Peripheral blood lymphocytes: A model for monitoring physiological adaptation to high altitude

High Altitude Medicine and Biology

Volumn 11, Issue 4, 2010, Pages 333-342

  Mariggiò, Maria A ^a   Falone, Stefano ^b   Morabito, Caterina ^a   Guarnieri, Simone ^a   Mirabilio, Alessandro ^b   Pilla, Raffaele ^a   Bucciarelli, Tonino ^a   Verratti, Vittore ^a   Amicarelli, Fernanda ^b  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

altitude adap; hypobaric hypoxia; intracellular calcium; lymphocytes; oxidative stress

Indexed keywords

GLUTATHIONE PEROXIDASE; REACTIVE OXYGEN METABOLITE; TROLOX C;

ALTITUDE; ALTITUDE ACCLIMATIZATION; ARTICLE; BIOSENSOR; CALCIUM CELL LEVEL; CELL ACTIVITY; CELL DAMAGE; CLIMBING; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HYPOXIA; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NORMAL HUMAN; OXIDATIVE STRESS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SERUM;

ACCLIMATIZATION; ALTITUDE; ANTIOXIDANTS; BETA CAROTENE; BIOLOGICAL MARKERS; CALCIUM; CAROTENOIDS; CELL COUNT; GLUTATHIONE PEROXIDASE; HUMANS; HYDROGEN PEROXIDE; LIPID PEROXIDATION; LYMPHOCYTES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MODELS, BIOLOGICAL; OXIDATIVE STRESS; PROTEIN CARBONYLATION; VITAMIN A; VITAMIN E;

EID: 78650777045     PISSN: 15270297     EISSN: None     Source Type: Journal    
DOI: 10.1089/ham.2009.1097     Document Type: Article

References (60)

