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Volumn 69, Issue 9, 2013, Pages 1717-1724

Actual drug-drug interactions in elderly patients discharged from internal medicine clinic: A prospective observational study

Author keywords

Adverse drug reactions; Croatia; Diminished therapeutic effect; Drug drug interactions; Elderly patients

Indexed keywords

ACETYLSALICYLIC ACID; ALENDRONIC ACID; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CLOPIDOGREL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FUROSEMIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; IPRATROPIUM BROMIDE; IRON SALT; LAXATIVE; LEVOTHYROXINE; NITRATE; POTASSIUM CHLORIDE; PROPYLTHIOURACIL; PROTON PUMP INHIBITOR; SPIRONOLACTONE; SULFONYLUREA; THIAZIDE DIURETIC AGENT; WARFARIN;

EID: 84882887932     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-013-1531-7     Document Type: Article
Times cited : (34)

References (46)
  • 1
    • 33645579519 scopus 로고    scopus 로고
    • Drug interaction: 1. General considerations
    • 16397305 10.1345/aph.140003
    • Hartshorn EA (2006) Drug interaction: 1. General considerations. Ann Pharmacother 40:116-118
    • (2006) Ann Pharmacother , vol.40 , pp. 116-118
    • Hartshorn, E.A.1
  • 2
    • 83555176128 scopus 로고    scopus 로고
    • Potentially harmful drug-drug interactions in the elderly: A review
    • 10.1016/j.amjopharm.2011.10.004 22078863 10.1016/j.amjopharm.2011.10.004 1:CAS:528:DC%2BC3MXhs1Skt7fN
    • Hines LE, Murphy JE (2011) Potentially harmful drug-drug interactions in the elderly: a review. Am J Geriatr Pharmacother 9:364-377. doi: 10.1016/j.amjopharm.2011.10.004
    • (2011) Am J Geriatr Pharmacother , vol.9 , pp. 364-377
    • Hines, L.E.1    Murphy, J.E.2
  • 3
    • 34447261692 scopus 로고    scopus 로고
    • The challenge of managing drug interactions in elderly people
    • 17630042 10.1016/S0140-6736(07)61092-7 1:CAS:528:DC%2BD2sXns12jtLY%3D
    • Mallet L, Spinewine A, Huang A (2007) The challenge of managing drug interactions in elderly people. Lancet 370:185-191
    • (2007) Lancet , vol.370 , pp. 185-191
    • Mallet, L.1    Spinewine, A.2    Huang, A.3
  • 4
    • 0242320969 scopus 로고    scopus 로고
    • Understanding and preventing drug interactions in elderly patients
    • 14607376 10.1016/j.critrevonc.2003.04.004
    • Delafuente JC (2003) Understanding and preventing drug interactions in elderly patients. Crit Rev Oncol Hematol 48:133-143
    • (2003) Crit Rev Oncol Hematol , vol.48 , pp. 133-143
    • Delafuente, J.C.1
  • 5
    • 0036841557 scopus 로고    scopus 로고
    • Drug-drug interactions in the elderly
    • Pharmaceutical Care of the Elderly in Europe Research (PEER) Group 12398558 10.1345/aph.1A484
    • Björkman IK, Fastbom J, Schmidt IK, Bernsten CB, Pharmaceutical Care of the Elderly in Europe Research (PEER) Group (2002) Drug-drug interactions in the elderly. Ann Pharmacother 36:1675-1681
    • (2002) Ann Pharmacother , vol.36 , pp. 1675-1681
    • Björkman, I.K.1    Fastbom, J.2    Schmidt, I.K.3    Bernsten, C.B.4
  • 7
    • 38949181992 scopus 로고    scopus 로고
    • Increasing exposure to drug-drug interactions between 1992 and 2005 in people aged ≥55 years
    • 18257601 10.2165/00002512-200825020-00006
    • Becker ML, Visser LE, van Gelder T, Hofman A, Stricker BH (2008) Increasing exposure to drug-drug interactions between 1992 and 2005 in people aged ≥55 years. Drugs Aging 25:145-152
