Methotrexate binds to recombinant thiopurine S-methyltransferase and inhibits enzyme activity after high-dose infusions in childhood leukaemia

European Journal of Clinical Pharmacology

Volumn 69, Issue 9, 2013, Pages 1641-1649

  Wennerstrand, Patricia ^a   Mårtensson, Lars Göran ^a   Söderhäll, Stefan ^b   Zimdahl, Anna ^a   Appell, Malin Lindqvist ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

6 Mercaptopurine; Leukaemia; Methotrexate; Pharmacogenetics; Thiopurine S methyltransferase

Indexed keywords

FOLINATE CALCIUM; MERCAPTOPURINE; METHOTREXATE; RECOMBINANT PROTEIN; THIOPURINE METHYLTRANSFERASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; CHILD; CLINICAL PROTOCOL; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; DRUG PROTEIN BINDING; DRUG UNDERDOSE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; EVENING DOSAGE; FEMALE; GENE; GENOTYPE; HUMAN; IN VITRO STUDY; LEUKEMIA; LEUKEMIA CELL LINE; MAINTENANCE CHEMOTHERAPY; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE DRUG DOSE; TPMT GENE;

6-MERCAPTOPURINE; ADOLESCENT; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL LINE, TUMOR; CHILD; CHILD, PRESCHOOL; ENZYME INHIBITORS; FEMALE; HUMANS; INFANT; INFUSIONS, INTRAVENOUS; MALE; METHOTREXATE; METHYLTRANSFERASES; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RECOMBINANT PROTEINS;

EID: 84882817545     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-013-1521-9     Document Type: Article

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