P38 MAP kinase inhibitor reverses stress-induced myocardial dysfunction in vivo

Journal of Applied Physiology

Volumn 106, Issue 4, 2009, Pages 1132-1141

  Chen, Fangping ^a   Kan, Hong ^a   Hobbs, Gerry ^b   Finkel, Mitchell S ^a,b,c  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Emotional stress; Heart failure; Hemodynamics

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ISOPRENALINE; MITOGEN ACTIVATED PROTEIN KINASE P38; TROPONIN I; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; TROPOMYOSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ECHOCARDIOGRAPHY; FEMALE; HEART FUNCTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; IN VIVO STUDY; INOTROPISM; MALE; MATERNAL STRESS; MYOCARDIAL DISEASE; NONHUMAN; PRENATAL STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SYSTOLIC BLOOD PRESSURE; ANESTHESIA; ANIMAL; CARDIOMYOPATHY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ELECTROCARDIOGRAPHY; EXERCISE; HEMODYNAMICS; IMMUNOPRECIPITATION; MENTAL STRESS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PREGNANCY; PRENATAL EXPOSURE; SPRAGUE DAWLEY RAT;

ADRENERGIC BETA-AGONISTS; ANESTHESIA; ANIMALS; CARDIOMYOPATHIES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; ENZYME INHIBITORS; FEMALE; HEMODYNAMICS; IMIDAZOLES; IMMUNOPRECIPITATION; ISOPROTERENOL; MALE; MYOCYTES, CARDIAC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RESTRAINT, PHYSICAL; STRESS, PSYCHOLOGICAL; TROPOMYOSIN;

EID: 66149091100     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.90542.2008     Document Type: Article

References (47)

