Epithelial Neoplasms of the Esophagus

Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas

Volumn , Issue , 2009, Pages 535-562

  Glickman, Jonathan N ^a,b,c   Odze, Robert D ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882851283     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-141604059-0.50023-0     Document Type: Chapter

References (181)

1. Parker SL, Tong T, Bolden S, et al. Cancer statistics, 1997. CA Cancer J Clin 1997, 47:5-27.
2. Devesa SS, Blot WJ, Fraumeni JF Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer 1998, 83:2049-2053.
3. Odze R, Antonioli D, Shocket D, et al. Esophageal squamous papillomas: Clinicopathologic study of 38 lesions and analysis of human papillomavirus by the polymerase chain reaction. Am J Surg Pathol 1993, 17:803-812.
4. Lavergne D, DeVilliers EM Papillomavirus in esophageal papillomas and carcinomas. Int J Cancer 1999, 80:680-684.
5. Carr NJ, Bratthauer GL, Lichy JH, et al. Squamous cell papillomas of the esophagus: A study of 23 lesions for human papillomavirus by in situ hybridization and the polymerase chain reaction. Hum Pathol 1994, 25:536-540.
6. Kato H, Orito E, Yoshinouchi T, et al. Regression of esophageal papillomatous polyposis caused by high-risk type human papilloma virus. J Gastroenterol 2003, 38:579-583.
7. Waluga M, Hartleb M, Sliwinski ZK, et al. Esophageal squamous cell papillomatosis complicated by carcinoma. Am J Gastroenterol 2000, 95:1592-1593.
8. Carr NJ, Moniham JM, Sobin LH, et al. Squamous cell papilloma of the esophagus: A clinicopathologic and follow-up study of 25 cases. Am J Gastroenterol 1994, 89:245-248.
9. Banducci D, Rees R, Bluett MK, et al. Pleomorphic adenoma of the cervical esophagus: A rare tumor. Ann Thorac Surg 1987, 44:653-655.
10. Tsutsumi M, Mizurnoto K, Tsubuchi T, et al. Serous cystadenoma of the esophagus. Acta Pathol Jpn 1990, 40:153-155.
11. Su JM, Hsu HK, Hsu PI, et al. Esophageal submucosal gland duct adenoma. Am J Gastroenterol 1998, 93:461-462.
12. Harada O, Ota H, Katsuyama T, et al. Esophageal gland duct adenoma: Immunohistochemical comparison with the normal esophageal gland and ultrastructural analysis. Am J Surg Pathol 2007, 31:469-475.
13. Rouse RV, Soetikno RM, Baker RJ, et al. Esophageal submucosal gland duct adenoma. Am J Surg Pathol 1995, 19:1191-1196.
14. Takubo K, Esaki Y, Watanabe A, et al. Adenoma accompanied by superficial squamous cell carcinoma of the esophagus. Cancer 1993, 71:2435-2438.
15. Kushima R, Vieth M, Mukaisho K, et al. Pyloric gland adenoma arising in Barrett's esophagus with mucin immunohistochemical and molecular cytogenetic evaluation. Virchows Arch 2006, 446:537-541.
16. Thurberg BL, Duray PH, Odze RD Polypoid dysplasia in Barrett's esophagus: A clinico-pathologic, immunohistochemical and molecular study of five cases. Hum Pathol 1999, 30:745-752.
17. Lim LL, Ho KY, Goh PM Preoperative diagnosis of a paraesophageal bronchogenic cyst using endosonography. Ann Thorac Surg 2002, 73:633-635.
18. Diaz de Liano A, Ciga MA, Trujillo R, et al. Congenital esophageal cysts: Two cases in adult patients. Hepatogastroenterology 1999, 46:2405-2408.
19. McNally J, Charles AK, Spicer RD, Grier D Mixed foregut cyst associated with esophageal atresia. J Pediatr Surg 2001, 36:939-940.
20. Asami S, Naomoto Y, Yamatsuji T, et al. Lymphoepithelial cyst of the cervical esophagus. J Gastroenterol 2006, 41:88-89.
21. Sen S, Bourne AJ, Morris LL, et al. Dorsal enteric cysts: A study of eight cases. Aust N Z J Surg 1988, 58:51-55.
22. Kitano Y, Iwanaka T, Tsuchida Y, Oka T Esophageal duplication cyst associated with pulmonary cystic malformations. J Pediatr Surg 1995, 30:1724-1727.
23. Lee MY, Jensen E, Kwak S, et al. Metastatic adenocarcinoma arising in a congenital foregut cyst of the esophagus: A case report with review of the literature. Am J Clin Oncol 1998, 21:64-66.
24. Singh S, Lal P, Sikora SS, Datta NR Squamous cell carcinoma arising from a congenital duplication cyst of the esophagus in a young adult. Dis Esophagus 2001, 14:258-261.
