Statins attenuate the development of atherosclerosis and endothelial dysfunction induced by exposure to urban particulate matter (PM10)

Toxicology and Applied Pharmacology

Volumn 272, Issue 1, 2013, Pages 1-11

  Miyata, Ryohei ^a   Hiraiwa, Kunihiko ^a   Cheng, Jui Chih ^a   Bai, Ni ^a   Vincent, Renaud ^b   Francis, Gordon A ^a   Sin, Don D ^a   Van Eeden, Stephan F ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Environmental Health Center   (Canada)

Author keywords

Atherosclerosis; COX 2; INOS; Particulate matter; Reactive oxygen species; Statins

Indexed keywords

ACETYLCHOLINE; CYCLOOXYGENASE 2; ENDOTHELIN 1; INDUCIBLE NITRIC OXIDE SYNTHASE; MEVINOLIN; NITRIC OXIDE; PHENYLEPHRINE; REACTIVE OXYGEN METABOLITE;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; BALLOON CATHETER; BLOOD VESSEL; CELL MIGRATION; CONTROLLED STUDY; DISEASE COURSE; ENDOTHELIAL DYSFUNCTION; EXPERIMENTAL RABBIT; HEART PROTECTION; LIPID DIET; LIPID STORAGE; MACROPHAGE; MALE; MYOGRAPHY; NONHUMAN; PARTICULATE MATTER; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; URBAN AREA; VASOCONSTRICTION; VASODILATATION;

ATHEROSCLEROSIS; COX-2; DIFFUSE INTIMAL THICKENING; DIT; INOS; NITROTYROSINE; NT; PARTICULATE MATTER; PARTICULATE MATTER LESS THAN 10ΜM; PM; PM(10); REACTIVE OXYGEN SPECIES; SNP; SODIUM NITROPRUSSIDE; STATINS; THE 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE INHIBITORS;

ANIMALS; ATHEROSCLEROSIS; BLOOD VESSELS; CHOLESTEROL, DIETARY; CYCLOOXYGENASE 2; CYTOKINES; ENDOTHELIN-1; ENDOTHELINS; ENDOTHELIUM, VASCULAR; ENVIRONMENTAL EXPOSURE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOHISTOCHEMISTRY; LIPIDS; LOVASTATIN; MALE; NITRIC OXIDE SYNTHASE TYPE II; PARTICULATE MATTER; PLAQUE, ATHEROSCLEROTIC; RABBITS; REACTIVE OXYGEN SPECIES; URBAN HEALTH; VASCULAR DISEASES;

EID: 84882789337     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.05.033     Document Type: Article

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