Folates and antifolates in rheumatoid arthritis

Pteridines

Volumn 24, Issue 1, 2013, Pages 21-26

  Jansen, Gerrit ^a   Weijers, Karin ^a   Blits, Marjolein ^b   Van Der Heijden, Joost ^a   Gent, Yoony ^a   Al, Marjon ^a   Van Der Laken, Conny ^a   Molthoff, Carla ^b   Verweij, Cor ^b   Voskuijl, Alexandre ^a   Lems, Willem ^a   Scheper, Rik ^b   Peters, Godefridus ^b   Ratnam, Manohar ^c   Aassaraf, Yehuda ^d   Dijkmans, Ben ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Antifolates; Folates; Rheumatoid arthritis

Indexed keywords

ABATACEPT; ADALIMUMAB; CYCLOSPORIN A; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; FOLIC ACID; FOLIC ACID ANTAGONIST; HYDROXYCHLOROQUINE; INDOMETACIN; INFLIXIMAB; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RITUXIMAB; SALAZOSULFAPYRIDINE; SULINDAC; TOCILIZUMAB;

CYTOTOXIC T LYMPHOCYTE; DRUG EFFICACY; DRUG MECHANISM; EARLY DIAGNOSIS; HELPER CELL; HUMAN; IMMUNOCOMPETENT CELL; POSITRON EMISSION TOMOGRAPHY; PREDICTION; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; T LYMPHOCYTE; VITAMIN SUPPLEMENTATION;

EID: 84882436012     PISSN: 09334807     EISSN: 21954720     Source Type: Journal    
DOI: 10.1515/pterid-2013-0012     Document Type: Review

References (35)

1. Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet 2010;376:1094-108.
2. McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011;365:2205-19.
3. Hamilton JA, Tak PP. The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases. Arthritis Rheum 2009;60:1210-21.
4. Nielen MM, van Schaardenburg D, Reesink HW, van de Stadt RJ, van der Horst-Bruinsma IE, de Koning MH, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum 2004;50:380-6.
5. Van der Laken CJ, Huisman MH, Voskuyl AE. Nuclear imaging in rheumatic diseases. Best Pract Res Clin Rheum 2012;26:787-804.
6. Turk MJ, Breur GJ, Widmer WR, Paulos CM, Xu LC, Grote LA, et al. Folate-Targeted imaging of activated macrophages in rats with adjuvant-induced arthritis. Arthritis Rheum 2002;46:1947-55.
7. Gent YY, Weijers K, Molthoff CF, Windhorst AD, Huisman MC, Smith DE, et al. Evaluation of the novel folate receptor ligand [ 18 F]fluoro-PEG.-folate for macrophage targeting in a rat model of arthritis. Arthritis Res Ther 2013;15:R37.
8. Kremer JM. Toward a better understanding of methotrexate. Arthritis Rheum 2004;50:1370-82.
9. Cronstein BN. Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis. Pharmacol Rev 2005;57:163-72.
10. Cutolo M, Sulli A, Pizzorni C, Seriolo B, Straub RH. Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis. Ann Rheum Dis 2001;60:729-35.
11. Wessels JA, Huizinga TW, Guchelaar HJ. Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis. Rheumatology 2008;47:249-55.
12. Van der Heijden JW, Dijkmans BA, Scheper RJ, Jansen G. Drug insight: resistance to methotrexate and other diseasemodifying antirheumatic drugs-from bench to bedside. Nat Clin Pract Rheumatol 2007;3:26-34.
13. Dervieux T, Furst D, Lein DO, Capps R, Smith K, Walsh M, et al. Polyglutamylation of methotrexate with common polymorphisms in the reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum 2004;50:2766-74.
14. Wessels JA, van der Kooij SM, le Cessie S, Kievit W, Barerra P, Allaart CF, et al. A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis. Arthritis Rheum 2007;56:1765-75.
15. Stamp LK, O'Donnell JL, Chapman PT, Zhang M, Frampton C, James J, et al. Determinants of red blood cell methotrexate polyglutamate concentrations in rheumatoid arthritis patients receiving long-Term methotrexate treatment. Arthritis Rheum 2009;60:2248-56.
16. Stamp LK, Roberts RL. Effect of genetic polymorphisms in the folate pathway on methotrexate therapy in rheumatic diseases. Pharmacogenomics 2011;12:1449-63.
17. Stamp LK, O'Donnell JL, Chapman PT, Zhang M, James J, Frampton C, et al. Methotrexate polyglutamate concentrations are not associated with disease control in rheumatoid arthritis patients receiving long-Term methotrexate therapy. Arthritis Rheum 2010;62:359-68.
18. Dervieux T, Wessels JA, Kremer JM, Padyukov L, Seddighzadeh M, Saevarsdottir S, et al. Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis. Pharmacogenet Genomics 2012;22:1-9.
19. Blits M, Jansen G, Vosslamber S, Assaraf YG, Verweij CL. Regulation of folate pathway related genes in methotrexate naive and methotrexate-Treated patients with rheumatoid arthritis. Arthritis Rheum 2012;64:S911.
20. Gonen N, Assaraf YG. Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance. Drug Resist Updates 2012;15:183-210.
21. Van der Heijden JW, Oerlemans R, Tak PP, Assaraf YG, Kraan MC, Scheffer GL, et al. Involvement of breast cancer resistance protein expression on rheumatoid arthritis synovial tissue macrophages in resistance to methotrexate and leflunomide. Arthritis Rheum 2009;60:669-77.
22. Van de Ven R, Oerlemans R, van der Heijden JW, Scheffer GL, de Gruijl TD, Jansen G, et al. ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer. J Leukoc Biol 2009;86:1075-87.
23. Walling J. From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates. Invest New Drugs 2006;24:37-77.
24. Van der Heijden JW, Gerards AH, Oerlemans R, Lems WF, Scheper RJ, Aarden LA, et al. Inhibition of TNF.-Alpha production by activated T.-cells of rheumatoid arthritis patients by novel antifolate drugs: an ex vivo pilot study. Ann Rheum Dis 2005;64:417.
25. Nagayoshi R, Nakamura M, Ijiri K, Yoshida H, Komiya S, Matsuyama T. LY309887, antifolate via the folate receptor suppresses murine type II collagen-induced arthritis. Clin Exp Rheumatol 2003;21:719-25.
26. Castaneda O, Nair MG. Controlled trail of methotrexate versus CH.-1504 in the treatment of rheumatoid arthritis. J Rheumatol 2006;33:862-4.
27. Gibbs DD, Theti DS, Wood N, Green M, Raynaud F, Valenti M, et al. BGC 945, a novel tumor selective thymidylate synthase inhibitor targeted to alpha folate receptor-overexpressing tumors. Cancer Res 2005;65:11721-8.
28. Xia W, Hilgenbrink AR, Matteson EL, Lockwood MB, Cheng JX, Low PS. A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages. Blood 2009;113: 438-46.
29. Van der Heijden JW, Oerlemans R, Dijkmans BA, Qi H, van der Laken CJ, Lems WF, et al. Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients. Arthritis Rheum 2009;60:12-21.
30. Khanna D, Park GS, Paulus HE, Simpson KM, Elashoff D, Cohen SB, et al. Reduction of the efficacy of methotrexate by the use of folic acid. Post hoc analysis of two randomized controlled studies. Arthritis Rheum 2005;52:3030-8.
31. Bailey SW, Ayling JE. The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. Proc Natl Acad Sci USA 2009;106:15424-9.
32. Assaraf YG. The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis. Drug Resist Updates 2006;9:227-46.
33. Smith AD, Kim YI, Refsum H. Is folic acid good for everyone? Am J Clin Nutr 2008;87:517-33.
34. Lucock M, Yates Z. Folic acid-vitamin and panacea or genetic time bomb? Nat Rev Genet 2005;6:235-40.
35. Arabelovic S, Sam G, Dallal GE, Jacques PF, Selhub J, Rosenberg IH, et al. Preliminary evidence shows that folic acid fortification of the food supply is associated with hiogher methotrexate dosing in patients with rheumatoid arthritis. J Am Coll Nutr 2007;26:453-5.