    • (2008) Drugs Aging , vol.25 , pp. 145-152
    • Becker, M.L.1    Visser, L.E.2    Van Gelder, T.3    Hofman, A.4    Stricker, B.H.5
  • 8
    • 84555217845 scopus 로고    scopus 로고
    • Epidemiology and characteristics of adverse drug reactions caused by drug-drug interactions
    • 22022824 10.1517/14740338.2012.631910 1:CAS:528:DC%2BC3MXhs1KqsrrF
    • Magro L, Moretti U, Leone R (2012) Epidemiology and characteristics of adverse drug reactions caused by drug-drug interactions. Expert Opin Drug Saf 11:83-94
    • (2012) Expert Opin Drug Saf , vol.11 , pp. 83-94
    • Magro, L.1    Moretti, U.2    Leone, R.3
  • 9
    • 84857389728 scopus 로고    scopus 로고
    • Adverse drug reactions caused by drug-drug interactions reported to Croatian Agency for Medicinal Products and Medical Devices: A retrospective observational study
    • 21990078 10.3325/cmj.2011.52.604
    • Mirosevic Skvrce N, Macolic Sarinic V, Mucalo I, Krnic D, Bozina N, Tomic S (2011) Adverse drug reactions caused by drug-drug interactions reported to Croatian Agency for Medicinal Products and Medical Devices: a retrospective observational study. Croat Med J 52:604-614
    • (2011) Croat Med J , vol.52 , pp. 604-614
    • Mirosevic Skvrce, N.1    Macolic Sarinic, V.2    Mucalo, I.3    Krnic, D.4    Bozina, N.5    Tomic, S.6
  • 10
    • 0031746034 scopus 로고    scopus 로고
    • Important drug-drug interactions in the elderly
    • 9638396 10.2165/00002512-199812060-00006 1:CAS:528:DyaK1cXkt1Kkt70%3D
    • Seymour RM, Routledge PA (1998) Important drug-drug interactions in the elderly. Drugs Aging 12:485-494
    • (1998) Drugs Aging , vol.12 , pp. 485-494
    • Seymour, R.M.1    Routledge, P.A.2
  • 11
    • 40349110843 scopus 로고    scopus 로고
    • Prevalence and predictors of potential drug-drug interactions in Regione Emilia-Romagna, Italy
    • 18315779 10.1111/j.1365-2710.2007.00891.x 1:STN:280: DC%2BD1c7lslKksA%3D%3D
    • Gagne JJ, Maio V, Rabinowitz C (2008) Prevalence and predictors of potential drug-drug interactions in Regione Emilia-Romagna, Italy. J Clin Pharm Ther 33:141-151
    • (2008) J Clin Pharm Ther , vol.33 , pp. 141-151
    • Gagne, J.J.1    Maio, V.2    Rabinowitz, C.3
  • 12
    • 84882818187 scopus 로고    scopus 로고
    • Lexi-Interact
    • Lexi-Comp Online Accessed 3 Aug 2012
    • Lexi-Comp Online (2012) Lexi-Interact. Wolters Kluwer Health Clinical Solutions, Minneapolis. Available at: http://online.lexi.com/lco/action/ interact. Accessed 3 Aug 2012
    • (2012) Wolters Kluwer Health Clinical Solutions, Minneapolis
  • 14
    • 0038669335 scopus 로고    scopus 로고
    • Causality assessment of adverse drug reactions: Comparison of the results obtained from published decisional algorithms and from the evaluations of an expert panel, according to different levels of imputability
    • 12713611 10.1046/j.1365-2710.2003.00475.x 1:STN:280: DC%2BD3s7psV2qtw%3D%3D
    • Macedo AF, Marques FB, Ribeiro CF, Teixeira F (2003) Causality assessment of adverse drug reactions: comparison of the results obtained from published decisional algorithms and from the evaluations of an expert panel, according to different levels of imputability. J Clin Pharm Ther 28:137-143
    • (2003) J Clin Pharm Ther , vol.28 , pp. 137-143
    • Macedo, A.F.1    Marques, F.B.2    Ribeiro, C.F.3    Teixeira, F.4
  • 16
    • 0033755482 scopus 로고    scopus 로고
