Mapping the protein-binding sites for novel iridium(III) anticancer complexes using electron capture dissociation

Rapid Communications in Mass Spectrometry

Volumn 27, Issue 17, 2013, Pages 2028-2032

  Qi, Yulin ^a   Liu, Zhe ^a   Li, Huilin ^a   Sadler, Peter J ^a   O'Connor, Peter B ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CALMODULIN; CROSSLINKING; DISSOCIATION; IRIDIUM COMPOUNDS; MASS SPECTROMETRY; PLATINUM COMPOUNDS;

COLLISIONALLY ACTIVATED DISSOCIATION; CYCLOPENTADIENYLS; ELECTRON CAPTURE DISSOCIATION; INFRARED MULTIPHOTON DISSOCIATION; ION CYCLOTRONS; PROTEIN-BINDING SITES; TANDEM MASS SPECTROMETRY; TANDEM-MASS SPECTROMETRY; TOPDOWN;

BINDING SITES;

EID: 84882397214     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.6643     Document Type: Article

References (24)

1. D. Wang, S. J. Lippard,. Cellular processing of platinum anticancer drugs. Nat. Rev. Drug Discov. 2005, 4, 307.
2. L. Kelland,. The resurgence of platinum-based cancer chemotherapy. Nat. Rev. Cancer 2007, 7, 573.
3. W. Hu, Q. Luo, K. Wu, X. Li, F. Wang, Y. Chen, X. Ma, J. Wang, J. Liu, S. Xiong, P. J. Sadler,. The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin. Chem. Commun. 2011, 47, 6006.
4. R. Safaei, S. B. Howell,. Copper transporters regulate the cellular pharmacology and sensitivity to Pt drugs. Crit. Rev. Oncol. Hematol. 2005, 53, 13.
5. C. G. Hartinger, Y. O. Tsybin, J. Fuchser, P. J. Dyson,. Characterization of platinum anticancer drug protein-binding sites using a top-down mass spectrometric approach. Inorg. Chem. 2008, 47, 17.
6. E. Meggers,. Exploring biologically relevant chemical space with metal complexes. Curr. Opin. Chem. Biol. 2007, 11, 287.
7. A. F. A. Peacock, A. Habtemariam, S. A. Moggach, A. Prescimone, S. Parsons, P. J. Sadler,. Chloro half-sandwich osmium(II) complexes: Influence of chelated N,N-ligands on hydrolysis, guanine binding, and cytotoxicity. Inorg. Chem. 2007, 46, 4049.
8. C. Scolaro, A. B. Chaplin, C. G. Hartinger, A. Bergamo, M. Cocchietto, B. K. Keppler, G. Sava, P. J. Dyson,. Tuning the hydrophobicity of ruthenium(II)-Arene (RAPTA) drugs to modify uptake, biomolecular interactions and efficacy. Dalton Trans. 2007, 5065.
9. S. J. Lucas, R. M. Lord, R. L. Wilson, R. M. Phillips, V. Sridharan, P. C. McGowan,. Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents. Dalton Trans. 2012, 41, 13800.
10. Z. Liu, A. Habtemariam, A. M. Pizarro, S. A. Fletcher, A. Kisova, O. Vrana, L. Salassa, P. C. A. Bruijnincx, G. J. Clarkson, V. Brabec, P. J. Sadler,. Organometallic half-sandwich iridium anticancer complexes. J. Med. Chem. 2011, 54, 3011.
11. Z. Liu, L. Salassa, A. Habtemariam, A. M. Pizarro, G. J. Clarkson, P. J. Sadler,. Contrasting reactivity and cancer cell cytotoxicity of isoelectronic organometallic iridium(III) complexes. Inorg. Chem. 2011, 50, 5777.
12. Z. Liu, A. Habtemariam, A. M. Pizarro, G. J. Clarkson, P. J. Sadler,. Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N-chelating ligands. Organometallics 2011, 30, 4702.
13. R. Kröning, A. K. Lichtenstein, G. T. Nagami,. Sulfur-containing amino acids decrease cisplatin cytotoxicity and uptake in renal tubule epithelial cell lines. Cancer Chemother. Pharmacol. 2000, 45, 43.
14. A. I. Ivanov, J. Christodoulou, J. A. Parkinson, K. J. Barnham, A. Tucker, J. Woodrow, P. J. Sadler,. Cisplatin binding sites on human albumin. J. Biol. Chem. 1998, 273, 14721.
15. H. Li, Y. Zhao, H. I. A. Phillips, Y. Qi, T.-Y. Lin, P. J. Sadler, P. B. O'Connor,. Mass spectrometry evidence for cisplatin as a protein cross-linking reagent. Anal. Chem. 2011, 83, 5369.
16. K. T. O'Neil, W. F. DeGrado,. How calmodulin binds its targets: sequence independent recognition of amphiphilic α-helices. Trends Biochem. Sci. 1990, 15, 59.
17. P. Caravatti, M. Allemann,. The 'Infinity cell': A new trapped-ion cell with radiofrequency covered trapping electrodes for Fourier transform ion cyclotron resonance mass spectrometry. Org. Mass Spectrom. 1991, 26, 514.
18. Y. Tsybin, J. Quinn, O. Tsybin, C. Hendrickson, A. Marshall,. Electron capture dissociation implementation progress in Fourier transform ion cyclotron resonance mass spectrometry. J. Am. Soc. Mass Spectrom. 2008, 19, 762.
19. H. Li, T.-Y. Lin, S. L. Van Orden, Y. Zhao, M. P. Barrow, A. M. Pizarro, Y. Qi, P. J. Sadler, P. B. O'Connor,. Use of top-down and bottom-up Fourier transform ion cyclotron resonance mass spectrometry for mapping calmodulin sites modified by platinum anticancer drugs. Anal. Chem. 2011, 83, 9507.
20. M. Belov, M. Gorshkov, H. Udseth, R. Smith,. Controlled ion fragmentation in a 2-D quadrupole ion trap for external ion accumulation in ESI FTICR mass spectrometry. J. Am. Soc. Mass Spectrom. 2001, 12, 1312.
21. R. A. Zubarev, D. M. Horn, E. K. Fridriksson, N. L. Kelleher, N. A. Kruger, M. A. Lewis, B. K. Carpenter, F. W. McLafferty,. Electron capture dissociation for structural characterization of multiply charged protein cations. Anal. Chem. 2000, 72, 563.
22. R. A. Zubarev,. Reactions of polypeptide ions with electrons in the gas phase. Mass Spectrom. Rev. 2003, 22, 57.
23. N. L. Kelleher, H. Y. Lin, G. A. Valaskovic, D. J. Aaserud, E. K. Fridriksson, F. W. McLafferty,. Top down versus bottom up protein characterization by tandem high-resolution mass spectrometry. J. Am. Chem. Soc. 1999, 121, 806.
24. H. Li, S. A. Wells, J. E. Jimenez-Roldan, R. A. Römer, Y. Zhao, P. J. Sadler, P. B. O'Connor,. Protein flexibility is key to cisplatin crosslinking in calmodulin. Protein Sci. 2012, 21, 1269.