High-resolution peripheral quantitative computed tomography and finite element analysis of bone strength at the distal radius in ovariectomized adult rhesus monkey demonstrate efficacy of odanacatib and differentiation from alendronate

Bone

Volumn 56, Issue 2, 2013, Pages 497-505

  Cabal, Antonio ^a   Jayakar, Richa Y ^a   Sardesai, Swanand ^a   Phillips, Eual A ^a   Szumiloski, John ^a   Posavec, Diane J ^a   Mathers, Parker D ^a   Savitz, Alan T ^a   Scott, Boyd B ^a   Winkelmann, Christopher T ^a   Motzel, Sherri ^a   Cook, Lynn ^a   Hargreaves, Richard ^a   Evelhoch, Jeffrey L ^a   Dardzinski, Bernard J ^a,c   Hangartner, Thomas N ^b   McCracken, Paul J ^a,d   Duong, Le T ^a   Williams, Donald S ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Wright State University   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d EISAI INC   (United States)

Author keywords

Finite element analysis; HR pQCT; Odanacatib

Indexed keywords

ALENDRONIC ACID; ODANACATIB;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE MASS; BONE STRENGTH; BONE STRESS; BONE STRUCTURE; COMPRESSION; CONTROLLED STUDY; CORTICAL THICKNESS (BONE); DRUG DOSE COMPARISON; DRUG EFFICACY; DUAL ENERGY X RAY ABSORPTIOMETRY; EX VIVO STUDY; FEMALE; FINITE ELEMENT ANALYSIS; HIGH RESOLUTION COMPUTER TOMOGRAPHY; IN VIVO STUDY; LONGITUDINAL STUDY; LOW DRUG DOSE; NONHUMAN; OVARIECTOMY; PRIMATE; QUANTITATIVE ANALYSIS; RADIUS; RHESUS MONKEY; VOLUMETRY;

FINITE ELEMENT ANALYSIS; HR-PQCT; ODANACATIB;

ALENDRONATE; ANIMALS; BIPHENYL COMPOUNDS; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; FINITE ELEMENT ANALYSIS; MACACA MULATTA; OVARIECTOMY; RADIUS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84882895596     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2013.06.011     Document Type: Article

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