Identification and Characterization of MicroRNAs by High Through-Put Sequencing in Mesenchymal Stem Cells and Bone Tissue from Mice of Age-Related Osteoporosis

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  He, Xiaoning ^a,b   Zhang, Wenkai ^a,b   Liao, Li ^a,b   Fu, Xin ^a,b   Yu, Qing ^a   Jin, Yan ^a,b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b Engineering Technology Center for Tissue Engineering of Xi'an   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 6; HISTONE DEACETYLASE 6; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; MICRORNA; MICRORNA 10B; MICRORNA 210; MICRORNA 22; MICRORNA 31; PROTEIN BCL 6; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SIRTUIN 1; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR SP1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE TISSUE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; GENE CONTROL; GENE TARGETING; HIGH THROUGHPUT SEQUENCING; MALE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSTEOPOROSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; STEADY STATE; UPREGULATION;

AGE FACTORS; ANIMALS; BONE AND BONES; BONE MARROW CELLS; CELLS, CULTURED; GENE EXPRESSION PROFILING; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; MALE; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; MICRORNAS; OSTEOGENESIS; OSTEOPOROSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84882682833     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071895     Document Type: Article

References (63)

1. Pietschmann P, Rauner M, Sipos W, Kerschan-Schindl K, (2009) Osteoporosis: an age-related and gender-specific disease-a mini-review. Gerontology 55: 3-12.
2. Sambrook P, Cooper C, (2006) Osteoporosis. Lancet 367: 2010-2018.
3. Cummings SR, Melton LJ, (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359: 1761-1767.
4. Wagner W, Ho AD, Zenke M, (2010) Different facets of aging in human mesenchymal stem cells. Tissue Eng Part B Rev 16: 445-453.
5. Wagner W, Horn P, Castoldi M, Diehlmann A, Bork S, et al. (2008) Replicative senescence of mesenchymal stem cells: a continuous and organized process. PLoS One 3: e2213.
6. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, et al. (2002) Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418: 41-49.
7. Marion NW, Mao JJ, (2006) Mesenchymal stem cells and tissue engineering. Methods Enzymol 420: 339-361.
8. Lakshmipathy U, Hart RP, (2008) Concise review: MicroRNA expression in multipotent mesenchymal stromal cells. Stem Cells 26: 356-363.
9. Rossi DJ, Jamieson CH, Weissman IL, (2008) Stems cells and the pathways to aging and cancer. Cell 132: 681-696.
10. Stolzing A, Jones E, McGonagle D, Scutt A, (2008) Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mech Ageing Dev 129: 163-173.
11. Abdallah BM, Haack-Sorensen M, Fink T, Kassem M, (2006) Inhibition of osteoblast differentiation but not adipocyte differentiation of mesenchymal stem cells by sera obtained from aged females. Bone 39: 181-188.
12. Fehrer C, Lepperdinger G, (2005) Mesenchymal stem cell aging. Exp Gerontol 40: 926-930.
13. Rando TA, (2006) Stem cells, ageing and the quest for immortality. Nature 441: 1080-1086.
14. Sethe S, Scutt A, Stolzing A, (2006) Aging of mesenchymal stem cells. Ageing Res Rev 5: 91-116.
15. Kasper G, Mao L, Geissler S, Draycheva A, Trippens J, et al. (2009) Insights into mesenchymal stem cell aging: involvement of antioxidant defense and actin cytoskeleton. Stem Cells 27: 1288-1297.
16. Dhahbi JM, Atamna H, Boffelli D, Magis W, Spindler SR, et al. (2011) Deep sequencing reveals novel microRNAs and regulation of microRNA expression during cell senescence. PLoS One 6: e20509.
17. Chen LH, Chiou GY, Chen YW, Li HY, Chiou SH, (2010) MicroRNA and aging: a novel modulator in regulating the aging network. Ageing Res Rev 9Suppl 1: S59-66.
18. Inukai S, de Lencastre A, Turner M, Slack F, (2012) Novel microRNAs differentially expressed during aging in the mouse brain. PLoS One 7: e40028.
19. Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, et al. (2012) Role of MicroRNA Processing in Adipose Tissue in Stress Defense and Longevity. Cell Metab 16: 336-347.
