Biology of anterior cruciate ligament injury and repair: Kappa delta ann doner vaughn award paper 2013

Journal of Orthopaedic Research

Volumn 31, Issue 10, 2013, Pages 1501-1506

  Murray, Martha Meaney ^a   Fleming, Braden C ^b,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BROWN UNIVERSITY   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

anterior cruciate ligament; in vivo; osteoarthritis; reconstruction; repair

Indexed keywords

COLLAGEN; CYTOKINE; FIBRINOGEN; FIBROBLAST GROWTH FACTOR 2; FIBRONECTIN; PLATELET DERIVED GROWTH FACTOR A; PROCOLLAGEN; SCLEROPROTEIN; TRANSFORMING GROWTH FACTOR BETA1; VON WILLEBRAND FACTOR;

ANTERIOR CRUCIATE LIGAMENT INJURY; ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION; COLLAGEN SYNTHESIS; HEALING; HEALING IMPAIRMENT; HUMAN; IMMUNOHISTOCHEMISTRY; JOINT INSTABILITY; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REVIEW; SYNOVIAL FLUID; TENSILE STRENGTH; TISSUE ENGINEERING; TISSUE REACTION;

ANTERIOR CRUCIATE LIGAMENT; IN VIVO; OSTEOARTHRITIS; RECONSTRUCTION; REPAIR;

ANIMALS; ANTERIOR CRUCIATE LIGAMENT; AWARDS AND PRIZES; DISEASE MODELS, ANIMAL; HUMANS; INCIDENCE; KNEE INJURIES; KNEE JOINT; ORTHOPEDIC PROCEDURES; OSTEOARTHRITIS; RECONSTRUCTIVE SURGICAL PROCEDURES; REGENERATION; TENSILE STRENGTH; TISSUE SCAFFOLDS; WEIGHT-BEARING;

EID: 84882857795     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22420     Document Type: Review

References (36)

