Microsomal prostaglandin e synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression

Gastroenterology

Volumn 140, Issue 7, 2011, Pages 2084-2094

  Lu, Dongdong ^a,b   Han, Chang ^a   Wu, Tong ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TONGJI UNIVERSITY   (China)

Author keywords

Bile Duct; Biliary Tract Cancer; Cancer Cell Signaling; Liver

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; EPIDERMAL GROWTH FACTOR; FORMALDEHYDE; MAMMALIAN TARGET OF RAPAMYCIN; PARAFFIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROSTAGLANDIN E SYNTHASE 1; PROTEIN KINASE B;

5' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE DUCT CARCINOMA; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CARCINOGENESIS; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CHROMOSOME 10; CHROMOSOME DELETION; COLONY FORMATION; CONTROLLED STUDY; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RNA INTERFERENCE; SCID MOUSE; SIGNAL TRANSDUCTION; SUMOYLATION; TUMOR GROWTH;

EID: 79958167345     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.02.056     Document Type: Article

References (42)

1. T. Wu Cyclooxygenase-2 and prostaglandin signaling in cholangiocarcinoma Biochim Biophys Acta 1755 2005 135 150 (Pubitemid 40982563)
2. P.J. Jakobsson, S. Thoren, and R. Morgenstern Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target Proc Natl Acad Sci U S A 96 1999 7220 7225 (Pubitemid 29299642)
3. M. Murakami, and I. Kudo Prostaglandin E synthase: a novel drug target for inflammation and cancer Curr Pharm Des 12 2006 943 954
4. D.W. Nebert, and V. Vasiliou Analysis of the glutathione S-transferase (GST) gene family Hum Genomics 1 2004 460 464
5. I. Kudo, and M. Murakami Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis J Biochem Mol Biol 38 2005 633 638 (Pubitemid 43240966)
6. B. Samuelsson, R. Morgenstern, and P.J. Jakobsson Membrane prostaglandin E synthase-1: a novel therapeutic target Pharmacol Rev 59 2007 207 224 (Pubitemid 47481434)
7. M. Murakami, H. Naraba, and T. Tanioka Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2 J Biol Chem 275 2000 32783 32792
8. Y. Takii, S. Abiru, and H. Fujioka Expression of microsomal prostaglandin E synthase-1 in human hepatocelluar carcinoma Liver Int 27 2007 989 996 (Pubitemid 47261954)
9. Y. Shaib, and H.B. El-Serag The epidemiology of cholangiocarcinoma Semin Liver Dis 24 2004 115 125 (Pubitemid 38738341)
10. G.J. Gores Cholangiocarcinoma: current concepts and insights Hepatology 37 2003 961 969 (Pubitemid 36538671)
11. A.E. Sirica Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy Hepatology 41 2005 5 15 (Pubitemid 40066375)
12. E.P. Berthiaume, and J. Wands The molecular pathogenesis of cholangiocarcinoma Semin Liver Dis 24 2004 127 137 (Pubitemid 38738342)
13. K.N. Lazaridis, and G.J. Gores Cholangiocarcinoma Gastroenterology 128 2005 1655 1667 (Pubitemid 40692558)
14. K. Okuda, Y. Nakanuma, and M. Miyazaki Cholangiocarcinoma: recent progress Part 2: molecular pathology and treatment J Gastroenterol Hepatol 17 2002 1056 1063 (Pubitemid 35013959)
15. K. Endo, B.I. Yoon, and C. Pairojkul ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions Hepatology 36 2002 439 450 (Pubitemid 34810365)
16. N. Hayashi, H. Yamamoto, and N. Hiraoka Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm Hepatology 34 2001 638 650 (Pubitemid 32927986)
17. S. Chariyalertsak, V. Sirikulchayanonta, and D. Mayer Aberrant cyclooxygenase isozyme expression in human intrahepatic cholangiocarcinoma Gut 48 2001 80 86 (Pubitemid 32042646)
18. C. Han, J. Leng, and A.J. Demetris Cyclooxygenase-2 promotes human cholangiocarcinoma growth: evidence for cyclooxygenase-2-independent mechanism in celecoxib-mediated induction of p21waf1/cip1 and p27kip1 and cell cycle arrest Cancer Res 64 2004 1369 1376 (Pubitemid 38235605)
