Nerve growth factor receptor TrkA, a new receptor in insulin signaling pathway in PC12 cells

Journal of Biological Chemistry

Volumn 288, Issue 33, 2013, Pages 23807-23813

  Geetha, Thangiah ^a,b   Rege, Shraddha D ^a   Mathews, Salome E ^a   Meakin, Susan O ^c   White, Morris F ^d   Babu, Jeganathan Ramesh ^a  

^a AUBURN UNIVERSITY   (United States)

^b AUBURN UNIVERSITY AT MONTGOMERY   (United States)

^c ROBARTS RESEARCH INSTITUTE   (Canada)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE UPTAKE; INSULIN RECEPTORS; INSULIN SIGNALING; MOLECULAR COMPLEXES; NERVE GROWTH FACTOR; PC-12 CELLS; TRANSMEMBRANE RECEPTORS;

AMINO ACIDS; NEURONS;

INSULIN;

INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE 7; PROTEIN KINASE B; PROTEIN TYROSINE KINASE A;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

AKT; INSULIN; INSULIN RECEPTOR; IRS-1; NEUROTROPHINS; NGF; PROTEIN-PROTEIN INTERACTIONS; SIGNAL TRANSDUCTION; TRKA;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ENZYME ACTIVATION; GLUCOSE; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 7; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTOR; PC12 CELLS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTOR, INSULIN; RECEPTOR, TRKA; SIGNAL TRANSDUCTION;

EID: 84882374282     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.436279     Document Type: Article

References (36)

