Gentamicin administration on the stapes footplate causes greater hearing loss and vestibulotoxicity than round window administration in guinea pigs

Hearing Research

Volumn 304, Issue , 2013, Pages 159-166

  King, E B ^a,b   Salt, A N ^c   Kel, G E ^a   Eastwood, H T ^a   O'Leary, S J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b Bionics Institute   (Australia)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENTAMICIN;

ANIMAL EXPERIMENT; ARTICLE; COCHLEA FENESTRA; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG TOXICITY; EVOKED BRAIN STEM AUDITORY RESPONSE; FEMALE; GUINEA PIG; HAIR CELL; HEARING IMPAIRMENT; HISTOPATHOLOGY; INNER EAR; INTRATYMPANIC DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SEMICIRCULAR CANAL; SPIRAL GANGLION; STAPES; STEREOCILIUM; SYMPTOMATOLOGY; UTRICLE; VESTIBULAR FUNCTION; VESTIBULAR TOXICITY; VESTIBULE;

ABR; AUDITORY BRAINSTEM RESPONSES; GADOLINIUM; GD; GPS; GUINEA PIGS; HAIR CELLS; HCS; IHCS; INNER HAIR CELLS; MAGNETIC RESONANCE IMAGING; MRI; OHCS; OUTER HAIR CELLS; OVAL WINDOW (OW); OW; ROUND WINDOW; ROUND WINDOW MEMBRANE; RW; RWM; SCALA TYMPANI; SCALA VESTIBULI; ST; STAPEDIOVESTIBULAR JOINT; SV; SVJ; TMPA; TRIMETHYLPHENYLAMMONIUM;

ANIMALS; ANTI-BACTERIAL AGENTS; COCHLEA; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; FEMALE; GENTAMICINS; GUINEA PIGS; HEARING LOSS; HUMANS; MALE; MENIERE DISEASE; ROUND WINDOW, EAR; STAPES; VESTIBULE, LABYRINTH;

EID: 84882785243     PISSN: 03785955     EISSN: 18785891     Source Type: Journal    
DOI: 10.1016/j.heares.2013.07.013     Document Type: Article

References (43)