    • Drug-drug interactions in medical patients: Effects of in-hospital treatment and relation to multiple drug use
    • 11097142
    • Köhler GI, Bode-Böger SM, Busse R, Hoopmann M, Welte T, Böger RH (2000) Drug-drug interactions in medical patients: effects of in-hospital treatment and relation to multiple drug use. Int J Clin Pharmacol Ther 38:504-513
    • (2000) Int J Clin Pharmacol Ther , vol.38 , pp. 504-513
    • Köhler, G.I.1    Bode-Böger, S.M.2    Busse, R.3    Hoopmann, M.4    Welte, T.5    Böger, R.H.6
  • 17
    • 79960441195 scopus 로고    scopus 로고
    • Assessment of potential drug-drug interactions at hospital discharge
    • 10.4414/smw.2010.13043 20373176
    • Bertoli R, Bissig M, Caronzolo D, Odorico M, Pons M, Bernasconi E (2010) Assessment of potential drug-drug interactions at hospital discharge. Swiss Med Wkly 140:w13043. doi: 10.4414/smw.2010.13043
    • (2010) Swiss Med Wkly , vol.140 , pp. 13043
    • Bertoli, R.1    Bissig, M.2    Caronzolo, D.3    Odorico, M.4    Pons, M.5    Bernasconi, E.6
  • 18
    • 33645391461 scopus 로고    scopus 로고
    • Drug-drug interactions among recently hospitalised patients - Frequent but mostly clinically insignificant
    • 16047138 10.1007/s00228-005-0978-6
    • Glintborg B, Andersen SE, Dalhoff K (2005) Drug-drug interactions among recently hospitalised patients - frequent but mostly clinically insignificant. Eur J Clin Pharmacol 61:675-681
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 675-681
    • Glintborg, B.1    Andersen, S.E.2    Dalhoff, K.3
  • 20
    • 33747878322 scopus 로고    scopus 로고
    • Detection of potential drug interactions - A model for a national pharmacy register
    • 16896788 10.1007/s00228-006-0143-x
    • Astrand B, Astrand E, Antonov K, Petersson G (2006) Detection of potential drug interactions - a model for a national pharmacy register. Eur J Clin Pharmacol 62:749-756
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 749-756
    • Astrand, B.1    Astrand, E.2    Antonov, K.3    Petersson, G.4
  • 22
    • 34250756681 scopus 로고    scopus 로고
    • The utility of adding retrospective medication profiling to computerized provider order entry in an ambulatory care population
    • 17460134 10.1197/jamia.M2313
    • Glassman PA, Belperio P, Lanto A, Simon B, Valuck R, Sayers J, Lee M (2007) The utility of adding retrospective medication profiling to computerized provider order entry in an ambulatory care population. J Am Med Inform Assoc 14:424-431
    • (2007) J Am Med Inform Assoc , vol.14 , pp. 424-431
    • Glassman, P.A.1    Belperio, P.2    Lanto, A.3    Simon, B.4    Valuck, R.5    Sayers, J.6    Lee, M.7
  • 23
    • 0029844498 scopus 로고    scopus 로고
    • Drug-drug interactions related to hospital admissions in older adults: A prospective study of 1000 patients
    • 8708305 1:STN:280:DyaK28zhtlSntw%3D%3D
    • Doucet J, Chassagne P, Trivalle C, Landrin I, Pauty MD, Kadri N, Ménard JF, Bercoff E (1996) Drug-drug interactions related to hospital admissions in older adults: a prospective study of 1000 patients. J Am Geriatr Soc 44:944-948
    • (1996) J Am Geriatr Soc , vol.44 , pp. 944-948
    • Doucet, J.1    Chassagne, P.2    Trivalle, C.3    Landrin, I.4    Pauty, M.D.5    Kadri, N.6    Ménard, J.F.7    Bercoff, E.8
  • 24
    • 0026649652 scopus 로고
    • Inappropriate medication is a major cause of adverse drug reactions in elderly patients