25. van Till JW, van Sandick JW, Cardozo ML, Obertop H Symptomatic mucocele of a surgically excluded esophagus. Dis Esophagus 2002, 15:96-98.
26. Martinez L, Tovar JA Ulcerated mucocele of the esophagus in a child. Ann Thorac Surg 2003, 75:1310-1311.
27. Tang P, McKinley MJ, Sporrer M, Kahn E Inlet patch: Prevalence, histologic type, and association with esophagitis, Barrett esophagus, and antritis. Arch Pathol Lab Med 2004, 128:444-447.
28. von Rahden BH, Stein HJ, Becker K Heterotopic gastric mucosa of the esophagus: Literature-review and proposal of a clinicopathologic classification. Am J Gastroenterol 2004, 99:543-551.
29. Gutierrez O, Akamatsu T, Cardona H, et al. Helicobacter pylori and heterotopic gastric mucosa in the upper esophagus (the inlet patch). Am J Gastroenterol 2003, 98:1266-1270.
30. Lauwers GY, Scott GV, Vauthey GN Adenocarcinoma of the upper esophagus arising in cervical ectopic gastric mucosa: Rare evidence of malignant potential of so-called "inlet patch. rdquo; Dig Dis Sci 1998, 43:901-907.
31. Alrawi SJ, Winston J, Tan D, et al. Primary adenocarcinoma of cervical esophagus. J Exp Clin Cancer Res 2005, 24:325-330.
32. Nakanishi Y, Ochiai A, Shimoda T, et al. Heterotopic sebaceous glands in the esophagus: Histopathological and immunohistochemical study of a resected esophagus. Pathol Int 1999, 49:364-368.
33. World Health Organization Classification of Tumors 2000, 10-974. IARC Press, Pathology and Genetics of Tumors of the Digestive System. Lyon. S.R. Hamilton, L.A. Aaltonen (Eds.).
34. Brown LM, Hoover RN, Greenberg RS, et al. Are racial differences in squamous cell esophageal cancer explained by alcohol and tobacco use?. J Natl Cancer Inst 1994, 86:1340-1345.
35. Tachimori Y, Watanabe H, Kato H, et al. Hypercalcemia in patients with esophageal carcinoma: The pathophysiologic role of parathyroid hormone-related protein. Cancer 1991, 68:2625-2629.
36. Ina H, Shibuya H, Ohashi I, et al. The frequency of a concomitant early esophageal cancer in male patients with oral and oropharyngeal cancer: Screening results using Lugol dye endoscopy. Cancer 1994, 73:2038-2041.
37. Ribiero U, Posner MC, Safatle-Ribiero AV, et al. Risk factors for squamous cell carcinoma of the oesophagus. Br J Surg 1996, 83:1174-1183.
38. Leeuwenburgh I, Haringsma J, Van Dekken H, et al. Long-term risk of oesophagitis, Barrett's oesophagus and oesophageal cancer in achalasia patients. Scand J Gastroenterol Suppl 2006, 243:7-10.
39. Iwaya T, Maesawa C, Ogasawara S, Tamura G Tylosis esophageal cancer locus on chromosome 17q25.1 is commonly deleted in sporadic human esophageal cancer. Gastroenterology 1998, 114:1206-1210.
40. Turner JR, Shen LH, Crum CP, et al. Low prevalence of human papillomavirus infection in esophageal squamous cell carcinomas from North America: Analysis by a highly sensitive and specific polymerase chain reaction-based approach. Hum Pathol 1997, 28:174-178.
41. Poljak M, Cerar A, Seme K Human papillomavirus infection in esophageal carcinomas: A study of 121 lesions using multiple broad-spectrum polymerase chain reactions and literature review. Hum Pathol 1998, 29:266-271.
42. Chang F, Syrjanen S, Shen Q, et al. Human papillomavirus involvement in esophageal carcinogenesis in the high-incidence area of China: A study of 700 cases by screening and type-specific in situ hybridization. Scand J Gastroenterol 2000, 35:123-130.
43. Farhadi M, Tahmasebi Z, Merat S, et al. Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population. World J Gastroenterol 2005, 11:1200-1203.
44. Lin J, Beer DG Molecular biology of upper gastrointestinal malignancies. Semin Oncol 2004, 31:476-486.
45. Parenti AR, Rugge M, Frizzera E, et al. p53 overexpression in the multistep process of esophageal carcinogenesis. Am J Surg Pathol 1995, 19:1418-1422.
46. Wei WQ, Abnet CC, Lu N, et al. Risk factors for oesophageal squamous dysplasia in adult inhabitants of a high risk region of China. Gut 2005, 54:759-763.
