Entry of substances into perilymph through the bone of the otic capsule after intratympanic applications in guinea pigs: Implications for local drug delivery in humans

Otology and Neurotology

Volumn 30, Issue 2, 2009, Pages 131-138

  Mikulec, Anthony A ^a   Plontke, Stefan K ^b   Hartsock, Jared J ^c   Salt, Alec N ^c  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cochlea; Intratympanic drug delivery; Round window membrane

Indexed keywords

GENTAMICIN; PHENYLTRIMETHYLAMMONIUM; ANTIINFECTIVE AGENT; DRUG; QUATERNARY AMMONIUM DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; COCHLEA; COCHLEA FENESTRA; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; EXPERIMENTAL MODEL; FEMALE; GUINEA PIG; INTRATYMPANIC DRUG ADMINISTRATION; ION SELECTIVE ELECTRODE; MALE; MIDDLE EAR; NONHUMAN; OTIC CAPSULE; PERILYMPH; PRIORITY JOURNAL; ANIMAL; BONE; EARDRUM; METABOLISM; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-BACTERIAL AGENTS; BONE AND BONES; COCHLEA; EAR, MIDDLE; FEMALE; GENTAMICINS; GUINEA PIGS; MALE; PERILYMPH; PHARMACEUTICAL PREPARATIONS; QUATERNARY AMMONIUM COMPOUNDS; ROUND WINDOW, EAR; TYMPANIC MEMBRANE;

EID: 64549084550     PISSN: 15317129     EISSN: 15374505     Source Type: Journal    
DOI: 10.1097/MAO.0b013e318191bff8     Document Type: Article

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