    • 1514459 10.1093/ageing/21.4.294 1:STN:280:DyaK38zosVWhtg%3D%3D
    • Lindley CM, Tully MP, Paramsothy V, Tallis RC (1992) Inappropriate medication is a major cause of adverse drug reactions in elderly patients. Age Ageing 21:294-300
    • (1992) Age Ageing , vol.21 , pp. 294-300
    • Lindley, C.M.1    Tully, M.P.2    Paramsothy, V.3    Tallis, R.C.4
  • 25
    • 12444318725 scopus 로고    scopus 로고
    • Potential drug-drug interactions in the medication of medical patients at hospital discharge
    • 12634985
    • Egger SS, Drewe J, Schlienger RG (2003) Potential drug-drug interactions in the medication of medical patients at hospital discharge. Eur J Clin Pharmacol 58:773-778
    • (2003) Eur J Clin Pharmacol , vol.58 , pp. 773-778
    • Egger, S.S.1    Drewe, J.2    Schlienger, R.G.3
  • 26
    • 79952702149 scopus 로고    scopus 로고
    • The incidence of potential drug-drug interactions in elderly patients with arterial hypertension
    • 20922479 10.1007/s11096-010-9442-5 1:CAS:528:DC%2BC3MXhtVegs7k%3D
    • Bacic-Vrca V, Marusic S, Erdeljic V, Falamic S, Gojo-Tomic N, Rahelic D (2010) The incidence of potential drug-drug interactions in elderly patients with arterial hypertension. Pharm World Sci 32:815-821
    • (2010) Pharm World Sci , vol.32 , pp. 815-821
    • Bacic-Vrca, V.1    Marusic, S.2    Erdeljic, V.3    Falamic, S.4    Gojo-Tomic, N.5    Rahelic, D.6
  • 27
    • 15044344552 scopus 로고    scopus 로고
    • Pharmacokinetics in older persons
    • 15903286 10.1016/j.amjopharm.2004.12.005 1:CAS:528:DC%2BD2MXktlajs7s%3D
    • Cusack BJ (2004) Pharmacokinetics in older persons. Am J Geriatr Pharmacother 2:274-302
    • (2004) Am J Geriatr Pharmacother , vol.2 , pp. 274-302
    • Cusack, B.J.1
  • 28
    • 0030799686 scopus 로고    scopus 로고
    • Hyperkalemia in the elderly: Drugs exacerbate impaired potassium homeostasis
    • 9346463 10.1046/j.1525-1497.1997.07128.x 1:STN:280:DyaK1c%2FgsVCnuw%3D%3D
    • Perazella MA, Mahnensmith RL (1997) Hyperkalemia in the elderly: drugs exacerbate impaired potassium homeostasis. J Gen Intern Med 12:646-656
    • (1997) J Gen Intern Med , vol.12 , pp. 646-656
    • Perazella, M.A.1    Mahnensmith, R.L.2
  • 29
    • 80054789751 scopus 로고    scopus 로고
    • Frequency of laboratory measurement and hyperkalaemia in hospitalised patients using serum potassium concentration increasing drugs
    • 21424384 10.1007/s00228-011-1028-1 1:CAS:528:DC%2BC3MXhtVWqtbnJ
    • Uijtendaal EV, Zwart-van Rijkom JE, van Solinge WW, Egberts TC (2011) Frequency of laboratory measurement and hyperkalaemia in hospitalised patients using serum potassium concentration increasing drugs. Eur J Clin Pharmacol 67:933-940
    • (2011) Eur J Clin Pharmacol , vol.67 , pp. 933-940
    • Uijtendaal, E.V.1    Zwart-Van Rijkom, J.E.2    Van Solinge, W.W.3    Egberts, T.C.4
  • 31
    • 0028471217 scopus 로고
    • Age-related changes in the gastrointestinal system. Effects on drug therapy
    • 7919638 10.2165/00002512-199405010-00004 1:STN:280:DyaK2M%2Fgtlegsw%3D%3D
    • Iber FL, Murphy PA, Connor ES (1994) Age-related changes in the gastrointestinal system. Effects on drug therapy. Drugs Aging 5:34-48
    • (1994) Drugs Aging , vol.5 , pp. 34-48
    • Iber, F.L.1    Murphy, P.A.2    Connor, E.S.3
  • 32
    • 78650920067 scopus 로고    scopus 로고
    • Proton pump inhibitor side effects and drug interactions: Much ado about nothing?
