High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 11, 2010, Pages 5045-5055

  Burghardt, Andrew J ^a   Issever, Ahi S ^a,b   Schwartz, Ann V ^a   Davis, Kevin A ^a,c   Masharani, Umesh ^d   Majumdar, Sharmila ^a   Link, Thomas M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT;

ADULT; AGED; AGING; ARTICLE; BIOMECHANICS; BODY HEIGHT; BONE DENSITY; BONE MASS; BONE STRENGTH; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CORTICAL BONE; CROSS-SECTIONAL STUDY; DIABETIC PATIENT; ETHNICITY; FEMALE; FINITE ELEMENT ANALYSIS; GEOMETRY; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HUMAN; HUMERUS FRACTURE; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTPATIENT DEPARTMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIUS; RADIUS FRACTURE; TIBIA; TIBIA FRACTURE; TRABECULAR BONE; VERTEBRA FRACTURE; VOLUMETRY;

EID: 78049515579     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-0226     Document Type: Article

References (63)

1. Janghorbani M, Van Dam RM, Willett WC, Hu FB 2007 Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture. Am J Epidemiol 166:495-505 (Pubitemid 47283633)
2. Yamamoto M, Yamaguchi T, Yamauchi M, Kaji H, Sugimoto T 2009 Diabetic patients have an increased risk of vertebral fractures independent of BMD or diabetic complications. J Bone Miner Res 24:702-709
3. Forsén L, Meyer HE, Midthjell K, Edna TH 1999 Diabetes mellitus and the incidence of hip fracture: results from the Nord-Trondelag Health Survey. Diabetologia 42:920-925 (Pubitemid 29369598)
4. Ottenbacher KJ, Ostir GV, Peek MK, Goodwin JS, Markides KS 2002 Diabetes mellitus as a risk factor for hip fracture in Mexican American older adults. J Gerontol A Biol Sci Med Sci 57:M648-M653
5. Nicodemus KK, Folsom AR 2001 Type 1 and type 2 diabetes and incident hip fractures in postmenopausal women. Diabetes Care 24:1192-1197
6. Schwartz AV, Sellmeyer DE, Ensrud KE, Cauley JA, Tabor HK, Schreiner PJ, Jamal SA, Black DM, Cummings SR 2001 Older women with diabetes have an increased risk of fracture: a prospective study. J Clin Endocrinol Metab 86:32-38
7. Chu SP, Kelsey JL, Keegan TH, Sternfeld B, Prill M, Quesenberry CP, Sidney S 2004 Risk factors for proximal humerus fracture. Am J Epidemiol 160:360-367
8. Keegan TH, Kelsey JL, Sidney S, Quesenberry Jr CP 2002 Foot problems as risk factors of fractures. Am J Epidemiol 155:926-931
9. Leidig-Bruckner G, Ziegler R 2001 Diabetes mellitus a risk for osteoporosis? Exp Clin Endocrinol Diabetes 109 Suppl 2:S493-S514
10. Buysschaert M, Cauwe F, Jamart J, Brichant C, De Coster P, Magnan A, Donckier J 1992 Proximal femur density in type 1 and 2 diabetic patients. Diabete Metab 18:32-37
11. Hampson G, Evans C, Petitt RJ, Evans WD, Woodhead SJ, Peters JR, Ralston SH 1998 Bone mineral density, collagen type 1 α 1 genotypes and bone turnover in premenopausal women with diabetes mellitus. Diabetologia 41:1314-1320
12. Tuominen JT, Impivaara O, Puukka P, Rönnemaa T 1999 Bone mineral density in patients with type 1 and type 2 diabetes. Diabetes Care 22:1196-1200
13. Vestergaard P 2007 Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes - a meta-analysis. Osteoporos Int 18:427-444 (Pubitemid 46354916)
14. Melton 3rd LJ, Riggs BL, Leibson CL, Achenbach SJ, Camp JJ, Bouxsein ML, Atkinson EJ, Robb RA, Khosla S 2008 A bone structural basis for fracture risk in diabetes. J Clin Endocrinol Metab 93:4804-4809
15. Orwoll ES, Bauer DC, Vogt TM, Fox KM 1996 Axial bone mass in older women. Study of Osteoporotic Fractures Research Group. Ann Intern Med 124:187-196
16. van Daele PL, Stolk RP, Burger H, Algra D, Grobbee DE, Hofman A, Birkenhäger JC, Pols HA 1995 Bone density in non-insulin-dependent diabetes mellitus. The Rotterdam Study. Ann Intern Med 122:409-414
17. Barrett-Connor E, Kritz-Silverstein D 1996 Does hyperinsulinemia preserve bone? Diabetes Care 19:1388-1392
18. Bauer DC, Browner WS, Cauley JA, Orwoll ES, Scott JC, Black DM, Tao JL, Cummings SR 1993 Factors associated with appendicular bone mass in older women. The Study of Osteoporotic Fractures Research Group. Ann Intern Med 118:657-665
19. MacNeil JA, Boyd SK 2007 Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys 29:1096-1105 (Pubitemid 350052626)