47. Kuwano H, Matsuda H, Matsuoka H, et al. Intra-epithelial carcinoma concomitant with esophageal squamous cell carcinoma. Cancer 1987, 59:783-787.
48. Morita M, Kuwano H, Yasuda M, et al. The multicentric occurrence of squamous epithelial dysplasia and squamous cell carcinoma in the esophagus. Cancer 1994, 74:2889-2895.
49. Hashimoto CL, Iriya K, Baba ER, et al. Lugol's dye spray chromoendoscopy establishes early diagnosis of esophageal cancer in patients with primary head and neck cancer. Am J Gastroenterol 2005, 100:275-282.
50. Dawsey SM, Yu Y, Taylor PR, et al. Esophageal cytology and subsequent risk of esophageal cancer: A prospective follow-up study from Linxian, China. Acta Cytol 1994, 38:183-192.
51. Tajima Y, Nakanishi Y, Tachimori Y, et al. Significance of involvement by squamous cell carcinoma of the ducts of esophageal submucosal glands: Analysis of 201 surgically resected superficial squamous cell carcinomas. Cancer 2000, 89:248-254.
52. Chu P, Stagias J, West AB, Traube M Diffuse pagetoid squamous cell carcinoma in situ of the esophagus: A case report. Cancer 1997, 79:1865-1870.
53. Singh SP, Odze R Multinucleated epithelial giant cell changes in esophagitis: A clinicopathologic study of 14 cases. Am J Surg Pathol 1998, 22:93-99.
54. Shimizu Y, Kato M, Yamamoto J, et al. Histologic results of EMR for esophageal lesions diagnosed as high-grade intraepithelial squamous neoplasia by endoscopic biopsy. Gastrointest Endosc 2006, 63:16-21.
55. Wang GQ, Abnet CC, Shen Q, et al. Histological precursors of oesophageal squamous cell carcinoma: Results from a 13 year prospective follow up study in a high risk population. Gut 2005, 54:187-192.
56. Qui S, Yang G Precursor lesions of esophageal cancer in high-risk populations in Henan Province, China. Cancer 1998, 62:551-557.
57. Goseki N, Koike M, Yoshida M Histopathologic characteristics of early stage esophageal carcinoma: A comparative study with gastric carcinoma. Cancer 1992, 69:1088-1093.
58. Bogomoletz WV, Molas G, Gayet B, Potet F Superficial squamous cell carcinoma of the esophagus: A report of 76 cases and review of the literature. Am J Surg Pathol 1989, 13:535-546.
59. Ando N, Ozawa S, Kitagawa Y, et al. Improvement in the results of surgical treatment of advanced squamous esophageal carcinoma during 15 consecutive years. Ann Surg 2000, 232:225-232.
60. Pesko P, Rakic S, Milicevic M, et al. Prevalence and clinicopathologic features of multiple squamous cell carcinoma of the esophagus. Cancer 1994, 73:2687-2690.
61. Mori M, Matsuda H, Kuwano H, et al. Oesophageal squamous cell carcinoma with lymphoid stroma: A case report. Virchows Arch A Pathol Anat Histopathol 1989, 415:473-479.
62. Kuwano H, Nagamatsu M, Ohno S, et al. Coexistence of intraepithelial carcinoma and glandular differentiation in esophageal squamous cell carcinoma. Cancer 1988, 62:1568-1572.
63. Edwards JM, Hillier VF, Lawson RA, et al. Squamous carcinoma of the oesophagus: Histological criteria and their prognostic significance. Br J Cancer 1989, 59:429-433.
64. Fujiwara Y, Nakagawa K, Tanaka T, et al. Small cell carcinoma of the esophagus combined with superficial esophageal cancer. Hepatogastroenterology 1996, 43:1360-1369.
65. Chu PG, Lyda MH, Weiss LM Cytokeratin 14 expression in epithelial neoplasms: A survey of 435 cases with emphasis on its value in differentiating squamous cell carcinomas from other epithelial tumours. Histopathology 2001, 39:9-16.
66. Takahashi H, Shikata N, Senzaki H, et al. Immunohistochemical staining patterns of keratins in normal oesophageal epithelium and carcinoma of the oesophagus. Histopathology 1995, 26:45-50.
67. Chu P, Wu E, Weiss LM Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: A survey of 435 cases. Mod Pathol 2000, 13:962-972.
68. Glickman JN, Yang A, Shahsafaei A, et al. Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders. Hum Pathol 2001, 32:1157-1165.
69. Casas F, Ferrer F, Farrus B, et al. Primary small cell carcinoma of the esophagus: A review of the literature with emphasis on therapy and prognosis. Cancer 1997, 80:1366-1372.