    • 21199906 10.3949/ccjm.77a.10087
    • Madanick RD (2011) Proton pump inhibitor side effects and drug interactions: much ado about nothing? Cleve Clin J Med 78:39-49
    • (2011) Cleve Clin J Med , vol.78 , pp. 39-49
    • Madanick, R.D.1
  • 33
    • 4544358142 scopus 로고    scopus 로고
    • Effect of omeprazole on oral iron replacement in patients with iron deficiency anemia
    • 15455980 10.1097/01.SMJ.0000110405.63179.69
    • Sharma VR, Brannon MA, Carloss EA (2004) Effect of omeprazole on oral iron replacement in patients with iron deficiency anemia. South Med J 97:887-889
    • (2004) South Med J , vol.97 , pp. 887-889
    • Sharma, V.R.1    Brannon, M.A.2    Carloss, E.A.3
  • 34
    • 79958077792 scopus 로고    scopus 로고
    • Drug and dietary interactions of warfarin and novel oral anticoagulants: An update
    • 21359645 10.1007/s11239-011-0561-1 1:CAS:528:DC%2BC3MXjtFWhurw%3D
    • Nutescu E, Chuatrisorn I, Hellenbart E (2011) Drug and dietary interactions of warfarin and novel oral anticoagulants: an update. J Thromb Thrombolysis 31:326-343
    • (2011) J Thromb Thrombolysis , vol.31 , pp. 326-343
    • Nutescu, E.1    Chuatrisorn, I.2    Hellenbart, E.3
  • 35
    • 33845910453 scopus 로고    scopus 로고
    • A pharmacoepidemiologic study of drug interactions in a Brazilian teaching hospital
    • 10.1590/S1807-59322006000600005
    • Cruciol-Souza JM, Thomson JC (2006) A pharmacoepidemiologic study of drug interactions in a Brazilian teaching hospital. Clinics (Sao Paulo) 61:515-520
    • (2006) Clinics (Sao Paulo) , vol.61 , pp. 515-520
    • Cruciol-Souza, J.M.1    Thomson, J.C.2
  • 36
    • 0142244564 scopus 로고    scopus 로고
    • Drug-induced esophageal injuries and dysphagia
    • 14565800 10.1345/aph.1D056
    • O'Neill JL, Remington TL (2003) Drug-induced esophageal injuries and dysphagia. Ann Pharmacother 37:1675-1684
    • (2003) Ann Pharmacother , vol.37 , pp. 1675-1684
    • O'Neill, J.L.1    Remington, T.L.2
  • 37
    • 33845448615 scopus 로고    scopus 로고
    • Oral solid potassium chloride and anticholinergic medications: A new drug interaction for an old drug?