1. Ames B.N., Shigenaga M.K., and Hagen T.M. (1993). Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. U S A. 90:7915-7922.
2. Balaban R.S., Nemoto S., and Finkel T. (2005). Mitochondria, oxidants, and aging. Cell. 120:483-495.
3. Balakrishnan S., and Rao S.B. (1999). Cytogenetic analysis of peripheral blood lymphocytes of occupational workers exposed to low levels of ionising radiation. Mutat. Res. 442: 37-42.
4. Behn C., Araneda O.F., Llanos A.J., Celedon G., and Gonzalez G. (2007). Hypoxia-related lipid peroxidation: Evidences, implications and approaches. Respir. Physiol. Neurobiol. 158:143-150.
5. Belia S., Santilli F., Beccafico S., De Feudis L., Morabito C., Davi G., Fano G., and Mariggio M.A. (2009). Oxidative-induced membrane damage in diabetes lymphocytes: Effects on intracellular Ca(2+) homeostasis. Free Radical Res. 43:138-148.
6. Boyum A. (1976). Isolation of lymphocytes, granulocytes and macrophages. Scand. J. Immunol. Suppl. 5:9-15.
7. Bradford M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytic Biochem. 72: 248-254.
8. Breen A.P., and Murphy J.A. (1995). Reactions of oxyl radicals with DNA. Free Radical Biol. Med. 18:1033-1077.
9. Brookes P.S., Levonen A.L., Shiva S., Sarti P., and Darley-Usmar V.M. (2002). Mitochondria: Regulators of signal transduction by reactive oxygen and nitrogen species. Free Radical Biol. Med. 33:755-764.
10. Brooks J.T., Elvidge G.P., Glenny L., Gleadle J.M., Liu C., Ragoussis J., Smith T.G., Talbot N.P., Winchester L., Maxwell P.H., and Robbins P.A. (2009). Variations within oxygenregulated gene expression in humans. J. Appl. Physiol. 106: 212-220.
11. Camello-Almaraz M.C., Pozo M.J., Murphy M.P., and Camello P.J. (2006). Mitochondrial production of oxidants is necessary for physiological calcium oscillations. J. Cell Physiol. 206: 487-494.
12. Camello C., Camello P.J., Pariente J.A., and Salido G.M. (2000). Effects of antioxidants on calcium signal induced by cholecystokinin in mouse pancreatic acinar cells. J. Physiol. Biochem. 56:173-180.
13. Chouker A., Demetz F., Martignoni A., Smith L., Setzer F., Bauer A., Holzl J., Peter K., Christ F., and Thiel M. (2005). Strenuous physical exercise inhibits granulocyte activation induced by high altitude. J. Appl. Physiol. 98:640-647.
14. Davidson S.M., and Duchen M.R. (2006). Calcium microdomains and oxidative stress. Cell Calcium. 40:561-574.
15. Dosek A., Ohno H., Acs Z., Taylor A.W., and Radak Z. (2007). High altitude and oxidative stress. Respir. Physiol. Neurobiol. 158:128-131.
16. Droge W. (2002). Free radicals in the physiological control of cell function. Physiol. Rev. 82:47-95.
17. Droge W., and Schipper H.M. (2007). Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell. 6:361-370.
18. Feissner R.F., Skalska J., Gaum W.E., and Sheu S.S. (2009). Crosstalk signaling between mitochondrial Ca2+ and ROS. Frontiers Biosci. 14:1197-1218.
19. Fisher-Wellman K., and Bloomer R.J. (2009). Acute exercise and oxidative stress: A 30 year history. Dyn. Med. 8:1.
20. Gonzalez N.C., and Wood J.G. (2001). Leukocyte-endothelial interactions in environmental hypoxia. Adv. Exp. Med. Biol. 502:39-60.
21. Gregoire E., Sorokine-Durm I., Bertho J.M., Jacquet N., Delbos M., Demarquay C., Voisin P., and Roy L. (2006). Follow-up of stable chromosomal aberrations in gamma-ray irradiated nonhuman primates. Int. J. Radiat. Biol. 82:493-502.
22. Grocott M., Montgomery H., and Vercueil A. (2007). Highaltitude physiology and pathophysiology: Implications and relevance for intensive care medicine. Crit. Care 11:203.
23. Guzy R.D., and Schumacker P.T. (2006). Oxygen sensing by mitochondria at complex III: The paradox of increased reactive oxygen species during hypoxia. Exp. Physiol. 91:807-819.
24. Hainsworth R., and Drinkhill M.J. (2007). Cardiovascular adjustments for life at high altitude. Respir. Physiol. Neurobiol. 158:204-211.
25. Hainsworth R., Drinkhill M.J., and Rivera-Chira M. (2007). The autonomic nervous system at high altitude. Clin. Auton. Res. 17:13-19.
26. Halliwell B., and Whiteman M. (2004). Measuring reactive species and oxidative damage in vivo and in cell culture: How should you do it and what do the results mean? Br. J. Pharmacol. 142:231-255.
27. Hong S., Johnson T.A., Farag N.H., Guy H.J., Matthews S.C,. Ziegler M.G., and Mills P.J. (2005). Attenuation of T-lymphocyte demargination and adhesion molecule expression in response to moderate exercise in physically fit individuals. J. Appl. Physiol. 98:1057-1063.
28. Hwang E.S., and Kim G.H. (2007). Biomarkers for oxidative stress status of DNA, lipids, and proteins in vitro and in vivo cancer research. Toxicology. 229:1-10.
29. Joanny P., Steinberg J., Robach P., Richalet J.P., Gortan C., Gardette B., and Jammes Y. (2001). Operation Everest III (Comex'97): The effect of simulated severe hypobaric hypoxia on lipid peroxidation and antioxidant defence systems in human blood at rest and after maximal exercise. Resuscitation. 49:307-314.
30. Karihtala P., and Soini Y. (2007). Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies. APMIS. 115:81-103.
31. Klokker M., Kharazmi A., Galbo H., Bygbjerg I., and Pedersen B.K. (1993). Influence of in vivo hypobaric hypoxia on function of lymphocytes, neutrocytes, natural killer cells, and cytokines. J. Appl. Physiol. 74:1100-1106.