20. (2003) Prevention and management of osteoporosis. World Health Organ Tech Rep Ser 921: 1-164, back cover.
21. Okamoto H, Matsumi Y, Hoshikawa Y, Takubo K, Ryoke K, et al. (2012) Involvement of microRNAs in regulation of osteoblastic differentiation in mouse induced pluripotent stem cells. PLoS One 7: e43800.
22. Lin RJ, Lin YC, Yu AL, (2010) miR-149* induces apoptosis by inhibiting Akt1 and E2F1 in human cancer cells. Mol Carcinog 49: 719-727.
23. Ugalde AP, Espanol Y, Lopez-Otin C, (2011) Micromanaging aging with miRNAs: new messages from the nuclear envelope. Nucleus 2: 549-555.
24. Park S, Kang S, Min KH, Woo Hwang K, Min H (2012) Age-Associated Changes in MicroRNA Expression in Bone Marrow Derived Dendritic Cells. Immunol Invest.
25. Pan C, Chen H, Wang L, Yang S, Fu H, et al. (2012) Down-regulation of MiR-127 facilitates hepatocyte proliferation during rat liver regeneration. PLoS One 7: e39151.
26. Vasa-Nicotera M, Chen H, Tucci P, Yang AL, Saintigny G, et al. (2011) miR-146a is modulated in human endothelial cell with aging. Atherosclerosis 217: 326-330.
27. Wang Y, Scheiber MN, Neumann C, Calin GA, Zhou D, (2011) MicroRNA regulation of ionizing radiation-induced premature senescence. Int J Radiat Oncol Biol Phys 81: 839-848.
28. Liu W, Liu C, Zhu J, Shu P, Yin B, et al. (2012) MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice. Neurobiol Aging 33: 522-534.
29. Mizuno Y, Tokuzawa Y, Ninomiya Y, Yagi K, Yatsuka-Kanesaki Y, et al. (2009) miR-210 promotes osteoblastic differentiation through inhibition of AcvR1b. FEBS Lett 583: 2263-2268.
30. Faraonio R, Salerno P, Passaro F, Sedia C, Iaccio A, et al. (2012) A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts. Cell Death Differ 19: 713-721.
31. Xu D, Takeshita F, Hino Y, Fukunaga S, Kudo Y, et al. (2011) miR-22 represses cancer progression by inducing cellular senescence. J Cell Biol 193: 409-424.
32. Huang S, Wang S, Bian C, Yang Z, Zhou H, et al. (2012) Upregulation of miR-22 promotes osteogenic differentiation and inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells by repressing HDAC6 protein expression. Stem Cells Dev 21: 2531-2540.
33. Xu RS, Wu XD, Zhang SQ, Li CF, Yang L, et al. (2013) The tumor suppressor gene RhoBTB1 is a novel target of miR-31 in human colon cancer. Int J Oncol 42: 676-682.
34. Hamrick MW, Herberg S, Arounleut P, He HZ, Shiver A, et al. (2010) The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice. Biochem Biophys Res Commun 400: 379-383.
35. Kahai S, Lee SC, Lee DY, Yang J, Li M, et al. (2009) MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7. PLoS One 4: e7535.
36. Sun F, Wang J, Pan Q, Yu Y, Zhang Y, et al. (2009) Characterization of function and regulation of miR-24-1 and miR-31. Biochem Biophys Res Commun 380: 660-665.
37. Guo L, Zhao RC, Wu Y, (2011) The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells. Exp Hematol 39: 608-616.
38. Chen X, Li Q, Wang J, Guo X, Jiang X, et al. (2009) Identification and characterization of novel amphioxus microRNAs by Solexa sequencing. Genome Biol 10: R78.
39. Chen X, Ba Y, Ma L, Cai X, Yin Y, et al. (2008) Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18: 997-1006.
40. Roura S, Farre J, Soler-Botija C, Llach A, Hove-Madsen L, et al. (2006) Effect of aging on the pluripotential capacity of human CD105+ mesenchymal stem cells. Eur J Heart Fail 8: 555-563.
41. Wilson A, Shehadeh LA, Yu H, Webster KA, (2010) Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells. BMC Genomics 11: 229.