70. Rubio CA, Liu FS, Zhao HZ Histological classification of intraepithelial neoplasias and microinvasive squamous carcinoma of the esophagus. Am J Surg Pathol 1989, 13:685-690.
71. Schlemper RJ, Dawsey SM, Itabashi M, et al. Differences in diagnostic criteria for esophageal squamous cell carcinoma between Japanese and Western pathologists. Cancer 2000, 88:996-1006.
72. DeVault KR, Cernigliaro JG Esophageal intramural pseudodiverticulosis. Curr Treat Options Gastroenterol 2003, 6:71-73.
73. Pelosi G, Fraggetta F, Pasini F, et al. Immunoreactivity for thyroid transcription factor-1 in stage I non-small cell carcinomas of the lung. Am J Surg Pathol 2001, 25:363-372.
74. Takubo K, Sasajima K, Yamashita K, et al. Prognostic significance of intramural metastasis in patients with esophageal carcinoma. Cancer 1990, 65:1816-1819.
75. Eguchi T, Nakanishi Y, Shimoda T, et al. Histopathological criteria for additional treatment after endoscopic mucosal resection for esophageal cancer: Analysis of 464 surgically resected cases. Mod Pathol 2006, 19:475-480.
76. Mandard AM, Chasle J, Marnay J, et al. Autopsy findings in 111 cases of esophageal cancer. Cancer 1981, 48:329-335.
77. Wang LS, Chow KC, Chi KH, et al. Prognosis of esophageal squamous cell carcinoma: Analysis of clinicopathological and biological factors. Am J Gastroenterol 1999, 94:1933-1940.
78. AJCC Cancer Staging Manual 2002, Springer, New York. 6th ed. F.L. Greene, D.L. Page, I.D. Fleming (Eds.).
79. Lee RG, Compton CC Protocol for the examination of specimens removed from patients with esophageal carcinoma. Arch Pathol Lab Med 1997, 121:925-929.
80. Tajima Y, Nakanishi Y, Ochiai A, et al. Histopathologic findings predicting lymph node metastasis and prognosis of patients with superficial esophageal carcinoma: Analysis of 240 surgically resected tumors. Cancer 2000, 88:1285-1293.
81. Sarbia M, Bittinger F, Porschen R, et al. Prognostic value of histopathologic parameters of esophageal squamous cell carcinoma. Cancer 1995, 76:922-927.
82. Brucher BL, Becker K, Lordick F, et al. The clinical impact of histopathologic response assessment by residual tumor cell quantification in esophageal squamous cell carcinomas. Cancer 2006, 106:2119-2127.
83. Torres CM, Wang HH, Turner JR, et al. Pathologic prognostic factors in esophageal squamous cell carcinoma: A follow-up study of 74 patients with or without preoperative chemoradiation therapy. Mod Pathol 1999, 12:961-968.
84. Hambraeus GM, Mercke CE, Willen R, et al. Prognostic factors influencing survival in combined radiotherapy and surgery of squamous cell carcinoma of the esophagus with special reference to a histopathologic grading system. Cancer 1988, 62:895-904.
85. Brucher BL, Stein HJ, Werner M, Siewert JR Lymphatic vessel invasion is an independent prognostic factor in patients with a primary resected tumor with esophageal squamous cell carcinoma. Cancer 2001, 92:2228-2233.
86. Kanamoto A, Kato H, Tachimori Y, et al. No prognostic significance of p53 expression in esophageal squamous cell carcinoma. J Surg Oncol 1999, 72:94-98.
87. Sarbia M, Verreet P, Bittinger F, et al. Basaloid squamous cell carcinoma of the esophagus: Diagnosis and prognosis. Cancer 1997, 79:1871-1878.
88. Cho KJ, Jang JJ, Lee SS, Zo JI Basaloid squamous carcinoma of the oesophagus: A distinct neoplasm with multipotential differentiation. Histopathology 2000, 36:331-340.
89. Abe K, Sasano H, Itakura Y, et al. Basaloid-squamous carcinoma of the esophagus: A clinicopathologic, DNA ploidy, and immunohistochemical study of seven cases. Am J Surg Pathol 1996, 20:453-461.
90. Tsubochi H, Suzuki T, Suzuki S, et al. Immunohistochemical study of basaloid squamous cell carcinoma, adenoid cystic and mucoepidermoid carcinoma in the upper aerodigestive tract. Anticancer Res 2000, 20:1205-1211.
91. Li TJ, Zhang YX, Wen J, et al. Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features. Arch Pathol Lab Med 2004, 128:1124-1130.
92. Owonikoko T, Loberg C, Gabbert HE, Sarbia M Comparative analysis of basaloid and typical squamous cell carcinoma of the oesophagus: A molecular biological and immunohistochemical study. J Pathol 2001, 193:155-161.