32. Lee B.L., Chua S.C., Ong H.Y., and Ong C.N. (1992). Highperformance liquid chromatographic method for routine determination of vitamins A and E and beta-carotene in plasma. J. Chromatogr. 581:41-47.
33. Lee H.J., Lee M., Kang C.M., Jeoung D., Bae S., Cho C.K., and Lee Y.S. (2007). Identification of possible candidate biomarkers for local or whole body radiation exposure in C57BL/6 mice. Int. J. Radiat. Oncol. Biol. Phys. 69:1272-1281.
34. Levine R.L, Williams J.A., Stadtman E.R., and Shacter E. (1994). Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol. 233:346-357.
35. Li N. (2008). Platelet-lymphocyte cross-talk. J. Leukoc. Biol. 83:1069-1078.
36. M'Bemba-Meka P., Lemieux N., and Chakrabarti S.K. (2005). Role of oxidative stress, mitochondrial membrane potential, and calcium homeostasis in nickel sulfate-induced human lymphocyte death in vitro. Chem. Biol. Interact. 156:69-80.
37. Moller P., Loft S., Lundby C., and Olsen N.V. (2001). Acute hypoxia and hypoxic exercise induce DNA strand breaks and oxidative DNA damage in humans. FASEB J. 15:1181-1186.
38. Murphy M.P. (2009). How mitochondria produce reactive oxygen species. Biochem. J. 417:1-13.
39. Nagaeva O., Bondestam K., Olofsson J., Damber M.G., and Mincheva-Nilsson L. (2002). An optimized technique for separation of human decidual leukocytes for cellular and molecular analyses. Am. J. Reprod. Immunol. 47:203-212.
40. Nicholls D.G. (2005). Mitochondria and calcium signaling. Cell Calcium. 38:311-317.
41. Niess A.M., Hartmann A., Grunert-Fuchs M., Poch B., and Speit G. (1996). DNA damage after exhaustive treadmill running in trained and untrained men. Int. J. Sports Med. 17:397-403.
42. Paglia D.E., and Valentine W.N. (1967). Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 70:158-169.
43. Pietrangelo T., Mariggio M.A., Lorenzon P., Fulle S., Protasi F., Rathbone M., Werstiuk E., and Fano G. (2002). Characterization of specific GTP binding sites in C2C12 mouse skeletal muscle cells. J. Muscle Res. Cell Motil. 23:107-118.
44. Radak Z., Asano K., Fu Y., Nakamura A., Nakamoto H., Ohno H., and Goto S. (1998). The effect of high altitude and caloric restriction on reactive carbonyl derivatives and activity of glutamine synthetase in rat brain. Life Sci. 62:1317-1322.
45. Radak Z., Asano K., Lee K.C., Ohno H., Nakamura A., Nakamoto H., and Goto S. (1997). High altitude training increases reactive carbonyl derivatives but not lipid peroxidation in skeletal muscle of rats. Free Radical Biol. Med. 22:1109-1114.
46. Radak Z., Chung H.Y., and Goto S. (2008a). Systemic adaptation to oxidative challenge induced by regular exercise. Free Radical Biol. Med. 44:153-159.
47. Radak Z., Chung H.Y., Koltai E., Taylor A.W., and Goto S. (2008b). Exercise, oxidative stress and hormesis. Ageing Res. Rev. 7:34-42.
48. Radak Z., Lee K., Choi W., Sunoo S., Kizaki T., Oh-ishi S., Suzuki K., Taniguchi N., Ohno H., and Asano K. (1994). Oxidative stress induced by intermittent exposure at a simulated altitude of 4000m decreases mitochondrial superoxide dismutase content in soleus muscle of rats. Eur. J. Appl. Physiol. Occup. Physiol. 69:392-395.
49. Radak Z., Taylor A.W., Ohno H., and Goto S. (2001). Adaptation to exercise-induced oxidative stress: From muscle to brain. Exerc. Immunol. Rev. 7:90-107.
50. Rice-Evans C., and Miller N.J. (1994). Total antioxidant status in plasma and body fluids. Methods Enzymol. 234:279-293.
51. Serrano J., Encinas J.M., Salas E., Fernandez A.P., Castro-Blanco S., Fernandez-Vizarra P., Bentura M.L., and Rodrigo J. (2003). Hypobaric hypoxia modifies constitutive nitric oxide synthase activity and protein nitration in the rat cerebellum. Brain Res. 976:109-119. (Pubitemid 36588542)
52. Shtemberg A.S., Uzbekov M.G., and Farber Iu. V. (2007). [Certain mechanisms of development of types of body tolerance to acute hypobaric hypoxia]. Izv. Akad. Nauk. Ser. Biol. 444-453.
53. Sinha S., Ray U.S., Tomar O.S., and Singh S.N. (2009). Different adaptation patterns of antioxidant system in natives and sojourners at high altitude. Respir. Physiol.Neurobiol. 167:255-260.
54. Vij A.G., Dutta R., and Satija N.K. (2005). Acclimatization to oxidative stress at high altitude. High Alt. Med. Biol. 6: 301-310.
55. Walsh N.P., and Whitham M. (2006). Exercising in environmental extremes: A greater threat to immune function? Sports Med. 36:941-976.
56. Wang J.S., and Lin C.T. (2010). Systemic hypoxia promotes lymphocyte apoptosis induced by oxidative stress during moderate exercise. Eur. J. Appl. Physiol. 108:371-382.
57. Wilson M.H., Newman S., and Imray C.H. (2009). The cerebral effects of ascent to high altitudes. Lancet Neurol. 8:175-191.
58. Xi Q., Cheranov S.Y., and Jaggar J.H. (2005). Mitochondriaderived reactive oxygen species dilate cerebral arteries by activating Ca2+ sparks. Circ. Res. 97:354-362.
59. Yagi K. (1998). Simple procedure for specific assay of lipid hydroperoxides in serum or plasma. Methods Mol. Biol. 108: 107-110.
60. Zhang Y., Hu Y., and Wang F. (2007). Effects of a 28-day ''living high-training low'' on T-lymphocyte subsets in soccer players. Int. J. Sports Med. 28:354-358.