Anti-atherosclerotic properties of the acyl-coenzyme A:cholesterol acyltransferase inhibitor F 12511 in casein-fed New Zealand rabbits

Journal of Cardiovascular Pharmacology

Volumn 39, Issue 2, 2002, Pages 181-191

  Rival, Yves ^a   Junquéro, Didier ^a   Bruniquel, Françoise ^a   N'Guyen, Xuan ^a   Fauré, Philippe ^a   Pomiès, Jean Pierre ^a   Degryse, Anne D ^a   Delhon, André ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Acyl coenzyme A:cholesterol acyltransferase; Atherosclerosis; Casein fed rabbit; F 12511; Hypercholesterolemia

Indexed keywords

CASEIN; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; EFLUCIMIBE; UNCLASSIFIED DRUG;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA INJURY; ARTICLE; ATHEROMA; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL INTAKE; CONTROLLED STUDY; DIETARY INTAKE; DISEASE ASSOCIATION; ENDOTHELIUM; ENDOTHELIUM INJURY; HYPERCHOLESTEROLEMIA; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; THORACIC AORTA; VASCULAR DISEASE;

ANILIDES; ANIMALS; ANTICHOLESTEREMIC AGENTS; AORTA, ABDOMINAL; AORTA, THORACIC; ARTERIOSCLEROSIS; BALLOON DILATATION; CASEINS; CHOLESTEROL; DIET, ATHEROGENIC; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HYPERCHOLESTEROLEMIA; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; MALE; RABBITS; STEROL O-ACYLTRANSFERASE; TRIGLYCERIDES; TUNICA INTIMA;

EID: 0036150483     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200202000-00004     Document Type: Article

References (18)

1. Relation of plaque lipid composition and morphology to the stability of human aortic plaques
2. Stability and instability: Two faces of coronary atherosclerosis
3. Atherosclerosis
4. The relationship between the degree of dietary-induced hypercholesterolemia in the rabbit and atherosclerotic lesion formation
5. Early lesion development in the aortas of rabbits fed low-fat, cholesterol-free, semipurified casein diet
6. Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: A potential mechanism of lesion stabilization
7. Cell composition, replication, and apoptosis in atherosclerotic plaques after 6 months of cholesterol withdrawal
8. The ACAT inhibitor avasimibe reduces macrophages and matrix metalloproteinase expression in atherosclerotic lesions of hypercholesterolemic rabbits
9. ACAT inhibition decreases LDL cholesterol in rabbits fed a cholesterol-free diet: Marked changes in LDL cholesterol without changes in LDL receptor mRNA abundance
10. F 12511, a novel ACAT inhibitor, and atorvastatin regulate endogenous hypercholesterolemia in a synergistic manner in New-Zealand rabbits fed a casein-rich diet
11. Cholesterol-fed and casein-fed models of atherosclerosis: Part 2: Differing morphologic severity of atherogenesis despite matched plasma cholesterol levels
12. Pharmacological profile of F 12511, a powerful and systemic ACAT inhibitor
13. Hypercholesterolemia in the rabbit induced by feeding graded amounts of low-level cholesterol: Methodological considerations regarding individual variability in response to dietary cholesterol and development of lesion type
14. Cholesterol-fed and casein-fed models of atherosclerosis: Part 1: Differing lesions area and volume despite equal plasma cholesterol levels
15. Lipid lowering promotes accumulation of mature smooth muscle cells expressing smooth muscle myosin heavy chain isoforms in rabbit atheroma
16. Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions: A biochemical, morphologic, and morphometric evaluation
17. Lipid regulating properties of the novel ACAT inhibitor F 12511 in rabbits fed a cholesterol-free casein-rich diet
18. Sulindac inhibits neointimal formation after arterial injury in wild-type and apolipoprotein E-deficient mice