93. Iascone C, Barreca M Carcinosarcoma and pseudosarcoma of the esophagus: Two names, one disease-Comprehensive review of the literature. World J Surg 1999, 23:153-157.
94. Balercia G, Bhan AK, Dickersin GR, et al. Sarcomatoid carcinoma: An ultrastructural study with light microscopic and immunohistochemical correlation of 10 cases from various anatomic sites. Ultrastruct Pathol 1995, 19:249-263.
95. Matsumoto T, Fujii H, Arakawa A, et al. Loss of heterozygosity analysis shows monoclonal evolution with frequent genetic progression and divergence in esophageal carcinosarcoma. Hum Pathol 2004, 35:322-327.
96. Lauwers GY, Grant LD, Scott GV, et al. Spindle cell squamous carcinoma of the esophagus: Analysis of ploidy and tumor proliferative activity in a series of 13 cases. Hum Pathol 1998, 29:863-868.
97. Carella R, Deleonardi G, D'Errico A, et al. Immunohistochemical panels for differentiating epithelial malignant mesothelioma from lung adenocarcinoma: A study with logistic regression analysis. Am J Surg Pathol 2001, 25:43-50.
98. Kavin H, Yaremko L, Valaitis J, Chowdhury L Chronic esophagitis evolving to verrucous squamous cell carcinoma: Possible role of exogenous chemical carcinogens. Gastroenterology 1996, 110:904-914.
99. Tajiri H, Muto M, Boku N, et al. Verrucous carcinoma of the esophagus completely resected by endoscopy. Am J Gastroenterol 2000, 95:1076-1077.
100. Malik AB, Bidani JA, Rich HG, McCully KS Long-term survival in a patient with verrucous carcinoma of the esophagus. Am J Gastroenterol 1996, 91:1031-1033.
101. Biemond P, ten Kate FJ, van Blankenstein M Esophageal verrucous carcinoma: Histologically a low-grade malignancy but clinically a fatal disease. J Clin Gastroenterol 1991, 13:102-107.
102. Sashiyama H, Nozawa A, Kimura M, et al. Case report: A case of lymphoepithelioma-like carcinoma of the oesophagus and review of the literature. J Gastroenterol Hepatol 1999, 14:534-539.
103. Shaheen NJ Advances in Barrett's esophagus and esophageal adenocarcinoma. Gastroenterology 2005, 128:1554-1566.
104. Bollschweiler E, Wolfgarten E, Gutschow C, Holscher AH Demographic variations in the rising incidence of esophageal adenocarcinoma in white males. Cancer 2001, 92:549-555.
105. Paraf F, Flejou JF, Pignon JP, et al. Surgical pathology of adenocarcinoma arising in Barrett's esophagus: Analysis of 67 cases. Am J Surg Pathol 1995, 19:183-191.
106. Torres C, Turner JR, Wang HH, et al. Pathologic prognostic factors in Barrett's associated adenocarcinoma: A follow-up study of 96 patients. Cancer 1999, 85:520-528.
107. Spechler SJ Barrett's esophagus. N Engl J Med 2002, 346:836-842.
108. Falk GW Barrett's esophagus. Gastroenterology 2002, 122:1569-1591.
109. Cameron AJ, Lomboy CT, Pera M, Carpenter HA Adenocarcinoma of the esophagogastric junction and Barrett's esophagus. Gastroenterology 1995, 109:1541-1546.
110. Shaheen NJ, Crosby MA, Bozymski EM, Sandler RS Is there publication bias in the reporting of cancer risk in Barrett's esophagus?. Gastroenterology 2000, 119:333-338.
111. Weston AP, Badr AS, Hassanein RS Prospective multivariate analysis of clinical, endoscopic, and histological factors predictive of the development of Barrett's multifocal high-grade dysplasia or adenocarcinoma. Am J Gastroenterol 1999, 94:3413-3419.
112. O'Connor JB, Falk GW, Richter JE The incidence of adenocarcinoma and dysplasia in Barrett's esophagus: Report on the Cleveland Clinic Barrett's Esophagus Registry. Am J Gastroenterol 1999, 94:2037-2042.
113. Conio M, Cameron AJ, Romero Y, et al. Secular trends in the epidemiology and outcome of Barrett's oesophagus in Olmsted County, Minnesota. Gut 2001, 48:304-309.
114. Weston AP, Sharma P, Topalovski M, et al. Long-term follow-up of Barrett's high-grade dysplasia. Am J Gastroenterol 2000, 95:1888-1893.
115. Dulai GS, Shekelel PG, Jensen DM, et al. Dysplasia and risk of further neoplastic progression in a Regional Veteran's Administration cohort. Am J Gastroenterol 2005, 100:775-783.
