Grape seed extract triggers apoptosis in Caco-2 human colon cancer cells through reactive oxygen species and calcium increase: Extracellular signal-regulated kinase involvement

British Journal of Nutrition

Volumn 110, Issue 5, 2013, Pages 797-809

  Dinicola, Simona ^a   Mariggiò, Maria Addolorata ^b   Morabito, Caterina ^b   Guarnieri, Simone ^b   Cucina, Alessandra ^a   Pasqualato, Alessia ^a,b   D'Anselmi, Fabrizio ^a,c   Proietti, Sara ^a   Coluccia, Pierpaolo ^a   Bizzarri, Mariano ^d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c ITALIAN SPACE AGENCY   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Apoptosis; Extracellular signal regulated kinase; Grape seed extract; Intracellular Ca 2+; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; CALCIUM ION; EGTAZIC ACID; GRAPE SEED EXTRACT; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CANCER CELL; CANCER INHIBITION; CELL STRAIN CACO 2; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTIVAR; DRUG EFFECT; DRUG MECHANISM; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS;

APOPTOSIS; CACO-2 CELLS; CALCIUM; CALCIUM SIGNALING; COLONIC NEOPLASMS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GRAPE SEED EXTRACT; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; REACTIVE OXYGEN SPECIES;

EID: 84882787321     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114512006095     Document Type: Article

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