Process-based expansion and neural differentiation of human pluripotent stem cells for transplantation and disease modeling

Journal of Neuroscience Research

Volumn 91, Issue 10, 2013, Pages 1247-1262

  Stover, Alexander E ^a   Brick, David J ^a   Nethercott, Hubert E ^a   Banuelos, Maria G ^a   Sun, Lei ^b   O'Dowd, Diane K ^b   Schwartz, Philip H ^a  

^a CHILDREN S HOSPITAL OF ORANGE COUNTY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cellular models of disease; Cellular therapy; CGMP; Differentiation; Drug discovery; Glia; IPSCs; Methods; Neural stem cells; Neurons; Nomenclature

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ASCORBIC ACID; BETA CATENIN; BETA TUBULIN; BONE MORPHOGENETIC PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CHEMOKINE RECEPTOR CXCR4; CYCLIC AMP; CYCLIC GMP; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GREEN FLUORESCENT PROTEIN; KRUPPEL LIKE FACTOR 4; NERVE CELL ADHESION MOLECULE; NESTIN; NOGGIN; NOTCH RECEPTOR; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN S100B; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX1; TRANSCRIPTION FACTOR SOX2; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

ARTICLE; CELL SURVIVAL; COCULTURE; CONTINUOUS CULTURE; CULTURE MEDIUM; CULTURE TECHNIQUE; DISEASE MODEL; DNA MODIFICATION; EMBRYOID BODY; EMBRYONIC STEM CELL; FEEDER CELL; FEMALE; FLOW CYTOMETRY; GENOTYPE; GLIA CELL; HEMATOPOIETIC STEM CELL; HLA TYPING; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE MICROSCOPY; MALE; NERVE CELL DIFFERENTIATION; NERVE POTENTIAL; NEURAL STEM CELL; NEURAL STEM CELL TRANSPLANTATION; ONCOGENE C MYC; PHENOTYPE; PLATING MEDIUM; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; QUALITY CONTROL; SENDAI VIRUS; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; SOMATIC CELL; STEM CELL EXPANSION; TISSUE DISTRIBUTION; UMBILICAL CORD BLOOD; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; IMMUNOHISTOCHEMISTRY; NERVE CELL; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; PROCEDURES; TRANSPLANTATION;

CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL PROLIFERATION; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; INDUCED PLURIPOTENT STEM CELLS; NEURAL STEM CELLS; NEURONS; PATCH-CLAMP TECHNIQUES;

EID: 84882901709     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23245     Document Type: Article

References (36)

