondary to hyperparathyroidism. Clin Res 1969, 17:169.
348. Ribeiro M., Alloisio N., Almeida H., Gomes C., Texier P., Lemos C., et al. Severe hereditary spherocytosis and distal renal tubular acidosis associated with complete absence of band 3. Blood 2000, 96:1602-1604.
349. Richards P., Wrong O.M. Dominant inheritance in a family with familial renal tubular acidosis. Lancet 1972, 2:998-999.
350. Richards P., Chamberlain M.M., Wrong O.M. Treatment of osteoamalacia of renal tubular acidosis by sodium bicarbonate alone. Lancet 1972, ii:994-997.
351. Ring T., Anderson P.T., Knudsen F., Nielsen F.B. Salicylate-induced hyperventilation. Lancet 1985, 1:1450.
352. Ritter J.M., Doktor H.S., Benjamin N. Paradoxical effect of bicarbonate on cytoplasmic pH. Lancet 1990, 335:1243-1246.
353. Rodriguez-Soriano J., Boichis H., Stark H., Edelmann C.M. Proximal renal tubular acidosis. A defect in bicarbonate reabsorption with normal urinary acidification. Pediatr Res 1967, 1:81-98.
354. Rosenbaum B.J., Makoff D.L., Maxwell M.H. Acid-base and electrolyte changes induced by acute isotonic saline infusion in the nephrectomized dog. J Lab Clin Med 1969, 74:427-435.
355. Roth G.J., Porte D. Chronic lactic acidosis and acute leukemia. Arch Intern Med 1970, 125:317-321.
356. Runebreg L., Miettinen A., Nikkila E.N. Effect of cholestyramine on mineral excretion in man. Acta Med Scand 1972, 192:71-76.
357. Rungroj N., Devonald M.A.J., Cuthbert A.W., Reimann F., Akkarapatumwong V., Yenchitsomanus P., Bennet W.M., Karet F.E. A novel missense mutation in AE1 causing autosomal dominant distal renal tubular acidosis retains normal transport function but is mistargeted in polarized epithelial cells. J Biol Chem 2004, 279:13833-13838.
358. Sanjed S.A., Keenan B.S., Hill L.L. Renal hypoprostaglandism, hypertension and type IV renal tubular acidosis reversed by furosemide. Ann Intern Med 1983, 93:624-627.
359. Sanders P.W., Herrera G.A., Galla J.H. Human Bence Jones protein in rat proximal tubule epithelium in vivo. Kidney Int 1987, 32:851-861.
360. Sartorius O.W., Roemmelt J.C., Pitts R.F. The renal regulation of acid-base balance in man. IV. The nature of renal compensation in ammonium chloride acidosis. J Clin Invest 1949, 28:423-433.
361. Sasaki S., Marumo F. Mechanisms of inhibition of proximal acidification by PTH. Am J Physiol 1991, 260:F833-F838.
362. Sawyer W.H., Solez C. Salt-losing nephritis simulating adrenocortical insufficiency. N Engl J Med 1949, 240:210-215.
363. Scandling J.D., Ornt D.B. Mechanism of potassium depletion during chronic metabolic acidosis in the rat. Am J Physiol 1987, 252:F122-F130.
364. Schambelan M., Sebastian A., Biglieri E.G. Prevalence, pathogenesis and functional significance of aldosterone deficiency in hyperkalemic patients with chronic renal failure. Kidney Int 1980, 17:89-101.
365. Schambelan M., Sebastian A., Rector F.C. Mineralocorticoid (MC) resistant renal K+ secretory defect: proposed distal chloride shunt. Kidney Int 1978, 14:662.
366. Schambelan M., Stockigt J.R., Biglieri M. Isolated hypoaldosteronism in adults. A renindeficiency syndrome. New Engl J Med 1972, 287:573-578.
367. Schambelan M., Sebastian A., Katuna B.A., Arteaga E. Adrenocortical hormone secretory response to chronic NH4CL-induced metabolic acidosis. Am J Physiol 1987, 252:E454-E460.
368. Schelling J.R., Howard R.L., Winter S.D., Linas S.L. Increased osmolal gap in alcoholic ketoacidosis and lactic acidosis. Ann Intern Med 1990, 113:580-582.
