The influence of hyperglycemia on the therapeutic effect of exercise on glycemic control in patients with type 2 diabetes mellitus

JAMA Internal Medicine

Volumn 173, Issue 19, 2013, Pages 1834-1836

  Solomon, Thomas P J ^a,b   Malin, Steven K ^c   Karstoft, Kristian ^a,b   Haus, Jacob M ^d   Kirwan, John P ^c,e  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c LERNER RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^e Endocrinology and Metabolism Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C;

ADULT; AEROBIC EXERCISE; BODY COMPOSITION; BODY MASS; BODY WEIGHT; CELL FUNCTION; EXERCISE; FEMALE; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; LETTER; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; EXERCISE; FEMALE; HUMANS; HYPERGLYCEMIA; MALE; MIDDLE AGED; TREATMENT OUTCOME;

EID: 84882663659     PISSN: 21686106     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamainternmed.2013.7783     Document Type: Letter

References (8)

1. Church TS, Blair SN, Cocreham S, et al. Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial. JAMA. 2010;304(20): 2253-2262.
2. Boulé NG, Weisnagel SJ, Lakka TA, et al; HERITAGE Family Study. Effects of exercise training on glucose homeostasis: the HERITAGE Family Study. Diabetes Care. 2005;28(1): 108-114.
3. Ruchat SM, Rankinen T, Weisnagel SJ, et al. Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study. Diabetologia. 2010;53(4): 679-689.
4. Malin SK, Kirwan JP. Fasting hyperglycaemia blunts the reversal of impaired glucose tolerance after exercise training in obese older adults. Diabetes Obes Metab. 2012;14(9): 835-841.
5. Dela F, von Linstow ME, Mikines KJ, Galbo H. Physical training may enhance beta-cell function in type 2 diabetes. Am J Physiol Endocrinol Metab. 2004;287(5): 1024-1031.
6. Gregg EW, Chen H, Wagenknecht LE, et al; Look AHEAD Research Group. Association of an intensive lifestyle intervention with remission of type 2 diabetes. JAMA. 2012;308(23): 2489-2496.
7. Burns N, Finucane FM, Hatunic M, et al. Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training. Diabetologia. 2007;50(7): 1500-1508.
8. Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321(7258): 405-412.