116. Sharma P, Falk GW, Weston AP, et al. Dysplasia and cancers in a large multicenter cohort of patients with Barrett's esophagus. Clin Gastroenterol Hepatol 2006, 4:566-572.
117. Conio M, Blanchi S, Lapertosa G, et al. Long-term endoscopic surveillance of patients with Barrett's esophagus: Incidence of dysplasia and adenocarcinoma-A prospective study. Am J Gastroenterol 2003, 98:1931-1939.
118. Reid BJ, Levine DS, Longton G, et al. Predictors of progression to cancer in Barrett's esophagus: Baseline histology and flow cytometry identify low- and high-risk patient subsets. Am J Gastroenterol 2000, 95:1669-1676.
119. Srivastava A, Hornick JL, Blount PL, et al. Extent of low-grade dysplasia is a risk factor for the development of esophageal adenocarcinoma in Barrett's esophagus. Am J Gastroenterol 2007, 102:483-493.
120. Rabinovitch PS, Longton G, Blount PL, et al. Predictors of progression in Barrett's esophagus: III. Baseline flow cytometric variables. Am J Gastroenterol 2001, 96:2071-2083.
121. Rudolph RE, Vaughan TL, Storer BE, et al. Effect of segment length on risk for neoplastic progression in patients with Barrett esophagus. Ann Intern Med 2000, 132:612-620.
122. Avidan B, Sonnenberg A, Schnell TG, et al. Hiatal hernia size, Barrett's length, and severity of acid reflux are all risk factors for esophageal adenocarcinoma. Am J Gastroenterol 2002, 97:1930-1936.
123. Weston AP, Sharma P, Mather S, et al. Risk stratification of Barrett's esophagus: Updated prospective multivariate analysis. Am J Gastroenterol 2004, 99:1657-1666.
124. Paulson TG, Reid BJ Focus on Barrett's esophagus and esophageal adenocarcinoma. Cancer Cell 2004, 6:11-16.
125. Wongsurawat VJ, Finley JC, Galipeau PC, et al. Genetic mechanisms of p53 LOH in Barrett's esophagus: Implications for biomarker validation. Cancer Epidemiol Biomarkers Prev 2006, 15:509-516.
126. Lai LA, Paulson TG, Li X, et al. Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-CGH. Genes Chromosomes Cancer 2007, 46:532-542.
127. Wong DJ, Paulson TG, Prevo LJ, et al. P16INK4a lesions are common, early abnormalities that undergo clonal expansion in Barrett's metaplastic epithelium. Cancer Res 2001, 61:8284-8289.
128. Yu C, Zhang X, Huang Q, et al. High fidelity DNA histograms in neoplastic progression in Barrett's esophagus. Lab Invest 2007, 87:466-472.
129. van Sandick JW, van Lanschot JJ, ten Kate FJ, et al. Pathology of early invasive adenocarcinoma of the esophagus or esophagogastric junction: Implications for therapeutic decision making. Cancer 2000, 88:2429-2437.
130. Dunne B, Reynolds JV, Mulligan E, et al. A pathological study of tumour regression in oesophageal adenocarcinoma treated with preoperative chemoradiotherapy. J Clin Pathol 2001, 54:841-845.
131. Hornick JL, Farraye FA, Odze RD Prevalence and significance of prominent mucin pools in the esophagus post neoadjuvant chemoradiotherapy for Barrett's-associated adenocarcinoma. Am J Surg Pathol 2006, 30:28-35.
132. Taniere P, Borghi-Scoazec G, Suarin J-C, et al. Cytokeratin expression in adenocarcinomas of the esophagogastric junction: A comparative study of adenocarcinomas of the distal esophagus and of the proximal stomach. Am J Surg Pathol 2002, 26:1213-1221.
133. Werling RW, Yaziji H, Bacchi CE, Gown AM CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: An immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol 2003, 27:303-310.
134. Hamilton K, Chiappori A, Olson S, et al. Prevalence and prognostic significance of neuroendocrine cells in esophageal adenocarcinoma. Mod Pathol 2000, 13:475-481.
135. Tot T The role of cytokeratins 20 and 7 and estrogen receptor analysis in separation of metastatic lobular carcinoma of the breast and metastatic signet ring cell carcinoma of the gastrointestinal tract. APMIS 2000, 108:467-472.
136. Shen B, Ormsby AH, Shen C, et al. Cytokeratin expression patterns in noncardia, intestinal metaplasia-associated gastric adenocarcinoma: Implication for the evaluation of intestinal metaplasia and tumors at the esophagogastric junction. Cancer 2002, 94:820-831.
137. +/CK20? in esophageal and cardiac cancer: Etiopathological and clinical implications. Mod Pathol 2004, 17:49-55.