19. T. Wu, J. Leng, and C. Han The cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of Akt and induces apoptosis in human cholangiocarcinoma cells Mol Cancer Ther 3 2004 299 307 (Pubitemid 39193705)
20. T. Wu, C. Han, and J.G. Lunz III Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells Hepatology 36 2002 363 373 (Pubitemid 34810355)
21. U.C. Nzeako, M.E. Guicciardi, and J.H. Yoon COX-2 inhibits Fas-mediated apoptosis in cholangiocarcinoma cells Hepatology 35 2002 552 559 (Pubitemid 34183958)
22. Z. Zhang, G.H. Lai, and A.E. Sirica Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation Hepatology 39 2004 1028 1037 (Pubitemid 38428942)
23. G.H. Lai, Z. Zhang, and A.E. Sirica Celecoxib acts in a cyclooxygenase-2-independent manner and in synergy with emodin to suppress rat cholangiocarcinoma growth in vitro through a mechanism involving enhanced Akt inactivation and increased activation of caspases-9 and -3 Mol Cancer Ther 2 2003 265 271
24. C. Han, and T. Wu Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt J Biol Chem 280 2005 24053 24063 (Pubitemid 40884893)
25. C. Vanchieri Vioxx withdrawal alarms cancer prevention researchers J Natl Cancer Inst 96 2004 1734 1735 (Pubitemid 39654560)
26. J. Couzin Clinical trials Nail-biting time for trials of COX-2 drugs Science 306 2004 1673 1675 (Pubitemid 39601361)
27. T. Grosser, S. Fries, and G.A. FitzGerald Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities J Clin Invest 116 2006 4 15 (Pubitemid 43121782)
28. J.A. Baron, R.S. Sandler, and R.S. Bresalier A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas Gastroenterology 131 2006 1674 1682 (Pubitemid 44958508)
29. I. Sansal, and W.R. Sellers The biology and clinical relevance of the PTEN tumor suppressor pathway J Clin Oncol 22 2004 2954 2963 (Pubitemid 41079915)
30. L. Salmena, A. Carracedo, and P.P. Pandolfi Tenets of PTEN tumor suppression Cell 133 2008 403 414 (Pubitemid 351622014)
31. X. Xu, S. Kobayashi, and W. Qiao Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice J Clin Invest 116 2006 1843 1852 (Pubitemid 44033309)
32. J.A. Engelman, J. Luo, and L.C. Cantley The evolution of phosphatidylinositol 3 kinases as regulators of growth and metabolism Nat Rev Genet 2006 606 619 (Pubitemid 44100518)
33. T. Maehama, and J.E. Dixon The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate J Biol Chem 273 1998 13375 13378 (Pubitemid 28268370)
34. J. Downward Mechanisms and consequences of activation of protein kinase B/Akt Curr Opin Cell Biol 10 1998 262 267 (Pubitemid 28174769)
35. T. Virolle, E.D. Adamson, and V. Baron The Egr-1 transcription factor directly activates PTEN during irradiation-induced signaling Nat Cell Biol 3 2001 1124 1128 (Pubitemid 33130464)
36. R.A. Moorehead, C.V. Hojilla, and I. De Belle Insulin-like growth factor-II regulates PTEN expression in the mammary gland J Biol Chem 278 2003 50422 50427 (Pubitemid 37548886)
37. J. Yu, S.S. Zhang, and K. Saito PTEN regulation by Akt-EGR1-ARF-PTEN axis EMBO J 28 2009 21 33
38. A. Alimonti, A. Carracedo, and J.G. Clohessy Subtle variations in Pten dose determine cancer susceptibility Nat Genet 42 2010 454 458
39. D.A. Guertin, and D.M. Sabatini Defining the role of mTOR in cancer Cancer Cell 12 2007 9 22 (Pubitemid 47001784)
40. J.Y. Chung, S.M. Hong, and B.Y. Choi The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma Clin Cancer Res 15 2009 660 667
41. P. Pineau, A. Marchio, and S. Nagamori Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis Hepatology 37 2003 852 861 (Pubitemid 36397396)
42. F. Meng, R. Henson, and H. Wehbe-Janek MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer Gastroenterology 133 2007 647 658 (Pubitemid 47187346)