42. Taipaleenmaki H, Bjerre Hokland L, Chen L, Kauppinen S, Kassem M, (2012) Mechanisms in endocrinology: micro-RNAs: targets for enhancing osteoblast differentiation and bone formation. Eur J Endocrinol 166: 359-371.
43. Gao J, Yang T, Han J, Yan K, Qiu X, et al. (2011) MicroRNA expression during osteogenic differentiation of human multipotent mesenchymal stromal cells from bone marrow. J Cell Biochem 112: 1844-1856.
44. Schoolmeesters A, Eklund T, Leake D, Vermeulen A, Smith Q, et al (2009) Functional profiling reveals critical role for miRNA in differentiation of human mesenchymal stem cells. PLoS One 4: e5605.
45. Izzotti A, Calin GA, Steele VE, Croce CM, De Flora S, (2009) Relationships of microRNA expression in mouse lung with age and exposure to cigarette smoke and light. FASEB J 23: 3243-3250.
46. Lafferty-Whyte K, Cairney CJ, Jamieson NB, Oien KA, Keith WN, (2009) Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms. Biochim Biophys Acta 1792: 341-352.
47. He L, He X, Lim LP, de Stanchina E, Xuan Z, et al. (2007) A microRNA component of the p53 tumour suppressor network. Nature 447: 1130-1134.
48. Tazawa H, Tsuchiya N, Izumiya M, Nakagama H, (2007) Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci U S A 104: 15472-15477.
49. Yang X, Feng M, Jiang X, Wu Z, Li Z, et al. (2009) miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev 23: 2388-2393.
50. Xiao J, Lin H, Luo X, Wang Z, (2011) miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress. EMBO J 30: 524-532.
51. Hackl M, Brunner S, Fortschegger K, Schreiner C, Micutkova L, et al. (2010) miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging. Aging Cell 9: 291-296.
52. Mizoguchi F, Izu Y, Hayata T, Hemmi H, Nakashima K, et al. (2010) Osteoclast-specific Dicer gene deficiency suppresses osteoclastic bone resorption. J Cell Biochem 109: 866-875.
53. Gaur T, Hussain S, Mudhasani R, Parulkar I, Colby JL, et al. (2010) Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse. Dev Biol 340: 10-21.
54. Lian JB, Stein GS, van Wijnen AJ, Stein JL, Hassan MQ, et al. (2012) MicroRNA control of bone formation and homeostasis. Nat Rev Endocrinol 8: 212-227.
55. Filipowicz W, Bhattacharyya SN, Sonenberg N, (2008) Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 9: 102-114.
56. Wang X, Guo B, Li Q, Peng J, Yang Z, et al. (2013) miR-214 targets ATF4 to inhibit bone formation. Nat Med 19: 93-100.
57. Lynam-Lennon N, Reynolds JV, Marignol L, Sheils OM, Pidgeon GP, et al. (2012) MicroRNA-31 modulates tumour sensitivity to radiation in oesophageal adenocarcinoma. J Mol Med (Berl).
58. Goff LA, Boucher S, Ricupero CL, Fenstermacher S, Swerdel M, et al. (2008) Differentiating human multipotent mesenchymal stromal cells regulate microRNAs: prediction of microRNA regulation by PDGF during osteogenesis. Exp Hematol 36: 1354-1369.
59. Rokah OH, Granot G, Ovcharenko A, Modai S, Pasmanik-Chor M, et al. (2012) Downregulation of miR-31, miR-155, and miR-564 in chronic myeloid leukemia cells. PLoS One 7: e35501.
60. Hay E, Laplantine E, Geoffroy V, Frain M, Kohler T, et al. (2009) N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation. Mol Cell Biol 29: 953-964.
61. DeCarolis NA, Wharton KA Jr, Eisch AJ, (2008) Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging. Bioessays 30: 102-106.
62. Levine AJ, Oren M, (2009) The first 30 years of p53: growing ever more complex. Nat Rev Cancer 9: 749-758.
63. Wang X, Kua HY, Hu Y, Guo K, Zeng Q, et al. (2006) p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J Cell Biol 172: 115-125.