    • 17174738 10.1016/j.gerinurse.2006.10.015
    • Zarowitz BJ (2006) Oral solid potassium chloride and anticholinergic medications: a new drug interaction for an old drug? Geriatr Nurs 27:329-333
    • (2006) Geriatr Nurs , vol.27 , pp. 329-333
    • Zarowitz, B.J.1
  • 38
    • 0021224857 scopus 로고
    • Effect of potassium chloride supplements on upper gastrointestinal mucosa
    • 6734038 10.1038/clpt.1984.124 1:CAS:528:DyaL2cXkslyktL4%3D
    • McMahon FG, Ryan JR, Akdamar K, Ertan A (1984) Effect of potassium chloride supplements on upper gastrointestinal mucosa. Clin Pharmacol Ther 35:852-855
    • (1984) Clin Pharmacol Ther , vol.35 , pp. 852-855
    • McMahon, F.G.1    Ryan, J.R.2    Akdamar, K.3    Ertan, A.4
  • 39
    • 23744474806 scopus 로고    scopus 로고
    • Effect of age-related changes in gastric physiology on tolerability of medications for older people
    • 16060716 10.2165/00002512-200522080-00003
    • Newton JL (2005) Effect of age-related changes in gastric physiology on tolerability of medications for older people. Drugs Aging 22:655-661
    • (2005) Drugs Aging , vol.22 , pp. 655-661
    • Newton, J.L.1
  • 40
    • 54349121974 scopus 로고    scopus 로고
    • Calcium-channel blockers reduce the antiplatelet effect of clopidogrel
    • 19007592 10.1016/j.jacc.2008.07.055 1:CAS:528:DC%2BD1cXhtlahtbnI
    • Siller-Matula JM, Lang I, Christ G, Jilma B (2008) Calcium-channel blockers reduce the antiplatelet effect of clopidogrel. J Am Coll Cardiol 52:1557-1563
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1557-1563
    • Siller-Matula, J.M.1    Lang, I.2    Christ, G.3    Jilma, B.4
  • 41
    • 84860864875 scopus 로고    scopus 로고
    • Is there a clinically significant interaction between calcium channel antagonists and clopidogrel?: Results from the Clopidogrel for the Reduction of Events during Observation (CREDO) trial
    • 22319066 10.1161/CIRCINTERVENTIONS.111.963405 1:CAS:528: DC%2BC38XnvVKnsbs%3D
    • Good CW, Steinhubl SR, Brennan DM, Lincoff AM, Topol EJ, Berger PB (2012) Is there a clinically significant interaction between calcium channel antagonists and clopidogrel?: results from the Clopidogrel for the Reduction of Events During Observation (CREDO) trial. Circ Cardiovasc Interv 5:77-81
    • (2012) Circ Cardiovasc Interv , vol.5 , pp. 77-81
    • Good, C.W.1    Steinhubl, S.R.2    Brennan, D.M.3    Lincoff, A.M.4    Topol, E.J.5    Berger, P.B.6
  • 42
    • 0033844234 scopus 로고    scopus 로고
    • Disagreement among drug compendia on inclusion and ratings of drug-drug interactions
    • 10.1016/S0011-393X(00)80036-3
    • Fulda TR, Valuck RJ, Vander Zanden J, Parker S, Byrns PJ (2000) Disagreement among drug compendia on inclusion and ratings of drug-drug interactions. Curr Ther Res 61:540-548
    • (2000) Curr Ther Res , vol.61 , pp. 540-548
    • Fulda, T.R.1    Valuck, R.J.2    Vander Zanden, J.3    Parker, S.4    Byrns, P.J.5
  • 43
    • 34248586434 scopus 로고    scopus 로고
    • Comparative assessment of four drug interaction compendia
    • 17166171 10.1111/j.1365-2125.2006.02809.x 1:CAS:528:DC%2BD2sXntl2rsrY%3D
    • Vitry AI (2007) Comparative assessment of four drug interaction compendia. Br J Clin Pharmacol 63:709-714
    • (2007) Br J Clin Pharmacol , vol.63 , pp. 709-714
    • Vitry, A.I.1
  • 45
    • 46149100957 scopus 로고    scopus 로고
    • Evaluation of frequently used drug interaction screening programs
    • 18415695 10.1007/s11096-008-9191-x
    • Vonbach P, Dubied A, Krähenbühl S, Beer JH (2008) Evaluation of frequently used drug interaction screening programs. Pharm World Sci 30:367-374
    • (2008) Pharm World Sci , vol.30 , pp. 367-374
    • Vonbach, P.1    Dubied, A.2    Krähenbühl, S.3    Beer, J.H.4
  • 46
    • 1642566572 scopus 로고    scopus 로고
    • Evaluation of personal digital assistant software for drug interactions
    • 15011766
    • Barrons R (2004) Evaluation of personal digital assistant software for drug interactions. Am J Health Syst Pharm 61:380-385
    • (2004) Am J Health Syst Pharm , vol.61 , pp. 380-385
    • Barrons, R.1


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