1. 1- and beta-adrenoceptor stimulation differentially activate p38-MAPK and atrial natriuretic peptide production in the perfused amphibian heart. J Exp Biol 205: 2387-2397, 2002.
2. Bacon SL, Sherwood A, Hinderliter AL, Coleman RE, Waugh R, Blumenthal JA. Changes in plasma volume associated with mental stress ischemia in patients with coronary artery disease. Int J Psychophysiol 61: 143-148, 2006. (Pubitemid 43947285)
3. Ballard-Croft C, Locklar AC, Keith BJ, Mentzer RM Jr, Lasley RD. Oxidative stress and adenosine A1 receptor activation differentially modulate subcellular cardiomyocyte MAPKs. Am J Physiol Heart Circ Physiol 294: H263-H271, 2008.
4. Börsch-Haubold AG, Pasquet S, Watson SP. Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase. J Biol Chem 273: 28766-28772, 1998.
5. Chen Y, Rajashree R, Liu Q, Hoffman P. Acute p38 MAPK activation decreases force development in ventricular myocytes. Am J Physiol Heart Circ Physiol 285: H2578-H2586, 2003. (Pubitemid 37443076)
6. Clinton S, Miller S, Watson SJ, Akil H. Prenatal stress does not alter innate novelty-seeking behavioral traits, but differentially affects individual differences in neuroendocrine stress responsivity. Psychoneuroendocrinology 33: 162-177, 2008.
7. Coplan JD, Andrews MW, Rosenblum LA, Owens MJ, Friedman S, Gorman JM, Nemeroff CB. Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders. Proc Natl Acad Sci USA 93: 1619-1623, 1996. (Pubitemid 26075175)
8. Cratty MS, Ward HE, Johnson EA, Azzaro AJ, Birkle DL. Prenatal stress increases corticotropin-releasing factor (CRF) content and release in rat amygdala minces. Brain Res 675: 297-302, 1995.
9. Derian W, Soundarraj D, Rosenberg MJ. Stress-induced cardiomyopathy: not always apical ballooning. Rev Cardiovasc Med 8: 228-233, 2007.
10. Ellison GM, Torella D, Karakikes I, Purushothaman S, Curcio A, Gasparri C, Indolfi C, Cable NT, Goldspink DF, Nadal-Ginard B. Acute β-adrenergic overload produces myocyte damage through calcium leakage from the ryanodine receptor 2 but spares cardiac stem cells. J Biol Chem 282: 11397-11409, 2007. (Pubitemid 47100807)
11. Fride E, Dan Y, Feldon J, Halevy G, Weinstock M. Effects of prenatal stress on vulnerability to stress in prepubertal and adult rats. Physiol Behav 37: 681-687, 1986. (Pubitemid 16049470)
12. Fride E, Weinstock M. Prenatal stress increases anxiety-related behavior and alters cerebral lateralization of dopamine activity. Life Sci 42: 1059-1065, 1988. (Pubitemid 18056843)
13. Hall-Jackson CA, Goedert M, Hedge P, Cohen P. Effect of SB 203580 on the activity of c-Raf in vitro and in vivo. Oncogene 18: 2047-2054, 1999. (Pubitemid 29178573)
14. Johnson G, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298: 1911-1912, 2002.
15. Joyeux M, Boumendjel A, Carroll R, Ribuot C, Godin-Ribuot D, Yellon DM. SB 203580, a mitogen-activated protein kinase inhibitor, abolishes resistance to myocardial infarction induced by heat stress. Cardiovasc Drugs Ther 14: 337-343, 2000. (Pubitemid 30447236)
16. Kan H, Birkle D, Jain AC, Failinger C, Xie S, Finkel MS. p38 MAP kinase inhibitor reverses stress-induced cardiac myocyte dysfunction. J Appl Physiol 98: 77-82, 2005. (Pubitemid 40041232)
17. Kan H, Finkel MS. Inflammatory mediators and reversible myocardial dysfunction. J Cell Physiol 195: 1-11, 2003. (Pubitemid 36297022)
18. Kan H, Xie Z, Finkel MS. iPLA2 inhibitor blocks negative inotropic effect of HIV gp120 on cardiac myocytes. J Mol Cell Cardiol 40: 131-137, 2006. (Pubitemid 43012124)
19. Kellogg AP, Converso K, Wiggin TD, Stevens MJ, Pop-Busui R. Effects of cyclooxygenase-2 gene inactivation on cardiac autonomic and left ventricular function in experimental diabetes. Am J Physiol Heart Circ Physiol 296: H453-H461, 2009.
20. Khanna D, Kan H, Failinger C, Jain AC, Finkel MS. Emotional stress and reversible myocardial dysfunction. Cardiovasc Toxicol 6: 183-198, 2006. (Pubitemid 46398615)
21. Khanna D, Kan H, Fang Q, Xie Z, Underwood BL, Jain AC, Williams HJ, Finkel MS. Inducible nitric oxide synthase attenuates adrenergic signaling in alcohol fed rats. J Cardiovasc Pharmacol 50: 692-696, 2007. (Pubitemid 350307040)
22. Kurisu S, Sato H, Kawagoe T, Ishihara M, Shimatani Y, Nishioka K, Kono Y, Umemura T, Nakamura S. Tako-tsubo-like left ventricular dysfunction with ST-segment elevation: a novel cardiac syndrome mimicking acute myocardial infarction. Am Heart J 143: 448-455, 2002. (Pubitemid 34185175)
