Loss of cytoplasmic KLF4 expression is correlated with the progression and poor prognosis of nasopharyngeal carcinoma

Histopathology

Volumn 63, Issue 3, 2013, Pages 362-370

  Liu, Zhen ^a,b   Yang, Huiling ^b,c   Luo, Weiren ^b,c   Jiang, Qingping ^a,b   Mai, Chunping ^b   Chen, Yan ^b   Zhen, Yan ^b   Yu, Xiaoli ^b   Long, Xiaobin ^b,d   Fang, Weiyi ^b  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c GUANGDONG MEDICAL UNIVERSITY   (China)

^d SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

KLF4; Nasopharyngeal carcinoma; Prognosis

Indexed keywords

KRUPPEL LIKE FACTOR 4; MESSENGER RNA; PROTEIN;

ARTICLE; CANCER PROGNOSIS; CANCER TISSUE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NASOPHARYNX CARCINOMA; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SQUAMOUS EPITHELIUM;

KLF4; NASOPHARYNGEAL CARCINOMA; PROGNOSIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CYTOPLASM; DISEASE PROGRESSION; DOWN-REGULATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84882648950     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/his.12176     Document Type: Article

References (21)

1. Luo WR, Wu AB, Fang WY et al. Nuclear expression of N-cadherin correlates with poor prognosis of nasopharyngeal carcinoma. Histopathology 2012; 61; 237-246.
2. Wang S, Fang W. Increased expression of hepatoma-derived growth factor correlates with poor prognosis in human nasopharyngeal carcinoma. Histopathology 2011; 58; 217-224.
3. Liu Z, Li X, He X et al. Decreased expression of updated NESG1 in nasopharyngeal carcinoma: its potential role and preliminarily functional mechanism. Int. J. Cancer 2011; 128; 2562-2571.
4. Alajez NM, Shi W, Hui AB et al. Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98. Cell Death Dis. 2010; 21; e85.
5. Fang W, Li X, Jiang Q et al. Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China. J. Transl. Med. 2008; 6; 32.
6. Tiwari N, Meyer-Schaller N, Arnold P et al. Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8). PLoS ONE 2013; 8; e57329.
7. Zhou Y, Hofstetter WL, He Y et al. KLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression. Cancer Biol. Ther. 2010; 9; 507-513.
8. Leng Z, Tao K, Xia Q et al. Krüppel-like factor 4 acts as an oncogene in colon cancer stem cell-enriched spheroid cells. PLoS ONE 2013; 8; e56082.
9. Yenamandra SP, Darekar SD, Kashuba V et al. Stem cell gene expression in MRPS18-2-immortalized rat embryonic fibroblasts. Cell Death Dis. 2012; 3; e357.
10. Drews K, Jozefczuk J, Prigione A et al. Human induced pluripotent stem cells from mechanisms to clinical applications. J. Mol. Med. (Berl.) 2012; 90; 735-745.
11. Yu F, Li J, Chen H et al. Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion. Oncogene 2011; 30; 2161-2172.
12. Li J, Zheng H, Yu F et al. Deficiency of the Kruppel-like factor KLF4 correlates with increased cell proliferation and enhanced skin tumorigenesis. Carcinogenesis 2012; 33; 1239-1246.
13. Hu R, Zuo Y, Zuo L et al. KLF4 expression correlates with the degree of differentiation in colorectal cancer. Gut Liver 2011; 5; 154-159.
14. Zammarchi F, Morelli M, Menicagli M et al. KLF4 is a novel candidate tumor suppressor gene in pancreatic ductal carcinoma. Am. J. Pathol. 2011; 178; 361-372.
15. Liu Y, Zhang C, Fan J et al. Comprehensive analysis of clinical significance of stem-cell related factors in renal cell cancer. World J. Surg. Oncol. 2011; 9; 121.
16. Hu W, Hofstetter WL, Li H et al. Putative tumor-suppressive function of Kruppel-like factor 4 in primary lung carcinoma. Clin. Cancer Res. 2009; 15; 5688-5695.
17. Yang WT, Zheng PS. Krüppel-like factor 4 functions as a tumor suppressor in cervical carcinoma. Cancer 2012; 118; 3691-3702.
18. Nagata T, Shimada Y, Sekine S et al. Prognostic significance of NANOG and KLF4 for breast cancer. Breast Cancer 2012. [Epub ahead of print].
19. Tai SK, Yang MH, Chang SY et al. Persistent Krüppel-like factor 4 expression predicts progression and poor prognosis of head and neck squamous cell carcinoma. Cancer Sci. 2011; 102; 895-902.
20. Yang Y, Goldstein BG, Chao HH et al. KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cells. Cancer Biol. Ther. 2005; 4; 1216-1221.
21. Ohnishi S, Ohnami S, Laub F et al. Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer. Biochem. Biophys. Res. Commun. 2003; 308; 251-256.