1. Alzamil K.S., Linthicum F.H. Extraneous round window membranes and plugs: possible effect on intratympanic therapy. Ann. Otol. Rhinol. Laryngol. 2000, 109:30-32.
2. Clark G. Cochlear Implants Fundamentals & Applications 2003, 71-73. Springer Science+Business Media Inc.
3. Dai C.F., Steyger P.S. Asystemic gentamicin pathway across the stria vascularis. Hear. Res. 2008, 235(1-2):114-124.
4. Desai S.S., Zeh C., Lysakowski A. Comparative morphology of rodent vestibular periphery. I. Saccular and utricular maculae. J.Neurophysiol. 2005, 93:251-266.
5. Franke K. Freeze fracture aspects of the junctional complexes in the round window membrane. Arch. Otolaryngol. Head Neck Surg. 1977, 217:331-337.
6. Govaerts P.J., Claes J., Van De Heyning Ph, Jorens P.H.G., Marquet J., De Broe M.E. Aminoglycoside-induced ototoxicity. Toxicol. Lett. 1990, 52:227-251.
7. Goycoolea M.V., Lundman L. Round window membrane. Structure function and permeability: a review. Microsc. Res. Tech. 1997, 36:201-211.
8. Goycoolea M.V., Muchow D., Schachern P.A. Experimental studies on round window membrane structure function and permeability. Laryngoscope 1998, (Suppl.44):1-20.
9. Hirvonen T.P., Minor L.B., Hullar T.E., Carey J.P. Effects of intratympanic gentamicin on vestibular afferents and hair cells in the chinchilla. J.Neurophysiol. 2005, 93(2):643-655.
10. King E.B., Salt A.N., Eastwood H.T., O'Leary S.J. Direct entry of gadolinium into the vestibule following intratympanic applications in guinea pigs and the influence of cochlear implantation. J.Assoc. Res. Otolaryngol. 2011, 12(6):741-751.
11. Lange G. The intratympanic treatment of Meniere's disease with ototoxic antibiotics. A follow-up study of 55 cases. Laryngol. Rhinol. Otol. 1977, 56:409-414.
12. Li H., Steyger P.S. Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells. Sci. Rep. 2011, 1:159.
13. Lindeman H.H. Regional differences in sensitivity of the vestibular sensory epithelia to ototoxic antibiotics. Acta Otolaryngol (Stockh.) 1969, 67:177-189.
14. Lopez I., Honrubia V., Lee S.C., Schoeman G., Beykirch K. Quantification of the process of hair cell loss and recovery in the chinchilla crista ampullaris after gentamicin treatment. Int. J. Dev. Neurosci. 1997, 15:447-461.
15. Lyford-Pike S., Vogelheim C., Chu E., Della Santina C.C., Carey J.P. Gentamicin is primarily localized in vestibular type I hair cells after intratympanic administration. J.Assoc. Res. Otolaryngol. 2007, 8:497-508.
16. Merchant S.N. Amethod for quantitative assessment of vestibular otopathology. Laryngoscope 1999, 109:1560-1569.
17. Merchant S.N., Nadol J.B. Schuknecht's Pathology of the Ear 2010, 44-47. People's Medical Publishing House, USA. third ed.
18. Mikulec A.A., Plontke S.K., Hartsock J.J., Salt A.N. Entry of substances into perilymph through the bone of the otic capsule after intratympanic applications in guinea pigs: implications for local drug delivery in humans. Otol. Neurotol. 2009, 30:131-138.
19. Nakagawa T., Yamane H., Shibata S., Nakia Y. Gentamicin ototoxicity induced apoptosis of the vestibular hair cells of guinea pigs. Eur. Arch. Otorhinolaryngol. 1997, 254:9-14.
20. Nakagawa T., Yamane H., Takayama M., Sunami K., Nakai Y. Apoptosis of guinea pig cochlear hair cells following chronic aminoglycoside treatment. Eur. Arch. Otorhinolaryngol. Suppl. 1998, 538:32-35.
21. Ohashi M., Sawaguchi A., Ide S., Kimitsuki T., Komune S., Suganuma T. Histochemical characterization of the rat ossicular joint cartilage with a special reference to stapediovestibular joint. Acta Histochem. Cytochem. 2005, 38(6):387-392.
22. Ohashi M., Idc S., Kimitsuki T., Komune S., Suganuma T. Three-dimensional regular arrangement of the annular ligament of the rat stapediovestibular joint. Hear. Res. 2006, 213:11-16.
23. Okumura A., Iwai-Liao Y. Developmental anatomy of the mouse stapediovestibular and temporomandibular joints. Okajimas Folia Anat. Jpn. 1993, 69:385-400.
24. Plontke S.K.R., Wood A.W.W., Salt A.N. Analysis of gentamicin kinetics in fluids of the inner ear with round window administration. Otol. Neurotol. 2002, 23:67-974.
25. Plontke S.K.R., Mynatt R., Gill R.M., Salt A.N. Concentration gradient along scala tympani following the local application of gentamicin to the round window membrane. Laryngoscope 2007, 117:1191-1198.
26. Plontke S.K. Evaluation of the round window niche before local drug delivery to the inner ear using a new mini-otoscope. Otol. Neurotol. 2011, 32:183-185.
27. Quaranta A., Aloisi A., De Benedittis G., Scaringi A. Intratympanic therapy for Ménière's disease. High-concentration gentamicin with round-window protection. Ann. N. Y. Acad. Sci. 1999, 884:410-424.
28. Saijo S., Kimura R.S. Distribution of HRP in the inner ear after injection into the middle ear cavity. Acta Otolaryngol. 1984, 97:593-610.
29. Salt A.N., Ohyama K., Thalmann R. Radial communication between the perilymphatic scalae of the cochlea. II: estimation by bolus injection of tracer into the sealed cochlea. Hear. Res. 1991, 56(1-2):37-43.
30. Salt A.N., Ma Y. Quantification of solute entry into cochlear perilymph through the round window membrane. Hear. Res. 2001, 154:88-97.
31. Salt A.N., Kellner C., Hale S. Contamination of perilymph sampled from the basal cochlear turn with cerebrospinal fluid. Hear. Res. 2003, 182:24-33.
32. Salt A.N., Gill R.M., Plontke S.K. Dependence of hearing changes on the dose of intratympanically applied gentamicin: a meta-analysis using mathematical simulations of clinical drug delivery protocols. Laryngoscope 2008, 118(10):1793-1800.
33. Salt A.N., King E.B., Hartsock J.J., Gill R.M., O'Leary S.J. Marker entry into vestibular perilymph via the stapes following applications to the round window niche of guinea pigs. Hear. Res. 2012, 283(1-2):14-23.
34. Schachern P.A., Paparella M.M., Duvall A.J., Choo Y.B. The human round window membrane. An electron microscopic study. Arch. Otolaryngol. 1984, 110:15-21.
35. Shepherd R.K., Colreavy M.P. Surface microstructure of the perilymphatic space: implications for cochlear implants and cell- or drug-based therapies. Arch. Otolaryngol. Head Neck Surg. 2004, 130(5):518-523.
36. Silverstein H., Arruda J., Rosenberg S., Deems D., Hester O. Direct round window membrane application of gentamicin in the treatment of Meniere's disease. Otolaryngol. Head Neck Surg. 1999, 120:649-655.
37. Tanaka K., Motomura S. Permeability of the labyrinthine windows in guinea pigs. Arch. Otorhinolaryngol. 1981, 233:67-73.
38. Tanyeri H., Lopez I., Honrubia V. Histological evidence for hair cell regeneration after ototoxic cell destruction with local application of gentamicin in the chinchilla crista ampullaris. Hear. Res. 1995, 89:194-202.
39. Tsuji K., Velázquez-Villaseñor L., Rauch S.D., Glynn R.J., Wall C., Merchant S.N. Temporal bone studies of the human peripheral vestibular system, aminoglycoside ototoxicity. Ann. Otol. Rhinol. Laryngol. Suppl. 2000, 181:20-25.
40. Wang Q., Steyger P.S. Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells. J.Assoc. Res. Otolaryngol. 2009, 10(2):205-219.
41. Wang Q., Kachelmeier A., Steyger P.S. Competitive antagonism of fluorescent gentamicin uptake in the cochlea. Hear. Res. 2010, 268(1-2):250-259.
42. Zou J., Pyykkö I., Bjelke B., Dastidar P., Toppila E. Communication between the perilymphatic scalae and spiral ligament visualized by invivo MRI. Audiol. Neurotol. 2005, 10:145-152.
43. Zou J., Poe D., Ramadan U.A., Pyykkö I. Oval window transport of Gd-DOTA from rat middle ear to vestibulum and scala vestibuli visualized by invivo magnetic resonance imaging. Ann. Otol. Rhinol. Laryngol. 2012, 121(2):119-128.