Cyclooxygenase-2 expression in chronic liver diseases and hepatocellular carcinoma: An immunohistochemical study

Annals of the New York Academy of Sciences

Volumn 1155, Issue , 2009, Pages 293-299

  Giannitrapani, Lydia ^a   Ingrao, Sabrina ^a   Soresi, Maurizio ^a   Florena, Ada Maria ^a   Spada, Emanuele La ^a   Sandonato, Luigi ^a   D'Alessandro, Natale ^a   Cervello, Melchiorre ^b   Montalto, Giuseppe ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b CNR   (Italy)

Author keywords

Carcinogenesis; Cyclooxygenase (COX); Liver disease

Indexed keywords

CYCLOOXYGENASE 2;

ADULT; AGED; CANCER GRADING; CHRONIC HEPATITIS; CONFERENCE PAPER; CYTOPLASM; ENDEMIC DISEASE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ITALY; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; PROTEIN EXPRESSION; TERTIARY HEALTH CARE; TUMOR DIFFERENTIATION;

EID: 61649088401     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.03698.x     Document Type: Conference Paper

References (23)

1. Montalto, G., M. Cervello, L. Giannitrapani, et al. 2002. Epidemiology, risk factors, and natural history of hepatocellular carcinoma. Ann. N. Y. Acad. Sci. 963 : 13 20.
2. La Vecchia, C., E. Negri & C. Pilucchi. 2002. The rise and fall in primary liver cancer mortality in Italy. Dig. Liver Dis. 34 : 169 171.
3. Colombo, M., R. de Franchis & E. Del Ninno. 1991. Hepatocellular carcinoma in Italian patients with cirrhosis. N. Engl. J. Med. 325 : 675 680.
4. Ascione, A., T. Tartaglione & G. Di Costanzo. 2007. Natural history of chronic hepatitis C virus infection. Dig. Liver Dis. 39 (Suppl 1 S4 7.
5. Fattovich, G. 2003. Natural history and prognosis of hepatitis B. Semin. Liver Dis. 23 : 47 58.
6. Cervello, M. & G. Montalto. 2006. Cyclooxygenases in hepatocellular carcinoma. World J. Gastroenterol. 12 : 5113 5121.
7. Sano, H., Y. Kawahito, R.L. Wilder, et al. 1995. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human colorectal cancer. Cancer Res. 55 : 3785 3789.
8. Brecher, A.R. 2002. The role of cyclooxygenase-2 in the pathogenesis of skin cancer. J. Drugs Dermatol. 1 : 44 47.
9. Hwang, D., D. Scollard, J. Byrne, et al. 1998. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. J. Natl. Cancer Inst. 90 : 455 460.
10. Cervello, M., D. Foderà, A.M. Florena, et al. 2005. Correlation between expression of cyclooxygenase-2 and the presence of inflammatory cells in human primary hepatocellular carcinoma: Possible role in tumor promotion and angiogenesis. World J. Gastroenterol. 11 : 4638 4643.
11. Qiu, D.K., X. Ma, Y.S. Peng & X.Y. Chen. 2002. Significance of cyclooxygenase-2 expression in human primary hepatocellular carcinoma. World J. Gastroenterol. 8 : 815 817.
12. Brunt, E.M., C.G. Janney, A.M. Di Bisceglie, et al. 1999. Nonalcoholic steatohepatitis: A proposal for grading and staging the histological lesions. Am. J. Gastroenterol. 94 : 2467 2474.
13. Scheuer, P.J., P. Ashrafzadeh, S. Sherlock, et al. 1992. The pathology of hepatitis C. Hepatology 15 : 567 571.
14. Bruix, J., M. Scherman, et al. 2001. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL Conference. European Association for the Study of the Liver. J. Hepatol. 35 : 421 430.
15. Sano, H., Y. Kawahito, R.L. Wilder, et al. 1995. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human colorectal cancer. Cancer Res. 55 : 3785 3789.
16. Dimberg, J., A. Samuelsson, A. Hugander, et al. 1999. Differential expression of cyclooxygenase-2 in human colorectal cancer. Gut 45 : 730 732.
17. Lim, H.Y., H.J. Joo, J.H. Choi, et al. 2000. Increased expression of cyclooxygenase 2 protein in human gastric carcinoma. Clin. Canc. Res. 6 : 519 525.
18. Ochiai, M., T. Oguri, T. Isobe, et al. 1999. COX-2 mRNA expression levels in normal lung tissues and non-small cell lung cancer. Jpn. J. Cancer Res. 90 : 1338 1343.
19. Koga, H., S. Sakisaka, M. Ohishi, et al. 1999. Expression of cyclooxygenase-2 in human hepatocellular carcinoma: Relevance to tumor dedifferentiation. Hepatology 29 : 688 689.
20. Rahman, M.A., D.K. Dhar, E. Yamaguchi, et al. 2001. Co-expression of inducible nitric oxide synthase and COX-2 in hepatocellular carcinoma and surrounding liver: Possible involvement of COX-2 in angiogenesis of hepatitis C virus-positive cases. Clin. Cancer Res. 7 : 1325 1332.
21. Foderà, D., N. D'Alessandro, A. Cusimano, et al. 2004. Induction of apoptosis and inhibition of cell growth in human hepatocellular carcinoma cells by COX-2 inhibitors. Ann. N. Y. Acad. Sci. 1028 : 440 449.
22. Lu, L., L. Wei, G. Peng, et al. 2008. NS3 protein of hepatitis C virus regulates cyclooxygenase-2 expression through multiple signaling pathways. Virology 371 : 61 70.
23. Trifan, O.C., R.M. Smith, B.D. Thompson & T. Hla. 1999. Overexpression of cyclooxygenase-2 induces cell cycle arrest. Evidence for a prostaglandin-independent mechanism. J. Biol. Chem. 274 : 34141 34147.