Differential binding of L-vs. D-isomers of cationic antimicrobial peptides to the biofilm exopolysaccharide alginate

Protein and Peptide Letters

Volumn 20, Issue 8, 2013, Pages 843-847

  Yin, Lois M ^a   Lee, Soyoung ^a   Mak, Jacky S W ^b   Helmy, Amr S ^b   Deber, Charles M ^a,c  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Alginate; Biofilm; Cationic antimicrobial peptides; Circular dichroism spectroscopy; Peptide exopolysaccharide complexes; Raman spectroscopy

Indexed keywords

ALGINIC ACID; ANTIMICROBIAL CATIONIC PEPTIDE; DEXTRO LYSYLLYSYLLYSYLLYSYLLYSYLLYSYLALANYLLEUCYLPHENYLALANYLALANYLLEUCYLTRYPTOPHYLLEUCYLALANYLPHENYLALANYLLEUCYLALANINAMIDE; LYSYLLYSYLLYSYLLYSYLLYSYLLYSYLALANYLLEUCYLPHENYLALANYLALANYLLEUCYLTRYPTOPHYLLEUCYLALANYLPHENYLALANYLLEUCYLALANINAMIDE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL POLYSACCHARIDE; EXOPOLYSACCHARIDE, PSEUDOMONAS; GLUCURONIC ACID; HEXURONIC ACID; PROTEIN BINDING;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; BETA SHEET; BINDING AFFINITY; BIOFILM; CIRCULAR DICHROISM; COMPLEX FORMATION; CONTROLLED STUDY; DRUG BINDING; DRUG CONFORMATION; ISOMER; MICROENVIRONMENT; NONHUMAN; PROTEIN CONFORMATION; PSEUDOMONAS AERUGINOSA; RAMAN SPECTROMETRY; CHEMISTRY; DRUG EFFECTS; METABOLISM; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; STEREOISOMERISM;

ALGINATES; AMINO ACID SEQUENCE; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BIOFILMS; CIRCULAR DICHROISM; GLUCURONIC ACID; HEXURONIC ACIDS; MOLECULAR SEQUENCE DATA; POLYSACCHARIDES, BACTERIAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PSEUDOMONAS AERUGINOSA; SPECTRUM ANALYSIS, RAMAN; STEREOISOMERISM;

EID: 84882401888     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929866511320080001     Document Type: Article

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