1. Barde, Y. A. (1989) Trophic factors and neuronal survival. Neuron 2, 1525-1534
2. Levi-Montalcini, R. (1987) The nerve growth factor 35 years later. Science 237, 1154-1162
3. Chao, M. V. (2000) Trophic factors: An evolutionary cul-de-sac or door into higher neuronal function? J. Neurosci. Res. 59, 353-355
4. Patapoutian, A., and Reichardt, L. F. (2001) Trk receptors: mediators of neurotrophin action. Curr. Opin. Neurobiol. 11, 272-280
5. Friedman, W. J., and Greene, L. A. (1999) Neurotrophin signaling via Trks and p75. Exp. Cell Res. 253, 131-142
6. Kaplan, D. R., and Miller, F. D. (1997) Signal transduction by the neurotrophin receptors. Curr. Opin. Cell Biol. 9, 213-221
7. Meakin, S. O., MacDonald, J. I., Gryz, E. A., Kubu, C. J., and Verdi, J. M. (1999) The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation. J. Biol. Chem. 274, 9861-9870
8. Holgado-Madruga, M., Moscatello, D. K., Emlet, D. R., Dieterich, R., and Wong, A. J. (1997) Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor. Proc. Natl. Acad. Sci. U.S.A. 94, 12419-12424
9. Grimes, M. L., Beattie, E., and Mobley, W. C. (1997) A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA. Proc. Natl. Acad. Sci. U.S.A. 94, 9909-9914
10. Riccio, A., Pierchala, B. A., Ciarallo, C. L., and Ginty, D. D. (1997) An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons. Science 277, 1097-1100
11. Geetha, T., Jiang, J., and Wooten, M. W. (2005) Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling. Mol. Cell 20, 301-312
12. Zhang, Y., Moheban, D. B., Conway, B. R., Bhattacharyya, A., and Segal, R. A. (2000) Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation. J. Neurosci. 20, 5671-5678
13. Geetha, T., and Wooten M. W. (2008) TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent. Traffic 9, 1146-1156
14. Wickelgren, I. (1998) Tracking insulin to the mind. Science 280, 517-519
15. Craft, S., Dagogo-Jack, S. E., Wiethop, B. V., Murphy, C., Nevins, R. T., Fleischman, S., Rice, V., Newcomer, J. W., and Cryer, P. E. (1993) Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: a longitudinal study. Behav. Neurosci. 107, 926-940
16. Craft, S., Newcomer, J., Kanne, S., Dagogo-Jack, S., Cryer, P., Sheline, Y., Luby, J., Dagogo-Jack, A., and Alderson, A. (1996) Memory improvement following induced hyperinsulinemia in Alzheimer's disease. Neurobiol. Aging 17, 123-130
17. Fujisawa, Y., Sasaki, K., and Akiyama, K. (1991) Increased insulin levels after OGTT load in peripheral blood and cerebrospinal fluid of patients with dementia of Alzheimer type. Biol. Psychiatry 30, 1219-1228
18. Hoyer, S., Henneberg, N., Knapp, S., Lannert, H., and Martin, E. (1996) Brain glucose metabolism is controlled by amplification and desensitization of the neuronal insulin receptor. Ann. N.Y. Acad. Sci. 777, 374-379
19. Lee, J., Pilch, P. F., Shoelson, S. E., and Scarlata, S. F. (1997) Conformational changes of the insulin receptor upon insulin binding and activation as monitored by fluorescence spectroscopy. Biochemistry 36, 2701-2708
20. Alessi, D. R., and Downes, C. P. (1998) The role of PI 3-kinase in insulin action. Biochim. Biophys. Acta 1436, 151-164
21. Geetha, T., Zheng, C., Vishwaprakash, N., Broderick, T. L., and Babu, J. R. (2012) Sequestosome 1/p62, a scaffolding protein, is a newly identified partner of IRS-1 protein. J. Biol. Chem. 287, 29672-29678
22. Virkamäki, A., Ueki, K., and Kahn, C. R. (1999) Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J. Clin. Invest. 103, 931-943
23. Valverde, A. M., Mur, C., Pons, S., Alvarez, A. M., White, M. F., Kahn, C. R., and Benito, M. (2001) Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis. Mol. Cell Biol. 21, 2269-2280
24. Uemura, E., and Greenlee, H. W. (2006) Insulin regulates neuronal glucose uptake by promoting translocation of glucose transporter GLUT3. Exp. Neurol. 198, 48-53
25. Watson, R. T., and Pessin, J. E. (2001) Intracellular organization of insulin signaling and GLUT4 translocation. Recent Prog. Horm. Res. 56, 175-193
26. Uemura, E., and Greenlee, H. W. (2001) Amyloid-peptide inhibits neuronal glucose uptake by preventing exocytosis. Exp. Neurol. 170, 270-276
27. Heather West Greenlee, M., Uemura, E., Carpenter, S. L., Doyle, R. T., and Buss, J. E. (2003) Glucose uptake in PC12 cells: GLUT3 vesicle trafficking and fusion as revealed with a novel GLUT3-GFP fusion protein. J. Neurosci. Res. 73, 518-525
28. O'Neill, T. J., Craparo, A., and Gustafson, T. A. (1994) Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system. Mol. Cell Biol. 14, 6433-6442
29. Chen, D., Van Horn, D. J., White, M. F., and Backer, J. M. (1995) Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif. Mol. Cell Biol. 15, 4711-4717
30. He, W., O'Neill, T. J., and Gustafson, T. A. (1995) Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains. J. Biol. Chem. 270, 23258-23262
31. Delahaye, L., Rocchi, S., and Van Obberghen, E. (2000) Potential involvement of FRS2 in insulin signaling. Endocrinology 141, 621-628
32. Sawka-Verhelle, D., Tartare-Deckert, S., White, M. F., and Van Obberghen, E. (1996) Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786. J. Biol. Chem. 271, 5980-5983
33. Lemmon, M. A., and Schlessinger, J. (2010) Cell signaling by receptor tyrosine kinases. Cell 141, 1117-1134
34. Miranda, C., Greco, A., Miele, C., Pierotti, M. A., Van Obberghen, E. (2001) IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1. J. Cell Physiol. 186, 35-46
35. Barbacid, M., Lamballe, F., Pulido, D., and Klein, R. (1991) The trk family of tyrosine protein kinase receptors. Biochim. Biophys. Acta 1072, 115-127
36. Berg, M. M., Sternberg, D. W., Parada, L. F., and Chao, M. V. (1992) K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity. J. Biol. Chem. 267, 13-16