369. Schiess W.A., Ayer J.L., Lotspeich W.D., Pitts R.F. The renal regulation of acid-base balance in man. II. Factors affecting the excretion of titratable acid by the normal human subject. J Clin Invest 1948, 27:57-64.
370. Schlatter E. Electrophysiological studies in principal cells of rat cortical collecting tubules. ADH increases the apical membrane Na+ conductance. Pflugers Arch 1987, 409:81-92.
371. Schrock H., Goldstein L. Interorgan relationships for glutamine metabolism in normal and acidotic rats. Am J Physiol 1981, 240:E519-E525.
372. Schwartz W.B., Hall P.W., Hays R.M., Relman A.S. On the mechanism of acidosis in chronic renal disease. J Clin Invest 1959, 338:39-52.
373. Schwartz W.B., Bank N., Cutler R.W.P. The influence of urinary ionic strength on the phosphate pK2' and the determination of titratable acid. J Clin Invest 1959, 38:247-256.
374. Schwartz W.B., Orning K.J., Porter R. The internal distribution of hydrogen ions with varying degrees of metabolic acidosis. J Clin Invest 1957, 36:373-382.
375. Schwartz W.B., Jenson R.L., Relman A.S. Acidification of the urine and increased ammonia excretion without changes in acid-base equilibrium. Sodium reabsorption as a stimulus to the acidifying proce. J Clin Invest 1955, 34:673-680.
376. Sealey J.E., Clark I., Bull M.B., Laragh J.H. Potassium balance and the control of renin secretion. J Clin Invest 1970, 49:2119-2127.
377. Sebastian A., Harris S.T., Ottaway M.A., Todd K.M., Morris R.C. Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate. N Engl J Med 1994, 330:1776-1781.
378. Sebastian A., Sutton J.M., Hulter H.N., Schambelan M., Poler S.M. Effect of mineralocorticoid replacement therapy on renal acid-base homeostasis in adrenalectomized patients. Kidney Int 1980, 18:762-777.
379. Sebastian A., McSherry E., Morris R.C. Renal potassium wasting in renal tubular acidosis (RTA). Its occurrence in types 1 and 2 RTA despite sustained correction of systemic acidosis. J Clin Invest 1971, 50:667-678.
380. Sebastian A., McSherry E., Ueki I., et al. Renal amyloidosis, nephrotic syndrome and impaired renal tubular reabsorption of bicarbonate. Ann Intern Med 1968, 69:541-548.
381. Sharpy-Schafer E.P., Semple S.J.G., Halls R.W., Howarth S. Venous constriction after exercise: its relation to the acid-base changes in venous blood. Clin Sci 1965, 29:397-406.
382. Shayakul C., Alper S.L. Defects in processing and trafficking of the AE+ CL-/HCO3- exchanger associated with inherited distal renal tubular acidosis. Clin Exp Nephrol 2004, 8:1-11.
383. Shechter Y., Ron A. Effect of depletion of bicarbonate or phosphate ions on insulin action in rat adipocytes: further characterization of the receptor-effector system. J Biol Chem 1986, 261:14951-14954.
384. Sicuro A., Mahlbacher K., Hulter H.N., Krapf R. Effect of growth hormone on renal and systemic acid-base homeostasis in humans. Am J Physiol 1998, 274:F650-F657.
385. Siebert D.J., Ebaugh F.G. Assessment of tissue anoxemia in chronic anemia by the arterial lactate/pyruvate ratio and excess lactate formation. J Lab Clin Med 1967, 69:177-182.
386. Simpson A.m., Schwartz G.J. Distal renal tubular acidosis with severe hypokalemia, probably caused by colonic H+/K+ ATPase. Arch Dis Child 2001, 84:504-507.
387. Simpson D.P. Effect of acetazolamide on citrate excretion in the dog. Am J Physiol 1964, 206:883-886.
388. Simpson D.P. Control of hydrogen ion homeostasis and renal acidosis. Med (Baltimore) 1971, 50:503-541.
389. Skinner R., Pearson A.D., English M.W., Wyllie R.A., Coulthard M.G., Craft A.W. Risk factors for ifosfamide nephrotoxicity in children. Lancet 1996, 348:578-580.