138. van Lier MG, Bomhof FJ, Leendertse I, et al. Cytokeratin phenotyping does not help in distinguishing oesophageal adenocarcinoma from cancer of the gastric cardia. J Clin Pathol 2005, 58:722-724.
139. Chandrasoma P, Wickramsinghe K, Ma Y, DeMeester T Adenocarcinomas of the distal esophagus and "gastric cardia" are predominantly esophageal carcinomas. Am J Surg Pathol 2007, 31:569-575.
140. Rice TW, Blackstone EH, Goldblum JR, et al. Superficial adenocarcinoma of the esophagus. J Thorac Cardiovasc Surg 2001, 122:1077-1090.
141. Eloubeidi MA, Desmond R, Arguedas MR, et al. Prognostic factors for the survival of patients with esophageal carcinoma in the U.S.: The importance of tumor length and lymph node status. Cancer 2002, 95:1434-1443.
142. Gu Y, Swisher SG, Ajani JA, et al. The number of lymph nodes with metastasis predicts survival in patients with esophageal or esophagogastric junction adenocarcinoma who receive preoperative chemoradiation. Cancer 2006, 106:1017-1025.
143. Glickman JN, Torres C, Wang HH, et al. The prognostic significance of lymph node micrometastasis in patients with esophageal carcinoma. Cancer 1999, 85:769-778.
144. Heeren PA, Kelder W, Blondeel I, et al. Prognostic value of nodal micrometastases in patients with cancer of the gastro-oesophageal junction. Eur J Surg Oncol 2005, 31:270-276.
145. Mueller JD, Stein HJ, Oyang T, et al. Frequency and clinical impact of lymph node micrometastasis and tumor cell microinvolvement in patients with adenocarcinoma of the esophagogastric junction. Cancer 2000, 89:1874-1882.
146. Siewert JR, Stein HJ, Feith M, et al. Histologic tumor type is an independent prognostic parameter in esophageal cancer: Lessons from more than 1,000 consecutive resections at a single center in the Western world. Ann Surg 2001, 234:360-367.
147. Rice TW, Zuccaro GJ, Adelstein DJ, et al. Esophageal carcinoma: Depth of tumor invasion is predictive of regional lymph node status. Ann Thorac Surg 1998, 65:787-792.
148. Liu L, Hofstetter WL, Rashid A, et al. Significance of the depth of tumor invasion and lymph node metastasis in superficially invasive (T1) esophageal adenocarcinoma. Am J Surg Pathol 2005, 29:1079-1085.
149. Shahsafaei A, Hahn HP, Odze RD Vascular and lymphatic properties of the superficial and deep lamina propria in Barrett's esophagus. Mod Pathol 2007, 20(Suppl 2):130A.
150. Chirieac LR, Swisher SG, Correa AM, et al. Signet-ring cell or mucinous histology after preoperative chemoradiation and survival in patients with esophageal or esophagogastric junction adenocarcinoma. Clin Cancer Res 2005, 11:2229-2236.
151. Chirieac LR, Swisher SG, Ajani JA, et al. Posttherapy pathologic stage predicts survival in patients with esophageal carcinoma receiving preoperative chemoradiation. Cancer 2005, 103:1347-1355.
152. Rohatgi P, Swisher SG, Correa AM, et al. Characterization of pathologic complete response after preoperative chemoradiotherapy in carcinoma of the esophagus and outcome after pathologic complete response. Cancer 2005, 104:2365-2372.
153. Entwistle JW, Goldberg M Multimodality therapy for resectable cancer of the thoracic esophagus. Ann Thorac Surg 2002, 73:1009-1015.
154. Hull MJ, Mino-Kenudson M, Nishioka NS, et al. Endoscopic mucosal resection: An improved diagnostic procedure for early gastroesophageal epithelial neoplasms. Am J Surg Pathol 2006, 30:114-118.
155. Mino-Kenudson M, Brugge WR, Puricelli WP, et al. Management of superficial Barrett's epithelium-related neoplasms by endoscopic mucosal resection: Clinicopathologic analysis of 27 cases. Am J Surg Pathol 2005, 29:680-686.
156. Mino-Kenudson M, Ban S, Ohana M, et al. Buried dysplasia and early adenocarcinoma arising in Barrett esophagus after porfimer-photodynamic therapy. Am J Surg Pathol 2007, 31:403-409.
157. Galipeau PC, Li X, Blount PL, et al. NSAIDs modulate risk of CDKN2A, TP53, and DNA content abnormalities for future esophageal adenocarcinoma in Barrett's esophagus. PloS Med 2007, 4:342-354.
158. Montgomery E, Bronner M, Goldblum JR, et al. Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation. Hum Pathol 2001, 32:368-378.
159. Lomo L, Blount PL, Sanchez CA, et al. Crypt dysplasia with surface maturation: A clinical, pathologic and molecular study of a Barrett's esophagus cohort. Am J Surg Pathol 2006, 30:423-435.