23. Lee YP, Poh KK, Lee CH, Tan HC, Razak A, Chia BL, Low AF. Diverse clinical spectrum of stress-induced cardiomyopathy. Int J Cardiol (January 10, 2008); doi:10.1016/j.ijcard.2007.11.039.
24. Liao P, Georgakopoulos D, Kovacs A, Zheng M, Lerner D, Pu H, Saffitz J, Chien K, Xiao RP, Kass DA, Wang Y. The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Proc Natl Acad Sci USA 98: 12283-12288, 2001. (Pubitemid 32959865)
25. Liao P, Wang SQ, Wang S, Zheng M, Zheng M, Zhang SJ, Cheng H, Wang Y, Xiao RP. p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes. Circ Res 90: 190-196, 2002. (Pubitemid 34627088)
26. Meijer A. Child psychiatric sequelae of maternal war stress. Acta Psychiatr Scand 72: 505-511, 1985.
27. Murata J, Matsukawa K, Shimizu J, Matsumoto M, Wada T, Ninomiya I. Effects of mental stress on cardiac and motor rhythms. J Auton Nerv Syst 75: 32-37, 1999. (Pubitemid 29034709)
28. Sawai A, Ohshige K, Yamasue K, Hayashi T, Tochikubo O. Influence of mental stress on cardiovascular function as evaluated by changes in energy expenditure. Hypertens Res 30: 1019-1027, 2007.
29. Sharkey SW, Lesser JR, Zenovich AG, Maron MS, Lindberg J, Longe TF, Maron BJ. Acute and reversible cardiomyopathy provoked by stress in women from the United States. Circulation 111: 472-479, 2005. (Pubitemid 40204432)
30. Shi Y, Gaestel M. In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance. Biol Chem 383: 1519-1536, 2002.
31. Singal PK, Kapur N, Dhillon KS, Beamish RE, Dhalla NS. Role of free radicals in catecholamine-induced cardiomyopathy. Can J Physiol Pharmacol 60: 1390-1397, 1982. (Pubitemid 13209544)
32. Spinale FG, Tempel GE, Mukherjee R, Eble DM, Brown R, Vacchiano CA, Zile MR. Cellular and molecular alterations in the beta adrenergic system with cardiomyopathy induced by tachycardia. Cardiovasc Res 28: 1243-1250, 1994. (Pubitemid 24264733)
33. Stott DH. Follow-up study from birth of the effects of prenatal stress. Dev Med Child Neurol 15: 770-787, 1973.
34. Sugden PH, Clerk A. "Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium. Circ Res 83: 345-352, 1998.
35. Sun H, Xu B, Inoue H, Chen QM. p38 MAPK mediates Cox-2 gene expression by corticosterone in cardiomyocytes. Cell Signal 20: 1952- 1959, 2008.
36. Ueyama T. Emotional stress-induced Tako-tsubo cardiomyopathy: animal model and molecular mechanism. Ann NY Acad Sci 1018: 437-444, 2004. (Pubitemid 38951438)
37. Ueyama T, Senba E, Kasamatsu K, Hano T, Yamamoto K, Nishio I, Tsuruo Y, Yoshida K. Molecular mechanism of emotional stress-induced and catecholamine-induced heart attack. J Cardiovasc Pharmacol 41, Suppl 1: S115-S118, 2003. (Pubitemid 36015045)
38. Ueyama T, Yoshida KI, Senba E. Emotional stress induces immediate-early gene expression in rat heart via activation of α- and β- adrenoceptors. Am J Physiol Heart Circ Physiol 277: H1553-H1561, 1999. (Pubitemid 29522689)
39. Vahebi S, Ota A, Li M, Warren CM, de Tombe PP, Wang Y, Solaro RJ. p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomere tension and ATPase activity. Circ Res 100: 408-415, 2007. (Pubitemid 46272413)
40. Ward AJ. Prenatal stress and child psychopathology. Child Psychiatry Hum Dev 22: 97-110, 1991.
41. Ward HE, Johnson EA, Salm AK, Birkle DL. Effects of prenatal stress on defensive withdrawal behavior and corticotropin releasing factor systems in rat brain. Physiol Behav 70: 359-366, 2000.
42. Weinstock M, Poltyrev T, Schorer-Apelbaum D, Men D, McCarty R. Effect of prenatal stress on plasma corticosterone and catecholamines in response to foot shock in rats. Physiol Behav 64: 439-444, 1998. (Pubitemid 28458838)
43. Weinstock M. Does prenatal stress impair coping and regulation of hypothalamic-pituitary-adrenal axis? Neurosci Biobehav Rev 21: 1-10, 1997.
44. Wittstein IS, Thiermann DR, Lima JAC, Baughman KL, Schulman SP, Gerstenblith G. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 352: 539-548, 2005. (Pubitemid 40204667)
45. Yang M, Wu J, Martin CM, Kvietys PR, Rui T. Important role of p38 MAP kinase/NF-kappaB signaling pathway in the sepsis-induced conversion of cardiac myocytes to a proinflammatory phenotype. Am J Physiol Heart Circ Physiol 294: H994-H1001, 2008.
46. Yu Z, McNeill JH. Altered inotropic responses in diabetic cardiomyopathy and hypertensive-diabetic cardiomyopathy. J Pharmacol Exp Ther 257: 64-71, 1991.
47. Zheng M, Zhang SJ, Zhu WZ, Ziman B, Kobilka BK, Xiao RP. Beta2-adrenergic receptor-induced p38 MAPK activation is mediated by protein kinase A rather than by Gi or Gbetagamma in adult mouse cardiomyocytes. J Biol Chem 275: 40635-40640, 2000. (Pubitemid 32064704)