1. Ausubel LJ, Lopez PM, Couture LA. 2011. GMP scale-up and banking of pluripotent stem cells for cellular therapy applications. Methods Mol Biol 767:147-159.
2. Bajpai R, Lesperance J, Kim M, Terskikh AV. 2008. Efficient propagation of single cells Accutase-dissociated human embryonic stem cells. Mol Reprod Dev 75:818-827.
3. Belmonte JC, Ellis J, Hochedlinger K, Yamanaka S. 2009. Induced pluripotent stem cells and reprogramming: seeing the science through the hype. Nat Rev Genet 10:878-883.
4. Bergstrom R, Strom S, Holm F, Feki A, Hovatta O. 2011. Xeno-free culture of human pluripotent stem cells. Methods Mol Biol 767:125-136.
5. Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, Li Y, Mu Y, Chen G, Yu D, McCarthy S, Sebat J, Gage FH. 2011. Modelling schizophrenia using human induced pluripotent stem cells. Nature 473:221-225.
6. Brustle O, Jones KN, Learish RD, Karram K, Choudhary K, Wiestler OD, Duncan ID, McKay RD. 1999. Embryonic stem cell-derived glial precursors: a source of myelinating transplants. Science 285:754-756.
7. Carpenter MK, Frey-Vasconcells J, Rao MS. 2009. Developing safe therapies from human pluripotent stem cells. Nat Biotechnol 27:606-613.
8. Chambers SM, Fasano CA, Papapetrou EP, Tomishima M, Sadelain M, Studer L. 2009. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol 27:275-280.
9. Csete M. 2010. Translational prospects for human induced pluripotent stem cells. Regen Med 5:509-519.
10. Dietz AB, Padley DJ, Gastineau DA. 2007. Infrastructure development for human cell therapy translation. Clin Pharmacol Ther 82:320-324.
11. Fink DW Jr. 2009. FDA regulation of stem cell-based products. Science 324:1662-1663.
12. Gage FH, Coates PW, Palmer TD, Kuhn HG, Fisher LJ, Suhonen JO, Peterson DA, Suhr ST, Ray J. 1995. Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain. Proc Natl Acad Sci U S A 92:11879-11883.
13. Gonzalez R, Lee JW, Snyder EY, Schultz PG. 2011. Dorsomorphin promotes human embryonic stem cell self-renewal. Angew Chem Int Ed Engl 50:3439-3441.
14. Hao J, Ho JN, Lewis JA, Karim KA, Daniels RN, Gentry PR, Hopkins CR, Lindsley CW, Hong CC. 2010. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem Biol 5:245-253.
15. Hilgenberg LG, Ho KD, Lee D, O'Dowd DK, Smith MA. 2002. Agrin regulates neuronal responses to excitatory neurotransmitters in vitro and in vivo. Mol Cell Neurosci 19:97-110.
16. Kambal A, Mitchell G, Cary W, Gruenloh W, Jung Y, Kalomoiris S, Nacey C, McGee J, Lindsey M, Fury B, Bauer G, Nolta JA, Anderson JS. 2011. Generation of HIV-1 resistant and functional macrophages from hematopoietic stem cell-derived induced pluripotent stem cells. Mol Ther 19:584-593.
17. Lee JP, Jeyakumar M, Gonzalez R, Takahashi H, Lee PJ, Baek RC, Clark D, Rose H, Fu G, Clarke J, McKercher S, Meerloo J, Muller FJ, Park KI, Butters TD, Dwek RA, Schwartz P, Tong G, Wenger D, Lipton SA, Seyfried TN, Platt FM, Snyder EY. 2007. Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Nat Med 13:439-447.
18. Morizane A, Doi D, Kikuchi T, Nishimura K, Takahashi J. 2011. Small-molecule inhibitors of bone morphogenic protein and activin/nodal signals promote highly efficient neural induction from human pluripotent stem cells. J Neurosci Res 89:117-126.
19. Muotri AR, Nakashima K, Toni N, Sandler VM, Gage FH. 2005. Development of functional human embryonic stem cell-derived neurons in mouse brain. Proc Natl Acad Sci U S A 102:18644-18648.
20. Neely MD, Litt MJ, Tidball AM, Li GG, Aboud AA, Hopkins CR, Chamberlin R, Hong CC, Ess KC, Bowman AB. 2012. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. ACS Chem Neurosci 3:482-491.
21. Nethercott HE, Brick DJ, Schwartz PH. 2011. Immunocytochemical analysis of human pluripotent stem cells. Methods Mol Biol 767:201-220.
22. Pankratz MT, Li XJ, Lavaute TM, Lyons EA, Chen X, Zhang SC. 2007. Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage. Stem Cells 25:1511-1520.
23. Robinson J, Waller MJ, Fail SC, McWilliam H, Lopez R, Parham P, Marsh SG. 2009. The IMGT/HLA database. Nucleic Acids Res 37:D1013-D1017.
24. Schwartz PH. 2006. The potential of stem cell therapies for neurological diseases. Expert Rev Neurother 6:153-161.
25. Schwartz PH, Bryant PJ, Fuja TJ, Su H, O'Dowd DK, Klassen H. 2003. Isolation and characterization of neural progenitor cells from post-mortem human cortex. J Neurosci Res 74:838-851.
26. Schwartz PH, Brick DJ, Stover AE, Loring JF, Muller FJ. 2008. Differentiation of neural lineage cells from human pluripotent stem cells. Methods 45:142-158.
27. Schwartz PH, Brick DJ, Nethercott HE, Stover AE. 2011. Traditional human embryonic stem cell culture. Methods Mol Biol 767:107-123.
28. Snyder EY, Taylor RM, Wolfe JH. 1995. Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain. Nature 374:367-370.
29. Stover AE, Schwartz PH. 2011. Adaptation of human pluripotent stem cells to feeder-free conditions in chemically defined medium with enzymatic single-cell passaging. Methods Mol Biol 767:137-146.
30. Svendsen CN, Caldwell MA, Ostenfeld T. 1999. Human neural stem cells: isolation, expansion and transplantation. Brain Pathol 9:499-513.
31. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. 2007. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-872.
32. Tamaki S, Eckert K, He D, Sutton R, Doshe M, Jain G, Tushinski R, Reitsma M, Harris B, Tsukamoto A, Gage F, Weissman I, Uchida N. 2002. Engraftment of sorted/expanded human central nervous system stem cells from fetal brain. J Neurosci Res 69:976-986.
33. Watanabe K, Ueno M, Kamiya D, Nishiyama A, Matsumura M, Wataya T, Takahashi JB, Nishikawa S, Nishikawa S, Muguruma K, Sasai Y. 2007. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol 25:681-686.
34. Yu J, Vodyanik MA, Smuga-Otto K, ntosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, Slukvin II, Thomson JA. 2007. Induced pluripotent stem cell lines derived from human somatic cells. Science 318:1917-1920.
35. Zhang SC, Wernig M, Duncan ID, Brustle O, Thomson JA. 2001. In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat. Biotechnol 19:1129-1133.
36. Zhao T, Zhang ZN, Rong Z, Xu Y. 2011. Immunogenicity of induced pluripotent stem cells. Nature 474:212-215.