20. Burghardt AJ, Kazakia GJ, Majumdar S 2007 A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone. Ann Biomed Eng 35:1678-1686
21. Liu XS, Zhang XH, Sekhon KK, Adams MF, McMahon DJ, Bilezikian JP, Shane E, Guo XE 2010 High-resolution peripheral quantitative computed tomography can assess microstructural and mechanical properties of human distal tibial bone. J Bone Miner Res 25:746-756
22. Boutroy S, Bouxsein ML, Munoz F, Delmas PD 2005 In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab 90:6508-6515
23. Khosla S, Riggs BL, Atkinson EJ, Oberg AL, McDaniel LJ, Holets M, Peterson JM, Melton 3rd LJ 2006 Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment. J Bone Miner Res 21:124-131
24. Kirmani S, Christen D, van Lenthe GH, Fischer PR, Bouxsein ML, McCready LK, Melton 3rd LJ, Riggs BL, Amin S, Müller R, Khosla S 2009 Bone structure at the distal radius during adolescent growth. J Bone Miner Res 24:1033-1042
25. Dalzell N, Kaptoge S, Morris N, Berthier A, Koller B, Braak L, van Rietbergen B, Reeve J 2009 Bone micro-architecture and determinants of strength in the radius and tibia: age-related changes in a population-based study of normal adults measured with high-resolution pQCT. Osteoporos Int 20:1683-1694
26. Mueller TL, van Lenthe GH, Stauber M, Gratzke C, Eckstein F, Müller R 2009 Regional, age and gender differences in architectural measures of bone quality and their correlation to bone mechanical competence in the human radius of an elderly population. Bone 45:882-891
27. Burrows M, Liu D, McKay H 2010 High-resolution peripheral QCT imaging of bone micro-structure in adolescents. Osteoporos Int 21:515-520
28. Melton 3rd LJ, Riggs BL, van Lenthe GH, Achenbach SJ, Müller R, Bouxsein ML, Amin S, Atkinson EJ, Khosla S 2007 Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal women. J Bone Miner Res 22:1442-1448
29. Sornay-Rendu E, Boutroy S, Munoz F, Delmas PD 2007 Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: the OFELY study. J Bone Miner Res 22:425-433
30. Boutroy S, Van Rietbergen B, Sornay-Rendu E, Munoz F, Bouxsein ML, Delmas PD 2008 Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women. J Bone Miner Res 23:392-399
31. Vico L, Zouch M, Amirouche A, Frère D, Laroche N, Koller B, Laib A, Thomas T, Alexandre C 2008 High-resolution pQCT analysis at the distal radius and tibia discriminates patients with recent wrist and femoral neck fractures. J Bone Miner Res 23:1741-1750
32. Chavassieux P, Asser Karsdal M, Segovia-Silvestre T, Neutzsky-Wulff AV, Chapurlat R, Boivin G, Delmas PD 2008 Mechanisms of the anabolic effects of teriparatide on bone: insight from the treatment of a patient with pycnodysostosis. J Bone Miner Res 23:1076-1083
33. Bacchetta J, Boutroy S, Vilayphiou N, Juillard L, Guebre-Egziabher F, Rognant N, Sornay-Rendu E, Szulc P, Laville M, Delmas PD, Fouque D, Chapurlat R 2010 Early impairment of trabecular microarchitecture assessed with HR-pQCT in patients with stage II-IV chronic kidney disease. J Bone Miner Res 25:849-857
34. Rubin MR, Dempster DW, Kohler T, Stauber M, Zhou H, Shane E, Nickolas T, Stein E, Sliney Jr J, Silverberg SJ, Bilezikian JP, Müller R 2010 Three dimensional cancellous bone structure in hypoparathyroidism. Bone 46:190-195
35. Schwartz AV, Sellmeyer DE 2007 Diabetes, fracture, and bone fragility. Curr Osteoporos Rep 5:105-111
36. Burghardt AJ, Kazakia GJ, Ramachandran S, Link TM, Majumdar S 2010 Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia. J Bone Miner Res 25:983-993
37. Feldkamp LA, Davis LC, Kress JW 1984 Practical cone-beam algorithm. J Opt Soc Am A 1:612-619
38. Burghardt AJ, Kazakia GJ, Laib A, Majumdar S 2008 Quantitative assessment of bone tissue mineralization with polychromatic microcomputed tomography. Calcif Tissue Int 83:129-138
39. Laib A, Häuselmann HJ, Rüegsegger P 1998 In vivo high resolution 3D-QCT of the human forearm. Technol Health Care 6:329-337
40. Laib A, Rüegsegger P 1999 Calibration of trabecular bone structure measurements of in vivo three-dimensional peripheral quantitative computed tomography with 28-microm-resolution microcomputed tomography. Bone 24:35-39 (Pubitemid 28546704)
