Development and application of simple pharmacokinetic models to study human exposure to di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP)

Environment International

Volumn 59, Issue , 2013, Pages 469-477

  Lorber, Matthew ^a   Koch, Holger M ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

DiBP; DnBP; Exposure modeling; Phthalates; PK modeling

Indexed keywords

BIOMOLECULES; BLOOD; EXPERIMENTS; METABOLITES; PHARMACOKINETICS; POTASSIUM COMPOUNDS;

DEVELOPMENT AND APPLICATIONS; DIBP; DNBP; EXPOSURE MODELING; METABOLITE CONCENTRATIONS; PHARMACOKINETIC MODEL; PHTHALATE METABOLITES; PHTHALATES;

ESTERS;

CARBOXY MONOPROPYLPHTHALATE; DIISOBUTYL PHTHALIC ACID; PHTHALIC ACID DERIVATIVE; PHTHALIC ACID DIBUTYL ESTER; UNCLASSIFIED DRUG;

BLOOD; CONCENTRATION (COMPOSITION); METABOLITE; PHTHALATE; URINE;

ADULT; ARTICLE; BLOOD LEVEL; CALIBRATION; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; DRUG USE; ENVIRONMENTAL EXPOSURE; HUMAN; MALE; METABOLITE; MICTURITION; PERSONAL HYGIENE; PHARMACOKINETIC MODEL; PREDICTIVE VALIDITY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS MODEL; URINALYSIS; URINE LEVEL;

2OH-MIBP; 2OH-MONO-ISO-BUTYL PHTHALATE; 3CARBOXY-MONO-PROPYLPHTHALATE; 3OH-MIBP; 3OH-MNBP; 3OH-MONO-ISO-BUTYL PHTHALATE; 3OH-MONO-N-BUTYL PHTHALATE; 4OH-MNBP; 4OH-MONO-N-BUTYLPHTHALATE; AGD; ANOGENITAL DISTANCE; DEHP; DI-2-ETHYLHEXYL PHTHALATE; DI-N-BUTYL PHTHALATE; DIBP; DIISOBUTYL PHTHALATE; DNBP; ENVIRONMENTAL PROTECTION AGENCY; EPA; EU; EUROPEAN UNION; EXPOSURE MODELING; F; FIRST-ORDER REMOVAL RATE USED IN PK MODEL; FRACTION PARAMETERS USED IN PK MODEL; K; MCPP; MIBP; MNBP; MONO-ISOBUTYLPHTHALATE; MONO-N-BUTYLPHTHALATE; PHARMACOKINETIC; PHTHALATES; PK; PK MODELING; REFERENCE DOSE; RFD; TDI; TOLERABLE DAILY INTAKE; VD; VOLUME OF DISTRIBUTION;

ADULT; DIBUTYL PHTHALATE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; HUMANS; MALE; MODELS, BIOLOGICAL;

EID: 84882749791     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2013.07.010     Document Type: Article

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