160. Endoh Y, Miyawaki M, Tamura G, et al. Esophageal adenocarcinoma that probably originated in the esophageal gland duct: A case report. Pathol Int 1999, 49:156-159.
161. Takagi A, Ema Y, Horii S, et al. Early adenocarcinoma arising from ectopic gastric mucosa in the cervical esophagus. Gastrointest Endosc 1995, 41:167-170.
162. Morisaki Y, Yoshizumi Y, Hiroyasu S, et al. Adenoid cystic carcinoma of the esophagus: Report of a case and review of the Japanese literature. Surg Today 1996, 26:1006-1009.
163. Kabuto T, Taniguchi K, Iwanaga T, et al. Primary adenoid cystic carcinoma of the esophagus: Report of a case. Cancer 1979, 43:2452-2456.
164. Kanamoto A, Nakanishi Y, Ochiai A, et al. A case of small polypoid esophageal carcinoma with multidirectional differentiation, including neuroendocrine, squamous, ciliated glandular, and sarcomatous components. Arch Pathol Lab Med 2000, 124:1685-1687.
165. van Rees BP, Rouse RW, de Wit MJ, et al. Molecular evidence for the same clonal origin of both components of an adenosquamous Barrett carcinoma. Gastroenterology 2002, 122:784-788.
166. Ter RB, Govil YK, Leite L, et al. Adenosquamous carcinoma in Barrett's esophagus presenting as pseudoachalasia. Am J Gastroenterol 1999, 94:268-270.
167. Newman J, Antonakopoulos GN, Darnton SJ, Matthews HR The ultrastructure of oesophageal carcinomas: Multidirectional differentiation-A transmission electron microscopic study of 43 cases. J Pathol 1992, 167:193-198.
168. Wilson CI, Summerall J, Willis I, et al. Esophageal collision tumor (large cell neuroendocrine carcinoma and papillary carcinoma) arising in a Barrett esophagus. Arch Pathol Lab Med 2000, 124:411-415.
169. Lam KY, Dickens P, Loke SL, et al. Squamous cell carcinoma of the oesophagus with mucin-secreting component (muco-epidermoid carcinoma and adenosquamous carcinoma): A clinicopathologic study and a review of literature. Eur J Surg Oncol 1994, 20:25-31.
170. Yachida S, Nakanishi Y, Shimoda T, et al. Adenosquamous carcinoma of the esophagus. Clinicopathologic study of 18 cases. Oncology 2004, 66:218-225.
171. Lindberg GM, Molberg KH, Vuitch MF, Albores-Saavedra J Atypical carcinoid of the esophagus: A case report and review of the literature. Cancer 1997, 79:1476-1481.
172. Hoang MP, Hobbs CM, Sobin LH, Albores-Saavedra J Carcinoid tumor of the esophagus: A clinicopathologic study of four cases. Am J Surg Pathol 2002, 26:517-522.
173. Hosokawa A, Shimada Y, Matsumura Y, et al. Small cell carcinoma of the esophagus: Analysis of 14 cases and literature review. Hepatogastroenterology 2005, 52:1738-1741.
174. Takubo K, Nakamura K, Sawabe M, et al. Primary undifferentiated small cell carcinoma of the esophagus. Hum Pathol 1999, 30:216-221.
175. Harmse JL, Carey FA, Baird AR, et al. Merkel cells in the human oesophagus. J Pathol 1999, 189:176-179.
176. Ishihara A, Mori T, Koono M, et al. Diffuse pagetoid squamous cell carcinoma of the esophagus combined with choriocarcinoma and mucoepidermoid carcinoma: An autopsy case report. Pathol Int 2002, 52:147-152.
177. Merimsky O, Jossiphov J, Asna N, et al. Choriocarcinoma arising in a squamous cell carcinoma of the esophagus. Am J Clin Oncol 2000, 23:203-206.
178. Volpin E, Sauvanet A, Couvelard A, Belghiti J Primary malignant melanoma of the esophagus: Case report and literature review. Dis Esophagus 2002, 15:244-249.
179. Mosnier JF, Balique J Pleomorphic giant cell carcinoma of the esophagus with coexpression of cytokeratin and vimentin and neuroendocrine differentiation. Arch Pathol Lab Med 2000, 124:135-138.
180. Mizobuchi S, Tachimori Y, Kato H, et al. Metastatic esophageal tumors from distant primary lesions: Report of three esophagectomies and study of 1835 autopsy cases. Jpn J Clin Oncol 1997, 27:410-414.
181. Simchuk EJ, Low DE Direct esophageal metastasis from a distant primary tumor is a submucosal process: A review of six cases. Dis Esophagus 2001, 14:247-250.