Opposing influence of intracellular and membrane thiols on the toxicity of reducible polycations

Biomaterials

Volumn 34, Issue 34, 2013, Pages 8843-8850

  Wu, Chao ^a   Li, Jing ^a,b   Zhu, Yu ^a,b   Chen, Jun ^a,c   Oupický, David ^a,b  

^a WAYNE STATE UNIVERSITY   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c INSTITUTE OF HIGH ENERGY PHYSICS   (China)

Author keywords

Bioreducible polycations; Glutathione; Non viral gene delivery; Polycations; Toxicity

Indexed keywords

CELLULAR MECHANISMS; GLUTATHIONES; GSH CONCENTRATIONS; INTRACELLULAR DEGRADATION; MICHAEL ADDITIONS; NON-VIRAL GENE DELIVERY; NORMOXIC CONDITIONS; POLYCATIONS;

ADDITION REACTIONS; CELL CULTURE; CELL MEMBRANES; COVALENT BONDS; GENE TRANSFER; PEPTIDES;

TOXICITY;

GLUTATHIONE; MALEIC ACID DIETHYL ESTER; POLYAMIDOAMINE; POLYCATION; THIOL DERIVATIVE;

ARTICLE; BIODEGRADABILITY; CELL MEMBRANE; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; DISULFIDE BOND; HUMAN; HUMAN CELL; MICHAEL ADDITION; PRIORITY JOURNAL;

BIOREDUCIBLE POLYCATIONS; GLUTATHIONE; NON-VIRAL GENE DELIVERY; POLYCATIONS; TOXICITY;

APOPTOSIS; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; CELL MEMBRANE; CELL SURVIVAL; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; GLUTATHIONE; HUMANS; L-LACTATE DEHYDROGENASE; POLYAMINES; SULFHYDRYL COMPOUNDS; TOXICITY TESTS, ACUTE; TRANSFECTION;

EID: 84882898489     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.07.095     Document Type: Article

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