390. Smith A.N., Skaug J., Choate K.A., Nayir A., Bakkaloglu A., Ozen S., Hulton S.A., Sanjad S.A., Al-Sabban E.A., Lifton R.P., Scherer S.W., Karet F.E. Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116 kd subunit, cause recessive distal renal tubular acidosis with preserved hearing. Nat Genet 1900, 26:71-75.
391. Solomon A., Weiss D.T., Kattine A. Nephrotoxic potential of Bence Jones proteins. N Engl J Med 1991, 324:1845-1851.
392. Speiser P.W., Agdere L., Ueshiba H., White P.C., New M.I. Aldosterone synthesis in saltwasting congenital adrenal hyperplasia with complete absence of adrenal 21-hydroxylase. N Engl J Med 1991, 324:145-149.
393. Stacpoole P.W. Lactic acidosis: the case against bicarbonate therapy. Ann Intern Med 1986, 105:276-279.
394. Stacpoole P.W., Wright E.C., Baumgartne T.G. A controlled trial of dichloroacetate for treatment of lactic acidosis in adults. N Engl J Med 1992, 327:1546-1550.
395. Stahl R.A., Kanz L., Mayer B., Schollmeyer P. Hyperchloremic metabolic acidosis with high serum potassium in renal transplant patients. A cyclosporine associated effect. Clin Nephrol 1986, 25:245-248.
396. Stanton B., Giebisch G. Effects of pH on potassium transport by renal distal tubule. Am J Physiol 1982, 242:F551-F555.
397. Stamey T.A. The pathogenesis and implications of the electrolyte imbalance in ureterosigmoidostomy. Surg Gynecol Obstet 1956, 103:736-758.
398. Steele T.W., Gyorky A.Z., Edwards K.D.G. Renal function in analgesic nephropathy. BMJ 1969, 2:213-216.
399. Steinhart B. Case report: severe ethylene glycol intoxication with normal osmolal gap"a chilling thought". J Emerg Med 1990, 8:583-585.
400. Steinmetz P.R., Lawson L.R. Defect in urinary acidification induced in vitro by amphotericin B. J Clin Invest 1970, 49:596-601.
401. Stokes J.B., Averon F. Prevention of organ damage in massive ethylene glycol ingestion. JAMA 1980, 243:2065-2066.
402. Stone D.K., Seldin D.W., Kokko J.P., Jacobson H.R. Mineralocorticoid modulation of rabbit medullary collecting duct acidification. A sodium-independent effect. J Clin Invest 1983, 72:77-83.
403. Stoner L.C., Burg M., Orloff J. Ion transport in cortical collecting tubule: effect of amiloride. Am J Physiol 1974, 227:45-453.
404. Stover E.H., Borthwick K.J., Bavalia C., Eady N., et al. Novel ATP6V1B1 and ATP6V0A4 mutations in autosomal recessive distal renal tubular acidosis with new evidence for hearing loss. J Med Genet 2002, 39:796-803.
405. Summitt R.C., Etteldorf J.N. Salicylate intoxication in children. Experience with peritoneal dialysis and alkalinization of the urine. J Pediatr 1964, 64:803-814.
406. Sutton R.A., Wong N.L., Dirks J.H. Effects of metabolic acidosis and alkalosis on sodium and calcium transport in the dog kidney. Kidney Int 1979, 15:520-533.
407. Szerlip H.M., Singer I. Hyperchloremic metabolic acidosis after chlorine inhalation. Am J Med 1984, 77:581-582.
408. Szylman P., Better O.S., Chaimowitz C., Rosler A. Role of hyperkalemia in the metabolic acidosis of isolated hypoaldosteronism. N Engl J Med 1975, 294:361-365.
409. Talal N. Sjögren's syndrome, lymphoproliferation, and renal tubular acidosis. Ann Intern Med 1971, 74:633-634.
410. Tannen R.L. Relationship of renal ammonia production and potassium homeostasis. Kidney Int 1977, 11:453-465.
411. Tannen R.L., Fallas W.E., Branckett N.C. Incomplete renal tubular acidosis: some clinical and physiological features. Nephron 1975, 15:111-123.
412. Taylor W.M., Halperin M.L. Regulation of pyruvate dehydrogenase in muscle. Inhibition by citrate. J Biol Chem 1973, 248:6080-6083.