1. Frobell RB, Lohmander LS, Roos HP., 2007. Acute rotational trauma to the knee: poor agreement between clinical assessment and magnetic resonance imaging findings. Scand J Med Sci Sports 17: 109-114.
2. Hewett TE, Lindenfeld TN, Riccobene JV, et al. 1999. The effect of neuromuscular training on the incidence of knee injury in female athletes. A prospective study. Am J Sports Med 27: 699-706.
3. Fithian DC, Paxton LW, Goltz DH., 2002. Fate of the anterior cruciate ligament-injured knee. Orthop Clin North Am 33: 621-636.
4. Feagin JA, Curl WW., 1976. Isolated tear of the anterior cruciate ligament: 5-year follow-up study. Am J Sports Med 4: 95-100.
5. Oiestad BE, Holm I, Aune AK, et al. 2010. Knee function and prevalence of knee osteoarthritis after anterior cruciate ligament reconstruction: a prospective study with 10-15 years of follow-up. Am J Sports Med 38: 2201-2210.
6. Murray MM, Martin SD, Martin TL, et al. 2000. Histological changes in the human anterior cruciate ligament after rupture. J Bone Joint Surg Am 82: 1387-1397.
7. Murray MM, Spindler KP, Ballard P, et al. 2007. Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold. J Orthop Res 25: 1007-1017.
8. Frank C, Schachar N, Dittrich D., 1983. Natural history of healing in the repaired medial collateral ligament. J Orthop Res 1: 179-188.
9. Spindler KP, Clark SW, Nanney LB, et al. 1996. Expression of collagen and matrix metalloproteinases in ruptured human anterior cruciate ligament: an in situ hybridization study. J Orthop Res 14: 857-861.
10. Murray MM, Spector M., 2001. The migration of cells from the ruptured human anterior cruciate ligament into collagen-glycosaminoglycan regeneration templates in vitro. Biomaterials 22: 2393-2402.
11. Spindler KP, Murray MM, Devin C, et al. 2006. The central ACL defect as a model for failure of intra-articular healing. J Orthop Res 24: 401-406.
12. Murray MM, Spindler KP, Devin C, et al. 2006. Use of a collagen-platelet rich plasma scaffold to stimulate healing of a central defect in the canine ACL. J Orthop Res 24: 820-830.
13. Meaney Murray M, Rice K, Wright RJ, et al. 2003. The effect of selected growth factors on human anterior cruciate ligament cell interactions with a three-dimensional collagen-GAG scaffold. J Orthop Res 21: 238-244.
14. Jacobson M, Fufa D, Abreu EL, et al. 2008. Platelets, but not erythrocytes significantly affect cytokine release and scaffold contraction in a provisional scaffold model. Wound Repair Regen 16: 370-378.
15. Fufa D, Shealy B, Jacobson M, et al. 2008. Activation of platelet-rich plasma using soluble type I collagen. J Oral Maxillofac Surg 66: 684-690.
16. Harrison SL, Vavken P, Murray MM., 2011. Erythrocytes inhibit ligament fibroblast proliferation in a collagen scaffold. J Orthop Res 29: 1361-1366.
17. Harrison S, Vavken P, Kevy S, et al. 2011. Platelet activation by collagen provides sustained release of anabolic cytokines. Am J Sports Med 39: 729-734.
18. Cheng M, Wang H, Yoshida R, et al. 2010. Platelets and plasma proteins are both required to stimulate collagen gene expression by anterior cruciate ligament cells in three-dimensional culture. Tissue Eng Part A 16: 1479-1489.
19. Spindler KP, Andrish JT, Miller RR, et al. 1996. Distribution of cellular repopulation and collagen synthesis in a canine anterior cruciate ligament autograft. J Orthop Res 14: 384-389.
20. Murray MM, Spindler KP, Abreu E, et al. 2007. Collagen-platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligament. J Orthop Res 25: 81-91.
21. Murray MM, Weiler A, Spindler KP., 2004. Interspecies variation in the fibroblast distribution of the anterior cruciate ligament. Am J Sports Med 32: 1484-1491.
22. Murray MM, Palmer M, Abreu E, et al. 2009. Platelet-rich plasma alone is not sufficient to enhance suture repair of the ACL in skeletally immature animals: an in vivo study. J Orthop Res 27: 639-645.
23. Fleming BC, Magarian EM, Harrison SL, et al. 2010. Collagen scaffold supplementation does not improve the functional properties of the repaired anterior cruciate ligament. J Orthop Res 28: 703-709.
24. Murray MM, Magarian E, Zurakowski D, et al. 2010. Bone-to-bone fixation enhances functional healing of the porcine anterior cruciate ligament using a collagen-platelet composite. Arthroscopy 29: S49-S57.
25. Fleming BC, Carey JL, Spindler KP, et al. 2008. Can suture repair of ACL transection restore normal anterioposterior laxity of the knee? An ex vivo study. J Orthop Res 26: 1500-1505.
26. Mastrangelo AN, Vavken P, Fleming BC, et al. 2011. Reduced platelet concentration does not harm PRP effectiveness for ACL repair in a porcine in vivo model. J Orthop Res 29: 1002-1007.
27. Murray MM, Magarian EM, Harrison SL, et al. 2010. The effect of skeletal maturity on functional healing of the anterior cruciate ligament. J Bone Joint Surg Am 92: 2039-2049.
28. Proffen B, Vavken P, Palmer R, et al. 2012. The Mature sheep as an animal model for bio-enhanced anterior cruciate ligament repair and reconstruction. In:, Mascarenhas R, editor. The knee: current concepts in kinematics, injury types, and treatment options. New York: Nova Science Publishers, Inc. p 117-129.
29. Magarian EM, Fleming BC, Harrison SL, et al. 2010. Delay of 2 or 6 weeks adversely affects the functional outcome of augmented primary repair of the porcine anterior cruciate ligament. Am J Sports Med 38: 2528-2534.
30. Joshi S, Mastrangelo A, Magarian E, et al. 2009. Collagen-platelet composite enhances biomechanical and histologic healing of the porcine ACL. Am J Sports Med 37: 2401-2410.
31. Vavken P, Fleming BC, Mastrangelo AN, et al. 2012. Biomechanical outcomes after bioenhanced anterior cruciate ligament repair and anterior cruciate ligament reconstruction are equal in a porcine model. Arthroscopy 28: 672-680.
32. Mastrangelo AN, Haus BM, Vavken P, et al. 2010. Immature animals have higher cellular density in the healing anterior cruciate ligament than adolescent or adult animals. J Orthop Res 28: 1100-1106.
33. Magarian EM, Vavken P, Murray MM., 2011. Human anterior cruciate ligament fibroblasts from immature patients have a stronger in vitro response to platelet concentrates than those from mature individuals. Knee 18: 247-251.
34. Mastrangelo AN, Magarian EM, Palmer MP, et al. 2010. The effect of skeletal maturity on the regenerative function of intrinsic ACL cells. J Orthop Res 28: 644-651.
35. Vavken P, Saad FA, Murray MM., 2010. Age dependence of expression of growth factor receptors in porcine ACL fibroblasts. J Orthop Res 28: 1107-1112.
36. Murray MM, Fleming BC., 2013. Use of a bioactive scaffold to stimulate ACL healing also minimizes post-traumatic osteoarthritis after surgery. Am J Sports Med DOI: 10.1177/0363546513483446