41. Burghardt AJ, Kazakia GJ, Link TM, Majumdar S 2009 Automated simulation of areal bone mineral density assessment in the distal radius from high-resolution peripheral quantitative computed tomography. Osteoporos Int 20:2017-2024
42. Laib A, Rüegsegger P 1999 Comparison of structure extraction methods for in vivo trabecular bone measurements. Comput Med Imaging Graph 23:69-74
43. Hildebrand T, Ruegsegger P 1997 A new method for the model-independent assessment of thickness in three-dimensional images. J Microsc 185:67-75
44. Laib A, Hildebrand T, Häuselmann HJ, Rüegsegger P 1997 Ridge number density: a new parameter for in vivo bone structure analysis. Bone 21:541-546
45. Kazakia GJ, Hyun B, Burghardt AJ, Krug R, Newitt DC, de Papp AE, Link TM, Majumdar S 2008 In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging. J Bone Miner Res 23:463-474
46. MacNeil JA, Boyd SK 2008 Improved reproducibility of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys 30:792-799
47. Mueller TL, Stauber M, Kohler T, Eckstein F, Müller R, van Lenthe GH 2009 Non-invasive bone competence analysis by high-resolution pQCT: an in vitro reproducibility study on structural and mechanical properties at the human radius. Bone 44:364-371
48. Buie HR, Campbell GM, Klinck RJ, MacNeil JA, Boyd SK 2007 Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis. Bone 41:505-515
49. Nishiyama KK, Macdonald HM, Buie HR, Hanley DA, Boyd SK 2010 Postmenopausal women with osteopenia have higher cortical porosity and thinner cortices at the distal radius and tibia than women with normal aBMD: an in vivo HR-pQCT study. J Bone Miner Res 25:882-890
50. Burghardt AJ, Buie HR, Laib A, Majumdar S, Boyd SK 1 June 2010 Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT. Bone doi:10.1016/j.bone.2010.05.034
51. Müller R, Rüegsegger P 1995 Three-dimensional finite element modelling of non-invasively assessed trabecular bone structures. Med Eng Phys 17:126-133
52. van Rietbergen B, Weinans H, Huiskes R, Odgaard A 1995 A new method to determine trabecular bone elastic properties and loading using micromechanical finite-element models. J Biomech 28:69-81
53. Van Rietbergen B, Odgaard A, Kabel J, Huiskes R 1996 Direct mechanics assessment of elastic symmetries and properties of trabecular bone architecture. J Biomech 29:1653-1657
54. Pistoia W, van Rietbergen B, Lochmüller EM, Lill CA, Eckstein F, Rüegsegger P 2002 Estimation of distal radius failure load with microfinite element analysis models based on three-dimensional peripheral quantitative computed tomography images. Bone 30:842-848
55. Genant HK, Wu CY, van Kuijk C, Nevitt MC 1993 Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8:1137-1148 (Pubitemid 23261108)
56. Petit MA, Paudel ML, Taylor BC, Hughes JM, Strotmeyer ES, Schwartz AV, Cauley JA, Zmuda JM, Hoffman AR, Ensrud KE 2010 Bone mass and strength in older men with type 2 diabetes: the Osteoporotic Fractures in Men Study. J Bone Miner Res 25:285-291
57. Yeni YN, Brown CU, Wang Z, Norman TL 1997 The influence of bone morphology on fracture toughness of the human femur and tibia. Bone 21:453-459
58. Voide R, Schneider P, Stauber M, Wyss P, Stampanoni M, Sennhauser U, van Lenthe GH, Müller R 2009 Time-lapsed assessment of microcrack initiation and propagation in murine cortical bone at submicrometer resolution. Bone 45:164-173
59. Zhang L, Liu Y, Wang D, Zhao X, Qiu Z, Ji H, Rong H 2009 Bone biomechanical and histomorphometrical investment in type 2 diabetic Goto-Kakizaki rats. Acta Diabetol 46:119-126
60. Prisby RD, Swift JM, Bloomfield SA, Hogan HA, Delp MD 2008 Altered bone mass, geometry and mechanical properties during the development and progression of type 2 diabetes in the Zucker diabetic fatty rat. J Endocrinol 199:379-388
61. Kawashima Y, Fritton JC, Yakar S, Epstein S, Schaffler MB, Jepsen KJ, LeRoith D 2009 Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis. Bone 44:648-655
62. Boyd SK 2008 Site-specific variation of bone micro-architecture in the distal radius and tibia. J Clin Densitom 11:424-430
63. Paul RG, Bailey AJ 1996 Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes. Int J Biochem Cell Biol 28:1297-1310