413. Teree T.M., Mirabal-Font E., Ortiz A., Wallace W.M. Stool losses and acidosis in diarrheal disease of infancy. Pediatrics 1965, 36:704-713.
414. Textor S.C., Bravo E.L., Fouad F.M., Tarazi R.C. Hyperkalemia in azotemic patients during angiotensin-converting enzyme inhibition and aldosterone reduction with captopril. Am J Med 1982, 73:719-725.
415. Thorn G.W., Koepf G.F., Clinton M. Renal failure simulating adrenocortical insufficiency. N Engl J Med 1944, 231:76-85.
416. Thurston J.H., Pollock P.G., Warren S.K., Jones E.M. Reduced brain glucose with normal plasma glucose in salicylate poisoning. J Clin Invest 1970, 49:2139-2145.
417. Torres V.E., Young W.F., Offord K.P., Hartery R.R. Association of hypokalemia, aldosteronism, and renal cysts. N Engl J Med 1990, 322:345-351.
418. Torres V.E., Cowley B.D., Branden M.G., Yoshida I., Gatoone V.H. Long-term ammonium chloride or sodium bicarbonate treatment in two models of polycystic kidney disease. Exp Nephrol 2001, 9:171-180.
419. Tuck M.L., Sambhi M.P., Levin L. Hyporeninemic hypoaldosteronism in diabetes mellitus. Studies of the autonomic nervous system's control of renin release. Diabetes 1979, 28:237-241.
420. Turnberg L.A., Breberdorf F.A., Morawski S.L., Fordtran J.S. Interrelationships of chloride, bicarbonate, sodium and hydrogen transport in the human ileum. J Clin Invest 1970, 49:557-567.
421. Uribarri J., Oh M.S., Carroll H.J. D-lactic acidosis. Medicine 1998, 77:73-82.
422. Uribarri J., Buquing J., Oh M.S. Acid-base balance in chronic peritoneal dialysis patients. Kidney Int 1995, 47:269-273.
423. Valimaki M., Pelkonen R., Tikkanen I., Tikkanen I., Fyhrgvist F. A deficient response of atrial naturetic peptide to volume overload in Gordon's syndrome. Acta Endocrinol 1989, 120:331-336.
424. van Ypersele de Strihou C. Importance of endogenous acid production in the regulation of acid-base equilibrium: the role of the digestive tract. Adv Nephrol 1969, 367-385.
425. van Ypersele de Strihou C., Frans A. The pattern of respiratory compensation in chronic uremic acidosis. Nephron 1970, 7:37-50.
426. Vasile B., Rasulo F., Candiani A., Latronico N. The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome. Intensive Care Med 1903, 29:1417-1425.
427. Velez R.J., Myers R., Guber M.S. Severe acute metabolic acidosis (acute beriberi): an avoidable complication of total parenteral nutrition. J Parenter Enteral Nutr 1985, 9:216-219.
428. Villoria J.G., Nunez J.FM., Miralles J.M., DeCastrode D., Pozo S., Romo J.M.T. Hyporeninemic hypoaldosteronism in diabetic patients with chronic renal failure. Am J Nephrol 1988, 8:127-137.
429. Wacker E.W.C., Haynes H., Druyan R., Risher W., Coleman J.E. Treatment of ethylene glycol poisoning with ethyl alcohol. JAMA 1965, 194:1231-1233.
430. Walker B.R., Alexander F., Tannenbaum P.J. Fanconi syndrome with renal tubular acidosis and light chain proteinuria. Nephron 1971, 8:103-110.
431. Wang T., Egbert A.L., Aronson P.S., Giebisch G. Effect of metabolic acidosis on NaCl transport in the proximal tubule. Am J Physiol 1998, 274:F1015-F1019.
432. Wang W., Geibel J., Giebisch G. Regulation of the small conductance K channels in the apical membrane of rat cortical collecting tubule. Am J Physiol 1990, 259:F494-F502.
433. Wanag F., Butler T., Rabban G.H., Jones P.K. The acidosis of cholera. Contributions of hyper-proteinemia, lactic acidemia and hyperphosphatemia. N Engl J Med 1986, 315:1591-1595.
434. Weger M., Deutschmann H., Weger W., Kotanko P., Skrabal F. Incomplete renal tubular acidosis in "primary" osteoporosis. Osteoporos Int 1999, 10:325-332.
435. Weidman P., Reinhart R., Maxwell M.H., Row P., Coburn J.W., Massry S.G. Syndrome of hyporeninemic hypoaldosteronism and hyperkalemia in renal disease. J Clin Endocrinol Metab 1973, 36:965-977.
436. Weinstein B., Irreverre I., Watkin D.M. Lung carcinoma, hypouricemia and aminoaciduria. Am J Med 1965, 39:520-526.
437. Wesson D.E. Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats. J Clin Invest 1997, 99:2203-2211.
438. Whang R. Bicarbonate overshoot: an indication for acetazolamide therapy. South Med J 1975, 68:733-734.
439. Whyte M.P., Murphy W.A., Fallon M.D., Sly W.S., Teitelbaum S.L., McAlister W.H., Avioli L.V. Osteopetrosis, renal tubular acidosis and basal ganglia calcification in three sisters. Am J Med 1980, 69:64-74.
440. Widmer B., Gerhardt R.E., Harrington J.T., Cohen J.J. Serum electrolyte and acid-base composition. The influence of graded degrees of chronic renal failure. Arch Intern Med 1979, 139:1099-1102.
441. Wiederkehr M.R., Kalogiros J., Krapf R. Correction of metabolic acidosis improves thyroid and growth hormone axes in haemodialysis patients. Nephrol Dial Transplant 2004, 1995:1190-1197.
442. Wiederseiner J.M., Muser J., Lutz T., Hulter H.N., Krapf R. Acute metabolic acidosis characterizatiom and diagnosis of the disorder and the plasma potassium response. J Am Soc Nephrol 2004, 15:1589-1596.
443. Wilson D.M., Goldstein N.P. Bicarbonate excretion in Wilson's disease (hepatolenticular degeneration). Mayo Clin Proc 1974, 49:394-400.
444. Wilson D.R., Siddiqui A.A. Renal tubular acidosis after kidney transplantation. Ann Intern Med 1973, 79:352-361.
445. Wilson D.R., Yendt E.R. Treatment of the adult Fanconi syndrome with oral phosphate supplements and alkali. Am J Med 1963, 35:487-511.
446. Wilson I.D., Goetz F.C. Selective hypoaldosteronism after prolonged heparin administration. Am J Med 1964, 36:635-640.
447. Wilson F.H., Disse-Nicomede S., Choate K.A., Ishikawa K., Nelson-Wiiliams C., Desitter I. Human hypertension caused by mutations in the WNK kinases. Science 2001, 293:1107-1112.
448. Winters R.W., White J.S., Hughes M.C., et al. Disturbances of acid-base equilibrium in salicylate intoxication. Pediatrics 1959, 23:260-285.
449. Worthen H.G., Good R.A. The deToni-Fanconi syndrome with cystinosis. Am J Dis Child 1958, 95:653-688.
450. Wrong O.M. Urinary anion gap in hyperchloremic metabolic acidosis. N Engl J Med 1988, 319:585-586.
451. Wrong O., Davies H.E.F. The excretion of acid in renal disease. Q J Med 1959, 28:259-313.
452. Wu M.S., Biemsderfer D., Giebisch G., Aronson P.S. Role of NHE3 in mediating renal brus border Na+/H+ exchange. J Biol Chem 1996, 271:32749-32752.
453. Yang C.L., Angell J., Mitchell R., Ellison D.H. WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest 2003, 111:1039-1045.
454. Yang S.S., Chu P., Lin Y.F., Chen A., Lin S.H. Aristolochic acid-induced Fanconi's syndrome and nephropathy presenting as hypokalemic paralayis. Am J Kidney Dis 1902, 39:E14.
455. Yong J.M., Sanderson K.V. Photosensitive dermatitis and renal tubular acidosis after ingestion of calcium cyclamate. Lancet 1969, 2:1273-1275.
456. Yu T.F., Gutman A.B. Study of the paradoxical effects of salicylates in intermediate and high dosages on the renal mechanism of excretion of urate in man. J Clin Invest 1959, 38:1298-1315.
457. Yudkin J., Cohen R.D. The contribution of the kidney to the removal of a lactic acid load under normal and acidotic conditions in the conscious rat. Clin Sci Mol Med 1975, 48:121-131.